Institute of Integrative Traditional Chinese & Western Medicine, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China Objective: To explore the effects of Houttuynia Cordata...Institute of Integrative Traditional Chinese & Western Medicine, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China Objective: To explore the effects of Houttuynia Cordata Thumb (HCT 鱼腥草 Yu Xing Cao) on expression of transforming growth factor-β1 (TGF-β1) and bone morphogenetic protein-7 (BMP-7) in the renal tissues of diabetic rats. Methods: The diabetic rats induced by intravenous injection of streptozotocin(STZ) were randomly divided into a model group, a HCT group and a lotensin group, with normal rats designated as the controls. 8 weeks later, the ratio of kidney weight to body weight, the glomerular area, the excretion of β2-microglobin (β2-MG) in 24-hr urine, the albumin excretion in 24-hr urine, and creatinine clearance rate (CCR) were investigated. The expression of TGF-β1, BMP-7 and collagenⅠin the renal tissues was observed with the immunohistochemical method and by the semi-quantitative assay. Results: The overgrowth of glomerulus, the excretion of β2-MG in 24-hr urine, the albumin excretion rate in 24-hr urine and CCR in the HCT group significantly reduced (P<0.05), and the expression of TGF-β1 and collagenⅠ significantly decreased (P<0.05), but BMP-7 significantly increased (P<0.05) in the HCT group as compared with those in the model group, with no significant difference as compared with the lotensin group (P>0.05). Conclusion: HCT has a protective effect on the renal tissues in diabetic rats, which is probably correlated with the decrease of the expression of TGF-β1 and collagenⅠand with the increase of the expression of BMP-7 in the renal tissues.展开更多
[Objectives] To study the underground stem tissue structure and agronomic traits of different populations of wild Houttuynia cordata Thumb. [Methods] 8 different populations of wild Houttuynia cordata Thumb. in southe...[Objectives] To study the underground stem tissue structure and agronomic traits of different populations of wild Houttuynia cordata Thumb. [Methods] 8 different populations of wild Houttuynia cordata Thumb. in southern China were selected,the preliminary study was carried out about underground stem tissue structure( stem wall thickness,underground stem cross section diameter,medullary cavity,large vascular bundle area,small vascular bundle area,and number of vascular bundles),and main agronomic traits of aboveground and underground parts. [Results]There were significant differences in the underground stem tissue structure and agronomic traits of some populations of wild Houttuynia cordata Thumb. [Conclusions] From comparison,it reached the conclusion that the populations of wild Houttuynia cordata Thumb. in Kunming of Yunnan,Hechuan of Chongqing,and Nanning of Guangxi showed better underground stem tissue structure and agronomic traits. The results are expected to provide certain guidance for cultivation,reasonable development,and utilization of wild populations of Houttuynia cordata Thumb.展开更多
基金Supported by the grant of National Natural Science Foundation of China(3047225).
文摘Institute of Integrative Traditional Chinese & Western Medicine, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China Objective: To explore the effects of Houttuynia Cordata Thumb (HCT 鱼腥草 Yu Xing Cao) on expression of transforming growth factor-β1 (TGF-β1) and bone morphogenetic protein-7 (BMP-7) in the renal tissues of diabetic rats. Methods: The diabetic rats induced by intravenous injection of streptozotocin(STZ) were randomly divided into a model group, a HCT group and a lotensin group, with normal rats designated as the controls. 8 weeks later, the ratio of kidney weight to body weight, the glomerular area, the excretion of β2-microglobin (β2-MG) in 24-hr urine, the albumin excretion in 24-hr urine, and creatinine clearance rate (CCR) were investigated. The expression of TGF-β1, BMP-7 and collagenⅠin the renal tissues was observed with the immunohistochemical method and by the semi-quantitative assay. Results: The overgrowth of glomerulus, the excretion of β2-MG in 24-hr urine, the albumin excretion rate in 24-hr urine and CCR in the HCT group significantly reduced (P<0.05), and the expression of TGF-β1 and collagenⅠ significantly decreased (P<0.05), but BMP-7 significantly increased (P<0.05) in the HCT group as compared with those in the model group, with no significant difference as compared with the lotensin group (P>0.05). Conclusion: HCT has a protective effect on the renal tissues in diabetic rats, which is probably correlated with the decrease of the expression of TGF-β1 and collagenⅠand with the increase of the expression of BMP-7 in the renal tissues.
基金Supported by Project of Key Discipline Pratacultural Science of Hunan Province during the Twelfth Five-Year Plan Period(540390211002)
文摘[Objectives] To study the underground stem tissue structure and agronomic traits of different populations of wild Houttuynia cordata Thumb. [Methods] 8 different populations of wild Houttuynia cordata Thumb. in southern China were selected,the preliminary study was carried out about underground stem tissue structure( stem wall thickness,underground stem cross section diameter,medullary cavity,large vascular bundle area,small vascular bundle area,and number of vascular bundles),and main agronomic traits of aboveground and underground parts. [Results]There were significant differences in the underground stem tissue structure and agronomic traits of some populations of wild Houttuynia cordata Thumb. [Conclusions] From comparison,it reached the conclusion that the populations of wild Houttuynia cordata Thumb. in Kunming of Yunnan,Hechuan of Chongqing,and Nanning of Guangxi showed better underground stem tissue structure and agronomic traits. The results are expected to provide certain guidance for cultivation,reasonable development,and utilization of wild populations of Houttuynia cordata Thumb.
