Objective To investigate the role of P- selectin in Ig A nephropathy (IgAN). Methods PlasmaP-selectin level was measured by ELISA and P- selectin expression in renal tissue was detected byimmunohistochemistry and in s...Objective To investigate the role of P- selectin in Ig A nephropathy (IgAN). Methods PlasmaP-selectin level was measured by ELISA and P- selectin expression in renal tissue was detected byimmunohistochemistry and in situ hybridization in 45 patients with IgAN Results Plasma P-selectin levels inthe patients with IgAN were significantly higher than those in the controls. In IgAN the levels in the patientswith nephrotic syndrome or renal function insuffciency were much higher than those in the patients with grosshematuria, abnormal urine analyses or nephritis syndrome. P- selectin was widely expressed within renal tissue inIgAN. Glomerular P- selectin expression was remarkably up - regulated in grade IV and V of IgAN than that ingrade H and Ⅲ. Moreover, the expression of P- selectin on tubular epithelium or within interstitium was stronglyassociated with the degree of tubulointerstitial lesions. Conclusion The results suggested that P-selectin mightplay an important role in IgAN and the level of P- selectin in plasma and renal tissue might predict the progressof IgAN.展开更多
文摘Objective To investigate the role of P- selectin in Ig A nephropathy (IgAN). Methods PlasmaP-selectin level was measured by ELISA and P- selectin expression in renal tissue was detected byimmunohistochemistry and in situ hybridization in 45 patients with IgAN Results Plasma P-selectin levels inthe patients with IgAN were significantly higher than those in the controls. In IgAN the levels in the patientswith nephrotic syndrome or renal function insuffciency were much higher than those in the patients with grosshematuria, abnormal urine analyses or nephritis syndrome. P- selectin was widely expressed within renal tissue inIgAN. Glomerular P- selectin expression was remarkably up - regulated in grade IV and V of IgAN than that ingrade H and Ⅲ. Moreover, the expression of P- selectin on tubular epithelium or within interstitium was stronglyassociated with the degree of tubulointerstitial lesions. Conclusion The results suggested that P-selectin mightplay an important role in IgAN and the level of P- selectin in plasma and renal tissue might predict the progressof IgAN.
