This paper studies the exciton-longitudinal-optical-phonon coupling in InGaN/GaN single quantum wells with various cap layer thicknesses by low temperature photoluminescence （PL） measurements. With increasing cap la...This paper studies the exciton-longitudinal-optical-phonon coupling in InGaN/GaN single quantum wells with various cap layer thicknesses by low temperature photoluminescence （PL） measurements. With increasing cap layer thickness, the PL peak energy shifts to lower energy and the coupling strength between the exciton and longitudinal- optical （LO） phonon, described by Huang-Rhys factor, increases remarkably due to an enhancement of the internal electric field. With increasing excitation intensity, the zero-phonon peak shows a blueshift and the Huang-Rhys factor decreases. These results reveal that there is a large built-in electric field in the well layer and the exciton-LO-phonon coupling is strongly affected by the thickness of the cap layer.展开更多
目的观察复方黄甘对5/6肾切除慢性肾衰模型大鼠的疗效,并探讨其可能的作用机制。方法用HPLC检测复方黄甘提取物组分并定量;构建5/6肾切除大鼠慢性肾衰模型,将模型大鼠随机分为尿毒清组、科素亚组、复方黄甘低、中、高剂量组和模型组,另...目的观察复方黄甘对5/6肾切除慢性肾衰模型大鼠的疗效,并探讨其可能的作用机制。方法用HPLC检测复方黄甘提取物组分并定量;构建5/6肾切除大鼠慢性肾衰模型,将模型大鼠随机分为尿毒清组、科素亚组、复方黄甘低、中、高剂量组和模型组,另加假手术组共7组,每组10只大鼠,经灌胃给药12周后用全自动生化分析仪检测Scr、BUN、Ucr及24 h UPr;对残余肾组织进行HE和Masson染色观察病理变化;用RT-PCR和免疫组化检测肾组织FN、MCP-1、ICAM-1的表达。结果复方黄甘提取物中主要成分及其含量为:甘草苷(0.06%)、丹皮酚(1.06%)、芦荟大黄素(0.1%)、大黄酸(0.47%)、大黄素(0.19%)、大黄酚(0.41%)和大黄素甲醚(0.13%);复方黄甘低、中、高剂量组Scr、BUN、Ucr、Ccr及24h UPr都显著低于模型组(P<0.05);复方黄甘给药组肾小球硬化和肾间质纤维化改善较为明显,且肾组织中FN、ICAM-1 mRNA表达和蛋白表达均显著低于模型组(P<0.05)。结论复方黄甘可改善慢性肾衰模型大鼠肾功能,减轻肾小球硬化和肾间质纤维化,在一定程度上延缓慢性肾功能衰竭的进展。展开更多
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 60876007 and 10974165)the Research Program of Xiamen Municipal Science and Technology Bureau,China (Grant No. 2006AA03Z110)
文摘This paper studies the exciton-longitudinal-optical-phonon coupling in InGaN/GaN single quantum wells with various cap layer thicknesses by low temperature photoluminescence （PL） measurements. With increasing cap layer thickness, the PL peak energy shifts to lower energy and the coupling strength between the exciton and longitudinal- optical （LO） phonon, described by Huang-Rhys factor, increases remarkably due to an enhancement of the internal electric field. With increasing excitation intensity, the zero-phonon peak shows a blueshift and the Huang-Rhys factor decreases. These results reveal that there is a large built-in electric field in the well layer and the exciton-LO-phonon coupling is strongly affected by the thickness of the cap layer.
文摘目的观察复方黄甘对5/6肾切除慢性肾衰模型大鼠的疗效,并探讨其可能的作用机制。方法用HPLC检测复方黄甘提取物组分并定量;构建5/6肾切除大鼠慢性肾衰模型,将模型大鼠随机分为尿毒清组、科素亚组、复方黄甘低、中、高剂量组和模型组,另加假手术组共7组,每组10只大鼠,经灌胃给药12周后用全自动生化分析仪检测Scr、BUN、Ucr及24 h UPr;对残余肾组织进行HE和Masson染色观察病理变化;用RT-PCR和免疫组化检测肾组织FN、MCP-1、ICAM-1的表达。结果复方黄甘提取物中主要成分及其含量为:甘草苷(0.06%)、丹皮酚(1.06%)、芦荟大黄素(0.1%)、大黄酸(0.47%)、大黄素(0.19%)、大黄酚(0.41%)和大黄素甲醚(0.13%);复方黄甘低、中、高剂量组Scr、BUN、Ucr、Ccr及24h UPr都显著低于模型组(P<0.05);复方黄甘给药组肾小球硬化和肾间质纤维化改善较为明显,且肾组织中FN、ICAM-1 mRNA表达和蛋白表达均显著低于模型组(P<0.05)。结论复方黄甘可改善慢性肾衰模型大鼠肾功能,减轻肾小球硬化和肾间质纤维化,在一定程度上延缓慢性肾功能衰竭的进展。
