Gastroprotection induced by capsaicin in healthy human subjects

AIM： To evaluate the gastro-protective effect of capsaicin against the ethanol- and indomethacin （IND）-induced gastric mucosal damage in healthy human subjects. METHODS： The effects of small doses （1-8 μg/mL, 100 mL） of capsaicin on the gastric acid secretion basal acid output （BAO） and its electrolyte concentration, gastric transmucosal potential difference （GTPD）, ethanol- （5 mL 300 mL/L i.g.） and IND- （3×25 mg/d） induced gastric mucosal damage were tested in a randomized, prospective study of 84 healthy human subjects. The possible role of desensitization of capsaicin-sensitive afferents was tested by repeated exposures and during a prolonged treatment. RESULTS： Intragastric application of capsaicin decreased the BAO and enhanced “non-parietal” component, GTPD in a dose-dependent manner. The decrease of GTPD evoked by ethanol was inhibited by the capsaicin application, which was reproducible. Gastric microbleeding induced by IND was inhibited by co-administration with capsaicin, but was not influenced by two weeks pretreatment with a daily capsaicin dose of 3×400μg i.g. CONCLUSION： Capsaicin in low concentration range protects against gastric injuries induced by ethanol or IND, which is attributed to stimulation of the sensory nerve endings.

Suppression of Radioactive Strontium Absorption by Sodium Alginate in Animals and Human Subjects

The effect of 23 sodium alginate preparations from different species of algae (Sargassum sp.) and kelp (Laminaria sp.) on reducing the absorption of strontium was studied in detail. A pilot production procedure has been established. Na alginate from S. siliquastrum was proven to be a potent agent for reducing Sr absorption, with high efficiency and virtually no toxicity. It reduced the body burden of strontium 3.3-4.2 fold in rats. Strontium absorption in human subjects was reduced by 78% ( ±8.9) or completely suppressed the increase of serum Sr at 2 h after ingestion of stable Sr in volunteers and decrease 24 h urine Sr to similar extent. No undesirable effects on gastrointestinal function was observed nor were Ca, Fe, Cu and Zn metabolism changed, both in the animal experiments and in human. It was concluded that alginate preparations derived from Sargassum species are a suitable antidote against radiostrontium absorption on a long-term basis, when added to bread at a 6% level. In cases of emergency, an alginate syrup preparation appears to be more suitable because of its rapid action.

World Medical Association Declaration of HelsinkiE thical Principles for Medical Research Involving Human Subjects

Document Of World Medical AssociationWorld medical association declaration of Helsinki Ethical principles for medical research involving human subjects

Hermeneutic Thinking on the Subject of Human Rights: Four Perspectives

from the view of human rights hermeneutics,the interpretation of the human rights subject can be understood as the philosophical foundation of human rights.as the rights of"ego"and"another",human rights will be rid of the supreme power of the"God"and"nation",while it dooms the dilemma of solipsism and hegemony.as the right of"the Other",human rights will correspond to the reality of political pluralism,however that theory appears to be too deconstructive and may lead to human rights nihilism.By accepting the continuity between individuality and community,a more feasible and non-exclusive approach is to adopt the idea of"Self"to better understand the nature of human rights,thus avoiding extreme human rights universality and relativism.

Application of fuzzy logic in content-based image retrieval

We propose a fuzzy logic-based image retrieval system, in which the image similarity can be inferred in a nonlinear manner as human thinking. In the fuzzy inference process, weight assignments of multi-image features were resolved impliedly. Each fuzzy rule was embedded into the subjectivity of human perception of image contents. A color histogram called the average area histogram is proposed to represent the color features. Experimental results show the efficiency and feasibility of the proposed algorithms.

Current state and progress of research on forensic biomechanics in China

Forensic biomechanics gradually has become a significant component of forensic science.Forensic biomechanics is evidence-based science that applies biomechanical principles and methods to forensic practice,which has constituted one of the most potential research areas.in this review,we introduce how finite element techniques can be used to simulate forensic cases,how injury criteria and injury scales can be used to describe injury severity,and how tests of postmortem human subjects and dummy can be used to provide essential validation data.This review also describes research progress and new applications of forensic biomechanics in China.