In order to improve the performance of the antenna at low frequency,short circuit branch and coupling feed structure are introduced into the folded broadband single antenna in this paper,then resonant frequency is mer...In order to improve the performance of the antenna at low frequency,short circuit branch and coupling feed structure are introduced into the folded broadband single antenna in this paper,then resonant frequency is merged into the antenna using method of stagger tuning,finally,a UWB antenna is designed to w ork betw een 800 MHz ~ 2700 MHz. Analysis are conducted to determine the antenna's properties. The short-circuit w ire location,feeding point location and the length of folded strip are discussed in detail. The SAR is calculated by HFSS simulation softw are w hile the antenna is close to a 3D human head model. The research results show that the antenna can cover eight commonly used commercial frequency bands at present,and electromagnetic radiation of the antenna has tiny influence on the human head model.展开更多
To cope with the problem of tracking a human head in a complicated scene,we propose a method that adopts human skin color and hair color integrated with a kind of particle filter named condensation algorithm.Firstly,a...To cope with the problem of tracking a human head in a complicated scene,we propose a method that adopts human skin color and hair color integrated with a kind of particle filter named condensation algorithm.Firstly,a novel method is presented to set up human head color model using skin color and hair color separately based on region growing.Compared with traditional human face model,this method is more precise and works well when human turns around and the face disappears in the image.Then a novel method is presented to use color model in condensation algorithm more effectively.In this method,a combination of edge detection result,color segmentation result and color edge detection result in an Omega window is used to measure the scale and position of human head in condensation.Experiments show that this approach can track human head in complicated scene even when human turns around or the distance of tracking a human head changes quickly.展开更多
In this paper we present the Projection Based Interpolation (PBI) technique for construction of continuous approximation of MRI scan data of the human head. We utilize the result of the PBI algorithm to perform three ...In this paper we present the Projection Based Interpolation (PBI) technique for construction of continuous approximation of MRI scan data of the human head. We utilize the result of the PBI algorithm to perform three dimensional (3D) Finite Element Method (FEM) simulations of the acoustics of the human head. The computational problem is a multi-physics problem modeled as acoustics coupled with linear elasticity. The computational grid contains tetrahedral finite elements with the number of equations and polynomial orders of approximation varying locally on finite element edges, faces, and interiors. We utilize our own out-of-core parallel direct solver for the solution of this multi-physics problem. The solver minimizes the memory usage by dumping out all local systems from all nodes of the entire elimination tree during the elimination phase.展开更多
In this paper, we present the Projection Based Interpolation (PBI) technique for construction of continuous approximation of MRI scan data of the human head. We utilize the result of the PBI algorithm to perform three...In this paper, we present the Projection Based Interpolation (PBI) technique for construction of continuous approximation of MRI scan data of the human head. We utilize the result of the PBI algorithm to perform three-dimensional (3D) Finite Element Method (FEM) simulations of the heating of the human head induced by cell phone. In particular, we utilize the Pennes equation to describe the bioheat transfer with the right hand side representing the heat generated by cell phone. We utilize our own non-stationary time dependent multi-thread parallel direct solver for the solution of this computational problem. From our numerical results it follows that 15 minutes (1000 seconds) exposure to the cell phone radiation implies up to 2 degrees Celsius increase of the temperature of the brain in the range close to the cell phone.展开更多
Head and neck cancer(HNC) arises from the skull base to the clavicles and is the fifth most common cancer in the world by incidence. Historically, in the developed world HNC was associated with tobacco use and alcohol...Head and neck cancer(HNC) arises from the skull base to the clavicles and is the fifth most common cancer in the world by incidence. Historically, in the developed world HNC was associated with tobacco use and alcohol consumption, and the combination of the two produced a synergistic increase in risk. However, beginning in 1983, investigators have found a significant and growing proportion of HNC patients with human papillomavirus-positive(HPV) tumors who neither drank nor used tobacco. Since that time, there has been increased interest in the molecular biology of HPV-positive HNC. Multiple studies now show that HPV has shifted the epidemiological landscape and prognosis of head and neck squamous cell carcinoma(HNSCC). These studies provide strong evidence for improved survival outcomes in patients with HPV-positive HNSCC compared to those with HPV-negative HNSCC. In many reports, HPV status is the strongest predictor of locoregional control, disease specific survival and overall survival. In response to these findings, there has been significant interest in the best management of HPV-positive disease. Discussions within major cooperative groups consider new trials designed to maintain the current strong survival outcomes while reducing the long-term treatment-re-lated toxicities. This review will highlight the epidemiological, clinical and molecular discoveries surrounding HPV-related HNSCC over the recent decades and we conclude by suggesting how these findings may guide future treatment approaches.展开更多
Lots of progress has been made recently on 2 D human pose tracking with tracking-by-detection approaches. However,several challenges still remain in this area which is due to self-occlusions and the confusion between ...Lots of progress has been made recently on 2 D human pose tracking with tracking-by-detection approaches. However,several challenges still remain in this area which is due to self-occlusions and the confusion between the left and right limbs during tracking. In this work,a head orientation detection step is introduced into the tracking framework to serve as a complementary tool to assist human pose estimation. With the face orientation determined,the system can decide whether the left or right side of the human body is exactly visible and infer the state of the symmetric counterpart. By granting a higher priority for the completely visible side,the system can avoid double counting to a great extent when inferring body poses. The proposed framework is evaluated on the HumanEva dataset. The results show that it largely reduces the occurrence of double counting and distinguishes the left and right sides consistently.展开更多
AIM To noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging(DW-MRI) and glucose metabolism measured by 18 Flabeled fluorodeoxyglucose positron emission tomography/co...AIM To noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging(DW-MRI) and glucose metabolism measured by 18 Flabeled fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG-PET/CT) during radiation therapy(RT) for human papillomavirus negative(HPV-) head and neck squamous cell carcinoma(HNSCC).METHODS In this prospective study, 6 HPV- HNSCC patients underwent a total of 34 multimodality imaging examinations(DW-MRI at 1.5 T Philips MRI scanner [(n = 24) pre-, during-(2-3 wk), and post-treatment(Tx), and 18F-FDG PET/CT pre- and post-Tx(n = 10)]. All patients received RT. Monoexponential modeling of the DW-MRI data yielded the imaging metric apparent diffusion coefficient(ADC) and the mean of standardized uptake value(SUV) was measured from 18F-FDG PET uptake. All patients had a clinical follow-up as the standard of care and survival status was documented at 1 year.RESULTS There was a strong negative correlation between the mean of pretreatment ADC(ρ =-0.67, P = 0.01) and the pretreatment 18F-FDG PET SUV. The percentage(%) change in delta(?) ADC for primary tumors and neck nodal metastases between pre- and Wk2-3 Tx were as follows: 75.4% and 61.6%, respectively, for the patient with no evidence of disease, 27.5% and 32.7%, respectively, for those patients who were alive with disease, and 26.9% and 7.31%, respectively, for those who were dead with disease.CONCLUSION These results are preliminary in nature and are indicative, and not definitive, trends rendered by the imaging metrics due to the small sample size of HPV- HNSCC patients in a Meixoeiro Hospital of Vigo Experience.展开更多
If you judge the progress of humanity by Homer Simpson, Paris Hilton, and Girls Gone Wild videos, you might conclude that our evolution has stalled-or even shifted into reverse. Not so, scientists say.……
To develop a simple,validated method for identifying and quantifying 1,3-butadiene(BD) in human blood by gas chromatography-mass spectrometry(GC-MS) and head-space gas chromatography(HS-GC).BD was identified by GC-MS ...To develop a simple,validated method for identifying and quantifying 1,3-butadiene(BD) in human blood by gas chromatography-mass spectrometry(GC-MS) and head-space gas chromatography(HS-GC).BD was identified by GC-MS and HS-GC,and quantified by HS-GC.The method showed that BD had a good linearity from 50 to 500μg/mL(r>0.99).The limits of detection and quantification were 10 μg/mL and 50 μg/mL,respectively.Both the intra-day precision and inter-day precision were <6.08%,and the accuracy was 96.98%-103.81%.The method was applied to an actual case,and the concentration of BD in the case was 242 μg/mL in human blood.This simple method is found to be useful for the routine forensic analysis of acute exposure to BD.展开更多
AIM To clone and identify the whole cDNA ofMXR7 gene and to find out its expression inhuman HCC,and normal tissues.METHODS The DNA primers were designed andsynthesized according to the whole cDNAsequence of MXR? gene....AIM To clone and identify the whole cDNA ofMXR7 gene and to find out its expression inhuman HCC,and normal tissues.METHODS The DNA primers were designed andsynthesized according to the whole cDNAsequence of MXR? gene.The cDNA of humanHCC was taken as the template while the cDNA ofMXR7 gene was synthesized by polymerasechain reaction(PCR).Recombinant DNAconforming to reading frame was constructed byconnecting purified PCR product of the cDNA ofMXR? gene with expression vector pGEX-5X-1 offusion protein.The plasmid MXRT/pGEX-5X-1was identified by sequencing.Using <sup>32</sup>p labeledMXR? cDNA as probe,MXR7 mRNA expressionwas detected by Northern blot analysis in 12different human normal tissues,7 preoperativelyuntreated non-liver tumor tissues,30preoperatively untreated HCC,theparacancerous liver tissues and 12 normal livertissues samples.RESULTS Restriction enzyme and sequenceanalysis confirmed that the insertion sequence invector pGEX-5X-1 was the same as the cDNAsequence of MXR7 gene.Northern blot analysisshowed no expression of MXR? mRNA in 12 kindsof normal human tissues including liver,7 tumortissues in other sites and 12 normal livertissues,the frequencies of MXR7 mRNA expression in HCC and paracancerous livertissues were 76.6% and 13.3%,respectively.The frequency of MXR7 mRNA expression in HCCwithout elevation of serum AFP and in HCC【5cm was 90%(9/10)and 83.3%(5/6),respectively.CONCLUSION MXR7 mRNA is highly expressedin human HCC,which is specific and occurs at anearly stage of HCC,suggesting MXR7 mRNA canbe a tumor biomarker for HCC.The detection ofMXR7 mRNA expression in the biopsied livertissue is helpful in discovering early subclinicalliver cancer in those with negative serum AFP.展开更多
Human papillomavirus(HPV) has been implicated in the pathogenesis of a subset of oropharyngeal squamous cell carcinoma. As a result, traditional paradigms in relation to the management of head and neck squamous cell c...Human papillomavirus(HPV) has been implicated in the pathogenesis of a subset of oropharyngeal squamous cell carcinoma. As a result, traditional paradigms in relation to the management of head and neck squamous cell carcinoma have been changing. Research into HPVrelated oropharyngeal squamous cell carcinoma is rapidly expanding, however many molecular pathological and clinical aspects of the role of HPV remain uncertain and are the subject of ongoing investigation. A detailed search of the literature pertaining to HPV-related oropharyngeal squamous cell carcinoma was performed and information on the topic was gathered. In this article, we present an extensive review of the current literature on the role of HPV in oropharyngeal squamous cell carcinoma, particularly in relation to epidemiology, risk factors, carcinogenesis, biomarkers and clinicalimplications. HPV has been established as a causative agent in oropharyngeal squamous cell carcinoma and biologically active HPV can act as a prognosticator with better overall survival than HPV-negative tumours. A distinct group of younger patients with limited tobacco and alcohol exposure have emerged as characteristic of this HPV-related subset of squamous cell carcinoma of the head and neck. However, the exact molecular mechanisms of carcinogenesis are not completely understood and further studies are needed to assist development of optimal prevention and treatment modalities.展开更多
基金supported by National Natural Science Foundation of China(grant No.61471002)The Natural Science Foundation of Higher Education of Anhui Province,China(grant No.KJ2016JD11)
文摘In order to improve the performance of the antenna at low frequency,short circuit branch and coupling feed structure are introduced into the folded broadband single antenna in this paper,then resonant frequency is merged into the antenna using method of stagger tuning,finally,a UWB antenna is designed to w ork betw een 800 MHz ~ 2700 MHz. Analysis are conducted to determine the antenna's properties. The short-circuit w ire location,feeding point location and the length of folded strip are discussed in detail. The SAR is calculated by HFSS simulation softw are w hile the antenna is close to a 3D human head model. The research results show that the antenna can cover eight commonly used commercial frequency bands at present,and electromagnetic radiation of the antenna has tiny influence on the human head model.
文摘To cope with the problem of tracking a human head in a complicated scene,we propose a method that adopts human skin color and hair color integrated with a kind of particle filter named condensation algorithm.Firstly,a novel method is presented to set up human head color model using skin color and hair color separately based on region growing.Compared with traditional human face model,this method is more precise and works well when human turns around and the face disappears in the image.Then a novel method is presented to use color model in condensation algorithm more effectively.In this method,a combination of edge detection result,color segmentation result and color edge detection result in an Omega window is used to measure the scale and position of human head in condensation.Experiments show that this approach can track human head in complicated scene even when human turns around or the distance of tracking a human head changes quickly.
文摘In this paper we present the Projection Based Interpolation (PBI) technique for construction of continuous approximation of MRI scan data of the human head. We utilize the result of the PBI algorithm to perform three dimensional (3D) Finite Element Method (FEM) simulations of the acoustics of the human head. The computational problem is a multi-physics problem modeled as acoustics coupled with linear elasticity. The computational grid contains tetrahedral finite elements with the number of equations and polynomial orders of approximation varying locally on finite element edges, faces, and interiors. We utilize our own out-of-core parallel direct solver for the solution of this multi-physics problem. The solver minimizes the memory usage by dumping out all local systems from all nodes of the entire elimination tree during the elimination phase.
文摘In this paper, we present the Projection Based Interpolation (PBI) technique for construction of continuous approximation of MRI scan data of the human head. We utilize the result of the PBI algorithm to perform three-dimensional (3D) Finite Element Method (FEM) simulations of the heating of the human head induced by cell phone. In particular, we utilize the Pennes equation to describe the bioheat transfer with the right hand side representing the heat generated by cell phone. We utilize our own non-stationary time dependent multi-thread parallel direct solver for the solution of this computational problem. From our numerical results it follows that 15 minutes (1000 seconds) exposure to the cell phone radiation implies up to 2 degrees Celsius increase of the temperature of the brain in the range close to the cell phone.
文摘Head and neck cancer(HNC) arises from the skull base to the clavicles and is the fifth most common cancer in the world by incidence. Historically, in the developed world HNC was associated with tobacco use and alcohol consumption, and the combination of the two produced a synergistic increase in risk. However, beginning in 1983, investigators have found a significant and growing proportion of HNC patients with human papillomavirus-positive(HPV) tumors who neither drank nor used tobacco. Since that time, there has been increased interest in the molecular biology of HPV-positive HNC. Multiple studies now show that HPV has shifted the epidemiological landscape and prognosis of head and neck squamous cell carcinoma(HNSCC). These studies provide strong evidence for improved survival outcomes in patients with HPV-positive HNSCC compared to those with HPV-negative HNSCC. In many reports, HPV status is the strongest predictor of locoregional control, disease specific survival and overall survival. In response to these findings, there has been significant interest in the best management of HPV-positive disease. Discussions within major cooperative groups consider new trials designed to maintain the current strong survival outcomes while reducing the long-term treatment-re-lated toxicities. This review will highlight the epidemiological, clinical and molecular discoveries surrounding HPV-related HNSCC over the recent decades and we conclude by suggesting how these findings may guide future treatment approaches.
文摘Lots of progress has been made recently on 2 D human pose tracking with tracking-by-detection approaches. However,several challenges still remain in this area which is due to self-occlusions and the confusion between the left and right limbs during tracking. In this work,a head orientation detection step is introduced into the tracking framework to serve as a complementary tool to assist human pose estimation. With the face orientation determined,the system can decide whether the left or right side of the human body is exactly visible and infer the state of the symmetric counterpart. By granting a higher priority for the completely visible side,the system can avoid double counting to a great extent when inferring body poses. The proposed framework is evaluated on the HumanEva dataset. The results show that it largely reduces the occurrence of double counting and distinguishes the left and right sides consistently.
基金National Health Institute of Spain: ISCIII Grant PI11/02035 and DTS14/00188BIOCAPS project (FP7/REGPOT-2012-2013.1), No. 316265+1 种基金MSKCC internal IMRAS grantin part through the NIH/NCI Cancer Center, No. P30 CA008748
文摘AIM To noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging(DW-MRI) and glucose metabolism measured by 18 Flabeled fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG-PET/CT) during radiation therapy(RT) for human papillomavirus negative(HPV-) head and neck squamous cell carcinoma(HNSCC).METHODS In this prospective study, 6 HPV- HNSCC patients underwent a total of 34 multimodality imaging examinations(DW-MRI at 1.5 T Philips MRI scanner [(n = 24) pre-, during-(2-3 wk), and post-treatment(Tx), and 18F-FDG PET/CT pre- and post-Tx(n = 10)]. All patients received RT. Monoexponential modeling of the DW-MRI data yielded the imaging metric apparent diffusion coefficient(ADC) and the mean of standardized uptake value(SUV) was measured from 18F-FDG PET uptake. All patients had a clinical follow-up as the standard of care and survival status was documented at 1 year.RESULTS There was a strong negative correlation between the mean of pretreatment ADC(ρ =-0.67, P = 0.01) and the pretreatment 18F-FDG PET SUV. The percentage(%) change in delta(?) ADC for primary tumors and neck nodal metastases between pre- and Wk2-3 Tx were as follows: 75.4% and 61.6%, respectively, for the patient with no evidence of disease, 27.5% and 32.7%, respectively, for those patients who were alive with disease, and 26.9% and 7.31%, respectively, for those who were dead with disease.CONCLUSION These results are preliminary in nature and are indicative, and not definitive, trends rendered by the imaging metrics due to the small sample size of HPV- HNSCC patients in a Meixoeiro Hospital of Vigo Experience.
文摘 If you judge the progress of humanity by Homer Simpson, Paris Hilton, and Girls Gone Wild videos, you might conclude that our evolution has stalled-or even shifted into reverse. Not so, scientists say.……
文摘To develop a simple,validated method for identifying and quantifying 1,3-butadiene(BD) in human blood by gas chromatography-mass spectrometry(GC-MS) and head-space gas chromatography(HS-GC).BD was identified by GC-MS and HS-GC,and quantified by HS-GC.The method showed that BD had a good linearity from 50 to 500μg/mL(r>0.99).The limits of detection and quantification were 10 μg/mL and 50 μg/mL,respectively.Both the intra-day precision and inter-day precision were <6.08%,and the accuracy was 96.98%-103.81%.The method was applied to an actual case,and the concentration of BD in the case was 242 μg/mL in human blood.This simple method is found to be useful for the routine forensic analysis of acute exposure to BD.
基金the National Natural Science Foundation of China,No.39770379the National Basic Research Project("973")SUGEN,USA.
文摘AIM To clone and identify the whole cDNA ofMXR7 gene and to find out its expression inhuman HCC,and normal tissues.METHODS The DNA primers were designed andsynthesized according to the whole cDNAsequence of MXR? gene.The cDNA of humanHCC was taken as the template while the cDNA ofMXR7 gene was synthesized by polymerasechain reaction(PCR).Recombinant DNAconforming to reading frame was constructed byconnecting purified PCR product of the cDNA ofMXR? gene with expression vector pGEX-5X-1 offusion protein.The plasmid MXRT/pGEX-5X-1was identified by sequencing.Using <sup>32</sup>p labeledMXR? cDNA as probe,MXR7 mRNA expressionwas detected by Northern blot analysis in 12different human normal tissues,7 preoperativelyuntreated non-liver tumor tissues,30preoperatively untreated HCC,theparacancerous liver tissues and 12 normal livertissues samples.RESULTS Restriction enzyme and sequenceanalysis confirmed that the insertion sequence invector pGEX-5X-1 was the same as the cDNAsequence of MXR7 gene.Northern blot analysisshowed no expression of MXR? mRNA in 12 kindsof normal human tissues including liver,7 tumortissues in other sites and 12 normal livertissues,the frequencies of MXR7 mRNA expression in HCC and paracancerous livertissues were 76.6% and 13.3%,respectively.The frequency of MXR7 mRNA expression in HCCwithout elevation of serum AFP and in HCC【5cm was 90%(9/10)and 83.3%(5/6),respectively.CONCLUSION MXR7 mRNA is highly expressedin human HCC,which is specific and occurs at anearly stage of HCC,suggesting MXR7 mRNA canbe a tumor biomarker for HCC.The detection ofMXR7 mRNA expression in the biopsied livertissue is helpful in discovering early subclinicalliver cancer in those with negative serum AFP.
文摘Human papillomavirus(HPV) has been implicated in the pathogenesis of a subset of oropharyngeal squamous cell carcinoma. As a result, traditional paradigms in relation to the management of head and neck squamous cell carcinoma have been changing. Research into HPVrelated oropharyngeal squamous cell carcinoma is rapidly expanding, however many molecular pathological and clinical aspects of the role of HPV remain uncertain and are the subject of ongoing investigation. A detailed search of the literature pertaining to HPV-related oropharyngeal squamous cell carcinoma was performed and information on the topic was gathered. In this article, we present an extensive review of the current literature on the role of HPV in oropharyngeal squamous cell carcinoma, particularly in relation to epidemiology, risk factors, carcinogenesis, biomarkers and clinicalimplications. HPV has been established as a causative agent in oropharyngeal squamous cell carcinoma and biologically active HPV can act as a prognosticator with better overall survival than HPV-negative tumours. A distinct group of younger patients with limited tobacco and alcohol exposure have emerged as characteristic of this HPV-related subset of squamous cell carcinoma of the head and neck. However, the exact molecular mechanisms of carcinogenesis are not completely understood and further studies are needed to assist development of optimal prevention and treatment modalities.