目的研究Aerospace Medicine and Human Performance更名前后的主要报道方向、国别、发文机构的变化情况等,以期为国内同行提供参考。方法主要利用CiteSpace的共词网络功能来对期刊报道方向、发刊国别、发文机构等变化进行分析。数据来...目的研究Aerospace Medicine and Human Performance更名前后的主要报道方向、国别、发文机构的变化情况等,以期为国内同行提供参考。方法主要利用CiteSpace的共词网络功能来对期刊报道方向、发刊国别、发文机构等变化进行分析。数据来自Web of Science核心合集的SCI拓展版,以期刊名“Aviation Space and Environmental Medicine”检索,时间跨度为1991年1月1日至2014年12月31日,剔除征稿启事、会议通知等非学术文献。导入NoteExpress软件进行去重,共有4830篇文章。该刊于2015年更名为“Aerospace Medicine and Human Performance”,检索策略为:时间跨度为2015年1月1日至2023年6月13日,数据清洗方法同上,共检索到1076篇文章。结果(1)主要发文机构:更名前主要供稿机构为美国空军(160篇)、美国国防部(93篇)和美国宇航局(NASA,77篇);更名后主要供稿机构未发生变化,但发文数量均较更名前减少,美国空军47篇,美国国防部24篇,NASA 24篇。(2)主要关键词对比:更名后主要关键词与飞行、航天相关的连接强度显著增加,而对一般健康问题的关注相对减少,出现了spaceflight、air travel等直接与飞行行为相关的内容。(3)主要国别:更名前美国发文2411篇(49.91%)、加拿大发文314篇(6.50%)、英国发文279篇(5.77%)、法国发文167篇(3.45%)、德国发文160篇(3.31%);更名后美国发文501篇(46.56%)、英国发文98篇(9.10%)、中国发文54篇(5.01%)、加拿大发文53篇(4.92%)、法国发文42篇(3.90%)。(4)年均发文量:根据检索结果,更名前共24年,年均发文201篇;更名后从2015年至本文检索截止时间共8.5年,年均发文127篇,年均报道量下降较多。(5)影响因子:截止2014年更名前共发文164篇,影响因子1.0051(含自引);2016年是该刊更名有影响因子等统计数据的第一年,共发文132篇,影响因子0.8250;2022年发文109篇,影响因子1.0001(含自引)。综合考量发文量和影响因子,该刊的综合影响力更名后并无显著提升。结论该刊在更名后,对于飞行环境的影响报道有所减少,主要讨论范围从之前的所有飞行类型聚焦为以太空飞行为主,关于飞行行为对人体健康的影响和绩效表现的报道大幅增长,同时也增加了关于飞行装备对飞行安全影响的讨论。随着航空航天技术的进步和航空装备的发展,更深入地探讨航空活动中环境因素对人体长时间复合作用的影响是必然。在该刊更名后,我国的发文数量排名第三,也在一定程度上说明存在高质量原创性成果外流的情况。我国期刊在坚持刊物原有特色的前提下,根据领域研究的发展,与时俱进,探索可持续发展的办刊模式;要进一步明确期刊定位与服务对象,以国家重大需求为导向,聚焦航空航天领域前沿、热点,适时调整栏目设置,提升期刊的学术质量和学科影响力,打造高质量的学术交流平台。展开更多
Life Expectancy Study International geriatric life science community, including medical and scientific communities, currently considers human life expectancy to be about 120 years. This is in congruence with recordin...Life Expectancy Study International geriatric life science community, including medical and scientific communities, currently considers human life expectancy to be about 120 years. This is in congruence with recordings from ＂Hong Fan-Book of Documents （Shang Shu Hong Fan）＂, and is also in general agreement with teachings from ＂Longevity-Yellow Emperor＇s Canon of Internal Medicine （Huang Di Nei Jing ~ Tian Nian）＂ where it is said ＇a man is to die at age of a hundred years＇ meaning ＇passing away after living a hundred years＇. Recently there is a report of people dying at the age of 150 years in England, I am afraid this is misinformed.展开更多
Objective： To determine whether patterns of enterovirus 71（EV71）-associated hand, foot, and mouth disease（HFMD） were classified based on symptoms and signs, and explore whether individual characteristics were cor...Objective： To determine whether patterns of enterovirus 71（EV71）-associated hand, foot, and mouth disease（HFMD） were classified based on symptoms and signs, and explore whether individual characteristics were correlated with membership in particular pattern. Methods： Symptom-based latent class analysis（LCA） was used to determine whether patterns of EV71-HFMD existed in a sample of 433 cases from a clinical data warehouse system. Logistic regression was then performed to explore whether demographic, and laboratory data were associated with pattern membership. Results： LCA demonstrated a two-subgroup solution with an optimal fit, deduced according to the Bayesian Information Criterion minima. Hot pattern（59.1% of all patients） was characterized by a very high fever and high endorsement rates for classical HFMD symptoms（i.e., rash on the extremities, blisters, and oral mucosa lesions）. Non-hot pattern（40.9% of all patients） was characterized by classical HFMD symptoms. The multiple logistic regression results suggest that white blood cell counts and aspartate transaminase were positively correlated with the hot pattern（adjust odds ratio=1.07, 95% confidence interval： 1.006–1.115; adjust odds ratio=1.051, 95% confidence interval： 1.019–1.084; respectively）. Conclusions： LCA on reported symptoms and signs in a retrospective study allowed different subgroups with meaningful clinical correlates to be defined. These findings provide evidence for targeted prevention and treatment interventions.展开更多
The identity of Eastern and Western cultures should include aspects such as its concepts of societal development and science and technology.Though this is related to issues like history of the culture and regional cul...The identity of Eastern and Western cultures should include aspects such as its concepts of societal development and science and technology.Though this is related to issues like history of the culture and regional cultural psychologies,the essence lies in the identity of social values at its core.展开更多
The journal Genomics, Proteomics ＆ Bioinformatics （GPB） is now inviting submissions for a special issue （to be published in the fall of 2016） on the topic of ＂Biomarkers for Human Diseases and Translational Medi...The journal Genomics, Proteomics ＆ Bioinformatics （GPB） is now inviting submissions for a special issue （to be published in the fall of 2016） on the topic of ＂Biomarkers for Human Diseases and Translational Medicine＂. In the personalized medicine era, disease biomarkers have potential application in diagnosis, prognosis, and guidance for treatment, and are important tools in translational medicine. Diagnosis upon biomarkers would aid in early and more efficient intervention, while prognostic biomarkers could lead to right decision of medical treatment.展开更多
The journal Genomics, Proteomics ＆ Bioinformatics （GPB） is now inviting submissions for a special issue （to be published in the fall of 2016） on the topic of ＂Biomarkers for Hunlan Diseases and Translational Med...The journal Genomics, Proteomics ＆ Bioinformatics （GPB） is now inviting submissions for a special issue （to be published in the fall of 2016） on the topic of ＂Biomarkers for Hunlan Diseases and Translational Medicine＂.展开更多
The journal Genomics, Proteomics ＆ Bioinformatics （GPB） is now inviting submissions for a special issue （to be published in the fall of 2016） on the topic of ＂Biomarkers for Human Diseases and Translational Medi...The journal Genomics, Proteomics ＆ Bioinformatics （GPB） is now inviting submissions for a special issue （to be published in the fall of 2016） on the topic of ＂Biomarkers for Human Diseases and Translational Medicine＂. In the personalized medicine era, disease biomarkers have potential application in diagnosis, prognosis, and guidance for treatment, and are important tools in translational medicine. Diagnosis upon biomarkers would aid in early and more efficient intervention, while prognostic biomarkers could lead to right decision of medical treatment.展开更多
Objective： To investigate the potential effect of pure total flavonoids from Citrus paradisi Macfad peel（PTFC） on the proliferation and apoptosis of human myeloid leukemia cells Kasumi-1, HL-60 and K562, and the un...Objective： To investigate the potential effect of pure total flavonoids from Citrus paradisi Macfad peel（PTFC） on the proliferation and apoptosis of human myeloid leukemia cells Kasumi-1, HL-60 and K562, and the underlying mechanisms. Methods： PTFC was extracted from Citrus paradisi Macfad peel and was identified by high performance liquid chromatography. The effect of PTFC on the proliferation and apoptosis of leukemia cells were determined by 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide, fluorescent microscopy and flow cytometry, respectively. The effect of PTFC on the expression levels of apoptosis-related regulators was determined by Western blot assay. Results： Treatment with PTFC inhibited leukemia cell proliferation in a dose-and time-dependent manner and triggered Kasumi-1 cell apoptosis. Treatment with PTFC significantly increased the levels of activated poly adenosine diphosphate-ribosepolymerase and caspase-3/-9, but reduced the levels of Mcl-1 expression in Kasumi-1 cells. However, PTFC did not obviously induce HL-60 cell apoptosis. Conclusion： PTFC inhibited leukemia cell proliferation and induced their apoptosis by modulating apoptosisrelated regulator expression in leukemia cells in vitro.展开更多
Special Issue on ＂Genome Stability＂ We are very pleased to announce a special issue, to be published in June, 2016, on ＂Genome Stability＂ in the journal Genomics, Proteomics ＆ Bioinformatics （GPB）. This special...Special Issue on ＂Genome Stability＂ We are very pleased to announce a special issue, to be published in June, 2016, on ＂Genome Stability＂ in the journal Genomics, Proteomics ＆ Bioinformatics （GPB）. This special issue aims to provide a platform for specialists or experts in the field to report their results and share their opinions on the topic. We are inviting you to submit high-quality papers to this special issue. The guest editors for this special issue are Dr. Zhao-Qi Wang （The Leibniz Institute on Aging - Fritz Lipmann Institute （FLI）, Germany）, Dr. Xingzhi Xu （Capital Normal University, China）, and Dr. Daochun Kong （Peking University, China）.展开更多
Special Issue on ＂Big Data and Precision Medicine＂The journal Genomics Proteomics ＆ Bioinformatics （GPB）is now inviting submissions for a special issue on the topic of ＂Big Data and Precision Medicine＂ to be pu...Special Issue on ＂Big Data and Precision Medicine＂The journal Genomics Proteomics ＆ Bioinformatics （GPB）is now inviting submissions for a special issue on the topic of ＂Big Data and Precision Medicine＂ to be published in the fall of 2016.展开更多
Special Issue on ＂Computational Cardiology＂We are pleased to announce a special issue on ＂Computational Cardiology＂ of the journal Genomics, Proteomics ＆ Bioinformatics （GPB）, aiming to provide a platform for h...Special Issue on ＂Computational Cardiology＂We are pleased to announce a special issue on ＂Computational Cardiology＂ of the journal Genomics, Proteomics ＆ Bioinformatics （GPB）, aiming to provide a platform for high-quality papers focusing on the topic and we invite submissions for this special issue （to be published in the Spring of 2016）. Dr. Benjamin Meder （University of Heidelberg and German Center for Cardiovascular Research - DZHK, Germany） and Dr. Andreas Keller （Saarland University, Germany） are Guest Editors of this issue.展开更多
文摘目的研究Aerospace Medicine and Human Performance更名前后的主要报道方向、国别、发文机构的变化情况等,以期为国内同行提供参考。方法主要利用CiteSpace的共词网络功能来对期刊报道方向、发刊国别、发文机构等变化进行分析。数据来自Web of Science核心合集的SCI拓展版,以期刊名“Aviation Space and Environmental Medicine”检索,时间跨度为1991年1月1日至2014年12月31日,剔除征稿启事、会议通知等非学术文献。导入NoteExpress软件进行去重,共有4830篇文章。该刊于2015年更名为“Aerospace Medicine and Human Performance”,检索策略为:时间跨度为2015年1月1日至2023年6月13日,数据清洗方法同上,共检索到1076篇文章。结果(1)主要发文机构:更名前主要供稿机构为美国空军(160篇)、美国国防部(93篇)和美国宇航局(NASA,77篇);更名后主要供稿机构未发生变化,但发文数量均较更名前减少,美国空军47篇,美国国防部24篇,NASA 24篇。(2)主要关键词对比:更名后主要关键词与飞行、航天相关的连接强度显著增加,而对一般健康问题的关注相对减少,出现了spaceflight、air travel等直接与飞行行为相关的内容。(3)主要国别:更名前美国发文2411篇(49.91%)、加拿大发文314篇(6.50%)、英国发文279篇(5.77%)、法国发文167篇(3.45%)、德国发文160篇(3.31%);更名后美国发文501篇(46.56%)、英国发文98篇(9.10%)、中国发文54篇(5.01%)、加拿大发文53篇(4.92%)、法国发文42篇(3.90%)。(4)年均发文量:根据检索结果,更名前共24年,年均发文201篇;更名后从2015年至本文检索截止时间共8.5年,年均发文127篇,年均报道量下降较多。(5)影响因子:截止2014年更名前共发文164篇,影响因子1.0051(含自引);2016年是该刊更名有影响因子等统计数据的第一年,共发文132篇,影响因子0.8250;2022年发文109篇,影响因子1.0001(含自引)。综合考量发文量和影响因子,该刊的综合影响力更名后并无显著提升。结论该刊在更名后,对于飞行环境的影响报道有所减少,主要讨论范围从之前的所有飞行类型聚焦为以太空飞行为主,关于飞行行为对人体健康的影响和绩效表现的报道大幅增长,同时也增加了关于飞行装备对飞行安全影响的讨论。随着航空航天技术的进步和航空装备的发展,更深入地探讨航空活动中环境因素对人体长时间复合作用的影响是必然。在该刊更名后,我国的发文数量排名第三,也在一定程度上说明存在高质量原创性成果外流的情况。我国期刊在坚持刊物原有特色的前提下,根据领域研究的发展,与时俱进,探索可持续发展的办刊模式;要进一步明确期刊定位与服务对象,以国家重大需求为导向,聚焦航空航天领域前沿、热点,适时调整栏目设置,提升期刊的学术质量和学科影响力,打造高质量的学术交流平台。
文摘Life Expectancy Study International geriatric life science community, including medical and scientific communities, currently considers human life expectancy to be about 120 years. This is in congruence with recordings from ＂Hong Fan-Book of Documents （Shang Shu Hong Fan）＂, and is also in general agreement with teachings from ＂Longevity-Yellow Emperor＇s Canon of Internal Medicine （Huang Di Nei Jing ~ Tian Nian）＂ where it is said ＇a man is to die at age of a hundred years＇ meaning ＇passing away after living a hundred years＇. Recently there is a report of people dying at the age of 150 years in England, I am afraid this is misinformed.
基金Supported by the Nation Health and Family Planning Commission of China(No.2012ZX10005009)Fundamental Research Funds for the Central Public Welfare Research Institutes(No.Z0474)National Natural Science Foundation of China(No.81503679)
文摘Objective： To determine whether patterns of enterovirus 71（EV71）-associated hand, foot, and mouth disease（HFMD） were classified based on symptoms and signs, and explore whether individual characteristics were correlated with membership in particular pattern. Methods： Symptom-based latent class analysis（LCA） was used to determine whether patterns of EV71-HFMD existed in a sample of 433 cases from a clinical data warehouse system. Logistic regression was then performed to explore whether demographic, and laboratory data were associated with pattern membership. Results： LCA demonstrated a two-subgroup solution with an optimal fit, deduced according to the Bayesian Information Criterion minima. Hot pattern（59.1% of all patients） was characterized by a very high fever and high endorsement rates for classical HFMD symptoms（i.e., rash on the extremities, blisters, and oral mucosa lesions）. Non-hot pattern（40.9% of all patients） was characterized by classical HFMD symptoms. The multiple logistic regression results suggest that white blood cell counts and aspartate transaminase were positively correlated with the hot pattern（adjust odds ratio=1.07, 95% confidence interval： 1.006–1.115; adjust odds ratio=1.051, 95% confidence interval： 1.019–1.084; respectively）. Conclusions： LCA on reported symptoms and signs in a retrospective study allowed different subgroups with meaningful clinical correlates to be defined. These findings provide evidence for targeted prevention and treatment interventions.
文摘The identity of Eastern and Western cultures should include aspects such as its concepts of societal development and science and technology.Though this is related to issues like history of the culture and regional cultural psychologies,the essence lies in the identity of social values at its core.
文摘The journal Genomics, Proteomics ＆ Bioinformatics （GPB） is now inviting submissions for a special issue （to be published in the fall of 2016） on the topic of ＂Biomarkers for Human Diseases and Translational Medicine＂. In the personalized medicine era, disease biomarkers have potential application in diagnosis, prognosis, and guidance for treatment, and are important tools in translational medicine. Diagnosis upon biomarkers would aid in early and more efficient intervention, while prognostic biomarkers could lead to right decision of medical treatment.
文摘The journal Genomics, Proteomics ＆ Bioinformatics （GPB） is now inviting submissions for a special issue （to be published in the fall of 2016） on the topic of ＂Biomarkers for Hunlan Diseases and Translational Medicine＂.
文摘The journal Genomics, Proteomics ＆ Bioinformatics （GPB） is now inviting submissions for a special issue （to be published in the fall of 2016） on the topic of ＂Biomarkers for Human Diseases and Translational Medicine＂. In the personalized medicine era, disease biomarkers have potential application in diagnosis, prognosis, and guidance for treatment, and are important tools in translational medicine. Diagnosis upon biomarkers would aid in early and more efficient intervention, while prognostic biomarkers could lead to right decision of medical treatment.
基金Supported by Zhejiang Provincial Natural Science Foundation of China(No.LY14H080003)
文摘Objective： To investigate the potential effect of pure total flavonoids from Citrus paradisi Macfad peel（PTFC） on the proliferation and apoptosis of human myeloid leukemia cells Kasumi-1, HL-60 and K562, and the underlying mechanisms. Methods： PTFC was extracted from Citrus paradisi Macfad peel and was identified by high performance liquid chromatography. The effect of PTFC on the proliferation and apoptosis of leukemia cells were determined by 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide, fluorescent microscopy and flow cytometry, respectively. The effect of PTFC on the expression levels of apoptosis-related regulators was determined by Western blot assay. Results： Treatment with PTFC inhibited leukemia cell proliferation in a dose-and time-dependent manner and triggered Kasumi-1 cell apoptosis. Treatment with PTFC significantly increased the levels of activated poly adenosine diphosphate-ribosepolymerase and caspase-3/-9, but reduced the levels of Mcl-1 expression in Kasumi-1 cells. However, PTFC did not obviously induce HL-60 cell apoptosis. Conclusion： PTFC inhibited leukemia cell proliferation and induced their apoptosis by modulating apoptosisrelated regulator expression in leukemia cells in vitro.
文摘Special Issue on ＂Genome Stability＂ We are very pleased to announce a special issue, to be published in June, 2016, on ＂Genome Stability＂ in the journal Genomics, Proteomics ＆ Bioinformatics （GPB）. This special issue aims to provide a platform for specialists or experts in the field to report their results and share their opinions on the topic. We are inviting you to submit high-quality papers to this special issue. The guest editors for this special issue are Dr. Zhao-Qi Wang （The Leibniz Institute on Aging - Fritz Lipmann Institute （FLI）, Germany）, Dr. Xingzhi Xu （Capital Normal University, China）, and Dr. Daochun Kong （Peking University, China）.
文摘Special Issue on ＂Big Data and Precision Medicine＂The journal Genomics Proteomics ＆ Bioinformatics （GPB）is now inviting submissions for a special issue on the topic of ＂Big Data and Precision Medicine＂ to be published in the fall of 2016.
文摘Special Issue on ＂Computational Cardiology＂We are pleased to announce a special issue on ＂Computational Cardiology＂ of the journal Genomics, Proteomics ＆ Bioinformatics （GPB）, aiming to provide a platform for high-quality papers focusing on the topic and we invite submissions for this special issue （to be published in the Spring of 2016）. Dr. Benjamin Meder （University of Heidelberg and German Center for Cardiovascular Research - DZHK, Germany） and Dr. Andreas Keller （Saarland University, Germany） are Guest Editors of this issue.
