目的比较低剂量放疗与高剂量放疗在老年局部晚期喉及下咽鳞癌(Locally Advanced Squamous Cell Carcinoma of Larynx or Hypopharynx,LA-SCCL/H)中的疗效。方法回顾性分析2011年1月至2015年12月于我院治疗的资料完整的LA-SCCL/H患者202...目的比较低剂量放疗与高剂量放疗在老年局部晚期喉及下咽鳞癌(Locally Advanced Squamous Cell Carcinoma of Larynx or Hypopharynx,LA-SCCL/H)中的疗效。方法回顾性分析2011年1月至2015年12月于我院治疗的资料完整的LA-SCCL/H患者202例,依据患者放疗剂量是否大于5000 cGy将患者分为低剂量放疗组(≤5000cGy)和高剂量放疗组(>5000 cGy)。分析两组患者临床病理特征与放疗剂量的相关性、总生存时间及影响LA-SCCL/H患者预后的因素。结果年龄、性别、T分期、N分期、原发灶位置、ECOG评分、居住环境、吸烟、饮酒及是否违背医嘱是影响患者放疗剂量耐受的因素。在给予同期化疗基础上,高剂量放疗组较低剂量放疗组总生存期未见延长。单因素及多因素分析发现,年龄、T分期、原发灶位置、ECOG评分、是否独居、饮酒及是否违背医嘱是影响患者总生存的因素(均P<0.05),而放疗剂量与患者的预后无明显相关性(P>0.05)。结论低剂量放疗在LA-SCCL/H老年患者中具有较好的生存获益。展开更多
Malignancy of otorhinolaryngeal region is the 6th common malignancy worldwide and nowadays the incidence is increasing in developing countries like India. This malignancy contributes to 23% of male and 6% of female po...Malignancy of otorhinolaryngeal region is the 6th common malignancy worldwide and nowadays the incidence is increasing in developing countries like India. This malignancy contributes to 23% of male and 6% of female population of India [1]. Malignancies included in this study are those of oralcavity, oropharynx, nasopharynx, hypopharynx, larynx, thyroid, nose, paranasal sinuses and salivary gland tumors. This study was conducted in the Department of Otorhinolaryngology and Head and Neck Surgery, Thanjavur Medical College, Thanjavur, Tamilnadu India, over a period of 2 years from August 2013 to February 2015. Histopathologically confirmed cases alone were taken for this study. In our study the laryngeal and hypopharyngeal malignancies outnumber the other regions. Males are more commonly affected and the age group of around 40 - 50 years is more commonly involved. Smoking and alcohol intake plays a major etiological factor. Cancer awareness programmes and health education regarding risk factors can help to reduce the incidence of malignancies in our Thanjavur delta region.展开更多
文摘Malignancy of otorhinolaryngeal region is the 6th common malignancy worldwide and nowadays the incidence is increasing in developing countries like India. This malignancy contributes to 23% of male and 6% of female population of India [1]. Malignancies included in this study are those of oralcavity, oropharynx, nasopharynx, hypopharynx, larynx, thyroid, nose, paranasal sinuses and salivary gland tumors. This study was conducted in the Department of Otorhinolaryngology and Head and Neck Surgery, Thanjavur Medical College, Thanjavur, Tamilnadu India, over a period of 2 years from August 2013 to February 2015. Histopathologically confirmed cases alone were taken for this study. In our study the laryngeal and hypopharyngeal malignancies outnumber the other regions. Males are more commonly affected and the age group of around 40 - 50 years is more commonly involved. Smoking and alcohol intake plays a major etiological factor. Cancer awareness programmes and health education regarding risk factors can help to reduce the incidence of malignancies in our Thanjavur delta region.
