Polyethylene glycol (PEG) supported (diacetoxy)iodobenzene as soluble polymer reagent can smoothly oxidize acid hydrazides into corresponding dimmers in good yields under very mild conditions.
A mild, general, convenient, and efficient one-pot synthesis of 4-arylpyridines (4) is described using conventional heating, ultrasound and microwave irradiation. Aryl aldehydes (2) were efficiently condensed with eth...A mild, general, convenient, and efficient one-pot synthesis of 4-arylpyridines (4) is described using conventional heating, ultrasound and microwave irradiation. Aryl aldehydes (2) were efficiently condensed with ethylacetoacetate (1) and ammonium acetate in acetonitrile to give dihydropyridine intermediates (4). The latter underwent a smooth Iodobenzene Diacetate (III) mediated aromatization reaction in the same pot to afford 4-arylpyridines (4) in good to excellent yields.展开更多
Treatment of N-alkoxyamides with bis（trifluoroacetoxy）iodobenzene generated electron deficient nitrogen species, which readily cyclized onto aromatic ring to give N-alkoxy-2- oxoindoles. The effect of different subs...Treatment of N-alkoxyamides with bis（trifluoroacetoxy）iodobenzene generated electron deficient nitrogen species, which readily cyclized onto aromatic ring to give N-alkoxy-2- oxoindoles. The effect of different substituent on aromatic ring to the electrophilic substitution was studied.展开更多
Herein we report a new general method for one-step synthesis of four kinds of fluoroiodane(Ⅲ)reagents by treating the corresponding aryl iodides with silver difluoride(AgF_(2)).This is the first method applicable for...Herein we report a new general method for one-step synthesis of four kinds of fluoroiodane(Ⅲ)reagents by treating the corresponding aryl iodides with silver difluoride(AgF_(2)).This is the first method applicable for the synthesis of all four fluoroiodane(Ⅲ)reagents including p-iodotoluene difluoride(1),fluoro-benziodoxole(2),fluoro-benziodoxolone(3),and fluoro-N-acetylbenziodazole(4).AgF_(2)was firstly employed in the direct oxidative fluorination of iodobenzene and thus has shown its outstanding oxidation and fluorine-transfer ability.The use of AgF_(2)has improved the synthesis of fluoroiodane(Ⅲ)reagents by shortening the reaction steps,avoiding the use of hazardous reagents,and simplifying the experimental operations.It was worth noting that we have developed the first one-step direct synthetic method for 3,while 3 can only be synthesized through Cl→F ligand exchange reaction previously.展开更多
基金We are grateful for the financial support from the Postdoctoral Foundation of China.
文摘Polyethylene glycol (PEG) supported (diacetoxy)iodobenzene as soluble polymer reagent can smoothly oxidize acid hydrazides into corresponding dimmers in good yields under very mild conditions.
文摘A mild, general, convenient, and efficient one-pot synthesis of 4-arylpyridines (4) is described using conventional heating, ultrasound and microwave irradiation. Aryl aldehydes (2) were efficiently condensed with ethylacetoacetate (1) and ammonium acetate in acetonitrile to give dihydropyridine intermediates (4). The latter underwent a smooth Iodobenzene Diacetate (III) mediated aromatization reaction in the same pot to afford 4-arylpyridines (4) in good to excellent yields.
文摘Treatment of N-alkoxyamides with bis（trifluoroacetoxy）iodobenzene generated electron deficient nitrogen species, which readily cyclized onto aromatic ring to give N-alkoxy-2- oxoindoles. The effect of different substituent on aromatic ring to the electrophilic substitution was studied.
基金financially supported by the National Natural Science Foundation of China(Nos.21772096 and 22071116)the National Key Research and Development Program of China(No.2017YFD020030202)。
文摘Herein we report a new general method for one-step synthesis of four kinds of fluoroiodane(Ⅲ)reagents by treating the corresponding aryl iodides with silver difluoride(AgF_(2)).This is the first method applicable for the synthesis of all four fluoroiodane(Ⅲ)reagents including p-iodotoluene difluoride(1),fluoro-benziodoxole(2),fluoro-benziodoxolone(3),and fluoro-N-acetylbenziodazole(4).AgF_(2)was firstly employed in the direct oxidative fluorination of iodobenzene and thus has shown its outstanding oxidation and fluorine-transfer ability.The use of AgF_(2)has improved the synthesis of fluoroiodane(Ⅲ)reagents by shortening the reaction steps,avoiding the use of hazardous reagents,and simplifying the experimental operations.It was worth noting that we have developed the first one-step direct synthetic method for 3,while 3 can only be synthesized through Cl→F ligand exchange reaction previously.
