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Chemical composition and biological activity of Houttuynia cordata
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作者 Yibo Wang Yunpeng Yang +3 位作者 Xinyao Wang Wenhan Wang Luming Pan Yu Chen 《Asian Journal of Traditional Medicines》 2024年第4期223-234,共12页
Houttuynia cordata is an important traditional Chinese medicine.It is widely used for clearing heat and detoxification,reducing swelling and treating sores,diuresis and dehumidification.It is also used to treat lung c... Houttuynia cordata is an important traditional Chinese medicine.It is widely used for clearing heat and detoxification,reducing swelling and treating sores,diuresis and dehumidification.It is also used to treat lung carbuncles,ulcers,hemorrhoids,rectal bleeding,spleen and stomach heat,which are caused by excess heat,heat toxicity,dampness,and disease heat.Modern pharmacological experiments have shown that H.cordata has antibacterial,antiviral,immune enhancing,diuretic and other effects.This article reviews the chemical components and biological activities of H.cordata to provide reference for clinical application. 展开更多
关键词 houttuynia cordata chemical composition biological activity
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峨眉山不同山峪和海拔高度鱼腥草(Houttuynia cordata Thunb.)居群挥发油成分的变化 被引量:24
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作者 刘雷 吴卫 +2 位作者 郑有良 黄春燕 刘仁健 《生态学报》 CAS CSCD 北大核心 2007年第6期2239-2250,共12页
以分布于峨眉山不同山峪不同海拔(500-1800m)的17个鱼腥草(Houttuynia cordata Thunb.)居群及生长地土样作为试验材料,按土壤农化分析常规方法对土壤pH值及土壤营养元素进行测定,用水蒸馏法提取植株地上部分的挥发油,并用GCMS对... 以分布于峨眉山不同山峪不同海拔(500-1800m)的17个鱼腥草(Houttuynia cordata Thunb.)居群及生长地土样作为试验材料,按土壤农化分析常规方法对土壤pH值及土壤营养元素进行测定,用水蒸馏法提取植株地上部分的挥发油,并用GCMS对挥发油化学成分进行分离和鉴定,峰面积归一法测定各成分含量。结果显示:峨眉山鱼腥草生长地土壤肥力水平较高,对鱼腥草的生长极为有利。从所有居群中共鉴定出35种化合物,各居群挥发油成分组成及含量存在较大的差异。月桂烯作为四个山峪唯一共有的主要成分在各居群中均能检测到,且在各居群中的平均含量最高。乙酸龙脑酯和trans-β-罗勒烯的含量与海拔高度间分别存在显著和极显著正相关。方差分析及多重比较的结果表明,不同山峪以及海拔高度对各居群挥发油成分和含量有显著影响。通过偏相关分析发现土壤微量元素对鱼腥草挥发油共有成分合成与积累的作用大于大量元素,微量元素中以有效钼的影响最为显著,大量元素中以速效钾的影响最为显著。采用逐步多元回归分析筛选出了对挥发油共有成分含量影响显著的土壤营养元素。 展开更多
关键词 鱼腥草 挥发油 居群 海拔 生态因子 土壤养分 气相色谱-质谱法
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Expression of Exogenous Antimicrobial Peptide and Resistance to Stem Rot Disease of Houttuynia cordata Thunb. 被引量:1
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作者 易浪 董燕 +2 位作者 周联 刁玲武 朱丹丹 《Agricultural Science & Technology》 CAS 2011年第3期466-468,共3页
[Objective] This study was to identify the expression of exogenous antimicrobial peptide in transgenic Houttuynia cordata Thunb. plants,and analyze their resistance to stem rot disease. [Methods] SDS-PAGE and Western ... [Objective] This study was to identify the expression of exogenous antimicrobial peptide in transgenic Houttuynia cordata Thunb. plants,and analyze their resistance to stem rot disease. [Methods] SDS-PAGE and Western blot analysis were employed to detect expression of exogenous antimicrobial peptide in transgenic H. cordata plants. Both wild type and transgenic H. cordata plants were inoculated with different concentrations of Rhizoctonia solani spores for detecting their resistance. [Results] The exogenous antimicrobial peptide was detected at translation level. The optimal parameters for detecting the resistance of transgenic H. cordata plants to R. solani was inoculation of spores at a concentration of 3×105 ind./ml and cultured for three days. The results showed that resistance of transgenic H. cordata plants to R. solani was enhanced in comparison with CKs. [Conclusion] Expression of exogenous antimicrobial peptide can enhance the resistance of transgenic H. cordata plants to stem rot disease. 展开更多
关键词 Transgenic houttuynia cordata thunb. Antimicrobial peptide Disease resistance
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Standard Operating Procedure of Houttuynia cordata Thunb.Plastic Greenhouse Cultivation 被引量:1
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作者 钟军 戴林建 《Agricultural Science & Technology》 CAS 2016年第7期1571-1576,共6页
This standard operating procedure stipulated the natural condition of pro- ducing area, cultivation technique, disease and pest control, harvest, quality stan- dard, packaging, transportation and storage of H. cordata... This standard operating procedure stipulated the natural condition of pro- ducing area, cultivation technique, disease and pest control, harvest, quality stan- dard, packaging, transportation and storage of H. cordata, in order to provide a ba- sis for the standard cultivation of H. cordata. 展开更多
关键词 houttuynia cordata l'hunb Plastic Greenhouse Standardization produc- tion Standard Operating Procedure
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Evaluation of antiviral activities of Houttuynia cordata Thunb.extract,quercetin,quercetrin and cinanserin on murine coronavirus and dengue virus infection 被引量:38
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作者 K.H.Chiow M.C.Phoon +2 位作者 Thomas Putti Benny K.H.Tan Vincent T.Chow 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2016年第1期1-7,共7页
Objective:To evaluate the in vitro activities of the ethyl acetate(EA) fraction of Houttuynia cordata(H.cordata) Thunb.(Saururaceae) and three of its constituent flavonoids(quercetin.quercitrin and rutin) against muri... Objective:To evaluate the in vitro activities of the ethyl acetate(EA) fraction of Houttuynia cordata(H.cordata) Thunb.(Saururaceae) and three of its constituent flavonoids(quercetin.quercitrin and rutin) against murine coronavirus and dengue virus(DENV).Methods:The antiviral activities of various concentrations of the EA fraction of H.cordata and flavonoids were assessed using virus neutralization tests against mouse hepatitis virus(MHV) and DENV type 2(DENV-2).Cinanserin hydrochloride was also tested against MHV.The EA fraction of H.cordata was tested for acute oral toxicity in C57BL/6 mice.Results:The EA fraction of H.cordata inhibited viral infectivity up to 6 d.Cinanserin hydrochloride was able to inhibit MHV for only 2 d.The 50%inhibitory concentrations(IC_(50)) of the EA fraction of H.cordata added before the viral adsorption stage were 0.98 μg/mL for MHV and 7.50 μg/mL for DENV-2with absence of cytotoxicity.The mice fed with the EA fraction up to 2 000 mg/kg did not induce any signs of acute toxicity,with normal histological features of major organs.Certain flavonoids exhibited comparatively weaker antiviral activity,notably quercetin which could inhibit both MHV and DENV-2.This was followed by quercitrin which could inhibit DENV-2but not MHV,whereas rutin did not exert any inhibitory effect on either virus.When quercetin was combined with quercitrin,enhancement of anti-DENV-2 activity and reduced cytotoxicity were observed.However,the synergistic efficacy of the flavonoid combination was still less than that of the EA fraction.Conclusions:The compounds in H.cordata contribute to the superior antiviral efficacy of the EA fraction which lacked cytotoxicity in vitro and acute toxicity in vim.H.cordata has much potential for the development of antiviral agents against coronavirus and dengue infections. 展开更多
关键词 houttuynia cordata MURINE CORONAVIRUS DENGUE virus QUERCETIN Quercetrin Cinanserin
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Inhibitory effect of Houttuynia cordata Thunb on LPS-induced retinal microglial activation 被引量:4
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作者 Ying-Hui Zhang Le-Meng Ren Xiao-Yun Wang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2019年第7期1095-1100,共6页
AIM: To identify the effect of Houttuynia cordata Thunb(HCT) on lipopolysaccharide(LPS)-induced microglial activation and investigate its possible molecular mechanisms. METHODS: The primary retinal microglial cells we... AIM: To identify the effect of Houttuynia cordata Thunb(HCT) on lipopolysaccharide(LPS)-induced microglial activation and investigate its possible molecular mechanisms. METHODS: The primary retinal microglial cells were cultured from the retinas of newborn Sprague-Dawley rats and exposed to LPS, and/or HCT with different concentrations. The survival ability of retinal microglia cells was tested by standard MTT method. BrdU cell proliferation assay was used to evaluate the proliferation of retinal microglia. Inflammatory factors in the culture supernatants, including TNF-α, iNOS and IL-1β, were measured using ELISA. Microglia cells’ migration was determined with Transwell migration assay. The total p38-MAPK and phosphorylation of p38-MAPK(p-p38-MAPK) were detected with Western blot.RESULTS: Primary retinal microglia in culture exposed to LPS to induce microglia activation. Pretreatment with HCT significantly inhibited the LPS-induced cell proliferation, but not the cell viability. LPS induced inflammatory reaction in microglia and cell migration. HCT significantly reduced LPS-stimulated release of pro-inflammatory factors and decreased the number of migrating cells substantially in a concentration-dependent manner. Moreover, the protein levels of p-p38 MAPK were identified as the up regulation and co-treatment with HCT obviously inhibited the upregulation of p-p38 MAPK, but had no effect on the levels of total p38-MAPK.CONCLUSION: The data suggest that HCT inhibits LPSinduced retinal microglial activation via suppression of the p-p38-MAPK. HCT may be used for the treatment of ocular diseases characterized by over-activated microglia. 展开更多
关键词 houttuynia cordata thunb MICROGLIA activation RETINA INHIBITORY effect
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Systematic analysis of components and contents in Houttuynia cordata Thunb 被引量:4
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作者 Xin-Yi Dong Yi Jin Li-Ping Yang 《Traditional Medicine Research》 2017年第4期176-188,共13页
Objective:This study aims to provide the material basis for the molecular mechanism of Yuxingcao(Houttuynia cordata Thunb,HCT)through the method of evidence-based study to summarize the natural constituents isolated f... Objective:This study aims to provide the material basis for the molecular mechanism of Yuxingcao(Houttuynia cordata Thunb,HCT)through the method of evidence-based study to summarize the natural constituents isolated from HCT.Methods:We searched CNKI,Wanfang,VIP,Pubmed and relevant conference compilations.The keywords were'Yuxingcao or Houttuynia cordata Thunb'and'components'or'ingredients'or'constituent'or'volatile oil'or'flavonoids'or'terpene'or'content',both in Chinese and English.According to the inclusion and exclusion criteria,the reported compositions and contents have been summarized,and SPSS software was used to draw the boxplot of contents.Results:A total of 603 natural compounds in 11 categories were obtained from pooled articles.In the diverse components,the number of aliphatic compounds(n=259)and terpenoids(n=158)are more than those of flavonoids(n=26),alkaloids(n=42)and aromatics(n=42).While,in the part of volatile oils of HCT,the largest components are aliphatic compounds(mainly distributed on the ground)and terpenoids(mainly distributed in the underground).Although,methyl n-nonylketone is distributed in the whole herb plant,a large proportion is present in the underground parts.As for non-volatiles,the flavonoid content(mainly distributed on the ground)was the highest,among which quercetin and its glycosyl derivatives were the prominent.Conclusion:The results of this study provide a more comprehensive material basis for the further study of HCT.It is also helpful to explain the mechanisms of anti-oxidant,anti-inflammatory,anti-bacterial,anti-viral and anti-cancer effects from the molecular target and molecular network levels. 展开更多
关键词 houttuynia cordata thunb INGREDIENT CONTENT Aliphatics TERPENOIDS FLAVONOIDS
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Macroporous Resin Adsorption for Purification of Flavonoids in Houttuynia cordata Thunb 被引量:34
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作者 张颖 李淑芬 +1 位作者 吴希文 赵星 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2007年第6期872-876,共5页
Flavonoids are one main kind of effective components in Houttuynia cordata Thunb., which display a wide range of pharmacological activity. In this study supercritical fluid extraction (SFE) with carbon dioxide was f... Flavonoids are one main kind of effective components in Houttuynia cordata Thunb., which display a wide range of pharmacological activity. In this study supercritical fluid extraction (SFE) with carbon dioxide was first used as preparat ion step to remove the volatile components, which are also active components, from Hout-tuynia cordata Thunb. Then ultrasound-assisted extraction was used to obtain the crude flavonoids and the macro-porous resin adsorption technology was further employed to purify the flavonoids. Nine kinds of macroporous resins with different properties were tested through static adsorption, and one macroporous resin labeled as D101 was selected. The effect of several factors, such as the ratio of column height to diameter, initial concentration and pH, on both flavonoids yield and content were explored by dynamic adsorption to obtain reasonable conditions of adsorption and desorption. The experimental results show that the content of fiavonoids can be above 60% with fia- vonoids recovery of 93.3 % under the optimum conditions of purification. HPLC analysis of the final flavonoids product shows it contains quercitrin, hypefin, rutin and quercetin. 展开更多
关键词 FLAVONOIDS Itouttuynia cordata thunb. macroporous resin ADSORPTION supercritical fluid extraction
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Effects of frying oil and Houttuynia cordata thunb on xenobiotic-metabolizing enzyme system of rodents 被引量:2
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作者 Ya-YenChen Chiao-MingChen +2 位作者 Pi-YuChao Tsan-JuChang Jen-FangLiu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第3期389-392,共4页
AIM: To evaluate the effects of frying oil and Houttuynia cordata Thunb (H. cordata), a vegetable traditionally consumed in Taiwan, on the xenobiotic-metabolizing enzyme system of rodents. METHODS: Forty-eight Sprague... AIM: To evaluate the effects of frying oil and Houttuynia cordata Thunb (H. cordata), a vegetable traditionally consumed in Taiwan, on the xenobiotic-metabolizing enzyme system of rodents. METHODS: Forty-eight Sprague-Dawley rats were fed with a diet containing 0%, 2% or 5% H. cordata powder and 15% fresh soybean oil or 24-h oxidized frying oil (OFO) for 28 d respectively. The level of microsomal protein, total cytochrome 450 content (CYP450) and enzyme activities including NADPH reductase, ethoxyresorufin 0-deethylase (EROD), pentoxyresorufin 0-dealkylase (PROD), aniline hydroxylase (ANH), aminopyrine demethylase (AMD), and quinone reductase (QR) were determined. QR represented phase Ⅱ enzymes, the rest of the enzymes tested represented phase Ⅰ enzymes. RESULTS: The oxidized frying oil feeding produced a significant increase in phase Ⅰ and Ⅱ enzyme systems, including the content of CYP450 and microsomal protein, and the activities of NADPH reductase, EROD, PROD, ANH, AMD and QR in rats (P<0.05). In addition, the activities of EROD, ANH and AMD decreased and QR increased after feeding with H. cordata in OFO-fed group (P<0.05). The feeding with 2% H. cordata diet showed the most significant effect. CONCLUSION: The OFO diet induces phases I and II enzyme activity, and the 2% H. cordata diet resulted in a better regulation of the xenobiotic-metabolizing enzyme system. 展开更多
关键词 Frying oil houttuynia cordata thunb Xenobiotic metabolizing enzyme system
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<i>Houttuynia cordata</i>Thunb: A Review of Phytochemistry and Pharmacology and Quality Control 被引量:9
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作者 Jiangang Fu Ling Dai +1 位作者 Zhang Lin Hongmei Lu 《Chinese Medicine》 2013年第3期101-123,共23页
Houttuynia cordata Thunb is an important medicinal plant widely distributed in East Asia. The collected information is an attempt to cover recent developments in the pharmacology, phytochemistry and quality control of... Houttuynia cordata Thunb is an important medicinal plant widely distributed in East Asia. The collected information is an attempt to cover recent developments in the pharmacology, phytochemistry and quality control of this species. During the past several decades, the medicinally important phyto-constituents have been identified including essential oil, flavonoids and other polyphenols, fatty acids and alkaloids. A survey of the literatures shows H. cordata possesses a variety of pharmacological activities including antiviral, antitumor, antimicrobial, anti-inflammatory, and antioxidative effects. Little attempt has been done to review the techniques used for its quality control. Future efforts should concentrate more on in vitro, in vivo studies and clinical trials in order to confirm traditional wisdom in the light of a rational phytotherapy. The information summarized here is intended to serve as a reference tool to practitioners in the fields of ethnopharmacology and natural products chemistry. 展开更多
关键词 houttuynia cordata thunb PHYTOCHEMICAL Constituents PHARMACOLOGICAL Activity Quality Control
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Houttuynia cordata Thunb rescues retinal ganglion cells through inhibiting microglia activation in a rat model of retinal ischemia-reperfusion 被引量:1
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作者 Le-Meng Ren Ying-Hui Zhang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2020年第12期1880-1886,共7页
AIM:To determine whether Houttuynia cordata Thunb(HCT)can increase the survival of the retinal ganglion cells(RGCs)and inhibit microglia activation following retinal ischemia-reperfusion(RIR)injury.METHODS:Rat model o... AIM:To determine whether Houttuynia cordata Thunb(HCT)can increase the survival of the retinal ganglion cells(RGCs)and inhibit microglia activation following retinal ischemia-reperfusion(RIR)injury.METHODS:Rat model of RIR was induced by transient elevation of the intraocular pressure(IOP).HCT was orally administered for 2 d before the performance of retinal RIR model and once a day for the next 14 d.After 14 d of RIR injury,the rats were sacrificed for further analysis.Survival RGCs were stained with haematoxylin and eosin(H&E).Apoptosis of RGCs was detected by TUNEL staining.Retinal function was examined by flash-electroretinography(F-ERG).Retinal microglia were labeled using Iba-1,one specific marker for microglia.The m RNA expression levels of inducible nitric oxide synthase(i NOS),tumor necrosis factor alpha(TNF-α),and interleukin 1 beta(IL-1β)were assessed by quantitative real time reverse transcription polymerase chain reaction(q RT-PCR).RESULTS:Systemic HCT treatment significantly reduced RGCs death by H&E staining and exhibited an anti-apoptotic effect as assessed by TUNEL staining at day 14 after RIR injury.HCT greatly improved the retinal function as examined by F-ERG.The number of activated microglia significantly increased after RIR injury,which was significantly attenuated by HCT treatment.Besides,RIR injury induced a strong upregulation of pro-inflammatory genes TNF-α,i NOS and IL-1βm RNAs at day 14 post injury,which was suppressed by HCT.CONCLUSION:Neuroprotective effects of HCT encourage the survival of RGCs through inhibiting microglia activation due to RIR injury.Together these results support the use of HCT as promising therapy for the ischemic events of the retina diseases. 展开更多
关键词 houttuynia cordata thunb retinal ganglion cell microglia activation retinal ischemia-reperfusion
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Phenolics and Antioxidant Activities of Houttuynia cordata Thunb. 被引量:1
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作者 Zhiyuan ZHANG Shiqiong LUO Zhannan YANG 《Medicinal Plant》 CAS 2019年第3期1-7,共7页
[Objectives] To evaluate the phenolic components of Houttuynia cordata Thunb. and their antioxidant activities from different sources. [Methods] Samples of 35 different sources of H. cordata were collected from Guizho... [Objectives] To evaluate the phenolic components of Houttuynia cordata Thunb. and their antioxidant activities from different sources. [Methods] Samples of 35 different sources of H. cordata were collected from Guizhou,and polyphenols,total flavonoids,total chlorogenic acid and 7 kinds of flavonoids( xanthol-3-O-glucoside,hyperoside,quercitrin,rutin,quercetin,kaempferol and isorhamnetin),and DPPH free radical scavenging rate of the extracts were determined. Relationship between the contents of phenolics and the DPPH free radical scavenging rate of the extracts were analyzed by SPSS software. [Results] There were some significant differences in polyphenols,total flavonoids,total chlorogenic acid and the seven flavonoids between samples of different habitats,and the contents of polyphenols,total flavonoids and total chlorogenic acid increased linearly with altitude. There was a significant positive correlation between polyphenols,total flavonoids and total chlorogenic acid content and DPPH free radical scavenging rate of extracts. The contents of kaempferol-3-O-glucoside,hyperoside,quercitrin,rutin,quercetin kaempferol and isorhamnetin were positively correlated with the DPPH free radical scavenging rates of the extracts,except for the significant correlation with quercitrin. [Conclusions]The experimental results suggest that the antioxidant capacity of H. cordata is derived from the total contribution of the phenolic components,indicating that these components have overall equivalence of antioxidant capacities. This provides a new research idea for solving the key problems of quality control of traditional Chinese medicine. 展开更多
关键词 houttuynia cordata thunb. POLYPHENOLS TOTAL FLAVONOIDS TOTAL chlorogenic ACID ANTIOXIDANT activity
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Isolation and Identification of Houttuynia cordata Endophytic Bacteria and Study of Antibiotic Activity
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作者 Kaifeng WANG Shunxin YANG Zhannan YANG 《Medicinal Plant》 CAS 2023年第3期1-4,共4页
[Objectives]To further explore the resources of biocontrol strains and provide new options for the control of pathogenic bacteria.[Methods]Houttuynia cordata endophytic bacteria were isolated and identified,and the an... [Objectives]To further explore the resources of biocontrol strains and provide new options for the control of pathogenic bacteria.[Methods]Houttuynia cordata endophytic bacteria were isolated and identified,and the antibiotic activity was explored.[Results]There are 8 strains(H1-H8)of endophytic bacteria isolated from the healthy plants of H.cordata,which had an antagonistic effect on the pathogenic bacteria.According to the gene sequence,the 8 strains were identified as Stenotrophomonas,Pseudomonas,and Bacillus,which strongly inhibited Colletotrichum(HC1),Fusarium(HC2),and Rhizoctonia(HC5)of H.cordata.On the PDA culture dish,the inhibition diameter of the 8 strains on Colletotrichum,Fusarium,and Rhizoctonia was 6,8,and 5 mm,respectively.[Conclusions]Pathogenic bacteria and endophytic bacteria inoculated with H.cordata seedlings showed that endophytic bacteria have certain antagonistic activity,and have the potential for development and application. 展开更多
关键词 houttuynia cordata Endophytic Bacteria Pathogenic bacteria Antibiotic
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Analysis of Amino Acids in Houttuynia Cordata Thunb. by High Performance Liquid Chromatography-Diode Array Detector (HPLC-DAD)
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作者 Xuan FENG Zhannan YANG +5 位作者 Zhu ZHENG Juan HU Xiaofang WEI Honghao HUO Cheng ZHAO Quling ZHANG 《Medicinal Plant》 CAS 2019年第2期28-34,共7页
[Objectives] The biologically active compounds of Houttuynia cordata Thunb. as a medicinal and edible plant are well documented. However, amino acid as an important indicator of the value of H. cordata is little repor... [Objectives] The biologically active compounds of Houttuynia cordata Thunb. as a medicinal and edible plant are well documented. However, amino acid as an important indicator of the value of H. cordata is little reported. [Methods] Amino acids of the H. cordata were analysed by pre-column derivatization with 2,4-dinitrochlorobenzne(CDNB) coupled to HPLC/DAD. The optimized conditions of the amino acids derivatized by CDNB were followed: 110 ℃ of hydrolysis temperature, 1∶12 of the equivalent proportion between amino acid and CDNB, 80 min of derivatization reaction time and 80 ℃ of derivatization reaction temperature. The method was used to determine the amino acids of H. cordata samples from 11 different geographical sites in Guizhou. [Results] The results suggested that the contents of 17 amino acids were quite variable at different H. cordata samples. [Conclusions] This study will provide a basis for the quality evaluation of H. cordata nutrition. 展开更多
关键词 houttuynia cordata thunb. AMINO acid High performance liquid chromatography MEDICINAL plant
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Responses of Houttuynia cordata Thunb.to Tetracycline Stress
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作者 Yuanshuai WANG Shiqiong LUO +2 位作者 Zhannan YANG Haitao YE Qian DING 《Medicinal Plant》 CAS 2021年第2期35-39,43,共6页
[Objectives]To study responses of Houttuynia cordata Thunb.to tetracycline(TC)stress in a sterile environment.[Methods]Aseptic H.cordata seedlings were cultured in the medium which added the different concentrations o... [Objectives]To study responses of Houttuynia cordata Thunb.to tetracycline(TC)stress in a sterile environment.[Methods]Aseptic H.cordata seedlings were cultured in the medium which added the different concentrations of TC,and then the contents of chlorophyll and malondialdehyde(MDA),and activity of catalase(CAT),peroxidase(POD)and superoxide dismutase(SOD)of H.cordata leaves were measured.[Results]Compared with the CK,the contents of chlorophyll of H.cordata leaves decreased,and the accumulation of MDA,and the activity of CAT,POD and SOD in H.cordata leaves increased when H.cordata was stressed by different concentration of TC.[Conclusions]The growth,metabolism and physiology of H.cordata were affected by the stress of TC.More importantly,this proved an insight into the effect or harm of undegraded antibiotics in the soil and water in the natural environment to plant growth all the time. 展开更多
关键词 houttuynia cordata thunb. TETRACYCLINE MALONDIALDEHYDE Antioxidant enzyme
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Effects of Climate Factors in Greenhouses on the Growth Development and Quality of Houttuynia cordata Thunb.
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作者 Weijun ZENG Xiyao ZENG Jun ZHONG 《Agricultural Biotechnology》 CAS 2022年第6期12-17,31,共7页
[Objectives]This study was conducted to demonstrate whether greenhouse planting can solve the problem of insufficient supply of fresh H.cordata Thunb.in winter and spring.[Methods]The effects of meteorological factors... [Objectives]This study was conducted to demonstrate whether greenhouse planting can solve the problem of insufficient supply of fresh H.cordata Thunb.in winter and spring.[Methods]The effects of meteorological factors on the growth and quality of H.cordata Thunb.were analyzed.[Results]The highest temperature and lowest temperature in greenhouses were 6-12℃and 5-10℃higher than those in the open fields,respectively,and the average temperature difference between the greenhouses and the open fields was large in the early stage,but small in the late stage.The effective accumulated temperature≥10℃was 3463℃in the greenhouses and 2046℃in the open fields.Although the humidity in the open fields was higher than that in the greenhouses,the humidity in the greenhouses was relatively stable and that in the open field changed greatly.The light intensity of the greenhouses was lower than that of the open fields.In terms of the periods from film covering day to seedling emergence,seedling emergence to full emergence,and full emergence to crop closure,greenhouse planting was shortened by 47,11,and 5 d,respectively,compared with open field planting,but the period from crop closure to flowering was extended by 40 d.The plant height of the plants planted in the greenhouses reached 0.1 cm on January 7,while those planted in the open fields did not have seedlings until February 25,and the plant height,daily growth rate,yield and effective components in volatile oil of the plants planted in the greenhouses were significantly higher than those planted in the open fields.The growth,development and quality of H.cordata Thunb.reached the extremely significant or significant level with temperature,but had no significant correlation with humidity and light intensity,indicating that temperature had the greatest impact on the growth,development and quality of H.cordata Thunb.when planted in the greenhouses.[Conclusions]This study provides a theoretical basis for protected cultivation and explores new planting methods for the further development of its industry. 展开更多
关键词 houttuynia cordata thunb. GREENHOUSE Climate factor Growth and development QUALITY
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Effects and safety of Chinese herbals containing Houttuynia cordata Thunb in the treatment of lung cancer:a systematic review
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作者 Li-Ting Yu Wei-Xiu Fan +1 位作者 Li-Ping Yang Ai-Xin Shi 《Asian Toxicology Research》 2019年第1期37-50,共14页
Objective:This study systematically evaluates the efficacy and safety of Houttuynia cordata in the treatment of lung cancer in order to provide clinical data support for better application of Houttuynia cordata.Method... Objective:This study systematically evaluates the efficacy and safety of Houttuynia cordata in the treatment of lung cancer in order to provide clinical data support for better application of Houttuynia cordata.Methods:PubMed,EMbase,Web of Science,ScienceDirect,Scopus,CNKI,WanFang Data,VIP and SinoMed were used to retrieve clinical observations and clinical controlled studies of Houttuynia cordata in the treatment of lung cancer.The retrieval time ranges from database building to January 2019.Two researchers independently screened literature,extracted data and conducted computational analysis.Result:In the clinical observational study,12 literatures of pure Chinese medicine treatment(1473 patients)and 4 literatures of combined Chinese and Western medicine treatment(193 patients)were compared.The total effective rate and total stable rate of combined Chinese and Western medicine treatment for tumour control were better,but the total improvement rate of quality of life of combined Chinese and Western medicine treatment was lower than that of pure Chinese medicine,and the incidence of adverse reactions such as bone marrow suppression and gastrointestinal tract reaction was also higher than that of pure Chinese medicine.Chinese medicine In the clinical control study,8 articles(567 patients)in the treatment group were treated by Chinese medicine and 9 articles in the treatment group(530 patients)were treated by combination of Chinese and Western medicine.Compared with Chinese medicine group,the total effective rate and total stability rate in the control of tumor size were higher in the combination of Chinese and Western medicine;The survival rate of 0.5~2 years was higher,and the total effective rate of body weight gain was slightly higher in the combination of Chinese and Western medicine.At the same time,the incidence of side effects was significantly higher than that of pure Chinese medicine treatment group.In addition,compared with the control group,the incidence of all side effects in the pure Chinese medicine group was lower.Compared with the control group,besides"bleeding","oral reaction"and"skin reaction",the probability interval of side effects in the treatment group was less than that in the control group,and the degree of side effects was also less than that in the chemotherapy group.Conclusion:In the treatment of lung cancer,the use of herbs containing Houttuynia cordata combined with western medicine or radiotherapy and chemotherapy not only has good curative effect,but also reduces toxicity and side effects.Therefore,the combination of herbs with western medicine has unique advantages,which deserves further in-depth research and development. 展开更多
关键词 houttuynia cordata thunb Chinese herbals lung cancer System Review META-ANALYSIS
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Mining potential adverse drug reactions of Houttuynia cordata Thunb from "real world" cases
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作者 Wei-Xiu Fan Li-Ting Yu Li-Ping Yang 《Food Therapy and Health Care》 2019年第3期78-88,共11页
Objective: Search the "real world" case reports of Houttuynia cordata Thunb (HCT)-associated adverse drug reactions (ADRs) to systematically mine potential ADRs of HCT and further investigate whether HCT con... Objective: Search the "real world" case reports of Houttuynia cordata Thunb (HCT)-associated adverse drug reactions (ADRs) to systematically mine potential ADRs of HCT and further investigate whether HCT contained preparations could cause aristolochic acid nephropathy or cancer. Methods: PubMed, EMBASE, Science Direct, Scopus, Web of Science, and CNKI, Wanfang, VIP, Sinomed databases were searched from databases setup to 1st January 2019. All case reports using HCT contained preparations were pooled according to inclusion and exclusion criteria. 15 items in case reportes including basic informations of studies/patients, characters/treaments of ADRs were extracted and analyzed. Results: A total of 346 case reports (441 patients) on the use of different preparations of HCT were finally pooled, among which 89 articles (117 patients) just presented efficacy reports without ADRs and 257 articles (324 patients) on the HCT-related ADRs were further analyzed.① HCT in vivo injections were recorded in 265 articles (338 patients) including 249 ADR reports (315 patients) and 16 efficacy reports (23 patients). As for the ADRs reports, allergic reaction was the major ADRs with different symptoms and onset time. The worst consequences were anaphylactic shock (116/315) and death (11/315), followed by dyspnea (228/315), change of complexion (181/315), heart of abnormality (180/315), chest tightness (147/315), cyanosis (142/315) and so on. The fast onset time was 10 seconds and the most ADRs happened in 30 minutes. Dexamethasone was the mainly medication to treat ADRs.② Oral HCT agents were descripted in 75 articles (94 patients) including 8 ADR reports (9 patients) and 67 efficacy reports (85 patients). Among the 8 ADR reports, 8 patients used Chinese patent medications contained HCT and only 1 patient used HCT decoction. The ADRs almost manifested as skin symptoms, including rubella, macula, rash and urticaria.③ HCT external preparations reported in 6 articles (9 patients), none of those presented any ADRs symptoms.④ No case was found to develop cancer, aristolochic acid nephropathy, interstitial nephritis, renal interstitial fibrosis or renal failure due to HCT preparations. Conclusion: The HCT-related ADRs were mostly caused by its processed preparations, including HCT injections and patent preparation. The oral HCT agents as docoction rearly caused ADRs. There were no reports of aristolochic acid nephropathy or cancer cases caused by HCT. 展开更多
关键词 houttuynia cordata In VIVO INJECTIONS ORAL agents ADVERSE DRUG REACTIONS
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铅、锌及其交互作用对鱼腥草(Houttuynia cordata)叶绿素含量及抗氧化酶系统的影响 被引量:77
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作者 李铮铮 伍钧 +1 位作者 唐亚 杨刚 《生态学报》 CAS CSCD 北大核心 2007年第12期5441-5446,共6页
采用营养液培养方法研究铅、锌及其交互作用对鱼腥草叶绿素含量及抗氧化酶系统的影响。实验结果显示,随着Pb浓度的增加,鱼腥草叶绿素含量逐渐降低但无显著变化。Zn在一定浓度下能提高鱼腥草叶绿素含量,而在高浓度Zn胁迫下,叶绿素含量急... 采用营养液培养方法研究铅、锌及其交互作用对鱼腥草叶绿素含量及抗氧化酶系统的影响。实验结果显示,随着Pb浓度的增加,鱼腥草叶绿素含量逐渐降低但无显著变化。Zn在一定浓度下能提高鱼腥草叶绿素含量,而在高浓度Zn胁迫下,叶绿素含量急剧下降。鱼腥草叶片中SOD、POD和CAT3种酶活性都是随着Pb浓度的增加先上升后下降。随着Zn浓度的增加,SOD和CAT也是先上升后下降,POD则是逐渐上升。Pb-Zn交互作用增加了鱼腥草叶绿素含量,对SOD和POD活性具有抑制作用,对CAT活性影响不明显。同时研究结果还表明,单一Pb、Zn对鱼腥草叶绿素含量和抗氧化酶系统的影响大于Pb、Zn二者的共同作用,其中高浓度Zn对鱼腥草的伤害作用最大,而当溶液Pb处理浓度达到400mg/L时,鱼腥草仍能正常生长,说明鱼腥草具有较强的耐Pb能力。 展开更多
关键词 交互作用 鱼腥草 叶绿素 抗氧化酶
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鱼腥草(Houttuynia cordata)提取物对结肠癌细胞HCT116增殖的抑制作用 被引量:2
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作者 尚姝明 张晓军 +6 位作者 马天宇 张昊 于凤超 齐宏玥 陈泳泽 庄松霖 王尚鹏 《牡丹江师范学院学报(自然科学版)》 2021年第4期36-39,共4页
运用细胞生存活力测定实验(MTT)研究鱼腥草提取物对人结肠癌细胞HCT116生长的抑制情况.采用倒置显微镜观察不同浓度鱼腥草提取物对结肠癌细胞HCT116形态的影响.实验结果表明,鱼腥草提取物对人结肠癌细胞HCT116的生长增殖有明显的抑制作... 运用细胞生存活力测定实验(MTT)研究鱼腥草提取物对人结肠癌细胞HCT116生长的抑制情况.采用倒置显微镜观察不同浓度鱼腥草提取物对结肠癌细胞HCT116形态的影响.实验结果表明,鱼腥草提取物对人结肠癌细胞HCT116的生长增殖有明显的抑制作用,且存在浓度和时间的依赖性.鱼腥草作为天然抗肿瘤化合物的筛选材料具有潜在的价值. 展开更多
关键词 鱼腥草 结肠癌细胞 MTT
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