Background Post-traumatic stress disorder (PTSD) is a mental disorder with delayed or chronic onset caused by unusual,threatening,or disastrous psychological trauma,and it is an important manifestation of post-disas...Background Post-traumatic stress disorder (PTSD) is a mental disorder with delayed or chronic onset caused by unusual,threatening,or disastrous psychological trauma,and it is an important manifestation of post-disaster mental and behavioral disorders.Studies have shown that IL-6 is a cytokine associated with PTSD occurrence.This study aimed to explore the role of cytokine and ethnicity in the pathogenesis of PTSD by examining levels of serum cytokines IL-2,IL-6,IL-8,TNF-α,and cortisol in PTSD patients of Li and Han ethnic groups.Methods Levels of serum cytokines IL-2,IL-6,IL-8,TNF-α,and cortisol were examined by enzyme-linked immunoabsorbent assay (ELISA) method and assessed by PCL-C scale among 30 PTSD patients of Han ethnicity and 30 of Li ethnicity,and compared with 30 normal controls of Han and Li ethnicity,respectively.Results PTSD patients of Li ethnicity scored higher than PTSD patients of Han ethnicity,and normal controls of Li and Han ethnic groups in each of the re-experiencing,avoidance/numbing,and hyperarousal symptoms.The differences reached statistical significance (P 〈0.05).In PTSD patients of Li ethnicity compared to patients of Han ethnicity and normal controls of either Li or Han ethnicity,the levels of IL-2,IL-6,IL-8,and TNF-α were higher,and the level of cortisol was lower.Conclusions There are ethnic differences in re-experiencing,avoidance/numbing,and hyperarousal symptoms among PTSD patients.The levels of serum cortisol and cytokines are strongly associated with the race.展开更多
Biomarkers indicate changes associated with disease. Blood is relatively stable due to the homeostatic mechanisms of the body;however, urine accumulates metabolites from changes in the body, making it a better source ...Biomarkers indicate changes associated with disease. Blood is relatively stable due to the homeostatic mechanisms of the body;however, urine accumulates metabolites from changes in the body, making it a better source for early biomarker discovery. The Li ethnic group is a unique minority ethnic group that has only lived on Hainan Island for approximately 5,000 years. Studies have shown that various specific genetic variations are different between the Li and Han ethnic groups. However, whether the urinary proteome between these two ethnic groups is significantly different remains unknown. In this study, differential urinary proteins were identified in the Li and Han ethnic groups using liquid chromatography tandem mass spectrometry(LC-MS/MS).In total, 1,555 urinary proteins were identified. Twenty-five of the urinary proteins were statistically significantly different, 16 of which have been previously reported to be biomarkers of many diseases, and that these significantly different proteins were caused by ethnic differences rather than random differences. Ethnic group differences may be an influencing factor in urine proteome studies and should be considered when human urine samples are used for biomarker discovery.展开更多
BACKGROUND The global prevalence of type 2 diabetes mellitus(T2DM)is increasing.T2DM is associated with alterations of the gut microbiota,which can be affected by age,illness,and genetics.Previous studies revealed tha...BACKGROUND The global prevalence of type 2 diabetes mellitus(T2DM)is increasing.T2DM is associated with alterations of the gut microbiota,which can be affected by age,illness,and genetics.Previous studies revealed that there are discriminating microbiota compositions between the Dai and the Han populations.However,the specific gut microbiota differences between the two populations have not been elucidated.AIM To compare the gut microbiota differences in subjects with and without T2DM in the Dai and Han populations.METHODS A total of 35 subjects of the Han population(including 15 healthy children,8 adult healthy controls,and 12 adult T2DM patients)and 32 subjects of the Dai population(including 10 healthy children,10 adult healthy controls,and 12 adult T2DM patients)were enrolled in this study.Fasting venous blood samples were collected from all the subjects for biochemical analysis.Fecal samples were collected from all the subjects for DNA extraction and 16S rRNA sequencing,which was followed by analyses of the gut microbiota composition.RESULTS No significant difference in alpha diversity was observed between healthy children and adults.The diversity of gut microbiota was decreased in T2DM patients compared to the healthy adults in both the Dai and Han populations. There was a significant difference in gut microbiota between healthy children and healthy adults in the Hanpopulation with an increased abundance of Bacteroidetes and decreased Firmicutes in children. However, thisdifference was less in the Dai population. Significant increases in Bacteroidetes in the Han population and Proteobacteriain the Dai population and decreases in Firmicutes in both the Han and Dai population were observed inT2DM patients compared to healthy adults. Linear discriminant analysis Effect Size analysis also showed that thegut microbiota was different between the Han and Dai populations in heathy children, adults, and T2DM patients.Four bacteria were consistently increased and two consistently decreased in the Han population compared to theDai population.CONCLUSION Differences in gut microbiota were found between the Han and Dai populations. A significant increase inBacteroidetes was related to the occurrence of T2DM in the Han population, while a significant increase in Proteobacteriawas related to the occurrence of T2DM in the Dai population.展开更多
Four decades are but the blink of an eye in human history,but for the various ethnic groups in China,the last 40 years have seen immense changes.Skyscrapers rose out of the once deserted riverbanks,and the monotonous ...Four decades are but the blink of an eye in human history,but for the various ethnic groups in China,the last 40 years have seen immense changes.Skyscrapers rose out of the once deserted riverbanks,and the monotonous skyline began to be decorated with streaks and streams of glowing neon in the night.Ethnic Image Records uses slices of life to reinvigorate the memory,and assemble village stories into history,thus recording a colorful history of reform and opening-up.展开更多
Han Fei presented a thought-provoking perspective on human nature and its implications for governance.Departing from traditional moral doctrines,Han Fei’s“non-moralistic”philosophy posited that human nature is inhe...Han Fei presented a thought-provoking perspective on human nature and its implications for governance.Departing from traditional moral doctrines,Han Fei’s“non-moralistic”philosophy posited that human nature is inherently self-interested and driven by personal gain.In this paper,we explore Han Fei’s keen insights into human nature and its practical application in political governance.His emphasis on aligning political strategies with human inclinations,rather than relying solely on moral preaching,highlights the complexity and pragmatism of his approach.However,we also examine the limitations of his philosophy,particularly in disregarding individual differences and idealism.By striking a balance between political expediency and moral considerations,Han Fei’s ideas continue to resonate with contemporary discussions on governance and human behavior.This study calls for a reflective and cautious assessment of the implications of Han Fei’s“non-moralistic”thought in today’s society.展开更多
The UN Human Rights Treaty Bodies have repeatedly raised concerns about the Chinese government’s fulfillment of its obligations to safeguard the right to work of ethnic minorities, including the insufficiency of mate...The UN Human Rights Treaty Bodies have repeatedly raised concerns about the Chinese government’s fulfillment of its obligations to safeguard the right to work of ethnic minorities, including the insufficiency of materials, the asymmetry of employment conditions between migrating Han and other ethnic groups, as well as so-called pervasive discrimination against non-Han ethnic workers. The UN Human Rights Treaty Bodies raised these concerns based on various facts and the rationality of their suggestions differ. China has replied accordingly. China should continue to reply based on the facts, and it should accept those suggestions that are reasonable and on facts.When addressing suggestions that are not based on facts, we should identify the nature of the problems and eliminate misunderstanding by clarifying the facts and encouraging friendly dialogue.展开更多
The Western system of human rights discourse plays a leading role in the world.Western media have used the human rights discourse to attack China,especially on ethnic issues in China.The theory of transcultural politi...The Western system of human rights discourse plays a leading role in the world.Western media have used the human rights discourse to attack China,especially on ethnic issues in China.The theory of transcultural political economy of communication is very inspiring to the innovation research on international communication of China's human rights discourse on ethnic issues.China's requires an innovation in the international communication of human rights discourse on ethnic issues so as to reconstruct the historical view of human rights discourse.In particular,the discourse resources of human rights protection in China should be explored from the social revolution in the 20 th century.Meanwhile,it is necessary to reconstruct the world discourse of human rights,that is,to construct the"human rights discourse of the Chinese nation,"and focus on human rights dialogue and cooperation with other civilizations and religious systems in the world.In particular,it is necessary to break through the"connection"or"integration"with the Western discourse,transcend the West-centered human rights discourse through competition and collision,reconstruct China's human rights discourse system,and improve the capability of international communication.展开更多
In this paper, ethnic minorities refer to the 55 minorities other than the Han ethnic group with- in the borders of the People's Republic of China; human rights mean the human rights connotations within the ken of in...In this paper, ethnic minorities refer to the 55 minorities other than the Han ethnic group with- in the borders of the People's Republic of China; human rights mean the human rights connotations within the ken of international human rights laws; legal principles mean the principles that all authoritative organizations, legislative organs, administrative departments, judicial organs and other departments should obey.展开更多
文摘Background Post-traumatic stress disorder (PTSD) is a mental disorder with delayed or chronic onset caused by unusual,threatening,or disastrous psychological trauma,and it is an important manifestation of post-disaster mental and behavioral disorders.Studies have shown that IL-6 is a cytokine associated with PTSD occurrence.This study aimed to explore the role of cytokine and ethnicity in the pathogenesis of PTSD by examining levels of serum cytokines IL-2,IL-6,IL-8,TNF-α,and cortisol in PTSD patients of Li and Han ethnic groups.Methods Levels of serum cytokines IL-2,IL-6,IL-8,TNF-α,and cortisol were examined by enzyme-linked immunoabsorbent assay (ELISA) method and assessed by PCL-C scale among 30 PTSD patients of Han ethnicity and 30 of Li ethnicity,and compared with 30 normal controls of Han and Li ethnicity,respectively.Results PTSD patients of Li ethnicity scored higher than PTSD patients of Han ethnicity,and normal controls of Li and Han ethnic groups in each of the re-experiencing,avoidance/numbing,and hyperarousal symptoms.The differences reached statistical significance (P 〈0.05).In PTSD patients of Li ethnicity compared to patients of Han ethnicity and normal controls of either Li or Han ethnicity,the levels of IL-2,IL-6,IL-8,and TNF-α were higher,and the level of cortisol was lower.Conclusions There are ethnic differences in re-experiencing,avoidance/numbing,and hyperarousal symptoms among PTSD patients.The levels of serum cortisol and cytokines are strongly associated with the race.
基金supported by the National Key Research and Development Program of China(2018YFC0910202,2016YFC1306300)Beijing Natural Science Foundation(7172076)+3 种基金the Key Basic Research Program of the Ministry of Science and Technology of China(2013FY114100)Beijing Cooperative Construction Project(110651103)Beijing Normal University(11100704)Peking Union Medical College Hospital(2016-2.27)
文摘Biomarkers indicate changes associated with disease. Blood is relatively stable due to the homeostatic mechanisms of the body;however, urine accumulates metabolites from changes in the body, making it a better source for early biomarker discovery. The Li ethnic group is a unique minority ethnic group that has only lived on Hainan Island for approximately 5,000 years. Studies have shown that various specific genetic variations are different between the Li and Han ethnic groups. However, whether the urinary proteome between these two ethnic groups is significantly different remains unknown. In this study, differential urinary proteins were identified in the Li and Han ethnic groups using liquid chromatography tandem mass spectrometry(LC-MS/MS).In total, 1,555 urinary proteins were identified. Twenty-five of the urinary proteins were statistically significantly different, 16 of which have been previously reported to be biomarkers of many diseases, and that these significantly different proteins were caused by ethnic differences rather than random differences. Ethnic group differences may be an influencing factor in urine proteome studies and should be considered when human urine samples are used for biomarker discovery.
基金the National Natural Science Foundation of China,No.82160402Special Fund for Training Leading Medical Talents in Yunnan Province,China,No.L-2019022。
文摘BACKGROUND The global prevalence of type 2 diabetes mellitus(T2DM)is increasing.T2DM is associated with alterations of the gut microbiota,which can be affected by age,illness,and genetics.Previous studies revealed that there are discriminating microbiota compositions between the Dai and the Han populations.However,the specific gut microbiota differences between the two populations have not been elucidated.AIM To compare the gut microbiota differences in subjects with and without T2DM in the Dai and Han populations.METHODS A total of 35 subjects of the Han population(including 15 healthy children,8 adult healthy controls,and 12 adult T2DM patients)and 32 subjects of the Dai population(including 10 healthy children,10 adult healthy controls,and 12 adult T2DM patients)were enrolled in this study.Fasting venous blood samples were collected from all the subjects for biochemical analysis.Fecal samples were collected from all the subjects for DNA extraction and 16S rRNA sequencing,which was followed by analyses of the gut microbiota composition.RESULTS No significant difference in alpha diversity was observed between healthy children and adults.The diversity of gut microbiota was decreased in T2DM patients compared to the healthy adults in both the Dai and Han populations. There was a significant difference in gut microbiota between healthy children and healthy adults in the Hanpopulation with an increased abundance of Bacteroidetes and decreased Firmicutes in children. However, thisdifference was less in the Dai population. Significant increases in Bacteroidetes in the Han population and Proteobacteriain the Dai population and decreases in Firmicutes in both the Han and Dai population were observed inT2DM patients compared to healthy adults. Linear discriminant analysis Effect Size analysis also showed that thegut microbiota was different between the Han and Dai populations in heathy children, adults, and T2DM patients.Four bacteria were consistently increased and two consistently decreased in the Han population compared to theDai population.CONCLUSION Differences in gut microbiota were found between the Han and Dai populations. A significant increase inBacteroidetes was related to the occurrence of T2DM in the Han population, while a significant increase in Proteobacteriawas related to the occurrence of T2DM in the Dai population.
文摘Four decades are but the blink of an eye in human history,but for the various ethnic groups in China,the last 40 years have seen immense changes.Skyscrapers rose out of the once deserted riverbanks,and the monotonous skyline began to be decorated with streaks and streams of glowing neon in the night.Ethnic Image Records uses slices of life to reinvigorate the memory,and assemble village stories into history,thus recording a colorful history of reform and opening-up.
文摘Han Fei presented a thought-provoking perspective on human nature and its implications for governance.Departing from traditional moral doctrines,Han Fei’s“non-moralistic”philosophy posited that human nature is inherently self-interested and driven by personal gain.In this paper,we explore Han Fei’s keen insights into human nature and its practical application in political governance.His emphasis on aligning political strategies with human inclinations,rather than relying solely on moral preaching,highlights the complexity and pragmatism of his approach.However,we also examine the limitations of his philosophy,particularly in disregarding individual differences and idealism.By striking a balance between political expediency and moral considerations,Han Fei’s ideas continue to resonate with contemporary discussions on governance and human behavior.This study calls for a reflective and cautious assessment of the implications of Han Fei’s“non-moralistic”thought in today’s society.
文摘The UN Human Rights Treaty Bodies have repeatedly raised concerns about the Chinese government’s fulfillment of its obligations to safeguard the right to work of ethnic minorities, including the insufficiency of materials, the asymmetry of employment conditions between migrating Han and other ethnic groups, as well as so-called pervasive discrimination against non-Han ethnic workers. The UN Human Rights Treaty Bodies raised these concerns based on various facts and the rationality of their suggestions differ. China has replied accordingly. China should continue to reply based on the facts, and it should accept those suggestions that are reasonable and on facts.When addressing suggestions that are not based on facts, we should identify the nature of the problems and eliminate misunderstanding by clarifying the facts and encouraging friendly dialogue.
基金a phased result of the“Study on International Communication Strategy of Xinjiang-related Issues”,a major special commissioned project of the National Social Science Fund of China in 2020(Project Approval No.20@ZH033)。
文摘The Western system of human rights discourse plays a leading role in the world.Western media have used the human rights discourse to attack China,especially on ethnic issues in China.The theory of transcultural political economy of communication is very inspiring to the innovation research on international communication of China's human rights discourse on ethnic issues.China's requires an innovation in the international communication of human rights discourse on ethnic issues so as to reconstruct the historical view of human rights discourse.In particular,the discourse resources of human rights protection in China should be explored from the social revolution in the 20 th century.Meanwhile,it is necessary to reconstruct the world discourse of human rights,that is,to construct the"human rights discourse of the Chinese nation,"and focus on human rights dialogue and cooperation with other civilizations and religious systems in the world.In particular,it is necessary to break through the"connection"or"integration"with the Western discourse,transcend the West-centered human rights discourse through competition and collision,reconstruct China's human rights discourse system,and improve the capability of international communication.
文摘In this paper, ethnic minorities refer to the 55 minorities other than the Han ethnic group with- in the borders of the People's Republic of China; human rights mean the human rights connotations within the ken of international human rights laws; legal principles mean the principles that all authoritative organizations, legislative organs, administrative departments, judicial organs and other departments should obey.