Burn victims around the world are forced to a life of long lasting morbidity and high mortality rate. Although physiotherapy and occupational therapy subside the painful side of morbidity after severe skin burns, pati...Burn victims around the world are forced to a life of long lasting morbidity and high mortality rate. Although physiotherapy and occupational therapy subside the painful side of morbidity after severe skin burns, patients are under huge financial pressure in order to return to health. Various treatment plans are used for severe burn injuries. Aloe Vera Gel is introduced recently as an alternative management for burn injuries through betterment of granulation tissue formation and epithelialization. Moreover, numerous studies reported Aloe Vera healing effect on chronic wounds by manipulating collagen layout. This study aims to present the therapeutic impact of Aloe Vera Gel on chronic skin burns of a 17-year-old female who was referred to our department because of rejected skin graft.展开更多
Objective:To formulate Pothos scandens Linn(P.scandens) leaf extract in to a gel and investigate their burn wound healing activity.Methods:Ethanolic extract of dried leaves of P. scandens were subjected to priliminery...Objective:To formulate Pothos scandens Linn(P.scandens) leaf extract in to a gel and investigate their burn wound healing activity.Methods:Ethanolic extract of dried leaves of P. scandens were subjected to priliminery phytochemical evaluation and wound healing activities studies.Different gel formulations of ethanolic extract of P.scandens(4%w/v) were prepared using polymers carbopol 934 and carbopol 940 bv varying their concentration.These formulations were evaluated for physical parameters,drug content.pH,viscosity,extrudability.spreadability. primary skin irritation,pharmacological activity and stability.Results:Wound healing studies of ethanolic extract revealed that P.scandens treated animals were found to epithelise in 22 days while the solvent control and the untreated rats epithelise within 35 and 40 days respectively. The formulation with 1.5%w/w carbopol 934 was found to be more promising as it shows better physicochemical characteristics,higher pharmacological activity and stability compared to other formulations.Conclusions:P.scandens alcoholic extract shows significant improvement in burn wound contraction and hence this is a promising candidate in burn wound healing.展开更多
目的探讨自体富血小板凝胶(APG)结合封闭负压引流(VSD)对深Ⅱ度烧伤患者创面愈合进程及表皮生长因子(EGF)、碱性成纤维细胞生长因子(bFGF)水平的影响。方法选取2018年7月—2021年7月在南通大学附属南通第三医院就诊的82例深Ⅱ度烧伤患...目的探讨自体富血小板凝胶(APG)结合封闭负压引流(VSD)对深Ⅱ度烧伤患者创面愈合进程及表皮生长因子(EGF)、碱性成纤维细胞生长因子(bFGF)水平的影响。方法选取2018年7月—2021年7月在南通大学附属南通第三医院就诊的82例深Ⅱ度烧伤患者作为研究对象,按随机数字表法分为观察组(APG结合VSD治疗)和对照组(VSD治疗),各41例。比较两组患者的疗效、创面愈合时间、肉芽生长面积、创面愈合率、住院时间、并发症,比较两组患者治疗前后的EGF、bFGF、C反应蛋白(CRP)、白细胞介素6(IL-6)、白细胞计数(WBC)、疼痛视觉模拟评分(VAS)的差值及治疗后1个月、2个月的温哥华瘢痕量表(VSS)评分的差值。结果观察组总有效率高于对照组(P<0.05)。观察组创面愈合时间、住院时间少于对照组,肉芽生长面积大于对照组,创面愈合率高于对照组(P<0.05)。观察组治疗前后EGF、bFGF、CRP、IL-6、WBC的差值高于对照组(P<0.05)。观察组治疗前与治疗后14 d VAS评分及治疗后1个月与2个月VSS评分的差值高于对照组(P<0.05)。两组患者并发症总发生率比较,差异无统计学意义(P>0.05)。结论APG结合VSD治疗深Ⅱ度烧伤可加快患者创面愈合进程,提高EGF、bFGF水平,减轻炎症反应和疼痛,减少瘢痕增生,且并发症少。展开更多
It has been introduced several ways for rising fuel burning rate. Using catalyzers is a common way to rising fuel burning rate. Cu-Chromite catalyzer used in solid fuels, as burning rate catalyzer in thermal decomposi...It has been introduced several ways for rising fuel burning rate. Using catalyzers is a common way to rising fuel burning rate. Cu-Chromite catalyzer used in solid fuels, as burning rate catalyzer in thermal decomposition of Ammonium Perchlorate and results were satisfying. This catalyzer is produced by several methods such as: ceramic, coprecipitating, sol-gel, vacuum depositioning, but this paper explains producing catalyzer by Citrate sol-gel. Thermal analysis is used for studying process also SEM, XRD, TEM, FTIR tests used for determination of particle sizes.展开更多
文摘Burn victims around the world are forced to a life of long lasting morbidity and high mortality rate. Although physiotherapy and occupational therapy subside the painful side of morbidity after severe skin burns, patients are under huge financial pressure in order to return to health. Various treatment plans are used for severe burn injuries. Aloe Vera Gel is introduced recently as an alternative management for burn injuries through betterment of granulation tissue formation and epithelialization. Moreover, numerous studies reported Aloe Vera healing effect on chronic wounds by manipulating collagen layout. This study aims to present the therapeutic impact of Aloe Vera Gel on chronic skin burns of a 17-year-old female who was referred to our department because of rejected skin graft.
文摘Objective:To formulate Pothos scandens Linn(P.scandens) leaf extract in to a gel and investigate their burn wound healing activity.Methods:Ethanolic extract of dried leaves of P. scandens were subjected to priliminery phytochemical evaluation and wound healing activities studies.Different gel formulations of ethanolic extract of P.scandens(4%w/v) were prepared using polymers carbopol 934 and carbopol 940 bv varying their concentration.These formulations were evaluated for physical parameters,drug content.pH,viscosity,extrudability.spreadability. primary skin irritation,pharmacological activity and stability.Results:Wound healing studies of ethanolic extract revealed that P.scandens treated animals were found to epithelise in 22 days while the solvent control and the untreated rats epithelise within 35 and 40 days respectively. The formulation with 1.5%w/w carbopol 934 was found to be more promising as it shows better physicochemical characteristics,higher pharmacological activity and stability compared to other formulations.Conclusions:P.scandens alcoholic extract shows significant improvement in burn wound contraction and hence this is a promising candidate in burn wound healing.
文摘目的探讨自体富血小板凝胶(APG)结合封闭负压引流(VSD)对深Ⅱ度烧伤患者创面愈合进程及表皮生长因子(EGF)、碱性成纤维细胞生长因子(bFGF)水平的影响。方法选取2018年7月—2021年7月在南通大学附属南通第三医院就诊的82例深Ⅱ度烧伤患者作为研究对象,按随机数字表法分为观察组(APG结合VSD治疗)和对照组(VSD治疗),各41例。比较两组患者的疗效、创面愈合时间、肉芽生长面积、创面愈合率、住院时间、并发症,比较两组患者治疗前后的EGF、bFGF、C反应蛋白(CRP)、白细胞介素6(IL-6)、白细胞计数(WBC)、疼痛视觉模拟评分(VAS)的差值及治疗后1个月、2个月的温哥华瘢痕量表(VSS)评分的差值。结果观察组总有效率高于对照组(P<0.05)。观察组创面愈合时间、住院时间少于对照组,肉芽生长面积大于对照组,创面愈合率高于对照组(P<0.05)。观察组治疗前后EGF、bFGF、CRP、IL-6、WBC的差值高于对照组(P<0.05)。观察组治疗前与治疗后14 d VAS评分及治疗后1个月与2个月VSS评分的差值高于对照组(P<0.05)。两组患者并发症总发生率比较,差异无统计学意义(P>0.05)。结论APG结合VSD治疗深Ⅱ度烧伤可加快患者创面愈合进程,提高EGF、bFGF水平,减轻炎症反应和疼痛,减少瘢痕增生,且并发症少。
文摘It has been introduced several ways for rising fuel burning rate. Using catalyzers is a common way to rising fuel burning rate. Cu-Chromite catalyzer used in solid fuels, as burning rate catalyzer in thermal decomposition of Ammonium Perchlorate and results were satisfying. This catalyzer is produced by several methods such as: ceramic, coprecipitating, sol-gel, vacuum depositioning, but this paper explains producing catalyzer by Citrate sol-gel. Thermal analysis is used for studying process also SEM, XRD, TEM, FTIR tests used for determination of particle sizes.
