BACKGROUND Hemorrhage lesions may lead to bilateral hypertrophic olivary degeneration(HOD)through interruption of the dentato-rubral-olivary pathway.The pathological features of HOD are unusual neuronal trans-synaptic...BACKGROUND Hemorrhage lesions may lead to bilateral hypertrophic olivary degeneration(HOD)through interruption of the dentato-rubral-olivary pathway.The pathological features of HOD are unusual neuronal trans-synaptic degenerative changes.CASE SUMMARY A 56-year-old female was admitted to our hospital because her lower extremities and left upper ones were unable to move for 3 mo,and the swelling of her right lower extremities became worse 3 days ago.She had a hypertension history.Her characteristic clinical manifestations are palatal myoclonus and nystagmus.The patient’s magnetic resonance imaging(MRI)results showed that she had bilateral HOD after an acute pontine hemorrhage.She was given symptomatic and supportive treatment.The gabapentin,the memantine and the trihexyphenidyl were taken twice a day each.The rehabilitation and psychotherapy were implemented.After 3 months of treatment,her eye symptoms improved.CONCLUSION Bilateral HOD is a rare phenomenon after pontine hemorrhage.The key to diagnosis lies in the clinical manifestations and MRI results.展开更多
基金Scientific Research Project of Sichuan Hospital Management and Development Research Center,No.SCYG2019-25Key Technology Plan of Yaan City,No.21KJH0006.
文摘BACKGROUND Hemorrhage lesions may lead to bilateral hypertrophic olivary degeneration(HOD)through interruption of the dentato-rubral-olivary pathway.The pathological features of HOD are unusual neuronal trans-synaptic degenerative changes.CASE SUMMARY A 56-year-old female was admitted to our hospital because her lower extremities and left upper ones were unable to move for 3 mo,and the swelling of her right lower extremities became worse 3 days ago.She had a hypertension history.Her characteristic clinical manifestations are palatal myoclonus and nystagmus.The patient’s magnetic resonance imaging(MRI)results showed that she had bilateral HOD after an acute pontine hemorrhage.She was given symptomatic and supportive treatment.The gabapentin,the memantine and the trihexyphenidyl were taken twice a day each.The rehabilitation and psychotherapy were implemented.After 3 months of treatment,her eye symptoms improved.CONCLUSION Bilateral HOD is a rare phenomenon after pontine hemorrhage.The key to diagnosis lies in the clinical manifestations and MRI results.
