Hurst’s memory that roots in early work of the British hydrologist H.E. Hurst remains an open problem in stochastic hydrology. Today, the Hurst analysis is widely used for the hydrological studies for the memory and ...Hurst’s memory that roots in early work of the British hydrologist H.E. Hurst remains an open problem in stochastic hydrology. Today, the Hurst analysis is widely used for the hydrological studies for the memory and characteristics of time series and many methodologies have been developed for the analysis. So, there are many different techniques for the estimation of the Hurst exponent (H). However, the techniques can produce different characteristics for the persistence of a time series each other. This study uses several techniques such as adjusted range, rescaled range (RR) analysis, modified rescaled range (MRR) analysis, 1/f power spectral density analysis, Maximum Likelihood Estimation (MLE), detrended fluctuations analysis (DFA), and aggregated variance time (AVT) method for the Hurst exponent estimation. The generated time series from chaos and stochastic systems are analyzed for the comparative study of the techniques. Then, this study discusses the advantages and disadvantages of the techniques and also the limitations of them. We found that DFA is the most appropriate technique for the Hurst exponent estimation for both the short term memory and long term memory. We analyze the SOI (Southern Oscillations Index) and 6 tree-ring series for USA sites by means of DFA and the BDS statistic is used for nonlinearity test of the series. From the results, we found that SOI series is nonlinear time series which has a long term memory of H = 0.92. Contrary to earlier work, all the tree ring series are not random from our analysis. A certain tree ring series show a long term memory of H = 0.97 and nonlinear property. Therefore, we can say that the SOI series has the properties of long memory and nonlinearity and tree ring series could also show long memory and non-linearity.展开更多
Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rode...Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s disease.However,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly understood.Recently,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in mice.Here,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse model.We found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control mice.This cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal neurogenesis.Adult hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor cells.RGS6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing neurons.Thus,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.展开更多
文摘Hurst’s memory that roots in early work of the British hydrologist H.E. Hurst remains an open problem in stochastic hydrology. Today, the Hurst analysis is widely used for the hydrological studies for the memory and characteristics of time series and many methodologies have been developed for the analysis. So, there are many different techniques for the estimation of the Hurst exponent (H). However, the techniques can produce different characteristics for the persistence of a time series each other. This study uses several techniques such as adjusted range, rescaled range (RR) analysis, modified rescaled range (MRR) analysis, 1/f power spectral density analysis, Maximum Likelihood Estimation (MLE), detrended fluctuations analysis (DFA), and aggregated variance time (AVT) method for the Hurst exponent estimation. The generated time series from chaos and stochastic systems are analyzed for the comparative study of the techniques. Then, this study discusses the advantages and disadvantages of the techniques and also the limitations of them. We found that DFA is the most appropriate technique for the Hurst exponent estimation for both the short term memory and long term memory. We analyze the SOI (Southern Oscillations Index) and 6 tree-ring series for USA sites by means of DFA and the BDS statistic is used for nonlinearity test of the series. From the results, we found that SOI series is nonlinear time series which has a long term memory of H = 0.92. Contrary to earlier work, all the tree ring series are not random from our analysis. A certain tree ring series show a long term memory of H = 0.97 and nonlinear property. Therefore, we can say that the SOI series has the properties of long memory and nonlinearity and tree ring series could also show long memory and non-linearity.
基金supported by the National Institutes of Health,Nos.AA025919,AA025919-03S1,and AA025919-05S1(all to RAF).
文摘Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s disease.However,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly understood.Recently,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in mice.Here,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse model.We found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control mice.This cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal neurogenesis.Adult hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor cells.RGS6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing neurons.Thus,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.
