Tilting homeostatic and dyshomeostatic microglial balance in health and disease:transforming growth factor-beta1 as a critical protagonist

Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological thresholds.Mild hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate intake.Severe hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left untreated.Individuals with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

Research on the Classification of Western Literary Criticism Under M. H. Abrams’Fourfold Model

This study explores the application of Abrams’Fourfold Model in the classification of Western literary criticism.Abrams’framework categorizes literary criticism into four fundamental elements:text,author,world,and audience.The text is viewed as an independent entity with intrinsic artistic value,necessitating a detailed analysis of its structure,style,themes,and symbols.Author study delves into the creator’s life and socio-cultural context,often to uncover the work’s deeper meanings.Contextual study situates the work within its historical and social milieu,examining its reflection of or response to societal norms and events.Audience response analysis considers the diverse interpretations shaped by readers’backgrounds,emphasizing the reader’s role in constructing the work’s meaning.The study concludes that Abrams’Fourfold Model offers a comprehensive and flexible analytical tool,enabling critics to engage with literary works from multiple perspectives,thereby enriching the understanding of literary complexity and diversity.

Innovative Teaching Research on Literary Theory and Criticism

As a core compulsory course for English majors majoring in teacher education,Literary Theory and Criticism plays an important role in enhancing text understanding,cultivating critical thinking,and shaping correct values in the future development of students.Influenced by traditional teaching ideas,students have many difficulties when learning this course,such as insufficient theoretical understanding,inadequate ability improvement,and not enough investment in course learning.In response to the above issues,this course focuses closely on the fundamental task of“cultivating virtue and nurturing people”,relying on modern information technology and introducing research methods of digital humanities.This course uses“7C”teaching mode under the“three-level integration”,in which“teaching”and“education”are carried out synchronously,and“teacher”and“student”are developed together,in order to greatly enhance students’learning participation and course satisfaction.

On Ethical Literary Criticism and Game Theory--An Interview with Professor Nie Zhenzhao

In 2014,Huang Kaihong,a professor at School of Foreign Languages and Cultures,Southwest University of Science and Technology,interviewed the Doctoral advisor Professor Nie Zhenzhao during the period of his academic visiting to Central China Normal University.As early as in 2005,Huang Kaihong conducted an interview with Professor Nie Zhenzhao on the topic of the general introduction of ethical literary criticism.So around 11 years later,the second interview mainly covers not only the ethical literary criticism theory,but the game theory and the relationship between them as well.Professor Nie thinks whether the game theory can be applied to literature research is still under discussion.The theory of ethical literary criticism is a kind of methodology based on science and it can get the attention of literary critics at home and abroad,which is because it fits the practical needs of literary criticism,draws the literary criticism away from only emphasizing criticism genres and the research of criticism terms,and pays attention to the true nature of the literary text in literature research.After consulting Professor Nie Zhenzhao about some related questions from the perspective of game theory.Huang Kaihong gets some significant information concerning literature research and understands the latest core terms and the concrete application method of ethical literary criticism,especially the relationship between the instructing and aesthetic functions of literature.

Deep eutectic solvents for separation and purification applications in critical metal metallurgy:Recent advances and perspectives

Solvent extraction,a separation and purification technology,is crucial in critical metal metallurgy.Organic solvents commonly used in solvent extraction exhibit disadvantages,such as high volatility,high toxicity,and flammability,causing a spectrum of hazards to human health and environmental safety.Neoteric solvents have been recognized as potential alternatives to these harmful organic solvents.In the past two decades,several neoteric solvents have been proposed,including ionic liquids(ILs)and deep eutectic solvents(DESs).DESs have gradually become the focus of green solvents owing to several advantages,namely,low toxicity,degradability,and low cost.In this critical review,their classification,formation mechanisms,preparation methods,characterization technologies,and special physicochemical properties based on the most recent advancements in research have been systematically described.Subsequently,the major separation and purification applications of DESs in critical metal metallurgy were comprehensively summarized.Finally,future opportunities and challenges of DESs were explored in the current research area.In conclusion,this review provides valuable insights for improving our overall understanding of DESs,and it holds important potential for expanding separation and purification applications in critical metal metallurgy.

An Analysis of The Widow’s Lament in Springtime in Terms of New Criticism

William Carlos Williams,a poet who has an immense influence on the course of 20th century poetry.whose poems characterized his close attention to nature,friendship and the Chinese Classical Poetry. The Widow’s Lament in Springtime is not only the representative of imitation of Chinese poetry about boudoir repining school but bringing poetry into natural relation with everyday life.

A Primary Study on the New Criticism in Robert Frost's Desert Places

A profound study from the viewpoint of New Criticism, can find that Robert Frost expresses his unique thoughts and attitudes to the world in Desert Places, which is rarely researched and concentrated on, through the distinct characters of New Criticism in tone, paradox, tension. The unpredicted and changeable nature which is depicted in Desert Places represent the author's doubt about the communication among the people in the society, and he loses the confidence for people.

The Criticism of Social Realities in the Human World of The Journey to the West

Given the descriptions of all those unworthy kings in the human world,The Journey to the West is more of a realistic work of fiction than a fantasy.Though the story comprises many superstitious elements,it is told in a very vivid and convincing way and it holds numerous indirect references to the conditions of the author's own day.The book is the author's most forceful means of criticizing the ugly appearances of the ruling classes of his time.

基于CRITIC-加权灰色关联分析的年度洪涝灾情评估模型及应用

洪涝灾情评估能够直观呈现洪涝灾害强度和破坏程度,准确评估洪涝灾情是有针对性开展防洪减灾工作的基础。为充分表征洪涝灾害范围及深度,基于洪涝灾害的主要承灾体,从人口受灾、农作物受灾、房屋倒损、水利防洪设施损坏和经济损失5个洪涝灾害主要影响层面筛选洪涝灾情评估指标,分目标层、因子层、指标层构建全国及各地区年度洪涝灾情评估指标体系;基于年度洪涝灾害等级和年度洪涝灾害综合损失程度评估年度洪涝灾情,通过耦合CRITIC权重法和灰色关联分析模型构建CRITIC-加权灰色关联分析模型进行年度洪涝灾害等级评估,采用灾情指数法进行年度洪涝灾害综合损失程度评估;基于ArcGIS直观呈现空间数据的优势,将各地区年度洪涝灾害等级及综合损失程度采用区划图的形式展现。基于以上方法对2006-2021年全国及各地区进行年度洪涝灾情评估,结果表明:在全国年度洪涝灾情评估结果中,2010年为特大洪涝灾害,2013年和2016年为重大洪涝灾害;在各地区年度洪涝灾情评估结果中,湖南省2006年和2017年、河南省2021年年度洪涝灾害等级达到特大洪涝灾害;历年洪涝灾情较重且灾情频次较高的省份依次是四川省、湖南、湖北、江西、广东、海南;基于CRITIC-加权灰色关联分析模型和灾情指数法的年度洪涝灾情评估结果,可作为地区开展防洪减灾工作的依据。

Criticism on the Critical Approaches in J. Hillis Miller's Fiction and Repetition:Seven English Novels

Fiction and Repetition is and will remain a distinguished deconstructionist guide of literary criticism. However, after detailed and systematic research, I also find some shortcomings in this important academic work: Firstly, written in the metaphysical language, Fiction and Repetition can never succeed in escaping the logocentrism and binary opposition inherent in this language.Secondly, based on Saussure's argument on langue, the monograph's view of indeterminacy of literary work's meaning is theoretically correct but practically inadequate. Last but not the least, Miller's proposal on repetition also has some limitations. By taking into account both the work's merits and demerits, we can gain a more comprehensive outlook on Miller's idea of repetition as well as the deconstruction theory of literary criticism in general.

基于CRITIC-TOPSIS模型的长三角地区物流竞争力研究

本文基于CRITIC-TOPSIS模型法,构建由经济实力、物流需求、物流基础设施、人力资源与信息化水平组成的区域物流竞争力评价指标体系及模型,对2015-2021年长三角地区城市群物流竞争力水平进行测度,并介绍长三角地区27个城市物流竞争力水平的时间与空间格局分布特征。结果表明,长三角地区整体物流竞争力水平在近几年保持增长趋势,但与此同时,长三角区域各城市之间物流竞争力水平存在一定区域差异。最后,基于研究结论,提出可以提升长三角地区物流竞争力的合理建议。

基于CRITIC-VIKOR的空域辐射源威胁目标评估

为占据空域主动权和加快战前决策,建立对空域辐射源的威胁评估刻不容缓。为此,提出基于CRITIC-VIKOR的空域辐射源威胁评估方法。首先,地面的侦察组网侦察空域辐射源威胁目标属性集,利用隶属度函数、层次分析法(Analytic Hierarchy Process,AHP)分别得到辐射源威胁目标的客观动态的定量威胁属性和主观定性分析的固有威胁属性。然后,利用指标相关性的权重确定(Criteria Importance Though Intercrieria Correlation,CRITIC)方法分配动态定量分析指标的属性权重,通过加权对主观固有威胁权重与客观态势属性权重进行主客观融合,同时根据决策者的主观偏好调整主客观属性的权重因子。最后,基于多准则妥协决策(VlseKriterijumska Optimizacija I Kompromisno Resenje,VIKOR)方法进行威胁等级排序。仿真实验结果验证了算法的合理性,所提方法能够弥补主观或客观方法单独分析的不足,具有较好的实用性和战场决策参考价值。

A Study of Archetypal Criticism

Archetypal criticism originates from anthropology, psychology and literary criticism. It is also a new and international attempt for us to discuss about the origin of literature and its development. Archetypal Criticism is an important genre of the Literature Criticism. It has great impact not only on the West Literature Criticism but also on the Chinese Literature. As a means for analyzing literary works, archetypal criticism expands the space of literature analysis. It is also propitious for people to reveal the deep thinking and deep human psychology in literary works. In the field of today's art and literary criticism, archetypal criticism is still of important significance and worth studying.

T.S Eliot——The Representative Figure of New Criticism & Love Song of J.Alfred Prufrock

This article discusses that the development of new criticism is the anti-romantic thrust of Eliot’s thinking. Famously he wrote: "Poetry is not a turning loose of emotion, but an escape from emotion; it is not the expression of personality, but an escape from personality". The Love Song of J.Alfred Prufrock is a poem with a notable modern emotional coloring.The title of the poem is ironic in that the "Love Song" is in fact about the absence of love. It is interesting also for its method of presentation.Eliot’s poetry said more about the moden chaos and their volumes put together.

A New Analysis on the Eco-criticism in The Catcher in the Rye

The Catcher in the Rye can be listed on the top of the world classic literature and won laurels of literary virtuoso for Salinger.In this article the author reexamines this novel from the perspective of eco-criticism and explores into the spiritual ecology reflected in it.

CRITIC-G1组合赋权模型在飞行签派员岗位胜任力评估中的应用研究

飞行签派员是航空公司组织飞行活动的主要负责人,完善其岗位胜任力评价体系有利于提高队伍的整体素质.文章采用CRITIC法与G1法组合赋权的评价模型,在飞行签派员“八大胜任力”基础上建立涵盖飞行签派员岗位胜任力的4个一级指标和21个二级指标的岗位胜任力评估模型.通过对样本飞行签派员岗位胜任力的验证,并结合航空公司运行实际,划分飞行签派员胜任力评价标准,提出航空公司飞行签派员评估与管理培训工作的建议,为改进飞行签派员岗位胜任力提供理论参考依据.

Future of Feminist criticism Research in China

As one indispensable part of the twentieth century western literary criticisms,Feminist Criticism has shown its charming feature and affected the world greatly.This paper briefly introduces the past,present and future of Feminist Criticism in China,showing that the research and application of it will have its bright future.

基于结构CRITIC法的学术期刊评价指标的赋权方法及比较

在复杂、多元的期刊评价过程中经常涉及各评价指标的赋权问题。不同的评价指标赋权方案直接影响期刊评价的结果,因此如何确定指标权重是一个重要问题。文章基于CRITIC法的赋权原理,结合层次分析法,提出了一种全新的主客观赋权法相结合的权重确定方法,即结构CRITIC法。采用2022年《中国学术期刊影响因子年报(自然科学与工程技术)》中17种数学学术期刊的数据,使用包括原始的CRITIC法在内的其他三种赋权方法进行对比分析。结果表明,主观赋权法和客观赋权法赋权结果的差异性影响了评价结果的公认性;赋权方法的选择应当考虑其适用性;结构CRITIC法是在期刊评价中更能从主观和客观两个方面反映指标权重的计算方法。结构CRITIC法为学术期刊评价提供了一种新的赋权方法。

The Criticism of Social Realities in the Three Worlds after the Human World of The Journey to the West

The three worlds after the human world in The Journey to the West, in spite of their religious elements, their implicit moralizing, and their involved allegory, hold up a mirror to the social vices of the author's day, showing on the one hand the corruption, injustice, ava rice, lust, faction, perfidiousness and cruelty among the ruling classes, and on the other hand the miseries of the oppressed.