取代金属(铁、锰、钴、铜、锌)卟啉的光谱分析

对系列取代金属(铁、锰、钴、铜、锌)卟啉化合物的紫外光谱、红外光谱、远红外光谱进行了详尽的测试和分析,揭示了不同结构金属卟啉的光谱规律,从理论上分析了形成光谱规律的原因。针对目前氯化铁卟啉轴向Fe—Cl键远红外表征的报道结果不一致性,采用理论分析与实验测定相结合的方法,探索了氯化铁卟啉中Fe—Cl键远红外吸收规律。研究结果表明:Fe—Cl键的振动吸收频率不是固定不变的,而是与卟啉环的结构有关,且和Fe—Cl的键长呈线性关系。

Comparison of the Vibrational Spectra of Copper Polysilicate, CuSiO₃, with Those of the Prototypic Copper Polygermanate, CuGeO₃

Orthorhombic copper polysilicate, CuSiO3, is isotypic to the spin-Peierls compound CuGeO3 and represents a further example of a quasi-one-dimensional spin = 1/2 antiferromagnetic Heisenberg chain system. This is a representation of the first Raman and IR/FIR spectra for CuSiO3, measured at room temperature on polycrystalline samples. A comparison of the optical phonons, predicted by a factor group analysis, with those observed for the CuGeO3 prototype, is presented. A mode assignment for the silicate is given. Surface effects due to a very small crystallite size may cause additional broad bands observed in the Raman spectrum of CuSiO3. From the analysis of the Davydov doublet an intralayer-to-interlayer bond strength of about 40 is derived for the silicate, which is about 20% lower than for the isotypic germanate, allowing for different magnetic responses at low temperature.

2型糖尿病病人的非糖尿病一级亲属胰岛β细胞功能和胰岛素抵抗的研究

目的 研究 2型糖尿病 (T2DM )及 2型糖尿病病人的非糖尿病一级亲属胰岛 β细胞功能、胰岛素抵抗 (IR)及早期胰岛素分泌功能 ,探讨其在糖尿病发生发展中的作用。方法 选取 59例正常对照组、58例T2DM病人糖耐量正常的T2DM病人一级亲属及 38例T2DM ,他们的体重指数 (BMI)均 <2 5kg/m2 ,计算并比较三组的血清胰岛素、血糖及稳态模型胰岛素抵抗指数 (HOMA IR)、β细胞功能指数 (HOMA β)及胰岛早期分泌指数 (△I30 /△G30 )。结果 非肥胖的糖耐量正常的一级亲属组的HOMA IR均高于正常对照 (P <0 0 5) ,但低于T2DM组 ;而HOMA βTI一级亲属组低于对照组 (P <0 0 5) ,但高于T2DM组 (P <0 0 1 ) ;△I30 /△G30 显示一级亲属组低于对照组 (P <0 0 5)。结论 非肥胖 2型糖尿病一级亲属在糖耐量正常时就已经存在胰岛β细胞功能的受损、胰岛素抵抗及胰岛素早期分泌指数减低 ;IR并非继发于肥胖和高血糖症。