Xingcuo lake,a closed one,is situated in eastern Tibetan Plateau.There are abundant snail shells Gy-raulus sibirica in its sediments.Here we display the determining results ofδ 13 C,δ 18 O in shell Gyraulus sibirica...Xingcuo lake,a closed one,is situated in eastern Tibetan Plateau.There are abundant snail shells Gy-raulus sibirica in its sediments.Here we display the determining results ofδ 13 C,δ 18 O in shell Gyraulus sibirica continuous-ly preserved in Xincuo Lake sediment s in the recent 50years.And by coupling the indexes ofδ 13 C,δ 18 O and instrumen-tal meteorological data in its basin to build relative function relation s among them,we probe quantitatively climatic sig-nals recorded in those indexes.The r esults show that there are remarkabl e relations betweenδ 13 C proxy and precipitation,δ 18 Oproxy and air temperature,of which correlative coefficient was 0.89an d 0.71,respectively.Besides,we also demon-strated that average variation betw eenδ 13 C proxy and precipitation(dδ 13 C /dP)was 0.027‰/mm and 1.64‰/℃forδ 18 O and air temperature(dδ 18 O /dT).展开更多
Digital design of a digital signal processor involves accurate and high-speed mathematical computation units.DSP units are one of the most power consuming and memory occupying devices.Multipliers are the common buildi...Digital design of a digital signal processor involves accurate and high-speed mathematical computation units.DSP units are one of the most power consuming and memory occupying devices.Multipliers are the common building blocks in most of the DSP units which demands low power and area constraints in the field of portable biomedical devices.This research works attempts multiple power reduction technique to limit the power dissipation of the proposed LUT multiplier unit.A lookup table-based multiplier has the advantage of almost constant area requirement’s irrespective to the increase in bit size of multiplier.Clock gating is usually used to reduce the unnecessary switching activities in idle circlet components.A clock tree structure is employed to enhance the SRAM based lookup table memory architecture.The LUT memory access operation is sequential in nature and instead of address decoder a ring counter is used to scan the memory contents and gated driver tree structure is implemented to control the clock and data switching activities.The proposed algorithm yields 20%of power reduction than existing.展开更多
This article extends a signal-based approach formerly proposed by the authors, which utilizes the fractal dimension of time frequency feature （FDTFF） of displacements, for earthquake damage detection of moment resis...This article extends a signal-based approach formerly proposed by the authors, which utilizes the fractal dimension of time frequency feature （FDTFF） of displacements, for earthquake damage detection of moment resist frame （MRF）, and validates the approach with shaking table tests. The time frequency feature （TFF） of the relative displacement at measured story is defined as the real part of the coefficients of the analytical wavelet transform. The fractal dimension （FD） is to quantify the TFF within the fundamental frequency band using box counting method. It is verified that the FDTFFs at all stories of the linear MRF are identical with the help of static condensation method and modal superposition principle, while the FDTFFs at the stories with localized nonlinearities due to damage will be different from those at the stories without nonlinearities using the reverse-path methodology. By comparing the FDTFFs of displacements at measured stories in a structure, the damage-induced nonlinearity of the structure under strong ground motion can be detected and localized. Finally shaking table experiments on a 1：8 scale sixteen-story three-bay steel MRF with added frictional dampers, which generate local nonlinearities, are conducted to validate the approach.展开更多
This paper proposed a new method to generate the complete sets of unique signals.It contains sequences comparing,improved exhaustive searches and ranking method.Characters of this new method are complete set;higher ef...This paper proposed a new method to generate the complete sets of unique signals.It contains sequences comparing,improved exhaustive searches and ranking method.Characters of this new method are complete set;higher effective;independent of certain mathematical constraints.And also some 24 bi-valued events sets generated by this method were discussed and these set are now used in our high consequence system.展开更多
Objective:To examine the therapeutic effect of Fangji Fuling Decoction(FFD) on sepsis through network pharmacological analysis combined with in vitro and in vivo experiments.Methods:A sepsis mouse model was constructe...Objective:To examine the therapeutic effect of Fangji Fuling Decoction(FFD) on sepsis through network pharmacological analysis combined with in vitro and in vivo experiments.Methods:A sepsis mouse model was constructed through intraperitoneal injection of 20 mg/kg lipopolysaccharide(LPS).RAW264.7 cells were stimulated by 250 ng/m L LPS to establish an in vitro cell model.Network pharmacology analysis identified the key molecular pathway associated with FFD in sepsis.Through ectopic expression and depletion experiments,the effect of FFD on multiple organ damage in septic mice,as well as on cell proliferation and apoptosis in relation to the mitogen-activated protein kinase 14/Forkhead Box O 3A(MAPK14/FOXO3A) signaling pathway,was analyzed.Results:FFD reduced organ damage and inflammation in LPS-induced septic mice and suppressed LPS-induced macrophage apoptosis and inflammation in vitro(P<0.05).Network pharmacology analysis showed that FFD could regulate the MAPK14/FOXO signaling pathway during sepsis.As confirmed by in vitro cell experiments,FFD inhibited the MAPK14 signaling pathway or FOXO3A expression to relieve LPS-induced macrophage apoptosis and inflammation(P<0.05).Furthermore,FFD inhibited the MAPK14/FOXO3A signaling pathway to inhibit LPS-induced macrophage apoptosis in the lung tissue of septic mice(P<0.05).Conclusion:FFD could ameliorate the LPS-induced inflammatory response in septic mice by inhibiting the MAPK14/FOXO3A signaling pathway.展开更多
DDS(直接数字频率合成,direct digital frequency synthesis)是一种全数字化设计信号发生器的方法。基于PSOC(programming system on chip)芯片技术,以Creator集成环境作为设计开发平台,实现DDS信号发生器各个模块的功能。根据DDS的结...DDS(直接数字频率合成,direct digital frequency synthesis)是一种全数字化设计信号发生器的方法。基于PSOC(programming system on chip)芯片技术,以Creator集成环境作为设计开发平台,实现DDS信号发生器各个模块的功能。根据DDS的结构和原理,推导得到参考频率与输出频率间的关系。利用Creator提供的固件元件,给出了元件的属性配置和使用方法。该设计充分体现了PSOC集成度高,图形化编程在嵌入式系统设计中的优势。展开更多
文摘Xingcuo lake,a closed one,is situated in eastern Tibetan Plateau.There are abundant snail shells Gy-raulus sibirica in its sediments.Here we display the determining results ofδ 13 C,δ 18 O in shell Gyraulus sibirica continuous-ly preserved in Xincuo Lake sediment s in the recent 50years.And by coupling the indexes ofδ 13 C,δ 18 O and instrumen-tal meteorological data in its basin to build relative function relation s among them,we probe quantitatively climatic sig-nals recorded in those indexes.The r esults show that there are remarkabl e relations betweenδ 13 C proxy and precipitation,δ 18 Oproxy and air temperature,of which correlative coefficient was 0.89an d 0.71,respectively.Besides,we also demon-strated that average variation betw eenδ 13 C proxy and precipitation(dδ 13 C /dP)was 0.027‰/mm and 1.64‰/℃forδ 18 O and air temperature(dδ 18 O /dT).
文摘Digital design of a digital signal processor involves accurate and high-speed mathematical computation units.DSP units are one of the most power consuming and memory occupying devices.Multipliers are the common building blocks in most of the DSP units which demands low power and area constraints in the field of portable biomedical devices.This research works attempts multiple power reduction technique to limit the power dissipation of the proposed LUT multiplier unit.A lookup table-based multiplier has the advantage of almost constant area requirement’s irrespective to the increase in bit size of multiplier.Clock gating is usually used to reduce the unnecessary switching activities in idle circlet components.A clock tree structure is employed to enhance the SRAM based lookup table memory architecture.The LUT memory access operation is sequential in nature and instead of address decoder a ring counter is used to scan the memory contents and gated driver tree structure is implemented to control the clock and data switching activities.The proposed algorithm yields 20%of power reduction than existing.
基金National Natural Science Foundation under Grant No.51161120359Ministry of Education under Grant No.20112302110050Special Fund for Earthquake Scientific Research in the Public Interest under Grant No.201308003
文摘This article extends a signal-based approach formerly proposed by the authors, which utilizes the fractal dimension of time frequency feature （FDTFF） of displacements, for earthquake damage detection of moment resist frame （MRF）, and validates the approach with shaking table tests. The time frequency feature （TFF） of the relative displacement at measured story is defined as the real part of the coefficients of the analytical wavelet transform. The fractal dimension （FD） is to quantify the TFF within the fundamental frequency band using box counting method. It is verified that the FDTFFs at all stories of the linear MRF are identical with the help of static condensation method and modal superposition principle, while the FDTFFs at the stories with localized nonlinearities due to damage will be different from those at the stories without nonlinearities using the reverse-path methodology. By comparing the FDTFFs of displacements at measured stories in a structure, the damage-induced nonlinearity of the structure under strong ground motion can be detected and localized. Finally shaking table experiments on a 1：8 scale sixteen-story three-bay steel MRF with added frictional dampers, which generate local nonlinearities, are conducted to validate the approach.
基金The National High Technology Research and Development Program of China(863program)(No.2005AA404250,No.2003AA404210,No.2006AA01Z443)
文摘This paper proposed a new method to generate the complete sets of unique signals.It contains sequences comparing,improved exhaustive searches and ranking method.Characters of this new method are complete set;higher effective;independent of certain mathematical constraints.And also some 24 bi-valued events sets generated by this method were discussed and these set are now used in our high consequence system.
文摘提出了一种2.5维(2.5D)系统封装高速输入/输出(I/O)全链路的信号/电源完整性(Signal integrity/power integrity,SI/PI)协同仿真方法。首先通过电磁全波仿真分析SiP内部“芯片I/O引脚-有源转接板-印刷电路板(即封装基板)-封装体I/O引脚”这一主要高速信号链路及相应的转接板/印刷电路板电源分配网络(Power distribution network,PDN)的结构特征和电学特性,在此基础上分别搭建对应有源转接板和印刷电路板两种组装层级的“信号链路+PDN”模型,并分别进行SI/PI协同仿真,提取出反映信号链路/PDN耦合特性的模块化集总电路模型,从而在电路仿真器中以级联模型实现快速的SI/PI协同仿真。与全链路的全波仿真结果的对比表明,模块化后的协同仿真有很好的可信度,而且仿真时间与资源开销大幅缩减,效率明显提升。同时总结了去耦电容的大小与布局密度对PDN电源完整性的影响及对信号完整性的潜在影响,提出了去耦电容布局优化的建议。
文摘Objective:To examine the therapeutic effect of Fangji Fuling Decoction(FFD) on sepsis through network pharmacological analysis combined with in vitro and in vivo experiments.Methods:A sepsis mouse model was constructed through intraperitoneal injection of 20 mg/kg lipopolysaccharide(LPS).RAW264.7 cells were stimulated by 250 ng/m L LPS to establish an in vitro cell model.Network pharmacology analysis identified the key molecular pathway associated with FFD in sepsis.Through ectopic expression and depletion experiments,the effect of FFD on multiple organ damage in septic mice,as well as on cell proliferation and apoptosis in relation to the mitogen-activated protein kinase 14/Forkhead Box O 3A(MAPK14/FOXO3A) signaling pathway,was analyzed.Results:FFD reduced organ damage and inflammation in LPS-induced septic mice and suppressed LPS-induced macrophage apoptosis and inflammation in vitro(P<0.05).Network pharmacology analysis showed that FFD could regulate the MAPK14/FOXO signaling pathway during sepsis.As confirmed by in vitro cell experiments,FFD inhibited the MAPK14 signaling pathway or FOXO3A expression to relieve LPS-induced macrophage apoptosis and inflammation(P<0.05).Furthermore,FFD inhibited the MAPK14/FOXO3A signaling pathway to inhibit LPS-induced macrophage apoptosis in the lung tissue of septic mice(P<0.05).Conclusion:FFD could ameliorate the LPS-induced inflammatory response in septic mice by inhibiting the MAPK14/FOXO3A signaling pathway.
文摘DDS(直接数字频率合成,direct digital frequency synthesis)是一种全数字化设计信号发生器的方法。基于PSOC(programming system on chip)芯片技术,以Creator集成环境作为设计开发平台,实现DDS信号发生器各个模块的功能。根据DDS的结构和原理,推导得到参考频率与输出频率间的关系。利用Creator提供的固件元件,给出了元件的属性配置和使用方法。该设计充分体现了PSOC集成度高,图形化编程在嵌入式系统设计中的优势。
