Sensitive and fast detection of ibuprofen( Ibu) in an aquatic environment often requires costly, time-consuming and sophisticated techniques. To tackle those limitations,a novel android smartphone application was deve...Sensitive and fast detection of ibuprofen( Ibu) in an aquatic environment often requires costly, time-consuming and sophisticated techniques. To tackle those limitations,a novel android smartphone application was developed based on a colorimetric analysis method using unmodified gold nanoparticles( AuNPs)aptamer probes to quantitatively detect Ibu. Under optimal conditions,it could detect Ibu as low as 0. 25 ng/mL with high selectivity. The determination of Ibu in real water samples was also carried out to confirm the practicability of the application.展开更多
Chitosan/cyclodextrin/trisodium citrate（CS/CD/TSC） nanoparticles with ibuprofen（IBU） loaded were prepared via the ionic cross-linking method, with trisodium citrate selected as the cross-linking agent. The drug-lo...Chitosan/cyclodextrin/trisodium citrate（CS/CD/TSC） nanoparticles with ibuprofen（IBU） loaded were prepared via the ionic cross-linking method, with trisodium citrate selected as the cross-linking agent. The drug-loading capacity, particle size, zeta potential and surface morphology of the obtained nanoparticles were inves tigated. The results show a good drug-loading capacity. The prepared nanoparticles were spherical in shape with an average size of 293.7 nm and a zeta potential of ＋30.72 mV. The in vitro release studies show that the controlled re lease of IBU from the nanoparticles was followed. The drug release from CS/β-CD/TSC nanoparticles followed non-Fickian or anomalous diffusion.展开更多
基金National Natural Science Foundation of China(No.21377023)
文摘Sensitive and fast detection of ibuprofen( Ibu) in an aquatic environment often requires costly, time-consuming and sophisticated techniques. To tackle those limitations,a novel android smartphone application was developed based on a colorimetric analysis method using unmodified gold nanoparticles( AuNPs)aptamer probes to quantitatively detect Ibu. Under optimal conditions,it could detect Ibu as low as 0. 25 ng/mL with high selectivity. The determination of Ibu in real water samples was also carried out to confirm the practicability of the application.
文摘考察了UV/H2O2体系中,H2O2投加量、水质参数对布洛芬(IBU)降解的影响。同时研究了该体系中,IBU降解、TOC去除及物质生物毒性三者的变化,并分析了降解产物的生成情况。结果表明IBU对T3发光杆菌有较大的抑制发光作用,EC50,15 min为68 mg/L。UV直接光解,随着IBU的降解,物质生物毒性逐渐增大,而TOC无变化。当紫外剂量达到3 816 m J/cm2时,IBU降解41%,反应液对发光菌的发光抑制率由17.48%升至43.58%。随着IBU的降解,物质生物毒性和TOC均逐渐减小。当紫外剂量达到7 632 m J/cm2时,IBU全部降解,TOC开始下降,反应液对发光菌的发光抑制率由18.20%降至0.8%。GC-MS分析检测表明此过程IBU降解生成对苯二甲酸、丙二酸、丙酸、苯甲酸、丙三醇等小分子羧酸。UV/H2O2体系中,污染物脱毒比矿化容易,母体污染物的降解及物质生物毒性的去除是决定该工艺最佳反应时间的关键因素。
基金Supported by the Key Scientific and Technological Projects of Chongqing Science and Technology Commission, China (No.CSTC2010AC5050)the Chongqing University(China) Postgraduates’ Science and Innovation Fund (No.CDJXS10220008)
文摘Chitosan/cyclodextrin/trisodium citrate（CS/CD/TSC） nanoparticles with ibuprofen（IBU） loaded were prepared via the ionic cross-linking method, with trisodium citrate selected as the cross-linking agent. The drug-loading capacity, particle size, zeta potential and surface morphology of the obtained nanoparticles were inves tigated. The results show a good drug-loading capacity. The prepared nanoparticles were spherical in shape with an average size of 293.7 nm and a zeta potential of ＋30.72 mV. The in vitro release studies show that the controlled re lease of IBU from the nanoparticles was followed. The drug release from CS/β-CD/TSC nanoparticles followed non-Fickian or anomalous diffusion.
