Adversarial attacks have been posing significant security concerns to intelligent systems,such as speaker recognition systems(SRSs).Most attacks assume the neural networks in the systems are known beforehand,while bla...Adversarial attacks have been posing significant security concerns to intelligent systems,such as speaker recognition systems(SRSs).Most attacks assume the neural networks in the systems are known beforehand,while black-box attacks are proposed without such information to meet practical situations.Existing black-box attacks improve trans-ferability by integrating multiple models or training on multiple datasets,but these methods are costly.Motivated by the optimisation strategy with spatial information on the perturbed paths and samples,we propose a Dual Spatial Momentum Iterative Fast Gradient Sign Method(DS-MI-FGSM)to improve the transferability of black-box at-tacks against SRSs.Specifically,DS-MI-FGSM only needs a single data and one model as the input;by extending to the data and model neighbouring spaces,it generates adver-sarial examples against the integrating models.To reduce the risk of overfitting,DS-MI-FGSM also introduces gradient masking to improve transferability.The authors conduct extensive experiments regarding the speaker recognition task,and the results demonstrate the effectiveness of their method,which can achieve up to 92%attack success rate on the victim model in black-box scenarios with only one known model.展开更多
目的探讨甲基转移酶5(methyltransferase-like 5,METTL5)在三阴乳腺癌(triple-negative breast cancer,TNBC)中的作用和潜在机制。方法采用免疫组织化学方法和Western blot检测TNBC肿瘤组织和细胞系中METTL5的表达情况。用靶向METTL5的s...目的探讨甲基转移酶5(methyltransferase-like 5,METTL5)在三阴乳腺癌(triple-negative breast cancer,TNBC)中的作用和潜在机制。方法采用免疫组织化学方法和Western blot检测TNBC肿瘤组织和细胞系中METTL5的表达情况。用靶向METTL5的shRNA(shRNA-METTL5)转染TNBC细胞后,用CCK-8、集落形成、伤口愈合以及Transwell实验分别检测细胞增殖活性、迁移与侵袭,Western blot检测Wnt/β-catenin信号关键蛋白的表达。构建异种移植瘤模型,验证敲降METTL5对TNBC细胞在体内生长以及Wnt/β-catenin信号活性的影响。结果METTL5在TNBC肿瘤组织和细胞系中表达上调(P<0.01)。敲降METTL5可抑制TNBC细胞的增殖、迁移和侵袭并降低了Wnt/β-catenin信号分子β-catenin、细胞周期蛋白(Cyclin)D1、基质金属蛋白酶(MMP)-2和MMP-7的表达(均P<0.01)。体内实验显示,敲降METTL5减缓了移植瘤生长和Wnt/β-catenin信号活性。结论敲降METTL5能抑制TNBC细胞的增殖、迁移与侵袭,其作用可能与抑制Wnt/β-catenin信号通路有关。展开更多
基金The Major Key Project of PCL,Grant/Award Number:PCL2022A03National Natural Science Foundation of China,Grant/Award Numbers:61976064,62372137Zhejiang Provincial Natural Science Foundation of China,Grant/Award Number:LZ22F020007。
文摘Adversarial attacks have been posing significant security concerns to intelligent systems,such as speaker recognition systems(SRSs).Most attacks assume the neural networks in the systems are known beforehand,while black-box attacks are proposed without such information to meet practical situations.Existing black-box attacks improve trans-ferability by integrating multiple models or training on multiple datasets,but these methods are costly.Motivated by the optimisation strategy with spatial information on the perturbed paths and samples,we propose a Dual Spatial Momentum Iterative Fast Gradient Sign Method(DS-MI-FGSM)to improve the transferability of black-box at-tacks against SRSs.Specifically,DS-MI-FGSM only needs a single data and one model as the input;by extending to the data and model neighbouring spaces,it generates adver-sarial examples against the integrating models.To reduce the risk of overfitting,DS-MI-FGSM also introduces gradient masking to improve transferability.The authors conduct extensive experiments regarding the speaker recognition task,and the results demonstrate the effectiveness of their method,which can achieve up to 92%attack success rate on the victim model in black-box scenarios with only one known model.
