Tubal obstructive in fertility is often due to insufficiency of kidney-Qi, dysfunction andvascular obstruction of the uterine collaterals, in view of these pahogenetic characteristics, we havetreated 116 cases of tuba...Tubal obstructive in fertility is often due to insufficiency of kidney-Qi, dysfunction andvascular obstruction of the uterine collaterals, in view of these pahogenetic characteristics, we havetreated 116 cases of tubal obstructive in fertility based on .differentiation of symptoms and signs byacupuncture at Guanyuan(CV4 ), Shuidao (ST 26), Guilai (ST 29 ), Diji (SP 8 ), Sanyinjiao (SP 6 ),Taixi(KI 3), Taichong(LR 3) which have functions of removing obstruction in collaterals by warmingkidney, regulating functions of the Chongmai and removing obstruction of the Renmai, increasihg levelsof female sex hormones, activating ovarian function, and external application to Guanyuan(CV 4) pointwith fresh Radix Aconiti Praeparata, Herb of Garden Balsam, Radix Salviae Miltiorrhizae, Fructus Evodiae, Fructus Foeniculi, Mirabilitum, Ramulus Cinnamomi, Fructus Liguidambaris, etc., which have thefunction of softening and resolving hard masses, subduing swelling and disintegrating masses, improvingblood circulation of the pelvic cavity, promoting absorption of the obstructed focus. AInong them 83cases were cured (pregnancy) accounting for 71. 6 %. The effective rate reached 90. 5 %. Clinically, itis proved that the combination of acupuncture with drugs has satis factory effects.展开更多
Chinese medicine (CM) has been used in clinical treatment for thousands of years in China, Japan, Korea, and other countries. CM is at present attracting many attentions around the world for reproductive health care a...Chinese medicine (CM) has been used in clinical treatment for thousands of years in China, Japan, Korea, and other countries. CM is at present attracting many attentions around the world for reproductive health care and disease prevention, including treatment of female infertility. This review focuses on the CM treatment for female infertility patients, and supplies a summary on the efficacy, safety, and mechanism of some Chinese herbal medicines, herbal medicine-derived active compounds, and acupuncture. A large number of researches have reported that CM could alleviate or even cure female infertility by regulating hormone, improving reproductive outcome of in vivo fertilization, affecting embryonic implantation, curing polycystic ovarian syndrome, endometriosis, pelvic inflammatory disease, relieving mental stress, and regulating immune system. Meanwhile, a few studies claimed that there was little adverse reaction of CM in randomized controlled trials. However, up to present there is a lack of adequate evidences with molecular mechanistic researches and randomized controlled trials to prove the CM as an effective and safe treatment for infertility. Thus, utility of CM as a complementary medicine will be a feasible method to improve the outcome of female infertility treatment.展开更多
目的观察针刺联合输卵管通液术治疗气滞血瘀型输卵管炎性不孕的临床疗效及对血清基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)、基质金属蛋白酶抑制剂-1(tissue inhibitor of metalloproteinase-1,TIMP-1)水平的影响。方法将69...目的观察针刺联合输卵管通液术治疗气滞血瘀型输卵管炎性不孕的临床疗效及对血清基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)、基质金属蛋白酶抑制剂-1(tissue inhibitor of metalloproteinase-1,TIMP-1)水平的影响。方法将69例气滞血瘀型输卵管炎性不孕患者随机分为针刺组(34例)和假针组(35例)。针刺组给予针刺联合输卵管通液术治疗;假针组给予输卵管通液术后针刺组穴位旁开1 cm非经非穴处进针,只刺破皮肤,不行针治疗。观察两组治疗前后中医证候和体征积分、输卵管通畅度及血清MMP-9和TIMP-1水平、MMP-9/TIMP-1比值变化,并比较两组中医证候、体征疗效及随访6个月内宫内妊娠率。结果假针组治疗后中医证候积分未见改变(P>0.05),针刺组治疗后低于治疗前和假针组(P<0.01)。两组治疗后体征积分降低(P<0.01),输卵管通畅情况呈现不同程度改善(P<0.05),血清MMP-9水平增高(P<0.01),血清TIMP-1降低(P<0.01),MMP-9/TIMP-1比值升高(P<0.01);针刺组治疗后优于假针组(P<0.01,P<0.05)。针刺组宫内妊娠率高于假针组(P<0.05)。结论针刺联合输卵管通液术治疗气滞血瘀型输卵管炎性不孕疗效显著,作用机制可能与升高MMP-9水平,降低TIMP-1水平,调节二者比值从而抑制纤维化过程有关。展开更多
文摘Tubal obstructive in fertility is often due to insufficiency of kidney-Qi, dysfunction andvascular obstruction of the uterine collaterals, in view of these pahogenetic characteristics, we havetreated 116 cases of tubal obstructive in fertility based on .differentiation of symptoms and signs byacupuncture at Guanyuan(CV4 ), Shuidao (ST 26), Guilai (ST 29 ), Diji (SP 8 ), Sanyinjiao (SP 6 ),Taixi(KI 3), Taichong(LR 3) which have functions of removing obstruction in collaterals by warmingkidney, regulating functions of the Chongmai and removing obstruction of the Renmai, increasihg levelsof female sex hormones, activating ovarian function, and external application to Guanyuan(CV 4) pointwith fresh Radix Aconiti Praeparata, Herb of Garden Balsam, Radix Salviae Miltiorrhizae, Fructus Evodiae, Fructus Foeniculi, Mirabilitum, Ramulus Cinnamomi, Fructus Liguidambaris, etc., which have thefunction of softening and resolving hard masses, subduing swelling and disintegrating masses, improvingblood circulation of the pelvic cavity, promoting absorption of the obstructed focus. AInong them 83cases were cured (pregnancy) accounting for 71. 6 %. The effective rate reached 90. 5 %. Clinically, itis proved that the combination of acupuncture with drugs has satis factory effects.
基金Supported by the National Natural Science Foundation of China(No.31571196,No.30801502)the Municipal Science and Technology Commission of Shanghai,China(Medical Guidance Technology Project No.15401932200)+2 种基金a FY2008 JSPS Postdoctoral Fellowship for Foreign Researchers(P08471)the Shanghai Pujiang Program(No.11PJ1401900)the Development Project of Shanghai Peak Disciplines-Integrated Chinese and Western Medicine(No.20150407)
文摘Chinese medicine (CM) has been used in clinical treatment for thousands of years in China, Japan, Korea, and other countries. CM is at present attracting many attentions around the world for reproductive health care and disease prevention, including treatment of female infertility. This review focuses on the CM treatment for female infertility patients, and supplies a summary on the efficacy, safety, and mechanism of some Chinese herbal medicines, herbal medicine-derived active compounds, and acupuncture. A large number of researches have reported that CM could alleviate or even cure female infertility by regulating hormone, improving reproductive outcome of in vivo fertilization, affecting embryonic implantation, curing polycystic ovarian syndrome, endometriosis, pelvic inflammatory disease, relieving mental stress, and regulating immune system. Meanwhile, a few studies claimed that there was little adverse reaction of CM in randomized controlled trials. However, up to present there is a lack of adequate evidences with molecular mechanistic researches and randomized controlled trials to prove the CM as an effective and safe treatment for infertility. Thus, utility of CM as a complementary medicine will be a feasible method to improve the outcome of female infertility treatment.
