Objective: To investigate the correlation of serum Hp-specific antibody and anti-HP-CagA antibody with coronary artery lesions in patients with coronary heart disease. Methods: A total of 119 patients with coronary he...Objective: To investigate the correlation of serum Hp-specific antibody and anti-HP-CagA antibody with coronary artery lesions in patients with coronary heart disease. Methods: A total of 119 patients with coronary heart disease were enrolled in coronary heart disease group and 100 healthy subjects were enrolled in normal control group. The differences in serum HP-IgG and anti-HP-CagA-IgG contents as well as lipid metabolism index, platelet function index and inflammatory mediator contents were compared between the two groups, and correlation analysis was used to determine the inner link of serum HP-IgG and anti-HP-CagA-IgG contents with coronary artery lesions in patients with coronary heart disease. Results:Serum HP-IgG and anti-HP-CagA-IgG contents of CHD group were higher than those of control group;peripheral blood lipid metabolism index TC content was higher than that of control group whereas HDL-C and apoA1 contents were lower than those of control group;serum platelet function indexes P-selectin, PAF and PDGF contents were higher than those of control group;serum inflammatory mediators hs-CRP, IL-8, IL-17 and TNF-α contents were higher than those of control group. Pearson correlation analysis showed that serum HP-IgG and anti-HP-CagA-IgG contents in patients with coronary heart disease were closely related to the degree of coronary artery lesions. Conclusion: Serum HP-IgG and anti-HP-CagA-IgG contents were extremely high in patients with coronary heart disease, and the specific contents are closely related to coronary artery lesions.展开更多
文摘Objective: To investigate the correlation of serum Hp-specific antibody and anti-HP-CagA antibody with coronary artery lesions in patients with coronary heart disease. Methods: A total of 119 patients with coronary heart disease were enrolled in coronary heart disease group and 100 healthy subjects were enrolled in normal control group. The differences in serum HP-IgG and anti-HP-CagA-IgG contents as well as lipid metabolism index, platelet function index and inflammatory mediator contents were compared between the two groups, and correlation analysis was used to determine the inner link of serum HP-IgG and anti-HP-CagA-IgG contents with coronary artery lesions in patients with coronary heart disease. Results:Serum HP-IgG and anti-HP-CagA-IgG contents of CHD group were higher than those of control group;peripheral blood lipid metabolism index TC content was higher than that of control group whereas HDL-C and apoA1 contents were lower than those of control group;serum platelet function indexes P-selectin, PAF and PDGF contents were higher than those of control group;serum inflammatory mediators hs-CRP, IL-8, IL-17 and TNF-α contents were higher than those of control group. Pearson correlation analysis showed that serum HP-IgG and anti-HP-CagA-IgG contents in patients with coronary heart disease were closely related to the degree of coronary artery lesions. Conclusion: Serum HP-IgG and anti-HP-CagA-IgG contents were extremely high in patients with coronary heart disease, and the specific contents are closely related to coronary artery lesions.
