Purpose: We evaluated the clinical usefulness of flicker perimetry in glaucoma and glaucoma suspect patients using the new Octopus 311 automated perimeter. Methods: A total of 52 eyes of 52 glaucoma patients, 26 eyes ...Purpose: We evaluated the clinical usefulness of flicker perimetry in glaucoma and glaucoma suspect patients using the new Octopus 311 automated perimeter. Methods: A total of 52 eyes of 52 glaucoma patients, 26 eyes of 26 glaucoma suspect patients and 61 eyes of 61 normal subjects were examined using standard automated perimetry (SAP), flicker perimetry and frequency doubling technology (FDT) perimetry. Flicker perimetry was performed using the Octopus 311 and its remote software package. Suprathreshold four-zone probability strategy was used to classify the critical fusion frequency probability level. The classified levels were set at 5% and 1% of probability of normality and 5 Hz. Frequency doubling technology perimetry was performed using 24- 2- 5, 24- 2- 1,N- 30- 5, N- 30- 1 screening programs using Humphrey Matrix perimetry. Standard automated perimetry was performed using the Humphrey field analyser program 24- 2 full threshold. Optical coherence tomography using Stratus OCT was used for evaluating the retinal nerve fibre layer thickness in all glaucoma and glaucoma suspect patients. Results: Receiver operating characteristic (ROC) curves were calculated. In the early stage of glaucoma, the areas under the ROC curve (AUCs) were 0.96 in flicker and 0.90 in Matrix perimetry. In the moderate and advanced stages of glaucoma, the AUCs were almost 1.0 in all tests. In glaucoma suspect patients, the AUC of the 5% probability level in flicker was significantly higher than in Matrix perimetry. Conclusion: The four-zone probability strategy using the Octopus 311 is a useful method for evaluating the flicker field in early glaucoma and glaucoma suspect patients.展开更多
Aims: To evaluate performance of frequency doubling technology (FDT) perimetry using the Humphrey Matrix 24-2 thresholding program in a hospital eye service (HES) glaucoma clinic. Methods: A random sample or individua...Aims: To evaluate performance of frequency doubling technology (FDT) perimetry using the Humphrey Matrix 24-2 thresholding program in a hospital eye service (HES) glaucoma clinic. Methods: A random sample or individuals referred consecut ively to the HES for suspected glaucoma were examined with 24-2 threshold FDT i n addition to routine clinical tests. The discriminatory power of FDTand standar d automated perimetry (SAP) were assessed using glaucomatous optic nerve head ap pearance as the reference gold standard. Results: 48 of 62 eligible referred ind ividualswere recruited. Glaucoma prevalence was 31%. Median test duration per e ye was 5 minutes 16 seconds for FDT and 5 minutes 9 seconds for SAP. There was n o significant difference (p=0.184) between proportions of individuals with relia ble test results (FDT 75%, SAP 63%). Using a clinically appropriate binary criterion for abnormal visual field, sensitivity and specificity levels were 100%and 26%respectively for FDT and 80%and 52%f or SAP. Both tests had higher negative than positive predictive values with marg inal differences between tests. Criterion free receiver operator characteristic analysis revealed minimal discriminatory power differences. Conclusions: In a HE S glaucoma clinic in which new referrals are evaluated, threshold 24-2 FDT test ing with the Humphrey Matrix has performance characteristics similar to SAP. The se findings suggest threshold testing using the FDT Matrix and SAP is comparable when the 24-2 test pattern is used.展开更多
文摘Purpose: We evaluated the clinical usefulness of flicker perimetry in glaucoma and glaucoma suspect patients using the new Octopus 311 automated perimeter. Methods: A total of 52 eyes of 52 glaucoma patients, 26 eyes of 26 glaucoma suspect patients and 61 eyes of 61 normal subjects were examined using standard automated perimetry (SAP), flicker perimetry and frequency doubling technology (FDT) perimetry. Flicker perimetry was performed using the Octopus 311 and its remote software package. Suprathreshold four-zone probability strategy was used to classify the critical fusion frequency probability level. The classified levels were set at 5% and 1% of probability of normality and 5 Hz. Frequency doubling technology perimetry was performed using 24- 2- 5, 24- 2- 1,N- 30- 5, N- 30- 1 screening programs using Humphrey Matrix perimetry. Standard automated perimetry was performed using the Humphrey field analyser program 24- 2 full threshold. Optical coherence tomography using Stratus OCT was used for evaluating the retinal nerve fibre layer thickness in all glaucoma and glaucoma suspect patients. Results: Receiver operating characteristic (ROC) curves were calculated. In the early stage of glaucoma, the areas under the ROC curve (AUCs) were 0.96 in flicker and 0.90 in Matrix perimetry. In the moderate and advanced stages of glaucoma, the AUCs were almost 1.0 in all tests. In glaucoma suspect patients, the AUC of the 5% probability level in flicker was significantly higher than in Matrix perimetry. Conclusion: The four-zone probability strategy using the Octopus 311 is a useful method for evaluating the flicker field in early glaucoma and glaucoma suspect patients.
文摘Aims: To evaluate performance of frequency doubling technology (FDT) perimetry using the Humphrey Matrix 24-2 thresholding program in a hospital eye service (HES) glaucoma clinic. Methods: A random sample or individuals referred consecut ively to the HES for suspected glaucoma were examined with 24-2 threshold FDT i n addition to routine clinical tests. The discriminatory power of FDTand standar d automated perimetry (SAP) were assessed using glaucomatous optic nerve head ap pearance as the reference gold standard. Results: 48 of 62 eligible referred ind ividualswere recruited. Glaucoma prevalence was 31%. Median test duration per e ye was 5 minutes 16 seconds for FDT and 5 minutes 9 seconds for SAP. There was n o significant difference (p=0.184) between proportions of individuals with relia ble test results (FDT 75%, SAP 63%). Using a clinically appropriate binary criterion for abnormal visual field, sensitivity and specificity levels were 100%and 26%respectively for FDT and 80%and 52%f or SAP. Both tests had higher negative than positive predictive values with marg inal differences between tests. Criterion free receiver operator characteristic analysis revealed minimal discriminatory power differences. Conclusions: In a HE S glaucoma clinic in which new referrals are evaluated, threshold 24-2 FDT test ing with the Humphrey Matrix has performance characteristics similar to SAP. The se findings suggest threshold testing using the FDT Matrix and SAP is comparable when the 24-2 test pattern is used.
