We aimed to explore the changes of laboratory indexes of IgD-λtype multiple myeloma with special cell morphology,and to improve the cognition of IgD-λtype MM.To explore the changes of laboratory indexes of IgD-λtyp...We aimed to explore the changes of laboratory indexes of IgD-λtype multiple myeloma with special cell morphology,and to improve the cognition of IgD-λtype MM.To explore the changes of laboratory indexes of IgD-λtype 1 multiple myeloma with special cell morphology,and to improve the cognition of IgD-λtype MM.The morphology of bone marrow cells,immunofixation electrophoresis,serum free light chain(sFLC)and other detection indexes of a patient with IgD-λtype MM treated in Handan Central Hospital in December 2020 were analyzed.The patient bone marrow smears showed 62%of abnormal cells-which were distributed in clusters and resembled lymphoma and metastatic cancer cells.The Flowcytometry indicates that the cell is a plasma cell tumor.Immunoglobulin IgG,IgA and IgM were all lower than the normal range.There is a monoclonal light chainλcomponent in immunofixation electrophoresis.The serum free light chainλwas 2700.00 mg/L,light chain k/λis 0.0023,the high of serum calcium,LDH,β2 microglobulin.IgD-λtype MM is a rare type of MM.The age of onset is young,the invasiveness is strong,the prognosis is poor,the clinical manifestation is complex,and it is easy to be misdiagnosed or missed.The analysis of the clinical symptoms and laboratory characteristics of the disease plays a positive role in the diagnosis,treatment and prognosis of the disease.展开更多
文摘We aimed to explore the changes of laboratory indexes of IgD-λtype multiple myeloma with special cell morphology,and to improve the cognition of IgD-λtype MM.To explore the changes of laboratory indexes of IgD-λtype 1 multiple myeloma with special cell morphology,and to improve the cognition of IgD-λtype MM.The morphology of bone marrow cells,immunofixation electrophoresis,serum free light chain(sFLC)and other detection indexes of a patient with IgD-λtype MM treated in Handan Central Hospital in December 2020 were analyzed.The patient bone marrow smears showed 62%of abnormal cells-which were distributed in clusters and resembled lymphoma and metastatic cancer cells.The Flowcytometry indicates that the cell is a plasma cell tumor.Immunoglobulin IgG,IgA and IgM were all lower than the normal range.There is a monoclonal light chainλcomponent in immunofixation electrophoresis.The serum free light chainλwas 2700.00 mg/L,light chain k/λis 0.0023,the high of serum calcium,LDH,β2 microglobulin.IgD-λtype MM is a rare type of MM.The age of onset is young,the invasiveness is strong,the prognosis is poor,the clinical manifestation is complex,and it is easy to be misdiagnosed or missed.The analysis of the clinical symptoms and laboratory characteristics of the disease plays a positive role in the diagnosis,treatment and prognosis of the disease.
