Background: Increased relative wall thickness in hypertensive left ventricular hypertrophy (LVH) has been shown by echocardiography to allow preserved shortening at the endocardium despite depressed LV midwall circumf...Background: Increased relative wall thickness in hypertensive left ventricular hypertrophy (LVH) has been shown by echocardiography to allow preserved shortening at the endocardium despite depressed LV midwall circumferential shortening (MWCS). Depressed MWCS is an adverse prognostic indicator, but whether this finding reflects reduced global or regional LV myocardial function, as assessed by three-dimensional (3D) myocardial strain, is unknown. Methods and Results: Cardiac Magnetic Resonance (CMR) tissue tagging permits direct evaluation of regional 3D intramyocardial strain, independent of LV geometry. We evaluated 21 hypertensive patients with electrocardiographic LVH in the LIFE study and 8 normal controls using 3D MR tagging and echocardiography. Patients had higher MR LV mass than normals (116 ± 40 versus 63 ± 6 g/m2, P = 0.002). Neither echocardiographic fractional shortening (32 ± 6 versus 33% ± 3%), LVEF (63% versus 64%) or mean end-systolic stress (175 ± 27 versus 146 ± 28 g/cm2) were significantly different, yet global MWCS was decreased by both echocardiography (13.4 ± 2.8 versus 18.2% ± 1.5%, P P P = 0.002) in LVH and greater in lateral and anterior regions versus septal and posterior regions ( P P P 0.60, P = 0.001 for both). Conclusions: In patients with hypertensive LVH, despite normal LV function via echocardiography or CMR, CMR intramyocardial tagging show depressed global MWCS while 3D MR strain revealed marked underlying regional heterogeneity of LV dysfunction.展开更多
This study investigated the effect of catheter-based renal sympathetic denervation （RD） on left ventricular hypertrophy （LVH） and systolic and diastolic function in patients with resistant hypertension. LVH and di...This study investigated the effect of catheter-based renal sympathetic denervation （RD） on left ventricular hypertrophy （LVH） and systolic and diastolic function in patients with resistant hypertension. LVH and diastolic dysfunction are associated with elevated sympathetic activity and increased morbidity and mortality. The effect of RD on LVH and LV function is unclear展开更多
目的探讨采用心脏彩色多普勒超声检查高血压左心室肥大合并左心衰竭的诊断效果情况。方法随机选取2020年2月—2023年5月南京市高淳中医院进行诊断的70例高血压左心室肥大合并左心衰竭患者为研究组;同时间段选取70例健康体检者为参照组;...目的探讨采用心脏彩色多普勒超声检查高血压左心室肥大合并左心衰竭的诊断效果情况。方法随机选取2020年2月—2023年5月南京市高淳中医院进行诊断的70例高血压左心室肥大合并左心衰竭患者为研究组;同时间段选取70例健康体检者为参照组;对于两组研究对象合理展开心脏彩色多普勒超声诊断,并且就心功能不同分级患者的结果展开对比。结果研究组的左室收缩末期内径(left ventricular end systolic diameter,LVESD)、左室舒张末期内径(left ventricular end diastolic diameter,LVEDD)、左心房内径(internal diameter of left atrium,LAD)以及E/EA高于参照组,差异有统计学意义(P<0.05);研究组的左心室射血分数(left ventricle ejection fraction,LVEF)(56.35±5.19)%低于参照组,差异有统计学意义(t=10.621,P<0.05)。Ⅲ级患者的LVESD、LVEDD、LAD以及E/EA高于Ⅰ级、Ⅱ级患者,差异有统计学意义(P<0.05);Ⅲ级患者的LVEF低于Ⅰ级、Ⅱ级患者,差异有统计学意义(P<0.05)。结论在诊断高血压左心室肥大合并左心衰竭患者中采用心脏彩色多普勒超声方法的效果较好,可对患者的心脏结构清晰显示,对患者的心脏功能可以进行有效评估。展开更多
文摘Background: Increased relative wall thickness in hypertensive left ventricular hypertrophy (LVH) has been shown by echocardiography to allow preserved shortening at the endocardium despite depressed LV midwall circumferential shortening (MWCS). Depressed MWCS is an adverse prognostic indicator, but whether this finding reflects reduced global or regional LV myocardial function, as assessed by three-dimensional (3D) myocardial strain, is unknown. Methods and Results: Cardiac Magnetic Resonance (CMR) tissue tagging permits direct evaluation of regional 3D intramyocardial strain, independent of LV geometry. We evaluated 21 hypertensive patients with electrocardiographic LVH in the LIFE study and 8 normal controls using 3D MR tagging and echocardiography. Patients had higher MR LV mass than normals (116 ± 40 versus 63 ± 6 g/m2, P = 0.002). Neither echocardiographic fractional shortening (32 ± 6 versus 33% ± 3%), LVEF (63% versus 64%) or mean end-systolic stress (175 ± 27 versus 146 ± 28 g/cm2) were significantly different, yet global MWCS was decreased by both echocardiography (13.4 ± 2.8 versus 18.2% ± 1.5%, P P P = 0.002) in LVH and greater in lateral and anterior regions versus septal and posterior regions ( P P P 0.60, P = 0.001 for both). Conclusions: In patients with hypertensive LVH, despite normal LV function via echocardiography or CMR, CMR intramyocardial tagging show depressed global MWCS while 3D MR strain revealed marked underlying regional heterogeneity of LV dysfunction.
文摘This study investigated the effect of catheter-based renal sympathetic denervation （RD） on left ventricular hypertrophy （LVH） and systolic and diastolic function in patients with resistant hypertension. LVH and diastolic dysfunction are associated with elevated sympathetic activity and increased morbidity and mortality. The effect of RD on LVH and LV function is unclear
文摘目的探讨采用心脏彩色多普勒超声检查高血压左心室肥大合并左心衰竭的诊断效果情况。方法随机选取2020年2月—2023年5月南京市高淳中医院进行诊断的70例高血压左心室肥大合并左心衰竭患者为研究组;同时间段选取70例健康体检者为参照组;对于两组研究对象合理展开心脏彩色多普勒超声诊断,并且就心功能不同分级患者的结果展开对比。结果研究组的左室收缩末期内径(left ventricular end systolic diameter,LVESD)、左室舒张末期内径(left ventricular end diastolic diameter,LVEDD)、左心房内径(internal diameter of left atrium,LAD)以及E/EA高于参照组,差异有统计学意义(P<0.05);研究组的左心室射血分数(left ventricle ejection fraction,LVEF)(56.35±5.19)%低于参照组,差异有统计学意义(t=10.621,P<0.05)。Ⅲ级患者的LVESD、LVEDD、LAD以及E/EA高于Ⅰ级、Ⅱ级患者,差异有统计学意义(P<0.05);Ⅲ级患者的LVEF低于Ⅰ级、Ⅱ级患者,差异有统计学意义(P<0.05)。结论在诊断高血压左心室肥大合并左心衰竭患者中采用心脏彩色多普勒超声方法的效果较好,可对患者的心脏结构清晰显示,对患者的心脏功能可以进行有效评估。
