In this work,important commercial pharmaceutical intermediates,phenylpropionic acid compounds,are successfully obtained by catalyzing the reaction of carbon dioxide with phenyl halides using MOF-5,a typical metal-orga...In this work,important commercial pharmaceutical intermediates,phenylpropionic acid compounds,are successfully obtained by catalyzing the reaction of carbon dioxide with phenyl halides using MOF-5,a typical metal-organic framework(MOF)material.The influence of temperature,pressure,catalyst type and light on the reaction is investigated,and a 90.3%selectivity towards fluorophenylpropionic acid is reached.Significantly,the catalysts are effective for varied benzyl compounds containing different substituent groups.The catalysts are stable and remain active after three cycles.展开更多
基金The authors acknowledge financial support from the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000.Z.Y.T.)the National Key Basic Research Program of China(2016YFA0200700,Z.Y.T.)+2 种基金the National Natural Science Foundation of China(Nos.21890381 and 21721002,Z.Y.T.)the Frontier Science Key Project of Chinese Academy of Sciences(No.QYZDJ-SSW-SLH038,Z.Y.T.)the K.C.Wong Education Foundation(Z.Y T.).
文摘In this work,important commercial pharmaceutical intermediates,phenylpropionic acid compounds,are successfully obtained by catalyzing the reaction of carbon dioxide with phenyl halides using MOF-5,a typical metal-organic framework(MOF)material.The influence of temperature,pressure,catalyst type and light on the reaction is investigated,and a 90.3%selectivity towards fluorophenylpropionic acid is reached.Significantly,the catalysts are effective for varied benzyl compounds containing different substituent groups.The catalysts are stable and remain active after three cycles.
