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Exploration of the Mining of Ideological and Political Elements and Teaching Integration of Bridge Engineering Courses in Applied Undergraduate Programs
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作者 Huali Jiao Liming Zhao 《Journal of Contemporary Educational Research》 2024年第9期210-218,共9页
The questions of what kind of individuals university education should cultivate,how to cultivate them,and for whom they are being trained are pressing issues that require immediate solutions.Implementing ideological a... The questions of what kind of individuals university education should cultivate,how to cultivate them,and for whom they are being trained are pressing issues that require immediate solutions.Implementing ideological and political education is a fundamental way to address these challenges.Integrating political education into professional courses is just as important as imparting knowledge,fostering interest,transmitting values,and shaping students’character and spirit.The excavation of ideological and political elements in bridge engineering courses should comprehensively consider the dependent subject of ideological and political elements,the source of cases,the depth of excavation,the trade-offs between courses,the commonality and multifaceted nature of ideological and political elements,as well as the two ways of ideological and political elements integration.Ideological and political elements should be integrated into all stages of classroom lectures,course assignments,final examinations,course design,discipline competitions,school-enterprise cooperation,etc.,so as to achieve the effect of educating people in the whole process. 展开更多
关键词 Ideological and political teaching bridge engineering Ideological and political elements mining integration of ideology and politics
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Application of engineered compressible inclusions to mitigating soilstructure interaction issues in integral bridge abutments
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作者 Lila Dhar Sigdel Minghao Lu +3 位作者 Ahmed Al-qarawi Chin Jian Leo Samanthika Liyanapathirana Pan Hu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2023年第8期2132-2146,共15页
The thermally induced cyclic loading on integral bridge abutments causes soil deformation and lateral stress ratcheting behind the abutment wall due to the expansion and contraction of the bridge deck.The forward and ... The thermally induced cyclic loading on integral bridge abutments causes soil deformation and lateral stress ratcheting behind the abutment wall due to the expansion and contraction of the bridge deck.The forward and backward movements of the abutment in response to the expansion/contraction of the bridge deck lead to the formation of settlement trough and surface heaving,frequently creating a bump at the bridge approach and increasing the lateral earth pressure behind the abutment.Measures to reduce the bump at the bridge approach,including several treatment methods,such as compaction of selected backfill materials,grout injection,installation of approach slab,and using a layer of compressible inclusion material behind the abutment were proposed.However,these guidelines still lack sufficient design details and there are limited experimental findings to validate design assumptions.In this paper,the use of engineered compressible materials to alleviate the lateral earth pressure ratcheting and settlement at the bridge approach is investigated.The comparative study is presented for the soil-inclusion,material-structure and soil-structure interactions for an integral bridge under three different backfill conditions,i.e.(a)sand,(b)sand and EPS geofoam,and(c)sand and Infinergy®.The study was conducted in a special large-scale test chamber with a semi-scale abutment to gain better insights into the soil-structure interaction(SSI).The kinematics and rearrangement of the soil during the cyclic loading have been investigated to identify the mitigating effects of compressible inclusions.The comparative study indicates that both compressible inclusions perform comparatively well,however,Infinergy®is a better alternative than the medium-density EPS geofoam,as it works more effectively to reduce the backfill settlement and heaving as well as soil ratcheting effects under cyclic translational movement. 展开更多
关键词 integral bridge Cyclic loading Stress ratcheting Settlement bump Earth pressure distribution Soil-structure interaction(SSI)
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Application Strategy of Digital Comprehensive Management and Maintenance System for Bridges
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作者 Shengzhong Xiang Linlong Wang +1 位作者 Manman Feng Jian Cao 《Journal of World Architecture》 2024年第2期154-159,共6页
Effective application of digital integrated management and maintenance systems is essential for successful operation and maintenance management of bridge projects.This article analyzes the application strategy of such... Effective application of digital integrated management and maintenance systems is essential for successful operation and maintenance management of bridge projects.This article analyzes the application strategy of such systems.It provides an overview of comprehensive digital management and maintenance of bridges,an analysis of the basic components of the integrated management and maintenance system,and its application strategies.This study aims to offer guidance for the application of the system and to improve the quality of modern bridge engineering management and maintenance work. 展开更多
关键词 bridge engineering Digital integrated management and maintenance system Component modules
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A Novel Topology of Single-Phase AC-DC Integrated Boost-SEPIC (IBS) Converter Using Common Part Sharing Method (CPSM) for High Step-Up Applications 被引量:1
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作者 Mohammad Bazlur Rashid Mohammad Abdul Moin Oninda +3 位作者 Fahim Faisal Mirza Muntasir Nishat Golam Sarowar Md. Ashraful Hoque 《Journal of Power and Energy Engineering》 2018年第6期38-47,共10页
A novel topology of Integrated Boost-SEPIC (IBS) AC-DC converter using common part sharing method (CPSM) has been proposed in this paper. Conventional boost converters with bridge rectifier configuration are inefficie... A novel topology of Integrated Boost-SEPIC (IBS) AC-DC converter using common part sharing method (CPSM) has been proposed in this paper. Conventional boost converters with bridge rectifier configuration are inefficient due to limited voltage step-up ratio which may not be applicable for high step-up applications as in the case of micro generators. The proposed IBS topology is based on the common part sharing method capable of operating both for positive and negative half cycle of the input signal. Result and simulation were conducted using PSIM environment. The proposed AC-DC IBS topology eliminates the requirement of bridge rectifier achieving high efficiency (about 99%), improved power factor (0.75, leading) and lower THD (about 38.8%) which is within IEEE standard. 展开更多
关键词 integrated Boost-SEPIC (ibs) bridgeless AC-DC CONVERTER Voltage Gain THD Minimization Efficiency Improvement Power Factor Correction
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Evaluation of vertical impact factor coefficients for continuous and integral railway bridges under high-speed moving loads 被引量:4
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作者 Anand M.Gharad Ranjan S.Sonparote 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2021年第2期495-504,共10页
In the railway bridge analysis and design method,dynamic train loads are regarded as static loads enhanced by an impact factor(IF).The IF coefficients for various railway bridges have been reported as a function of sp... In the railway bridge analysis and design method,dynamic train loads are regarded as static loads enhanced by an impact factor(IF).The IF coefficients for various railway bridges have been reported as a function of span length or frequency of the bridges in Eurocode(2003).However,these IF coefficient values neglect the effects of very high speeds(>200 km/h)and soil-structure interaction(SSI).In this work,a comprehensive study to assess the impact factor coefficients of mid-span vertical displacements for continuous and integral railway bridges subjected to high-speed moving loads is reported.Three different configurations,each for the three-dimensional(3D)continuous and integral bridge,are considered.Also,single-track(1-T)and two-track(2-T)“real train”loading cases for both these bridge types are considered.Subsequently,finite element analysis of the full-scale 3D bridge models,to identify their IF values,considering the effects of SSI for three different soil conditions,is conducted.The IF values obtained from the study for both bridge types are comparable and are greater than the values recommended by Eurocode(2003).The results reveal that with a loss of soil stiffness,the IF value reduces;thus,it confirms the importance of SSI analysis. 展开更多
关键词 impact factor dynamic soil-structure interaction high-speed moving loads finite element analysis continuous bridge integral bridge
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MIBS分组密码的改进积分攻击
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作者 毛永霞 吴文玲 张丽 《计算机研究与发展》 EI CSCD 北大核心 2023年第12期2697-2708,共12页
MIBS算法是由Izadi等人在CANS 2009上提出的一个轻量级分组密码算法,整体采用Feistel结构,轮函数使用SP结构,分组长度为64 b,包含MIBS-64和MIBS-80这2个版本,适用于资源受限的环境,例如RFID(radio frequency identification)标签.研究M... MIBS算法是由Izadi等人在CANS 2009上提出的一个轻量级分组密码算法,整体采用Feistel结构,轮函数使用SP结构,分组长度为64 b,包含MIBS-64和MIBS-80这2个版本,适用于资源受限的环境,例如RFID(radio frequency identification)标签.研究MIBS算法针对积分攻击的安全性.首先,针对该算法的密钥编排算法,利用密钥搭桥技术,分别得到了MIBS-64和MIBS-80的轮密钥的相关性质.其次,利用基于MILP(mixed integer linear programming)的比特可分性的自动化建模搜索方法,构造了MIBS的8轮和9轮积分区分器.然后,基于8轮积分区分器,给出了12轮MIBS-64的密钥恢复攻击,数据复杂度为2^(60),时间复杂度为2^(63.42);最后,基于9轮积分区分器,给出了14轮MIBS-64的密钥恢复攻击,数据复杂度为2^(63),时间复杂度为2^(66).这是目前对MIBS-64和MIBS-80轮数最长的积分攻击. 展开更多
关键词 积分攻击 Mibs 密钥搭桥技术 部分和技术 密钥恢复
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IB物理课程对普通高中物理教学的启示——以跨学科部分为例 被引量:1
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作者 张东升 《教育参考》 2024年第4期25-29,共5页
现代社会的高速发展加深了各学科的交叉融合,IB物理课程特别是它的跨学科部分对普通高中物理课程的教学有一定的启示。文章比较了普通高中物理课程与IB课程在理念上的异同,从课程实施、课程评价等维度评价学生的学习效果,能够有效地促... 现代社会的高速发展加深了各学科的交叉融合,IB物理课程特别是它的跨学科部分对普通高中物理课程的教学有一定的启示。文章比较了普通高中物理课程与IB课程在理念上的异同,从课程实施、课程评价等维度评价学生的学习效果,能够有效地促进物理学科核心素养和课堂教学的深度融合,培养学生解决真问题的能力。 展开更多
关键词 ib课程 跨学科融合 高中物理
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Integrity Design Strategy in Steel Structure Bridge Design 被引量:1
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作者 Meng Wan 《Journal of World Architecture》 2021年第4期21-24,共4页
Nowadays,the scope of bridge construction projects in China is becoming wider,which promotes China's economic development to a large extent and also improves China's transportation system.Meanwhile,people also... Nowadays,the scope of bridge construction projects in China is becoming wider,which promotes China's economic development to a large extent and also improves China's transportation system.Meanwhile,people also put forward new requirements for the quality of steel structure bridges.However,in actual design,due to the influence of many fectors,some problems are inevitable,which will affect the integrity of the design.Therefore,the designer needs to fully grasp the possible design problems,and then take efiective measures to improve the integrity of the design scheme,so as to ensure the quality of the steel structure bridge and improves the safety of the steel structure bridge from the fundamentals.This paper mainly focuses on steel structure bridges,analyzed the current status of steel structure bridge types and their selection,and proposes the integrity design strategy of steel structure bridges. 展开更多
关键词 Steel structure bridge integrITY DESIGN
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Preservation Strategies of Timber-framed Arch Bridges as Cultural Landscape Heritage
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作者 王丽娴 龙松亮 项赟 《Journal of Landscape Research》 2011年第11期73-77,共5页
Theoretical study on and safeguarding of cultural landscape heritage has been put on the agenda of heritage protection in Zhejiang and Fujian provinces.The safeguarding of timber-framed arch bridge heritage in the pas... Theoretical study on and safeguarding of cultural landscape heritage has been put on the agenda of heritage protection in Zhejiang and Fujian provinces.The safeguarding of timber-framed arch bridge heritage in the past 5 decades could be classified into 3 stages,and heritage protection in all 3 stages was closely related to original meaning of "landscape",which proved that timber-framed arch bridge heritage had profound inside information,and the safeguarding of timber-framed arch bridge from the perspective of cultural landscape heritage was worth further study.Safeguarding of timber-framed arch bridge cultural landscape heritage focused on integrated conservation,but not protection of individual bridges.Integrated conservation of world heritage is to maintain and restore the integrated environment landscape of the heritage,thus protection of timber-framed arch bridge heritage is not only to explore its architectural craftsmanship,but also to lay a foundation for the dynamic succession of such craftsmanship as intangible cultural heritage.Value of the existing timber-framed arch bridges as historic building heritage was discussed,and it was proposed that ultimate objectives of the safeguarding could be realized step by step from 3 layers. 展开更多
关键词 Timber-framed ARCH bridge of China HERITAGE CULTURAL landscapes integrated CONSERVATION
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Developments and Prospects of Long-Span High-Speed Railway Bridge Technologies in China 被引量:61
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作者 Shunquan Qin Zongyu Gao 《Engineering》 SCIE EI 2017年第6期787-794,共8页
With the rapid developments of the high-speed railway in China, a great number of long-span bridges have been constructed in order to cross rivers and gorges. At present, the longest main span of a constructed high-sp... With the rapid developments of the high-speed railway in China, a great number of long-span bridges have been constructed in order to cross rivers and gorges. At present, the longest main span of a constructed high-speed railway bridge is only 630 m. The main span of Hutong Yangtze River Bridge and of Wufengshan Yangtze River Bridge, which are under construction, will be much longer, at 1092 m each. In order to overcome the technical issues that originate from the extremely large dead loading and the relatively small structural stiffness of long-span high-speed railway bridges, many new technologies in bridge construction, design, materials, and so forth have been developed. This paper carefully reviews progress in the construction technologies of multi-function combined bridges in China, including com- bined highway and railway bridges and multi-track railway bridges. Innovations and practices regarding new types of bridge and composite bridge structures, such as bridges with three cable planes and three main trusses, inclined main trusses, slab-truss composite sections, and steel-concrete composite sections, are introduced. In addition, investigations into high-performance materials and integral fabrication and erection techniques for long-span railway bridges are summarized. At the end of the paper, prospects for the future development of long-span high-speed railwav bridges are provided. 展开更多
关键词 High-speed railway Long-span bridges Multi-function combined bridges High-performance materials Spatial structures with three cable planes integral fabrication
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Density Functional Approach Based on Numerically Obtained Bridge Functional
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作者 ZHOU Shi-Qi 《Communications in Theoretical Physics》 SCIE CAS CSCD 2002年第9期355-360,共6页
The Ornstein Zernike equation is solved with the Rogers Young approximation for bulk hard sphere fluidand Lennard-Jones fluid for several state points. Then the resulted bulk fluid radial distribution function combine... The Ornstein Zernike equation is solved with the Rogers Young approximation for bulk hard sphere fluidand Lennard-Jones fluid for several state points. Then the resulted bulk fluid radial distribution function combinedwith the test particle method is employed to determine numerically the function relationship of bridge functional as afunction of indirect correlation function. It is found that all of the calculated points from different phase space statepoints for a same type of fluid collapse onto a same smooth curve. Then the numerically obtained curve is used tosubstitute the analytic expression of the bridge functional as a function of indirect correlation function required in themethodology [J. Chem. Phys. 112 (2000) 8079] to deterrnine the density distribution of non-uniform hard spherefluid and Lennard Jones fluid. The good agreement of theoretical predictions with the computer simulation data isobtained. The present numerical procedure incorporates the knowledge of bulk fluid radial distribution function intothe constructing of the density functional approximation and makes the original methodology more accurate and moreflexible for various interaction potential fluid. 展开更多
关键词 DENSITY FUNCTIONAL theory bridge functional integrAL EQUATION THEORY
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基于FMEA方法的船舶IBS航行安全分析 被引量:3
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作者 董翔 《船舶与海洋工程》 2020年第2期72-77,共6页
以某型船为例,介绍故障模式和影响分析(Failure Mode and Effect Analysis,FMEA)的基本方法和分析步骤。采用该方法对船舶综合桥楼系统(Integrated Bridge System,IBS)的航行安全性进行深入分析,验证某型船IBS的航行安全性,为今后类似船... 以某型船为例,介绍故障模式和影响分析(Failure Mode and Effect Analysis,FMEA)的基本方法和分析步骤。采用该方法对船舶综合桥楼系统(Integrated Bridge System,IBS)的航行安全性进行深入分析,验证某型船IBS的航行安全性,为今后类似船舶IBS的设计提供参考。 展开更多
关键词 故障模式和影响分析 综合桥楼系统 航行安全
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Density Functional Approach Based on Numerically Obtained Bridge Functional
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作者 ZHOUShi-Qi 《Communications in Theoretical Physics》 SCIE CAS CSCD 2002年第3期355-360,共6页
The Ornstein-Zernike equation is solved with the Rogers-Young approximation for bull, hard sphere fluid and Lennard-Jones fluid for several state points. Then the resulted bulk fluid radial distribution function combi... The Ornstein-Zernike equation is solved with the Rogers-Young approximation for bull, hard sphere fluid and Lennard-Jones fluid for several state points. Then the resulted bulk fluid radial distribution function combined with the test particle method is employed to determine numerically the function relationship of bridge functional as a function of indirect correlation function. It is found that all of the calculated points from different phase space state points for a same type of fluid collapse onto a same smooth curve. Then the numerically obtained curve is used to substitute the analytic expression of the bridge functional as a function of indirect correlation function required in the methodology [J. Chem. Phys. 112 (2000) 8079] to determine the density distribution of non-uniform hard sphere fluid and Lennard-Jones fluid. The good agreement of theoretical predictions with the computer simulation data is obtained. The present numerical procedure incorporates the knowledge of bulk fluid radial distribution function into the constructing of the density functional approximation and makes the original methodology more accurate and more flexible for various interaction potential fluid. 展开更多
关键词 density functional theory bridge functional integral equation theory
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新工科下基于科教融合的“桥梁工程”教学改革 被引量:1
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作者 焦驰宇 龙佩恒 乔宏 《教育教学论坛》 2024年第3期69-72,共4页
如何立足新工科思维,开展针对“桥梁工程”的探索性教学改革成为道桥专业人才亟须解决的关键问题。在结合学科特点和当代大学生特征的基础上,深入分析当前桥梁课程教学方式的不足。基于科教融合理念,以“创新工程教育模式”为指引,提出... 如何立足新工科思维,开展针对“桥梁工程”的探索性教学改革成为道桥专业人才亟须解决的关键问题。在结合学科特点和当代大学生特征的基础上,深入分析当前桥梁课程教学方式的不足。基于科教融合理念,以“创新工程教育模式”为指引,提出了将工程实践引入教学内容、将科研成果引入教学过程、将科研思维引入教学组织的教改实施路径,并给出“课堂教学催生问题提出”“实践教学推动科研进展”“学科竞赛提升科研质量”等创新理念。成果可为同类课程教学改革提供借鉴。 展开更多
关键词 新工科 科教融合 桥梁工程 工程实践
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无砟轨道对不同地形下简支梁桥地震反应的影响
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作者 张永亮 刘沛 +1 位作者 王春阳 刘苗 《铁道工程学报》 EI CSCD 北大核心 2024年第7期41-46,共6页
研究目的:为研究CRTSⅡ型板式无砟轨道系统对多跨简支梁桥下部结构地震反应的影响,以32 m简支梁桥为研究对象,分别建立线桥一体化模型与单墩模型,采用反应谱法研究3种典型地形条件下轨道纵向约束效应对桥墩地震反应的影响规律。研究结论... 研究目的:为研究CRTSⅡ型板式无砟轨道系统对多跨简支梁桥下部结构地震反应的影响,以32 m简支梁桥为研究对象,分别建立线桥一体化模型与单墩模型,采用反应谱法研究3种典型地形条件下轨道纵向约束效应对桥墩地震反应的影响规律。研究结论:(1)跨越平坦地形时,受轨道系统与端刺的影响,线桥一体化模型的墩底内力呈边界处小、中跨大的抛物线型分布,与单墩模型相比,中跨区域的桥墩处在地震反应放大区;(2)跨越V字形地形时,该区域各墩底内力呈现临界墩底内力显著增大、中跨高墩的墩底内力明显减小的U字形分布特征;(3)跨越Λ字形地形时,该区域各墩底内力呈现以中跨矮墩为中心、且其墩底内力显著增大、相邻墩底内力明显减小的Λ字形分布特征,中跨矮墩在抗震设计时应加以重视;(4)本研究成果可应用于类似典型地形条件下的高速铁路简支梁桥的抗震设计。 展开更多
关键词 高速铁路 简支梁 线桥一体化模型 桥墩 地震反应
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马鞍山长江公铁大桥Z3号桥塔施工关键技术 被引量:1
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作者 潘博 李维 刘爱林 《世界桥梁》 北大核心 2024年第2期29-35,共7页
巢马城际铁路马鞍山长江公铁大桥主航道桥为(112+392+2×1120+392+112)m三塔钢桁梁斜拉桥,Z3号桥塔为超高多肢钢-混组合塔,高308 m。上塔柱钢结构高87.5 m,分13个吊装节段,最重505 t;中、下塔柱混凝土结构高217.5 m,分38个节段液压... 巢马城际铁路马鞍山长江公铁大桥主航道桥为(112+392+2×1120+392+112)m三塔钢桁梁斜拉桥,Z3号桥塔为超高多肢钢-混组合塔,高308 m。上塔柱钢结构高87.5 m,分13个吊装节段,最重505 t;中、下塔柱混凝土结构高217.5 m,分38个节段液压爬模施工;钢-混结合段高3 m,内部采用PBL键+剪力钉+高强度钢锚杆+高强度混凝土结构形式。在中塔柱设置钢管临时横撑控制塔柱线形及应力;下横梁采用落地支架法分层施工,与对应塔柱同步浇筑;钢-混结合段混凝土采用C60细石补偿收缩混凝土+高强度灌浆料,保证了混凝土施工质量;采用工厂“2+1”立体匹配制造、“提升站+运输栈桥”钢塔节段转运等技术,并研制15000 t•m超大型塔吊,实现了钢塔柱大节段的制造、整体滩地运输和吊装;钢塔节段间采用栓焊组合连接形式,通过设置工艺隔板、双面坡口等措施控制了钢塔焊接变形;利用定位桁架临时锁定钢塔合龙段实现了钢塔的精确合龙,定位桁架受力及变形均满足要求。 展开更多
关键词 斜拉桥 钢-混组合桥塔 超高多肢 钢-混结合段 整体吊装 钢塔合龙 栓焊组合连接 施工技术
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参数冻结精细指数积分法在非线性车桥耦合振动分析中的应用
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作者 张宇 李韶华 任剑莹 《力学学报》 EI CAS CSCD 北大核心 2024年第1期258-272,共15页
描述车桥耦合作用的基本问题是一个时变系统问题,且很多工况下需考虑非线性特性,使得该问题难以得到解析解,甚至数值解也可能很复杂.针对该问题的求解,提出了一种参数冻结精细指数积分法,将其应用于车桥耦合动力学模型的数值分析中.该... 描述车桥耦合作用的基本问题是一个时变系统问题,且很多工况下需考虑非线性特性,使得该问题难以得到解析解,甚至数值解也可能很复杂.针对该问题的求解,提出了一种参数冻结精细指数积分法,将其应用于车桥耦合动力学模型的数值分析中.该方法结合了精细积分和指数积分特点,并将时变系数矩阵在每一积分步参数冻结,用于获得系统振动响应的数值解.考虑汽车轮胎与桥面的力和位移耦合关系、桥面沥青铺装层、桥梁材料黏弹性和几何非线性特性,建立了车桥耦合动力学模型,并应用参数冻结精细指数积分法对该模型进行了求解.通过与近似解析解、辛Runge-Kutta算法以及经典的Newmark-β数值积分法计算结果进行对比,验证了所提出方法计算结果的有效性和准确性.在此基础上,制作了缩尺车桥耦合系统模型,测试了跨中挠度响应,进一步验证了理论建模和所提算法的有效性和实用性.通过数值计算分析了所提算法的数值特性,结果表明:提出的参数冻结精细指数积分法不仅可以处理时变、非线性问题,且具有良好的数值计算精度和长时间数值稳定性;由于精细积分的特点,参数冻结精细指数积分法的计算时间步长可以取的较大,可有效提高计算效率.因此,所提出的参数冻结精细指数积分法预期可成为求解车桥耦合动力学问题的一种新的高效算法. 展开更多
关键词 精细指数积分法 车桥耦合振动 参数冻结 非线性时变系统 辛Runge-Kutta算法
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组织桥接整合因子1、Ⅰ型胶原蛋白基因、核转运蛋白基因2与三阴性乳腺癌术后复发关系
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作者 郇金亮 高庆佳 +3 位作者 唐小龙 易宜 吴凯铠 黄雄 《安徽医药》 CAS 2024年第7期1343-1347,共5页
目的探究组织桥接整合因子1(BIN1)、Ⅰ型胶原蛋白基因(COL1A1)、核转运蛋白基因2(KPNA2)表达与三阴性乳腺癌(TNBC)术后复发关系及联合检测意义。方法选取2019年5月至2020年5月上海市第八人民医院行手术治疗的TNBC病人80例,根据术后2年... 目的探究组织桥接整合因子1(BIN1)、Ⅰ型胶原蛋白基因(COL1A1)、核转运蛋白基因2(KPNA2)表达与三阴性乳腺癌(TNBC)术后复发关系及联合检测意义。方法选取2019年5月至2020年5月上海市第八人民医院行手术治疗的TNBC病人80例,根据术后2年是否复发分为复发组、未复发组,比较两组临床资料、组织BIN1、COL1A1、KPNA2基因表达,复发的相关影响因素采用单因素与多因素logistic回归分析,组织BIN1、COL1A1、KPNA2基因表达预测术后复发的价值采用受试者操作特征曲线(ROC曲线)分析,组织BIN1、COL1A1、KPNA2基因表达与复发时间关系采用Pearson分析,比较不同组织BIN1、COL1A1、KPNA2基因表达病人无复发生存期(RFS)。结果复发组T分期、N分期与未复发组比较,差异有统计学意义(P<0.05);复发组组织BIN1mRNA表达为0.24±0.07,低于未复发组的0.35±0.10(P<0.05),复发组组织COL1A1mRNA、KPNA2mRNA表达分别为2.07±0.62、2.91±0.84,高于未复发组的1.48±0.43、1.85±0.60(P<0.05);T分期、N分期、COL1A1 mRNA、KPNA2 mRNA均是复发相关独立危险因素,BIN1 mRNA是复发相关独立保护因素(P<0.05);BIN1 mRNA、COL1A1 mRNA、KPNA2 mRNA的AUC分别为0.76、0.80、0.78,三者联合的AUC为0.94;BIN1mRNA与复发时间呈负相关(r=-0.79,P<0.001),COL1A1mRNA、KPNA2mRNA与复发时间呈正相关(r=0.77、0.78,均P<0.001);BIN1mRNA高水平病人RFS长于低水平病人,COL1A1mRNA、KPNA2mRNA高水平病人RFS短于低水平病人(P<0.05)。结论BIN1mRNA、COL1A1mRNA、KPNA2mRNA与TNBC术后复发风险、复发时间有关,联合检测可作为早期预测术后复发的一个可靠方案,为临床治疗提供重要的参考信息。 展开更多
关键词 三阴性乳腺癌 组织桥接整合因子1 Ⅰ型胶原蛋白基因 核转运蛋白基因2(KPNA2) 复发 预测价值
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横向贯通式中低速磁浮一体轨道梁钢-混结合部试验研究
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作者 秦世强 黄春雷 +2 位作者 龚俊虎 毛羚 王秋萍 《铁道学报》 EI CAS CSCD 北大核心 2024年第4期138-147,共10页
为解决中低速磁浮分离式轨道梁存在的养护难、构件多,以及无法考虑F轨刚度贡献等问题,提出一种横向贯通式梁轨一体轨道梁结构,针对其钢-混结合部的静力性能开展有限元分析和足尺模型试验研究,并对关键设计参数进行参数分析。结果表明,在... 为解决中低速磁浮分离式轨道梁存在的养护难、构件多,以及无法考虑F轨刚度贡献等问题,提出一种横向贯通式梁轨一体轨道梁结构,针对其钢-混结合部的静力性能开展有限元分析和足尺模型试验研究,并对关键设计参数进行参数分析。结果表明,在5倍设计荷载内,钢-混结合部基本处于弹性状态,承载力满足设计要求,且具备较高富裕量;竖向荷载主要通过钢板承压作用传递至混凝土梁体,焊钉对竖向荷载的传递作用较小;设计参数分析表明,适量提高钢连接件钢板厚度有利于竖向荷载的平顺传递。研究结果可以为梁轨一体轨道梁设计提供参考。 展开更多
关键词 桥梁工程 中低速磁浮 模型试验 分离式轨道梁 梁轨一体轨道梁 钢-混结合部
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地铁连续刚构桥上无砟轨道无缝线路纵向力分析
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作者 张鹏飞 江浩宇 胡达贵 《华东交通大学学报》 2024年第2期64-71,共8页
【目的】为研究地铁连续刚构桥上无砟轨道无缝线路纵向受力与变形规律,对地铁连续刚构桥上无砟轨道无缝线路设计改进、运营养护维修提供理论指导。【方法】根据梁-板-轨相互作用原理,建立地铁连续刚构桥上整体道床式无砟轨道无缝线路空... 【目的】为研究地铁连续刚构桥上无砟轨道无缝线路纵向受力与变形规律,对地铁连续刚构桥上无砟轨道无缝线路设计改进、运营养护维修提供理论指导。【方法】根据梁-板-轨相互作用原理,建立地铁连续刚构桥上整体道床式无砟轨道无缝线路空间耦合模型,计算伸缩、挠曲、制动、断轨工况下轨道结构和桥梁纵向力及位移,并对轨道结构静力特性进行对比分析,为地铁连续刚构桥上无缝线路轨道结构设计提供参考。【结果】结果表明:双线列车荷载中点与中部梁端处重合时为列车垂向荷载最不利工况,此时钢轨纵向力与钢轨、桥梁纵向位移均为最大,均出现在中部梁端附近,数值分别为70.3 kN与0.6,0.8 mm;双线制动荷载列车尾部位于两侧梁端时为列车制动荷载最不利工况,此时钢轨纵向力与钢轨、桥梁纵向位移均为最大,数值分别为107.8 kN与1.6,1.7 mm。【结论】伸缩力作用下各个端部桥缝处为薄弱部位,在平时养护中应特别注意梁端部桥缝处轨道结构,防止因伸缩力过大而产生断轨;钢轨发生断轨时,在断缝处纵向力、纵向位移均发生突变,严重影响线路行车安全。 展开更多
关键词 地铁连续刚构桥 整体道床 桥上无缝线路 纵向力
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