Objective:To explore the effect of rosuvastatin on the blood glucose, blood lipid, inflammatory cytokines, and liver function in patients with diabetes and hypercholesteremia.Methods: A total of 108 patients with diab...Objective:To explore the effect of rosuvastatin on the blood glucose, blood lipid, inflammatory cytokines, and liver function in patients with diabetes and hypercholesteremia.Methods: A total of 108 patients with diabetes and hypercholesteremia who were admitted in our hospital were included in the study and randomized into the treatment group and the control group with 54 cases in each group. The patients in the treatment group were given rosuvastatin, while the patients in the control group were given atorvastatin. The patients in the two groups were continuously treated for 8 weeks. The blood glucose, blood lipid, inflammatory cytokines, and liver function in the two groups were detected and compared.Results: FBG, PBG, CRP, and IL-6 levels after treatment in the two groups were significantly reduced when compared with before treatment, and those in the treatment group were significantly lower than those in the control group. TC, TG, and LDL-C levels after treatment in the two groups were significantly reduced when compared with before treatment, while HDL-C level was significantly elevated when compared with before treatment. The comparison of TC and LDL-C levels between the two groups was not statistically significant. The comparison of AST, ALT, and CK levels before and after treatment between the two groups was not statistically significant. Conclusions: Rosuvastatin in the treatment of diabetes and hypercholesteremia can effectively reduce the blood glucose and blood lipid levels, and improve the inflammatory cytokines, with a significant effect;therefore, it deserves to be widely recommended in the clinic.展开更多
文摘Objective:To explore the effect of rosuvastatin on the blood glucose, blood lipid, inflammatory cytokines, and liver function in patients with diabetes and hypercholesteremia.Methods: A total of 108 patients with diabetes and hypercholesteremia who were admitted in our hospital were included in the study and randomized into the treatment group and the control group with 54 cases in each group. The patients in the treatment group were given rosuvastatin, while the patients in the control group were given atorvastatin. The patients in the two groups were continuously treated for 8 weeks. The blood glucose, blood lipid, inflammatory cytokines, and liver function in the two groups were detected and compared.Results: FBG, PBG, CRP, and IL-6 levels after treatment in the two groups were significantly reduced when compared with before treatment, and those in the treatment group were significantly lower than those in the control group. TC, TG, and LDL-C levels after treatment in the two groups were significantly reduced when compared with before treatment, while HDL-C level was significantly elevated when compared with before treatment. The comparison of TC and LDL-C levels between the two groups was not statistically significant. The comparison of AST, ALT, and CK levels before and after treatment between the two groups was not statistically significant. Conclusions: Rosuvastatin in the treatment of diabetes and hypercholesteremia can effectively reduce the blood glucose and blood lipid levels, and improve the inflammatory cytokines, with a significant effect;therefore, it deserves to be widely recommended in the clinic.
