万古霉素(vancomycin)属于糖肽类抗生素,临床应用十分广泛,是治疗耐药性革兰阳性菌感染最有效的抗生素之一,其控制难治性感染的同时,也可能带来多种不良反应。其中,以红人综合征(red man syndrome, RMS)为代表的类过敏反应、Ig-E介导的...万古霉素(vancomycin)属于糖肽类抗生素,临床应用十分广泛,是治疗耐药性革兰阳性菌感染最有效的抗生素之一,其控制难治性感染的同时,也可能带来多种不良反应。其中,以红人综合征(red man syndrome, RMS)为代表的类过敏反应、Ig-E介导的超敏反应即过敏反应发生率均较高,临床后果严重,且两者临床表现、诊断方式类似,均需及时识别、干预。但2种反应发生后的治疗方法及后续是否可继续应用万古霉素有所不同,因此两者的预防、诊断及鉴别诊断十分重要。针对RMS、Ig-E介导的超敏反应的异同,本文回顾了既往相关文献,并对两者的临床表现、鉴别诊断、高风险人群识别、预防方式、治疗措施做出综述。展开更多
We report a disorder resembling Guillain Barre′syndrome, occurring on initia tion of simvastatin, in a 58 year old man, who had experienced a similar but m ilder episode after starting pravastatin 6 months earlier. T...We report a disorder resembling Guillain Barre′syndrome, occurring on initia tion of simvastatin, in a 58 year old man, who had experienced a similar but m ilder episode after starting pravastatin 6 months earlier. This case suggests th at acute polyradiculoneuropathy may represent a rare but serious side effect of statin treatment. It also raises the issue of the pathophysiology of acute neur opathy on statin exposure, with a hypersensitivity reaction resulting in an immu ne mediated process being possible instead of the hypothesized mitochondrial dy sfunction in chronic cases.展开更多
Magnaporthe grisea special races 98-186-1G1 and 97-23-2D1 induce incompatible and compatible reactions respectively with rice Xiushui? The elicitor from the cell wall of M. grisea race 98-186-1G1, termed IE, strongly ...Magnaporthe grisea special races 98-186-1G1 and 97-23-2D1 induce incompatible and compatible reactions respectively with rice Xiushui? The elicitor from the cell wall of M. grisea race 98-186-1G1, termed IE, strongly in-duced the HR response in suspension cultures of rice Xiushui? including increased PAL activity, transcription of pal , pr1, chi, cell death and the generation of NO. The elici-tor prepared from the cell wall of M. grisea race 97-23-2D1, named CE, was much less efficient at inducing such effects. The NOS enzyme inhibitors L-NAA and PBITU suppressed the production of NO induced by IE in Xiushui?rice. The increased PAL activity and transcription of pr1, pal, chi genes induced by IE were blocked by L-NAA, PBITU or CPTIO pretreatment. Direct treatment of rice cultures with the NO donor (SNP) also induced the transcription of pr1, pal and chi genes. These data implicated that NO acted as a signal mediating the HR induced by IE in rice and showed that NO, in combination with H2O2, is necessary for induc-tion of cell death by IE in rice suspension cells.展开更多
文摘万古霉素(vancomycin)属于糖肽类抗生素,临床应用十分广泛,是治疗耐药性革兰阳性菌感染最有效的抗生素之一,其控制难治性感染的同时,也可能带来多种不良反应。其中,以红人综合征(red man syndrome, RMS)为代表的类过敏反应、Ig-E介导的超敏反应即过敏反应发生率均较高,临床后果严重,且两者临床表现、诊断方式类似,均需及时识别、干预。但2种反应发生后的治疗方法及后续是否可继续应用万古霉素有所不同,因此两者的预防、诊断及鉴别诊断十分重要。针对RMS、Ig-E介导的超敏反应的异同,本文回顾了既往相关文献,并对两者的临床表现、鉴别诊断、高风险人群识别、预防方式、治疗措施做出综述。
文摘We report a disorder resembling Guillain Barre′syndrome, occurring on initia tion of simvastatin, in a 58 year old man, who had experienced a similar but m ilder episode after starting pravastatin 6 months earlier. This case suggests th at acute polyradiculoneuropathy may represent a rare but serious side effect of statin treatment. It also raises the issue of the pathophysiology of acute neur opathy on statin exposure, with a hypersensitivity reaction resulting in an immu ne mediated process being possible instead of the hypothesized mitochondrial dy sfunction in chronic cases.
基金supported by the National Natural Science Foundation of China(Grant No.39870050).
文摘Magnaporthe grisea special races 98-186-1G1 and 97-23-2D1 induce incompatible and compatible reactions respectively with rice Xiushui? The elicitor from the cell wall of M. grisea race 98-186-1G1, termed IE, strongly in-duced the HR response in suspension cultures of rice Xiushui? including increased PAL activity, transcription of pal , pr1, chi, cell death and the generation of NO. The elici-tor prepared from the cell wall of M. grisea race 97-23-2D1, named CE, was much less efficient at inducing such effects. The NOS enzyme inhibitors L-NAA and PBITU suppressed the production of NO induced by IE in Xiushui?rice. The increased PAL activity and transcription of pr1, pal, chi genes induced by IE were blocked by L-NAA, PBITU or CPTIO pretreatment. Direct treatment of rice cultures with the NO donor (SNP) also induced the transcription of pr1, pal and chi genes. These data implicated that NO acted as a signal mediating the HR induced by IE in rice and showed that NO, in combination with H2O2, is necessary for induc-tion of cell death by IE in rice suspension cells.
