Objective： To study the clinical efficacy and methods of permanent implantation of radioactive I-125 seed in surgery for local advanced non small lung cancer （LANSCLC）. Methods： From Apr. 2004 to Apr. 2006, the I-...Objective： To study the clinical efficacy and methods of permanent implantation of radioactive I-125 seed in surgery for local advanced non small lung cancer （LANSCLC）. Methods： From Apr. 2004 to Apr. 2006, the I-125 seeds were implanted into 30 patients with LANSCLC in surgery. The numbers of seeds were 10-40. The chemotherapy was performed in 10 to 14 days after operation. Results： There was no operative death, and the distribution of seeds and complications were reviewed by CT and X-ray after treatment. The distribution of seeds was satisfactory in all patients. The complete response rate （CR） was 56.6% and the part response （PR） was 26.6%. The overall response rate was 83.3% after 4-24 months of surgery. There was no one occurred radiation pneumonia. Prospective efficacy await further follow-up. Conclusion： Permanent implantation of 1-125 seed in surgery for LANSCLC, is a safe and effective method with mild complications.展开更多
For local radiotherapy, a three-dimensional(3D)conformal localized dose planning protocol has been established in this paper to develop a precise and reasonable dose plan. A precalculated 3D dose map for a single sour...For local radiotherapy, a three-dimensional(3D)conformal localized dose planning protocol has been established in this paper to develop a precise and reasonable dose plan. A precalculated 3D dose map for a single source is obtained using the Monte Carlo method, and the spatial dose maps are combined linearly to acquire the dose distribution. The dose distribution is visualized through the real-time display of the isodose line and isodose surface combined with the reconstructed 3D organ groups. By observing 3D dose coverage to the target volume and surrounding tissues, dose planning could be initiated with greater accuracy and precision to avoid dose dead zones and excessively high-dose levels, thus achieving the 3D conformal dose planning objective. Further research into the impact that blockages have on a needle trajectory can be conducted to optimize the insertion accuracy. A treatment planning system was developed to formulate and implement the 3D local treatment plan before the surgery,during the surgery, and after the surgery. Several experiments pertaining to both single-seed and multiple-seed dose distributions were conducted to verify the accuracy of the single-seed dose calculation module and 3D superposition dose calculation in the treatment planning system.展开更多
文摘Objective： To study the clinical efficacy and methods of permanent implantation of radioactive I-125 seed in surgery for local advanced non small lung cancer （LANSCLC）. Methods： From Apr. 2004 to Apr. 2006, the I-125 seeds were implanted into 30 patients with LANSCLC in surgery. The numbers of seeds were 10-40. The chemotherapy was performed in 10 to 14 days after operation. Results： There was no operative death, and the distribution of seeds and complications were reviewed by CT and X-ray after treatment. The distribution of seeds was satisfactory in all patients. The complete response rate （CR） was 56.6% and the part response （PR） was 26.6%. The overall response rate was 83.3% after 4-24 months of surgery. There was no one occurred radiation pneumonia. Prospective efficacy await further follow-up. Conclusion： Permanent implantation of 1-125 seed in surgery for LANSCLC, is a safe and effective method with mild complications.
基金supported by the National Natural Science Foundation of China(no.51175373)the Key Technology and Development Program of the Tianjin Municipal Science and Technology Commission(no.14ZCDZGX00490)
文摘For local radiotherapy, a three-dimensional(3D)conformal localized dose planning protocol has been established in this paper to develop a precise and reasonable dose plan. A precalculated 3D dose map for a single source is obtained using the Monte Carlo method, and the spatial dose maps are combined linearly to acquire the dose distribution. The dose distribution is visualized through the real-time display of the isodose line and isodose surface combined with the reconstructed 3D organ groups. By observing 3D dose coverage to the target volume and surrounding tissues, dose planning could be initiated with greater accuracy and precision to avoid dose dead zones and excessively high-dose levels, thus achieving the 3D conformal dose planning objective. Further research into the impact that blockages have on a needle trajectory can be conducted to optimize the insertion accuracy. A treatment planning system was developed to formulate and implement the 3D local treatment plan before the surgery,during the surgery, and after the surgery. Several experiments pertaining to both single-seed and multiple-seed dose distributions were conducted to verify the accuracy of the single-seed dose calculation module and 3D superposition dose calculation in the treatment planning system.
