Objective To isolate and identify bioactive constituents from the stem barks of I//icium difengpi. Methods The chemical constituents were isolated and purified by repeated silica gel, Sephadex LH-20, recrystallization...Objective To isolate and identify bioactive constituents from the stem barks of I//icium difengpi. Methods The chemical constituents were isolated and purified by repeated silica gel, Sephadex LH-20, recrystallization, and preparative HPLC techniques. The structures of the compounds were identified on the basis of spectral data including NMR, MS, and IR. Results Two sesquiterpene lactones, majucin （I） and anisatin （2）, two steroids, l^-sitosterol （3） and daucosterol （4）, three carboxylic acids, 2-ethyldecanoic acid （5）, shikimic acid （6）, and 3,4-dihydrobenzoic acid （7）, and a flavonoid, quercetin （8）, were successively isolated from the stem barks of L difengpL Conclusion Apart from compound 3, other seven compounds are reported in this plant for the first time. The results suggested that the current studies on L difengpi is still far from being well known and therefore more studies need to be done for better understanding of this plant.展开更多
Two new compounds, jiadifenlactone acid monomethyl ester （1） and jiadifenin （3）, and five known compounds were isolated from the fruits of I. jiadifengpi. Their structures were determined using spectroscopic techn...Two new compounds, jiadifenlactone acid monomethyl ester （1） and jiadifenin （3）, and five known compounds were isolated from the fruits of I. jiadifengpi. Their structures were determined using spectroscopic techniques, in- cluding 1D, 2D NMR and HR-ESI-MS experiments. The relative stereochemistry ofjiadifenlactone acid monome- theyl ester （1） was further confirmed by X-ray crystallographic data. All isolates were evaluated for their effects on nerve growth factor （NGF）-mediated neurite outgrowth in pheochromocytoma （PC12） cells and two compounds showed promoting effects.展开更多
文摘Objective To isolate and identify bioactive constituents from the stem barks of I//icium difengpi. Methods The chemical constituents were isolated and purified by repeated silica gel, Sephadex LH-20, recrystallization, and preparative HPLC techniques. The structures of the compounds were identified on the basis of spectral data including NMR, MS, and IR. Results Two sesquiterpene lactones, majucin （I） and anisatin （2）, two steroids, l^-sitosterol （3） and daucosterol （4）, three carboxylic acids, 2-ethyldecanoic acid （5）, shikimic acid （6）, and 3,4-dihydrobenzoic acid （7）, and a flavonoid, quercetin （8）, were successively isolated from the stem barks of L difengpL Conclusion Apart from compound 3, other seven compounds are reported in this plant for the first time. The results suggested that the current studies on L difengpi is still far from being well known and therefore more studies need to be done for better understanding of this plant.
文摘Two new compounds, jiadifenlactone acid monomethyl ester （1） and jiadifenin （3）, and five known compounds were isolated from the fruits of I. jiadifengpi. Their structures were determined using spectroscopic techniques, in- cluding 1D, 2D NMR and HR-ESI-MS experiments. The relative stereochemistry ofjiadifenlactone acid monome- theyl ester （1） was further confirmed by X-ray crystallographic data. All isolates were evaluated for their effects on nerve growth factor （NGF）-mediated neurite outgrowth in pheochromocytoma （PC12） cells and two compounds showed promoting effects.
