Definite Answer for Riemann Hypothesis Zeta 3/2 Function Provided by New Material Yb2Si2O7 in Quantum Mechanics

This paper indicates the problem of the famous Riemann hypothesis (RH), which has been well-verified by a definite answering method using a Bose-Einstein Condensate (BEC) phase. We adopt mathematical induction, mappings, and laser photons governed by electromagnetically induced transparency (EIT) to examine the existence of the RH. In considering the well-developed as Riemann zeta function, we find that the existence of RH has a corrected and self-consistent solution. Specifically, there is the only one pole at s = 1 on the complex plane for Riemann’s functions, which generalizes to all non-trivial zeros while s > 1. The essential solution is based on the BEC phases and on the nature of the laser photon(s). This work also incorporates Heisenberg commutators [ x^,p^]=1/2in the field of quantum mechanics. We found that a satisfactory solution for the RH would be incomplete without the formalism of Heisenberg commutators, BEC phases, and EIT effects. Ultimately, we propose the application of qubits in connection with the RH.

The Proof Dilemma of Porter’s Hypothesis:Analysis of Its Verification Difficulties

The Porter Hypothesis,proposed by Michael E.Porter,suggests that stringent environmental regulations can enhance corporate innovation and competitiveness,challenging the traditional view that regulations increase business costs.It argues that regulations motivate firms to innovate,leading to improved productivity,cost reductions,and new market opportunities.However,there are proponents and critics in academia regarding the hypothesis.Supporters claim regulations change corporate behavior,reducing agency costs and boosting research and development.Critics argue that if win-win situations exist,businesses would naturally pursue them without regulatory incentives.Key challenges in proving or refuting the hypothesis include its various versions,the difficulty in quantifying innovation and competitiveness,the complex interplay between regulation,innovation,and competitiveness,and the varying impacts across industries and regions.Additionally,the effects may require a long time to manifest,and the hypothesis’s applicability is influenced by evolving environmental policies and market environments.Despite mixed empirical findings,the Porter Hypothesis provides a valuable framework for understanding the relationships among environmental regulation,innovation,and competitiveness,but its validation requires a more comprehensive assessment.

人工智能赋能人文社会科学研究方法变革

以AlphaFold和ChatGPT为代表的人工智能,正在改变整个人类社会,驱动科学研究也驱动人文社会科学研究新范式的形成。“人工智能驱动的人文社会科学研究(AI4SS)”又称人文社科研究第五范式。与分别基于实验、基于理论、基于仿真、基于数据驱动的科学研究第一、二、三、四范式不同,人文社科研究第五范式具有AI全学科全过程赋能人文社会科学研究、机器涌现的智能成为人文社会科学研究的组成部分、利用AI概率统计模型解决社会科学研究中的组合爆炸问题、AI为人文社会科学研究构筑多节点的复杂网络、AI虚拟现实促进人文社会科学理论研究与实践结合以及以大模型为特征的科研大平台成为人文社会科学研究的必需等六大特点。AI4SS引发人文社会科学领域的革命,在人文社会科学研究中全面驱动选题与学术史梳理、假设生成及假设论证的方法变革。为加快推进AI赋能人文社会科学研究方法变革,加快面向其研究的开源开放大模型建设是必需的。

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same individuals.The comorbidity of the two neurological disorders represents a grave health threat to older populations.This review presents a brief background of the development of novel concepts and their clinical potentials.The activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal function.An ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic site.This Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute excitotoxicity.Furthermore,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death pathways.Based on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic neuropathogenesis.The N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic excitotoxicity.Ischemic stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time courses.It is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related dementia.This early treatment simultaneously serves as a preconditioning therapy against ischemic stroke that often attacks the same individuals during abnormal aging.

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

The Enlightment on Task-based Teaching Derived from Input Hypothesis

Aiming at gradually developing and perfecting the task-based teaching method, the essay, with enlightment from the Krashen＇s Input Hypothesis, discusses some issues about input, output, activities and teacher＇s role in this method.

Rules Governing Pressure Distribution for a Traveling Charge Under the Condition of Lagrange Hypothesis

Aim To study the rules governing pressure distribution of traveling charge under the condition of Lagrange hypothesis. Methods\ The study is based on the laws of conservation of momentum and energy. Results\ The gas flow velocity distribution formula at the back of a projectile and the momentum equation of a traveling charge are deduced, and rules governing their pressure distribution under the Lagrange hypothesis conditions are established. The pressure distribution of a traveling charge is compared with that of a conventional charge. Conclusion\ The pressure distribution in the bore of a traveling charge can be accurately predicted. A parabolic pressure distribution type is revealed.

科学工作假说(Working Hypothesis)是科学创新的基础

中国第四纪研究委员会成立50年来,第四纪科学已进于一个新的后第四纪研究时代了。显著的特点是研究工作由描述性向理念性,由区域性向全球性,由学科性向系统科学性迈进。在此过程中“科学工作假说”的不断出现,是促进其生长的动力。在1950年代对中国黄土成因的许多不同的假说促进了后来中国黄土研究的发展。当前中国第四纪研究的许多关于全球变化问题的科学假说,将开辟一个第四纪研究的新时代。

人类“绿色基因”假说(Human"Green-Gene"Hypothesis):核心内容、科学佐证与实践意义

首先,对人类“绿色基因”的形成进行探讨,包括人类(动物)与植物共同维持大气中碳氧平衡、人类(动物)与植物互为食物链关系、人体功能中存在植物性功能、绿色是人类眼睛最易看到的颜色、人类血红蛋白的结构相似于叶绿素结构、作为人体呼吸器官的肺部相似于树木地上部形状(树形)、人类肠道绒毛相似于植物根系毛细根等方面。进而对支持早期人类生活的植物类型与栽培植物诞生进行研究。在此基础上,提出人类“绿色基因”假说及其核心内容,归纳该假说的科学佐证。人类“绿色基因”假说从整体的、发展的思维解释人类与植物关系,奠定了园艺疗法、园林康养、森林康养的坚实基础,并指出接触植物、进行园艺操作与田园劳作是人们实现接地、激发触觉潜在功能的途径。

Multi-Angle Exploration on the Inner Relationship among Language,Thought and Culture with “Sapir-Whorf Hypothesis”

“Sapir-Whorf hypothesis"holds that human thoughts are shaped by their native languages,and speakers of different languages think differently relevantly.The hypothesis is controversial partly because it seems to deny the possibility of a general principle for human cognition,and partly because some findings taken to support it have not reliably replicated.The author argued that considering this hypothesis through the lens of probabilistic inference has the potential to figure out both issues,at least with respect to certain prominent findings in the two languages—Chinese and English.After exploring on the inner relationship among language,thought and culture with the comparison between English and Chinese based on a series of examples including“numbers,Wuhan dialect and some different understandings of idioms”,the author made an inference that language can somewhat affect human thought under the different culture contexts.Besides,it also provides some reference for educators to take in-depth studies on the relationship among language,thought and culture,which is vitally significant for ESL educators and learners.

Sapir-Whorf Hypothesis and Translation

Sapir-Whorf hypothesis has its implication in translation studies. Each language is a peculiar whole. It is a product, even an expression, of the spiritual personality and the cultural particularity. Translation is a kind of interlingual and intercultural communication. It involves not only the transference from one language into another, but a whole set of extra-linguistic criteria. In translating we are always crossing a greater or lesser barrier or divide.

A Critical Review of Critical Period Hypothesis in Second Language Acquisition

The researches on Critical Period Hypothesis(CPH) aims to explain the importance of the age factor in the process of learning a second language.In this essay,a critical review of the theoretical issues and empirical research on the CPH will spread out.Meanwhile,the discussion of implication and limitation of the CPH research will be concerned as well.

A Brief Analysis of Contrastive Analysis Hypothesis

This paper makes a brief analysis on the contrastive analysis hypothesis, and it is hoped to be helpful for the English teachers.

上古前元音假说与闽语中“面”和“眠”的读音

文章指出,“面脸”和“眠”的上古音分别是*C.me[n]-s和*m■i[n]。原始闽语形式则为*mhin^(tone3)和*min^(tone1)。原始闽语的主要元音*i可以理解为上古前元音*i或*e之前高或前半高舌位的反映。

Krashen's Input Hypothesis and Its Pedagogical Implications on Second Language Teaching

Krashen has developed the Input Hypothesis, which has deep influence on teaching method of second language. This thesis focuses on the Krashen's Input Hypothesis, which includes the following five hypotheses: the acquisition- learning hypothesis, the monitor hypothesis, the natural order hypothesis, the input hypothesis and the effective filter hypothesis. The thesis tries to explore the pedagogical implications of Krashen's Input Hypothesis on second language teaching in the aspects of the input quantity and input quality. The thesis tries to explore the most effective methods of second language teaching, in the hope that it will help to improve the efficiency of second language teaching.

Hygiene hypothesis in inflammatory bowel disease: A criticalreview of the literature

The hygiene hypothesis is thought to be a significant contributor to the growing incidence of inflammatory bowel disease (IBD) around the world, although the evidence for specific factors that underlie the hygiene hypothesis in IBD is unclear. We aimed to systematically review the literature to determine which hygiene-related factors are associated with the development of IBD. Publications identified from a broad based MEDLINE and Current Contents search between 1966 and 2007 on key terms relevant to the 'hygiene hypothesis' and IBD including H pylori exposure, helminths, cold chain hypothesis, measles infection and vaccination, antibiotic use, breastfeeding, family size, sibship, urban upbringing, day care attendance and domestic hygiene were reviewed. The literature suggests that the hygiene hypothesis and its association with decreased microbial exposure in childhood probably plays an important role in the development of IBD, although the strength of the supporting data for each of the factors varies considerably. The most promising factors that may potentially be associated with development of IBD include H pylori exposure, helminths, breastfeeding and sibship. However, the vast majority of studies in this area are plagued by serious methodological shortcomings, particularly the reliance on retrospective recall of information making it difficult to truly ascertain the importance of a 'hygiene hypothesis' in IBD. The 'hygiene hypothesis' in IBD is an important area of research that may give clues to the aetiology of this disease. Directions for future research are recommended.

Pharmacokinetics of traditional Chinese syndrome and recipe:a hypothesis and its verification(Ⅰ)

AIM To propose a hypothesis defining theabsorption,distribution,metabolism andelimination of traditional Chinese recipe（TCR）-component in blood of healthy subjects andpatients,and estimate its correctness.METHODS The pharmacokinetics（PK）of samedose of drug was studied in the animal model oftraditional Chinese syndrome（S）and healthyanimals.The classification,terminology,concept and significance of the hypothesis wereset forth with evidence provided in the presentstudy.The hypotheses consisted of traditionalChinese syndrome PK（S-PK）and traditionalChinese recipe PK（R-PK）.Firstly,the observedtetramethylpyrazine（TMP）PK in healthy,chronically reserpinized rats（rat model ofspleen deficiency syndrome,RMSDS）andRMSDS treated with Sijunzi decoction（SJZD）forconfirmation were used to verify S-PK; secondly,the ferulic acid（FA）PK in healthy andhigh molecular weight dextran（HMWD）-inducedrabbit model with blood stasis syndrome（RDBSS）was also used to verify S-PK;andlastly,TMP PK parameters in serum of healthyrats after orally taken Ligusticum wallichii（LW）,LW and Salvia miltiorrhiza（LW&SM）decoctions were compared to verify R-PK.RESULTS The apparent first-order absorption[Ka,（13.61±2.56）h-1,area under the blooddrug concentration-time curve[AUC,（24.88±9.76）μg.h-1mL-1],maximum drug concentration[Cmax,（4.82±1.23）μg·mL-1]of serum TMP inRMSDS were increased markedly（P【0.05）compared with those[Ka=（5.41±1.91）h-1,AUC=（5.20±2.57）μg·h-1·mL-1,Cmax=（2.33±1.77）μg·mL-1]of healthy rats（HR）.Theapparent first-order rate constant for α and βdistribution phase[α=（0.38±0.09）h-1,β=（0.06±0.03）h-1,the apparent first-orderintercompartmental transfer rate constants[K10=（0.24±0.07）h-1,K12=（0.11±0.02）h-1,K21=（0.11±0.02）h-1]of serum TMP in RMSDS weredecreased significantly（P【0.01）comparedwith those[K10=（0.88±0.20）h-1,K12=（1.45±0.47）h-1,K21=（0.72±0.22）h-1]of HR.However,no apparent differences occurredbetween HR and RMSDS treated with SJZD.Theserum FA concentration and its AUC[（5.6690±2.3541）μg·h-1·mL-1] in RMBSS were also higherthan those[AUC=（2.7566±0.8232）μg·h-1·mL-1]of healthy rabbits（P【0.05）.The Ka（11.51±2.82）h-1,AUC（0.84±0.17）μg·h-1·mL-1of LW & SM-derived TMP in serum weremuch lower（P【0.05）than those[Ka=（19.58±4.14）h-1,AUC=（1.27±0.26）μg·h-1·mL-1]ofLW-derived TMP in serum after oral decoctions.CONCLUSION The SDS and blood stasissyndrome state could affect significantly thepharmacokinetic parameters of drugs and theabnormal SDS pharmacokinetic parameters couldbe normalized by SJZD.The combination ofChinese medicine in TCR could reciprocallyaffect the pharmacokinetic parameters of othercomponents absorbed into the systemiccirculation.These results support the S-and R-PK hypothesis.

分析族群冲突问题的新模式——试评Ethnic Conflict:Commerce,Culture,and Contact Hypothesis

加拿大多伦多大学政治学系福布斯(H.D.Forbes)教授的著作《族群冲突:贸易、文化及接触理论》在分析、借鉴其它社会科学研究成果的基础上,向人们展示了一种理解和诠释族群冲突问题的新视角。该著作通过评析"接触理论"的利弊,提出了一个替代性的"语言模型"。以"语言模型"为基础的研究表明接触怎样能够同时改善和恶化族群关系:在个人层面上,接触能使族群关系更加和谐;但在群体层面上,接触可能会激发人们保留各自的群体认同,从而避免他们在同化中付出沉重代价。福布斯认为,接触是一个过程,而不是一个结果,它能打破社会分层,减少文化差异,但同化威胁到一个群体的存在,因此增加了彼此间的紧张关系。毋庸置疑,族群间的差异是冲突合理存在且不可避免的重要原因。

古DNA解析东亚南北方人群的迁徙与演化历史

过去10余年里,古基因组学技术和研究不断发展,极大提高了学界和公众对人类演化历史的理解和认识。2017年起,东亚,特别是中国地区早期人类古基因组研究大规模开展,使得东亚不同时间和地点人类古基因组数据得以大量涌现,为东亚数万年来人群演化历史带来许多全新的认识。特别是2022年以来,中国南北方万年内古人群基因组研究成果大量涌现,为揭示东亚不同区域人群之间的迁徙扩散与互动交流历史带来诸多新证据,但目前尚无针对东亚地区该时段古人群基因组研究最新进展的系统性综述。因此,本文以中国地区古人群基因组研究为重点,系统梳理了东亚地区自旧石器时代晚期以来人群的遗传格局和迁移交流历史。综合现有研究表明,东亚古人群早在1.9万年前已经发生南北分化,形成不同的人群谱系,并从新石器时代早期开始发生双向的基因交流与互动;新石器时代中期,这种互动出现强化趋势;到历史时期,以东亚北方人群相关祖源成分对南方地区古人群影响更为显著,形成现今中国人群的遗传结构。在这一过程中,中国南北方古人群通过沿海和内陆通道与西伯利亚、日韩、东南亚、太平洋岛屿等其他周边地区古人群发生广泛的互动交流,对不同语系人群的形成发挥了重要作用。这些研究揭示出东亚万年以来人群遗传演化与交流融合的历史脉络,但仍留有许多尚未解决的谜团,有待更多时间段和更广泛区域范围的古人群样本基因组数据得以展开更加全面和细致的探索研究,推动相关科学问题进一步突破。

The Comparison of the Input Hypothesis and the Interaction Hypothesis

This paper present and compare the similarities and differences of the Input Hypothesis and and give guidence in English Teaching practice.