Objective:To observe the intervention influence and effect of simvastatin on the expression of interleukin 17(L117),high mobility group protein 1(HMGB1)and TLR4 path in Lupus nephritis(LN)rats.Methods:A total of 28 BS...Objective:To observe the intervention influence and effect of simvastatin on the expression of interleukin 17(L117),high mobility group protein 1(HMGB1)and TLR4 path in Lupus nephritis(LN)rats.Methods:A total of 28 BSXSB male mice with LN(16 weeks)were randomlv divided into observation group and the comparison group,observation group was given 6 mg·kg^(-1)·d^(-1)simvastatin in 0.1%PBS lavage for 4 weeks.the comparison group was not given any trestment.Blood urea nitrogen(BUN)level and urine trace albumin(Scr)level of two groups were determined.The expression of IL17.HMGB1 and TLR4 protein was detected using immune histochemical method,and the kidney histological damage was observed.Results:BNU,LI17.HMGB1,TLR4protein and HMGB1 mRNA in observation group was significantly lower than that in control group(P<0.05):There was no statistical difference of Scr level between two goups(P<0.05).Histological observation showed glomerular lesions integral of observation group was obviously lower than that of control group.Conclusions:Simvastatin can reduce the expression of IL17.HMGB1 and TLR4 protein in LN mice,thereby can inhibit the autoimmune response as a potential treatment function of LN.展开更多
Hepatitis B virus(HBV)infection,which affects 90 million people in China,remains a prominent cause of liver cancer and liver cirrhosis.[1]Chronic HBV infection has a complicated course,which is a dynamic process forme...Hepatitis B virus(HBV)infection,which affects 90 million people in China,remains a prominent cause of liver cancer and liver cirrhosis.[1]Chronic HBV infection has a complicated course,which is a dynamic process formed by the interaction between the virus and the immune system.[2,3]Hepatic fibrosis is the basis of liver cirrhosis and liver cancer.[4]In recent years,accumulating studies have indicated potential roles of intestinal microbiota,bile acids,and T helper(Th)17/interleukin(IL)-17 axis in the process of HBV-related liver fibrosis.Gut microbiota actively communicates with bile acids and plays an important role in the pathogenesis of HBV-related liver fibrosis.In the following content,we are going to summarize current evidence of the role of intestinal microbiota,bile acids,and Th17/IL-17 axis in HBV-related liver fibrosis.展开更多
基金supported by National Science Foundation of China:81273731
文摘Objective:To observe the intervention influence and effect of simvastatin on the expression of interleukin 17(L117),high mobility group protein 1(HMGB1)and TLR4 path in Lupus nephritis(LN)rats.Methods:A total of 28 BSXSB male mice with LN(16 weeks)were randomlv divided into observation group and the comparison group,observation group was given 6 mg·kg^(-1)·d^(-1)simvastatin in 0.1%PBS lavage for 4 weeks.the comparison group was not given any trestment.Blood urea nitrogen(BUN)level and urine trace albumin(Scr)level of two groups were determined.The expression of IL17.HMGB1 and TLR4 protein was detected using immune histochemical method,and the kidney histological damage was observed.Results:BNU,LI17.HMGB1,TLR4protein and HMGB1 mRNA in observation group was significantly lower than that in control group(P<0.05):There was no statistical difference of Scr level between two goups(P<0.05).Histological observation showed glomerular lesions integral of observation group was obviously lower than that of control group.Conclusions:Simvastatin can reduce the expression of IL17.HMGB1 and TLR4 protein in LN mice,thereby can inhibit the autoimmune response as a potential treatment function of LN.
文摘Hepatitis B virus(HBV)infection,which affects 90 million people in China,remains a prominent cause of liver cancer and liver cirrhosis.[1]Chronic HBV infection has a complicated course,which is a dynamic process formed by the interaction between the virus and the immune system.[2,3]Hepatic fibrosis is the basis of liver cirrhosis and liver cancer.[4]In recent years,accumulating studies have indicated potential roles of intestinal microbiota,bile acids,and T helper(Th)17/interleukin(IL)-17 axis in the process of HBV-related liver fibrosis.Gut microbiota actively communicates with bile acids and plays an important role in the pathogenesis of HBV-related liver fibrosis.In the following content,we are going to summarize current evidence of the role of intestinal microbiota,bile acids,and Th17/IL-17 axis in HBV-related liver fibrosis.
