Objective: To compare the antihypertensive effects of tuina at Taichong (LR 3), Neiguan (PC 6) and Qiaogong (Extra) to screen the best tuina protocol for primary hypertension due to liver-fire flaming-up. Methods: A t...Objective: To compare the antihypertensive effects of tuina at Taichong (LR 3), Neiguan (PC 6) and Qiaogong (Extra) to screen the best tuina protocol for primary hypertension due to liver-fire flaming-up. Methods: A total of 102 patients with primary hypertension due to liver-fire flaming-up were randomly divided into a Taichong (LR 3) group, a Neiguan (PC 6) group and a Qiaogong (Extra) group according to the random number table, with 34 cases in each group. Patients in the three groups received 4-week tuina treatment with the corresponding acupoint respectively. The blood pressure was recorded by ben chtop mercury sphygmoma no meter before tuina, immediately after tuina treatment, 30 min and 60 min after tuina treatment with the patient in a supine position in a quiet treatment room. The total effective rate was observed. Results: The systolic and diastolic blood pressures of the three groups all decreased after treatment (all P<0.05). The decrease of systolic and diastolic blood pressure at different time points after treatment in the Qiaogong (Extra) group and the Taichong (LR 3) group were better than those in the Neiguan (PC 6) group (all P<0.05). Qiaogong (Extra) group had the highest total effective rate though there was no statistical differenee in the total effective rate among the three groups (P>0.05). Con elusion: Treati ng primary hypertensi on due to liver-fire flami ng-up with tuina at Taich ong (LR 3), Neigua n (PC 6) and Qiaogong (Extra) can reduce systolic and diastolic blood pressure respectively, among which Qiaogong (Extra) has the highest total effective rate.展开更多
AIM: To investigate how the saturated and unsaturated fatty acid composition influences the susceptibility of developing acute pancreatitis. METHODS: Primary pancreatic acinar cells were treated with low and high conc...AIM: To investigate how the saturated and unsaturated fatty acid composition influences the susceptibility of developing acute pancreatitis. METHODS: Primary pancreatic acinar cells were treated with low and high concentrations of different saturated and unsaturated fatty acids, and changes in the cytosolic Ca2+ signal and the expression of protein kinase C(PKC) were measured after treatment. RESULTS: Unsaturated fatty acids at high concentrations, including oleic acid, linoleic acid, palmitoleic acid, docosahexaenoic acid, and arachidonic acid, induced a persistent rise in cytosolic Ca2+ concentrations in acinar cells. Unsaturated fatty acids at low concentrations and saturated fatty acids, including palmitic acid, stearic acid, and triglycerides, at low and high concentrations were unable to induce a rise in Ca2+ concentrations in acinar cells. Unsaturated fatty acids at high concentrations but not saturated fatty acids induced intra-acinar cell trypsin activation and cell damage and increased PKC expression.CONCLUSION: At sufficiently high concentrations, unsaturated fatty acids were able to induce acinar cells injury and promote the development of pancreatitis. Unsaturated fatty acids may play a distinctive role in the pathogenesis of pancreatitis through the activation of PKC family members.展开更多
文摘Objective: To compare the antihypertensive effects of tuina at Taichong (LR 3), Neiguan (PC 6) and Qiaogong (Extra) to screen the best tuina protocol for primary hypertension due to liver-fire flaming-up. Methods: A total of 102 patients with primary hypertension due to liver-fire flaming-up were randomly divided into a Taichong (LR 3) group, a Neiguan (PC 6) group and a Qiaogong (Extra) group according to the random number table, with 34 cases in each group. Patients in the three groups received 4-week tuina treatment with the corresponding acupoint respectively. The blood pressure was recorded by ben chtop mercury sphygmoma no meter before tuina, immediately after tuina treatment, 30 min and 60 min after tuina treatment with the patient in a supine position in a quiet treatment room. The total effective rate was observed. Results: The systolic and diastolic blood pressures of the three groups all decreased after treatment (all P<0.05). The decrease of systolic and diastolic blood pressure at different time points after treatment in the Qiaogong (Extra) group and the Taichong (LR 3) group were better than those in the Neiguan (PC 6) group (all P<0.05). Qiaogong (Extra) group had the highest total effective rate though there was no statistical differenee in the total effective rate among the three groups (P>0.05). Con elusion: Treati ng primary hypertensi on due to liver-fire flami ng-up with tuina at Taich ong (LR 3), Neigua n (PC 6) and Qiaogong (Extra) can reduce systolic and diastolic blood pressure respectively, among which Qiaogong (Extra) has the highest total effective rate.
文摘AIM: To investigate how the saturated and unsaturated fatty acid composition influences the susceptibility of developing acute pancreatitis. METHODS: Primary pancreatic acinar cells were treated with low and high concentrations of different saturated and unsaturated fatty acids, and changes in the cytosolic Ca2+ signal and the expression of protein kinase C(PKC) were measured after treatment. RESULTS: Unsaturated fatty acids at high concentrations, including oleic acid, linoleic acid, palmitoleic acid, docosahexaenoic acid, and arachidonic acid, induced a persistent rise in cytosolic Ca2+ concentrations in acinar cells. Unsaturated fatty acids at low concentrations and saturated fatty acids, including palmitic acid, stearic acid, and triglycerides, at low and high concentrations were unable to induce a rise in Ca2+ concentrations in acinar cells. Unsaturated fatty acids at high concentrations but not saturated fatty acids induced intra-acinar cell trypsin activation and cell damage and increased PKC expression.CONCLUSION: At sufficiently high concentrations, unsaturated fatty acids were able to induce acinar cells injury and promote the development of pancreatitis. Unsaturated fatty acids may play a distinctive role in the pathogenesis of pancreatitis through the activation of PKC family members.