Background:According to traditional Chinese medicine(TCM),drugs supplementing the vital energy,Qi,can eliminate tumors by restoring host immunity.The objective of this study is to investigate the underlying immune mec...Background:According to traditional Chinese medicine(TCM),drugs supplementing the vital energy,Qi,can eliminate tumors by restoring host immunity.The objective of this study is to investigate the underlying immune mechanisms of anti-tumor activity associated with Qi-supplementing herbs,specifically the paired use of Huangqi and Danggui.Methods:Analysis of compatibility regularity was conducted to screen the combination of Qi-supplementing TCMs.Using the MTT assay and a transplanted tumor mice model,the anti-tumor effects of combination TCMs were investigated in vitro and in vivo.High content analysis and flow cytometry were then used to evaluate cellular immunity,followed by network pharmacology and molecular docking to dissect the significant active compounds and potential mechanisms.Finally,the anti-tumor activity and the mechanism of the active ingredients were verified by molecular experiments.Results:There is an optimal combination of Huangqi and Danggui that,administered as an aqueous extract,can activate immunity to suppress tumor and is more effective than each drug on its own in vitro and in vivo.Based on network pharmacology analysis,PIK3R1 is the core target for the anti-tumor immunity activity of combined Huangqi and Danggui.Molecular docking analysis shows 6 components of the combined Danggui and Huangqi extract(quercetin,jaranol,isorhamnetin,kaempferol,calycosin,and suchilactone)that bind to PIK3R1.Jaranol is the most important component against breast cancer.The suchilactone/jaranol combination and,especially,the suchilactone/kaempferol combination are key for immunity enhancement and the anti-tumor effects of the extract.Conclusions:The combination of Huangqi and Danggui can activate immunity to suppress breast cancer and is more effective than the individual drugs alone.展开更多
Built in 1252 during the Southern Song Dynasty(1127-1279),Nanxun boasts a rich cultural legacy that has accumulated throughout 700 years.THE ancient town of Nanxun is located in Nanxun District of Huzhou City,east Ch...Built in 1252 during the Southern Song Dynasty(1127-1279),Nanxun boasts a rich cultural legacy that has accumulated throughout 700 years.THE ancient town of Nanxun is located in Nanxun District of Huzhou City,east China’s Zhejiang Province,nestled in the prosperous heart of the Yangtze River Delta region.展开更多
Nanyang,a city with a long history,offers many kinds of delicious food.Xinye board noodles stand out as a remarkable(显著的)one.With unique taste and local features,they have become a significant(重要的)symbol of Nany...Nanyang,a city with a long history,offers many kinds of delicious food.Xinye board noodles stand out as a remarkable(显著的)one.With unique taste and local features,they have become a significant(重要的)symbol of Nanyang cuisine.展开更多
Nanyang pyrography is a special art from Nanyang that is important in the art world.It has a unique way of showing things with good skills.This art shows the deep culture and beauty of Nanyang and is a famous symbol o...Nanyang pyrography is a special art from Nanyang that is important in the art world.It has a unique way of showing things with good skills.This art shows the deep culture and beauty of Nanyang and is a famous symbol of its culture.展开更多
Objective:To explore the efficacy of auricular acupoint pressure patch combined with modified Huangqi Decoction in treating diabetic nephropathy.Methods:60 patients with diabetic nephropathy treated in our hospital fr...Objective:To explore the efficacy of auricular acupoint pressure patch combined with modified Huangqi Decoction in treating diabetic nephropathy.Methods:60 patients with diabetic nephropathy treated in our hospital from January 2021 to December 2022 were selected for this study.The patients were randomly divided into two groups using the random number table method,with 30 patients in each group.Among them,the control group was treated with conventional Western medicine,while the experimental group was treated with auricular acupoint pressure patches combined with modified Huangqi Decoction.The patients’fasting blood glucose(FPG),2-hour postprandial blood glucose(2hPG),glycated hemoglobin(HbA1c),urinary protein quantification,urea nitrogen(BUN),serum creatinine(SCr),and other indicators were detected and recorded before and after treatment.Results:Before treatment,there was no statistically significant difference in the FPG,the 2hPG,and the HbA1c between the two groups of patients(P>0.05);after treatment,the FPG,the 2hPG,and the HbA1c of the patients in the experimental group were significantly lower than those in the control group(P<0.05).Before treatment,there was no statistically significant difference in the urinary protein quantification,the BUN,and the SCr between the two groups of patients(P>0.05);after treatment,the urinary protein quantification,BUN,and SCr of the patients in the experimental group were significantly lower than those in the control group(P<0.05).The experimental group showed better improvement in symptoms such as fatigue,backache,and frequency of nocturia(P<0.05).Conclusion:Auricular acupoint pressure patch combined with modified Huangqi Decoction effectively treats diabetic nephropathy and it helps control blood sugar and renal function indicators and improve clinical symptoms,therefore improving the patients’quality of life.展开更多
By using GIS, RS and landscape ecology, LandsatTM (1993 and 2009) and ETM (2001) remote sensing images of Licheng District of Ji’nan City, Shandong Province were interpreted, and dynamic changes of landscape pattern ...By using GIS, RS and landscape ecology, LandsatTM (1993 and 2009) and ETM (2001) remote sensing images of Licheng District of Ji’nan City, Shandong Province were interpreted, and dynamic changes of landscape pattern in the district were analyzed at the levels of class and landscape. The results showed that during the 16 years the landscape pattern in the district had changed significantly. (a) From the perspective of patch category, areas of arable land, woodland and grassland decreased unceasingly, and arable land accounted for the largest reduction from 488.15 km 2 in 1993 down to 324.37 km 2 in 2009, witnessing a reduction rate of 33.56%. But the patch quantity and fragmentation increased, patch connectivity reduced. Spatial pattern of construction land expanded and its area witnessed a significant increase of 147.05%. Patch cohesion index increased and connectivity grew better. (b) From the perspective of overall landscape, patch quantity, contagion and perimeter-area fractal dimension decreased, patch shape became simple, the Shannon’s diversity index, Shannon’s evenness index and splitting index increased, landscape heterogeneity rose. With the rapid social and economic development, landscape pattern will be more and more influenced by human behaviors展开更多
基金Natural Science Foundation of Shanxi Province for Youths,Grant/Award Number:20210302123310 and 20210302124668Science and technology innovation ability cultivation program project of Shanxi University of Chinese Medicine,Grant/Award Number:2022PY-TH-17The immune regulation Chinese medicine research and development innovation team project,Grant/Award Number:2022TD1017。
文摘Background:According to traditional Chinese medicine(TCM),drugs supplementing the vital energy,Qi,can eliminate tumors by restoring host immunity.The objective of this study is to investigate the underlying immune mechanisms of anti-tumor activity associated with Qi-supplementing herbs,specifically the paired use of Huangqi and Danggui.Methods:Analysis of compatibility regularity was conducted to screen the combination of Qi-supplementing TCMs.Using the MTT assay and a transplanted tumor mice model,the anti-tumor effects of combination TCMs were investigated in vitro and in vivo.High content analysis and flow cytometry were then used to evaluate cellular immunity,followed by network pharmacology and molecular docking to dissect the significant active compounds and potential mechanisms.Finally,the anti-tumor activity and the mechanism of the active ingredients were verified by molecular experiments.Results:There is an optimal combination of Huangqi and Danggui that,administered as an aqueous extract,can activate immunity to suppress tumor and is more effective than each drug on its own in vitro and in vivo.Based on network pharmacology analysis,PIK3R1 is the core target for the anti-tumor immunity activity of combined Huangqi and Danggui.Molecular docking analysis shows 6 components of the combined Danggui and Huangqi extract(quercetin,jaranol,isorhamnetin,kaempferol,calycosin,and suchilactone)that bind to PIK3R1.Jaranol is the most important component against breast cancer.The suchilactone/jaranol combination and,especially,the suchilactone/kaempferol combination are key for immunity enhancement and the anti-tumor effects of the extract.Conclusions:The combination of Huangqi and Danggui can activate immunity to suppress breast cancer and is more effective than the individual drugs alone.
文摘Built in 1252 during the Southern Song Dynasty(1127-1279),Nanxun boasts a rich cultural legacy that has accumulated throughout 700 years.THE ancient town of Nanxun is located in Nanxun District of Huzhou City,east China’s Zhejiang Province,nestled in the prosperous heart of the Yangtze River Delta region.
文摘Nanyang,a city with a long history,offers many kinds of delicious food.Xinye board noodles stand out as a remarkable(显著的)one.With unique taste and local features,they have become a significant(重要的)symbol of Nanyang cuisine.
文摘Nanyang pyrography is a special art from Nanyang that is important in the art world.It has a unique way of showing things with good skills.This art shows the deep culture and beauty of Nanyang and is a famous symbol of its culture.
文摘Objective:To explore the efficacy of auricular acupoint pressure patch combined with modified Huangqi Decoction in treating diabetic nephropathy.Methods:60 patients with diabetic nephropathy treated in our hospital from January 2021 to December 2022 were selected for this study.The patients were randomly divided into two groups using the random number table method,with 30 patients in each group.Among them,the control group was treated with conventional Western medicine,while the experimental group was treated with auricular acupoint pressure patches combined with modified Huangqi Decoction.The patients’fasting blood glucose(FPG),2-hour postprandial blood glucose(2hPG),glycated hemoglobin(HbA1c),urinary protein quantification,urea nitrogen(BUN),serum creatinine(SCr),and other indicators were detected and recorded before and after treatment.Results:Before treatment,there was no statistically significant difference in the FPG,the 2hPG,and the HbA1c between the two groups of patients(P>0.05);after treatment,the FPG,the 2hPG,and the HbA1c of the patients in the experimental group were significantly lower than those in the control group(P<0.05).Before treatment,there was no statistically significant difference in the urinary protein quantification,the BUN,and the SCr between the two groups of patients(P>0.05);after treatment,the urinary protein quantification,BUN,and SCr of the patients in the experimental group were significantly lower than those in the control group(P<0.05).The experimental group showed better improvement in symptoms such as fatigue,backache,and frequency of nocturia(P<0.05).Conclusion:Auricular acupoint pressure patch combined with modified Huangqi Decoction effectively treats diabetic nephropathy and it helps control blood sugar and renal function indicators and improve clinical symptoms,therefore improving the patients’quality of life.
文摘By using GIS, RS and landscape ecology, LandsatTM (1993 and 2009) and ETM (2001) remote sensing images of Licheng District of Ji’nan City, Shandong Province were interpreted, and dynamic changes of landscape pattern in the district were analyzed at the levels of class and landscape. The results showed that during the 16 years the landscape pattern in the district had changed significantly. (a) From the perspective of patch category, areas of arable land, woodland and grassland decreased unceasingly, and arable land accounted for the largest reduction from 488.15 km 2 in 1993 down to 324.37 km 2 in 2009, witnessing a reduction rate of 33.56%. But the patch quantity and fragmentation increased, patch connectivity reduced. Spatial pattern of construction land expanded and its area witnessed a significant increase of 147.05%. Patch cohesion index increased and connectivity grew better. (b) From the perspective of overall landscape, patch quantity, contagion and perimeter-area fractal dimension decreased, patch shape became simple, the Shannon’s diversity index, Shannon’s evenness index and splitting index increased, landscape heterogeneity rose. With the rapid social and economic development, landscape pattern will be more and more influenced by human behaviors
