On the basis of the successful establishment of an animal model in tree shrews experimentally in fected with human hepatitis B virus (HHBV), a study on the hepatocarcinogenic effects of HHBV and aflatoxin B1 (AFB1) by...On the basis of the successful establishment of an animal model in tree shrews experimentally in fected with human hepatitis B virus (HHBV), a study on the hepatocarcinogenic effects of HHBV and aflatoxin B1 (AFB1) by using this animal model was conducted through a lifelong experiment. Among 41 tree shrews exposed to AFB1, 17 were experimentally infected by HHBV and 24 were uninfected. After 158 weeks, significant difference of primary liver cancer (PLC) incidence was present between the HHBV infected (52.94%) and uninfected (12.5%) groups (p<0.05). No difference was found between these two groups in the amount of AFB4 ingestion. Moreover, 1/9 of the tree shrews infected only by HHBV but not exposed to AFB4 developed PLC. No PLC was found in 6 tree shrews that had neither been infected with HHBV nor been exposed to AFB4. These results suggest the possible etiologic relationship between HHBV infection and PLC, as well as the synergetic effects of HHBV and AFB4 during PLC development.展开更多
The X protein （HBx） of Human hepatitis B virus （HBV） acts as an indirect transcriptional transactivator to regulate the expression of many viral and cellular genes, as well as playing a critical role in pathogenes...The X protein （HBx） of Human hepatitis B virus （HBV） acts as an indirect transcriptional transactivator to regulate the expression of many viral and cellular genes, as well as playing a critical role in pathogenesis and the deve!opment of Hepatocellular carcinoma （HCC）. Here we described the biological effects of HBx in association with four cellular factors, including inflammatory factors （COX-2 and iNOS）, oncoprotein （Ras）, and a newly identified tumor suppressor （YueF）. The characteristics of these effectors, which might be associated with hepatocellular carcinoma, are also discussed.展开更多
文摘On the basis of the successful establishment of an animal model in tree shrews experimentally in fected with human hepatitis B virus (HHBV), a study on the hepatocarcinogenic effects of HHBV and aflatoxin B1 (AFB1) by using this animal model was conducted through a lifelong experiment. Among 41 tree shrews exposed to AFB1, 17 were experimentally infected by HHBV and 24 were uninfected. After 158 weeks, significant difference of primary liver cancer (PLC) incidence was present between the HHBV infected (52.94%) and uninfected (12.5%) groups (p<0.05). No difference was found between these two groups in the amount of AFB4 ingestion. Moreover, 1/9 of the tree shrews infected only by HHBV but not exposed to AFB4 developed PLC. No PLC was found in 6 tree shrews that had neither been infected with HHBV nor been exposed to AFB4. These results suggest the possible etiologic relationship between HHBV infection and PLC, as well as the synergetic effects of HHBV and AFB4 during PLC development.
基金the Major State Basic Research Development Program of China("973"project No.2005CB52290and No.2005CB522905)The National Natural SciencFoundation of China(No.30470087and No.30730001)+1 种基金ThDepartment of Science Technology of Hubei Province(No2005S2354)Program for Changjiang Scholars anInnovative Research Team in University(PCSIRT)
文摘The X protein （HBx） of Human hepatitis B virus （HBV） acts as an indirect transcriptional transactivator to regulate the expression of many viral and cellular genes, as well as playing a critical role in pathogenesis and the deve!opment of Hepatocellular carcinoma （HCC）. Here we described the biological effects of HBx in association with four cellular factors, including inflammatory factors （COX-2 and iNOS）, oncoprotein （Ras）, and a newly identified tumor suppressor （YueF）. The characteristics of these effectors, which might be associated with hepatocellular carcinoma, are also discussed.
