Objective:To explore expression level of interferon-stimulated genes PKR,OAS1,MX1,and ISG15 in peripheral blood mononuclear cells of COVID-19 patients.Methods:In this study,changes in the expression of four interferon...Objective:To explore expression level of interferon-stimulated genes PKR,OAS1,MX1,and ISG15 in peripheral blood mononuclear cells of COVID-19 patients.Methods:In this study,changes in the expression of four interferon-stimulated genes(ISGs),including PKR,OAS1,MX1,and ISG15,in peripheral blood mononuclear cells of 45 COVID-19 patients with different severities were evaluated by real-time PCR method.Results:OAS1,MX1,PKR,and ISG15 were differently expressed in COVID-19 patients with different severity.The results showed that the expression of OAS1,MX1,PKR,and ISG15 genes was significantly(P=0.001)lower in severe patients.Conclusions:Weak and defective IFN response and subsequent disruption of ISGs may be associated with COVID-19 severity.展开更多
西安交通大学机械学院为了探索如何更好地应对新形势下的国际化高等教育挑战,在全英文“机械表面工程概论”课程中提出了一种全新概念的教学模式——ISG(Integrated Small Groups)。该模式深入融合国际及中国学生,强调跨文化合作与交流...西安交通大学机械学院为了探索如何更好地应对新形势下的国际化高等教育挑战,在全英文“机械表面工程概论”课程中提出了一种全新概念的教学模式——ISG(Integrated Small Groups)。该模式深入融合国际及中国学生,强调跨文化合作与交流,以促进不同背景学生的学术合作和文化理解。ISG教学模式通过外籍学生与中国学生结组,以工程问题为导引,理论讲授和科研实践相结合的形式开展。教学中采用全英文授课,帮助学生克服文化及语言习惯差异,同时采用多样化的教学方法,帮助学生适应课程学习节奏。课程的ISG教学模式对于应对国际化高等教育挑战有着重要意义。展开更多
基金the research council of Kerman University of Medical Sciences,Kerman,Iran(Grant Number:400000232).
文摘Objective:To explore expression level of interferon-stimulated genes PKR,OAS1,MX1,and ISG15 in peripheral blood mononuclear cells of COVID-19 patients.Methods:In this study,changes in the expression of four interferon-stimulated genes(ISGs),including PKR,OAS1,MX1,and ISG15,in peripheral blood mononuclear cells of 45 COVID-19 patients with different severities were evaluated by real-time PCR method.Results:OAS1,MX1,PKR,and ISG15 were differently expressed in COVID-19 patients with different severity.The results showed that the expression of OAS1,MX1,PKR,and ISG15 genes was significantly(P=0.001)lower in severe patients.Conclusions:Weak and defective IFN response and subsequent disruption of ISGs may be associated with COVID-19 severity.
文摘西安交通大学机械学院为了探索如何更好地应对新形势下的国际化高等教育挑战,在全英文“机械表面工程概论”课程中提出了一种全新概念的教学模式——ISG(Integrated Small Groups)。该模式深入融合国际及中国学生,强调跨文化合作与交流,以促进不同背景学生的学术合作和文化理解。ISG教学模式通过外籍学生与中国学生结组,以工程问题为导引,理论讲授和科研实践相结合的形式开展。教学中采用全英文授课,帮助学生克服文化及语言习惯差异,同时采用多样化的教学方法,帮助学生适应课程学习节奏。课程的ISG教学模式对于应对国际化高等教育挑战有着重要意义。
