Administration Rule of Hyperlipidemic Acute Pancreatitis Based on Data Mining

Objective:To excavate the medical pattern of hyperlipidemic acute pancreatitis based on Chinese Medicine Inheritance Assistant Platform software,hope to offer ideas for the treatment of the disease.Methods:Inpatient cases admitted to the Department of Gastroenterology of Shenzhen Hospital of Traditional Chinese Medicine for HLAP from September 2013 to June 2020 were collected,information on evidence patterns and formulations was extracted,an Excel database was established and professional terms were standardized,and data mining methods such as association rules and entropy clustering of complex systems were used to analyze medical patterns.Results:The main symbols of HLAP include abdominal pain,abdominal distinction,vomiting,fever,etc.The common used drags include Immature Orange Fruit,Baical Skullcap Root,Rhubarb and Chinese Thorowax Root,etc.The main drug pairs based on association rule analysis are"Baical Skullcap Root,Immature Orange Fruit","Rhubarb,Immature Orange Fruit","Baical Skullcap Root,Rhubarb,Immature Orange Fruit",etc,and 14 drug core combinations and 7 new formulations were extracted.Conclusion:The main synthesis of HLAP are solid-heat knots in the internal organs and dam-heat in the liver and gallbladder,and the formula is based on Da-chai-hu Decoction,the clinical treatment is based on attacking stagnation,activating blood circulation and removing dampness,which can offer reference for the clinical treatment of the disease.

Therapeutic plasma exchange for hyperlipidemic pancreatitis:Current evidence and unmet needs

With changes in lifestyle and diet worldwide,the prevalence of hyperlipidemic acute pancreatitis(HLAP)has greatly increased,and it has become the most common cause of acute pancreatitis not due to gallstones or alcohol.There are many available therapies for HLAP,including oral lipid-lowering agents,intravenous insulin,heparin,and therapeutic plasmapheresis(TPE).It is believed that the risk and severity of HLAP increase with rising levels of serum triglycerides(TG),thus a rapid decrease in serum TG level is the key to the successful management of HLAP.TPE has emerged as an effective modality in rapidly reducing serum TG levels.However,due to its cost and accessibility,TPE remains poorly evaluated until now.Some studies revealed its efficacy in helping to treat and prevent the recurrence,while some studies suggested that TG levels were not correlated with disease severity,mortality,or length of hospital stay.Thus TPE might have no beneficial effect for the outcome.This article gives an overview of the published evidence of TPE in the treatment of HLAP and outlines current evidence regarding individual outcome predictors,adverse effects of the procedure,and TPE in special occasions such as for pregnant patients and patients with diabetic ketoacidosis.Future direction of TPE research for HLAP is also discussed in this review.