Hyperoside is a bioactive flavonoid galactoside in both medicinal and edible plants.It plays an important physiological role in the growth of flower buds.However,the hyperoside biosynthesis pathway has not been system...Hyperoside is a bioactive flavonoid galactoside in both medicinal and edible plants.It plays an important physiological role in the growth of flower buds.However,the hyperoside biosynthesis pathway has not been systematically elucidated in plants,including its original source,Hypericaceae.Our group found abundant hyperoside in the flower buds of Hypericum monogynum,and we sequenced its transcriptome to study the biosynthetic mechanism of hyperoside.After gene screening and functional verification,four kinds of key enzymes were identified.Specifically,HmF3Hs(flavanone 3-hydroxylases)and HmFLSs(flavonol synthases)could catalyze flavanones into dihydroflavonols,as well as catalyzing dihydroflavonols into flavonols.HmFLSs could also convert flavanones into flavonols and flavones with varying efficiencies.HmF3′H(flavonoid 3′-hydroxylase)was found to act broadly on 4′-hydroxyl flavonoids to produce 3′,4′-diydroxylated flavanones,dihydroflavonols,flavonols,and flavones.HmGAT(flavonoid 3-O-galactosyltransferase)would transform flavonols into the corresponding 3-O-galactosides,including hyperoside.The parallel hyperoside biosynthesis routes were thus depicted,one of which was successfully reconstructed in Escherichia coli BL21(DE3)by feeding naringenin,resulting in a hyperoside yield of 25 mg/l.Overall,this research not only helped us understand the interior catalytic mechanism of hyperoside in H.monogynum concerning flower development and bioactivity,but also provided valuable insights into these enzyme families.展开更多
Software cost estimation is a crucial aspect of software project management,significantly impacting productivity and planning.This research investigates the impact of various feature selection techniques on software c...Software cost estimation is a crucial aspect of software project management,significantly impacting productivity and planning.This research investigates the impact of various feature selection techniques on software cost estimation accuracy using the CoCoMo NASA dataset,which comprises data from 93 unique software projects with 24 attributes.By applying multiple machine learning algorithms alongside three feature selection methods,this study aims to reduce data redundancy and enhance model accuracy.Our findings reveal that the principal component analysis(PCA)-based feature selection technique achieved the highest performance,underscoring the importance of optimal feature selection in improving software cost estimation accuracy.It is demonstrated that our proposed method outperforms the existing method while achieving the highest precision,accuracy,and recall rates.展开更多
In this paper,we propose a novel secure image communication system that integrates quantum key distribution and hyperchaotic encryption techniques to ensure enhanced security for both key distribution and plaintext en...In this paper,we propose a novel secure image communication system that integrates quantum key distribution and hyperchaotic encryption techniques to ensure enhanced security for both key distribution and plaintext encryption.Specifically,we leverage the B92 Quantum Key Distribution(QKD)protocol to secure the distribution of encryption keys,which are further processed through Galois Field(GF(28))operations for increased security.The encrypted plaintext is secured using a newly developed Hyper 3D Logistic Map(H3LM),a chaotic system that generates complex and unpredictable sequences,thereby ensuring strong confusion and diffusion in the encryption process.This hybrid approach offers a robust defense against quantum and classical cryptographic attacks,combining the advantages of quantum-level key distribution with the unpredictability of hyperchaos-based encryption.The proposed method demonstrates high sensitivity to key changes and resilience to noise,compression,and cropping attacks,ensuring both secure key transmission and robust image encryption.展开更多
ObjectiveTo highlight the role of hyper accuracy three-dimensional(3D)reconstruction in facilitating surgical planning and guiding selective clamping during robot-assisted partial nephrectomy(RAPN).MethodsA transperit...ObjectiveTo highlight the role of hyper accuracy three-dimensional(3D)reconstruction in facilitating surgical planning and guiding selective clamping during robot-assisted partial nephrectomy(RAPN).MethodsA transperitoneal RAPN was performed in a 62-year-old male patient presenting with a 4 cm right anterior interpolar renal mass(R.E.N.A.L nephrometry score 7A).An abnormal vasculature was observed,with a single renal vein and two right renal arteries originating superiorly to the vein and anterior,when dividing in their segmental branches.According to the hyper accuracy 3D(HA3D^(®))rainbow model(MEDICS Srl,Turin,Italy),one branch belonging to one of the segmental arteries was feeding the tumor.This allowed for an accurate prediction of the area vascularized by each arterial branch.The 3D model was included in the intraoperative console view during the whole procedure,using the TilePro feature.A step-by-step explanation of the procedure is provided in the video attached to the present article.ResultsThe operative time was 90 min with a warm ischemia time on selective clamping of 13 min.Estimated blood loss was 180 mL.No intraoperative complication was encountered and no drain was placed at the end of the procedure.The patient was discharged on postoperative Day 2,without any early postoperative complications.The final pathology report showed a pathological tumor stage 1 clear cell renal cell carcinoma with negative surgical margins.ConclusionThe present study and the attached video illustrate the value of 3D rainbow model during the planning and execution of a RAPN with selective clamping.It shows how the surgeon can rely on this model to be more efficient by avoiding unnecessary surgical steps,and to safely adopt a“selective”clamping strategy that can translate in minimal functional impact.展开更多
When discovering the potential of canards flying in 4-dimensional slow-fast system with a bifurcation parameter, the key notion “symmetry” plays an important role. It is of one parameter on slow vector field. Then, ...When discovering the potential of canards flying in 4-dimensional slow-fast system with a bifurcation parameter, the key notion “symmetry” plays an important role. It is of one parameter on slow vector field. Then, it should be determined to introduce parameters to all slow/fast vectors. It is, however, there might be no way to explore for another potential in this system, because the geometrical structure is quite different from the system with one parameter. Even in this system, the “symmetry” is also useful to obtain the potentials classified by R. Thom. In this paper, via the coordinates changing, the possible way to explore for the potential will be shown. As it is analyzed on “hyper finite time line”, or done by using “non-standard analysis”, it is called “Hyper Catastrophe”. In the slow-fast system which includes a very small parameter , it is difficult to do precise analysis. Thus, it is useful to get the orbits as a singular limit. When trying to do simulations, it is also faced with difficulty due to singularity. Using very small time intervals corresponding small , we shall overcome the difficulty, because the difference equation on the small time interval adopts the standard differential equation. These small intervals are defined on hyper finite number N, which is nonstandard. As and the intervals are linked to use 1/N, the simulation should be done exactly.展开更多
The controller design and digital simulation for the hyper velocity kinetic energy missile is investigated. A mathematical model of the trajectory deviation from the line of sight was established, the guidance closed ...The controller design and digital simulation for the hyper velocity kinetic energy missile is investigated. A mathematical model of the trajectory deviation from the line of sight was established, the guidance closed loop was compensated with a phase advance lag corrective network, a selecting algorithm of the attitude control motors used to steer the missile's attitude was presented. In the presence of a wide variety of disturbances the results of digital simulation are satisfactory to circular error probability(CEP) being less than 0 5?m. The steering scheme utilizing attitude control motors as actuators to control the attitude of the missile is feasible.展开更多
基金supported by the National Natural Science Foundation of China(No.32070389)the‘Double First-Class’University project of China Pharmaceutical University(CPU2022QZ29).
文摘Hyperoside is a bioactive flavonoid galactoside in both medicinal and edible plants.It plays an important physiological role in the growth of flower buds.However,the hyperoside biosynthesis pathway has not been systematically elucidated in plants,including its original source,Hypericaceae.Our group found abundant hyperoside in the flower buds of Hypericum monogynum,and we sequenced its transcriptome to study the biosynthetic mechanism of hyperoside.After gene screening and functional verification,four kinds of key enzymes were identified.Specifically,HmF3Hs(flavanone 3-hydroxylases)and HmFLSs(flavonol synthases)could catalyze flavanones into dihydroflavonols,as well as catalyzing dihydroflavonols into flavonols.HmFLSs could also convert flavanones into flavonols and flavones with varying efficiencies.HmF3′H(flavonoid 3′-hydroxylase)was found to act broadly on 4′-hydroxyl flavonoids to produce 3′,4′-diydroxylated flavanones,dihydroflavonols,flavonols,and flavones.HmGAT(flavonoid 3-O-galactosyltransferase)would transform flavonols into the corresponding 3-O-galactosides,including hyperoside.The parallel hyperoside biosynthesis routes were thus depicted,one of which was successfully reconstructed in Escherichia coli BL21(DE3)by feeding naringenin,resulting in a hyperoside yield of 25 mg/l.Overall,this research not only helped us understand the interior catalytic mechanism of hyperoside in H.monogynum concerning flower development and bioactivity,but also provided valuable insights into these enzyme families.
文摘Software cost estimation is a crucial aspect of software project management,significantly impacting productivity and planning.This research investigates the impact of various feature selection techniques on software cost estimation accuracy using the CoCoMo NASA dataset,which comprises data from 93 unique software projects with 24 attributes.By applying multiple machine learning algorithms alongside three feature selection methods,this study aims to reduce data redundancy and enhance model accuracy.Our findings reveal that the principal component analysis(PCA)-based feature selection technique achieved the highest performance,underscoring the importance of optimal feature selection in improving software cost estimation accuracy.It is demonstrated that our proposed method outperforms the existing method while achieving the highest precision,accuracy,and recall rates.
文摘In this paper,we propose a novel secure image communication system that integrates quantum key distribution and hyperchaotic encryption techniques to ensure enhanced security for both key distribution and plaintext encryption.Specifically,we leverage the B92 Quantum Key Distribution(QKD)protocol to secure the distribution of encryption keys,which are further processed through Galois Field(GF(28))operations for increased security.The encrypted plaintext is secured using a newly developed Hyper 3D Logistic Map(H3LM),a chaotic system that generates complex and unpredictable sequences,thereby ensuring strong confusion and diffusion in the encryption process.This hybrid approach offers a robust defense against quantum and classical cryptographic attacks,combining the advantages of quantum-level key distribution with the unpredictability of hyperchaos-based encryption.The proposed method demonstrates high sensitivity to key changes and resilience to noise,compression,and cropping attacks,ensuring both secure key transmission and robust image encryption.
文摘ObjectiveTo highlight the role of hyper accuracy three-dimensional(3D)reconstruction in facilitating surgical planning and guiding selective clamping during robot-assisted partial nephrectomy(RAPN).MethodsA transperitoneal RAPN was performed in a 62-year-old male patient presenting with a 4 cm right anterior interpolar renal mass(R.E.N.A.L nephrometry score 7A).An abnormal vasculature was observed,with a single renal vein and two right renal arteries originating superiorly to the vein and anterior,when dividing in their segmental branches.According to the hyper accuracy 3D(HA3D^(®))rainbow model(MEDICS Srl,Turin,Italy),one branch belonging to one of the segmental arteries was feeding the tumor.This allowed for an accurate prediction of the area vascularized by each arterial branch.The 3D model was included in the intraoperative console view during the whole procedure,using the TilePro feature.A step-by-step explanation of the procedure is provided in the video attached to the present article.ResultsThe operative time was 90 min with a warm ischemia time on selective clamping of 13 min.Estimated blood loss was 180 mL.No intraoperative complication was encountered and no drain was placed at the end of the procedure.The patient was discharged on postoperative Day 2,without any early postoperative complications.The final pathology report showed a pathological tumor stage 1 clear cell renal cell carcinoma with negative surgical margins.ConclusionThe present study and the attached video illustrate the value of 3D rainbow model during the planning and execution of a RAPN with selective clamping.It shows how the surgeon can rely on this model to be more efficient by avoiding unnecessary surgical steps,and to safely adopt a“selective”clamping strategy that can translate in minimal functional impact.
文摘When discovering the potential of canards flying in 4-dimensional slow-fast system with a bifurcation parameter, the key notion “symmetry” plays an important role. It is of one parameter on slow vector field. Then, it should be determined to introduce parameters to all slow/fast vectors. It is, however, there might be no way to explore for another potential in this system, because the geometrical structure is quite different from the system with one parameter. Even in this system, the “symmetry” is also useful to obtain the potentials classified by R. Thom. In this paper, via the coordinates changing, the possible way to explore for the potential will be shown. As it is analyzed on “hyper finite time line”, or done by using “non-standard analysis”, it is called “Hyper Catastrophe”. In the slow-fast system which includes a very small parameter , it is difficult to do precise analysis. Thus, it is useful to get the orbits as a singular limit. When trying to do simulations, it is also faced with difficulty due to singularity. Using very small time intervals corresponding small , we shall overcome the difficulty, because the difference equation on the small time interval adopts the standard differential equation. These small intervals are defined on hyper finite number N, which is nonstandard. As and the intervals are linked to use 1/N, the simulation should be done exactly.
文摘The controller design and digital simulation for the hyper velocity kinetic energy missile is investigated. A mathematical model of the trajectory deviation from the line of sight was established, the guidance closed loop was compensated with a phase advance lag corrective network, a selecting algorithm of the attitude control motors used to steer the missile's attitude was presented. In the presence of a wide variety of disturbances the results of digital simulation are satisfactory to circular error probability(CEP) being less than 0 5?m. The steering scheme utilizing attitude control motors as actuators to control the attitude of the missile is feasible.
