Seven new triterpenoid saponins,including five ursane-type saponins,ilexchinenosides R–V(1–5),and two oleananetype saponins,ilexchinenosides W–X(6–7),with four known triterpenoid saponins(8–11)were isolated from ...Seven new triterpenoid saponins,including five ursane-type saponins,ilexchinenosides R–V(1–5),and two oleananetype saponins,ilexchinenosides W–X(6–7),with four known triterpenoid saponins(8–11)were isolated from the leaves of Ilex chinensis.Their structures were elucidated by comprehensive spectroscopic 1 D and 2 D NMR and HR-ESI-MS data.Their sugar moieties were determined by HPLC analysis compared with standards after hydrolysis and derivatization.Compounds 1,2,4,9 and 10 exhibited potential hepatoprotective activity against N-acetyl-p-aminophenol(APAP)-induced Hep G2 cell injury in vitro.展开更多
A new triterpene saponin with 28-nor-urs-12（13）,18（17）-dien-3β-ol as aglycone,named ilexsaponin C（1） was isolated from the roots of Ilex pubescens,together with three known saponins 2,3 and 4.The structure of 1...A new triterpene saponin with 28-nor-urs-12（13）,18（17）-dien-3β-ol as aglycone,named ilexsaponin C（1） was isolated from the roots of Ilex pubescens,together with three known saponins 2,3 and 4.The structure of 1 was elucidated on the basis of spectral analysis including 1D and 2D NMR and HR-ESI-MS.Saponins 1 and 4 exhibited significant XOD inhibitory activity in the test.展开更多
Phytochemical investigation of the leaves of Ilex aspralla （Hook. et Am.） Champ. ex Benth. led to the isolation of eleven compounds （1-11）. By comparison with those reported data in the literatures their structure...Phytochemical investigation of the leaves of Ilex aspralla （Hook. et Am.） Champ. ex Benth. led to the isolation of eleven compounds （1-11）. By comparison with those reported data in the literatures their structures were identified as kaempferol-3-O-β-D- 6＂-acetylglucopyranoside （1）, kaempferol-4＇-methylether （2）, quercetin （3）, quercetin-3-O-glucopyranoside （4）, tormentoside （5）, suavissimoside R1 （6）, 3β,19α-dihydroxyolean-12-ene-24,28-dioicacid-28-O-β-D-glucopyranoside （7）, 3-O-β-sulfooxy-19-hydroxy- urs-12-ene-28-oic acid （8）, coniferin （9）, adenoside （10）, 1＇-O-benzyl-ct-L-rhamnopyranosyl-（l＂→6＇）-β-D-glucopyranoside （11）. Among these, six compounds （1, 2, 5, 9-11） were firstly reported from the genus Ilex, and five compounds （3, 4, 6-8） were isolated for the first time from llex aspralla.展开更多
从枸骨(IlexcornutaLindl.exPaxt.)中分离得到20个化合物,鉴定了16个,分别为:枸骨甙1(Gouguside1,Ⅴ)即坡摸酸3 β O α L 吡喃阿拉伯糖甙;枸骨甙2(Gouguside2,Ⅵ)即3 β O D 吡喃葡萄糖基坡摸酸 β 28 O D 吡喃葡萄糖酯;枸骨甙3(Gougus...从枸骨(IlexcornutaLindl.exPaxt.)中分离得到20个化合物,鉴定了16个,分别为:枸骨甙1(Gouguside1,Ⅴ)即坡摸酸3 β O α L 吡喃阿拉伯糖甙;枸骨甙2(Gouguside2,Ⅵ)即3 β O D 吡喃葡萄糖基坡摸酸 β 28 O D 吡喃葡萄糖酯;枸骨甙3(Gouguside3,Ⅶ)即3 β O (β D 吡喃葡萄糖基) α L 吡喃葡萄糖基坡摸酸 β 28 O D 吡喃葡萄糖酯的类似物;枸骨甙4(Gouguside4,ⅩⅦ)即3 β O (β D 吡喃葡萄糖基) α L 吡喃葡萄糖基坡摸酸 β 28 O D 吡喃葡萄糖酯;枸骨甙5(Gouguside5,ⅩⅧ)即坡摸酸3 β O α L 2′ 乙酰氧基吡喃阿拉伯糖基 28 O β D 吡喃葡萄糖酯,枸骨甙6(Gouguside6,ⅩⅨ)即3 β O (β D 吡喃葡萄糖基) α L 4 乙酰氧基吡喃阿拉伯糖基坡摸酸 β 28 O D 吡喃葡萄糖酯;枸骨甙7(Gouguside7,ⅩⅩ)即3 β O α L 吡喃阿拉伯糖基 28 O β D 吡喃葡萄糖酯;胡萝卜甙(daucostorolⅧ);2,4 二羟基苯甲酸(2,4 dihydroxybenzoicacidⅠ);3,4 二羟基桂皮酸(3,4 dihyroxycinnamunicacidⅡ、Ⅳ);长链脂肪酸或醇5个(Longchainfattyacid,Ⅲ、Ⅵ、Ⅶ、Ⅷ、ⅩⅣ)。在鉴定的16个化合物中,枸骨甙1、枸骨甙2、枸骨甙6和枸骨甙7为首次从枸骨中分离得到,枸骨甙3和枸骨甙4为新化合物。展开更多
The title compound of pedunculoside （C36H58O10）, a main active triterpenoid saponin of Ilicis Rotundae Cortex, was isolated from the dried bark of Ilex rotunda Thunb., and characterized by X-ray diffraction analysis...The title compound of pedunculoside （C36H58O10）, a main active triterpenoid saponin of Ilicis Rotundae Cortex, was isolated from the dried bark of Ilex rotunda Thunb., and characterized by X-ray diffraction analysis. It crystallizes in the orthorhombic system, space group P212121 with C36H58O10, a = 13.046（3）, b = 21.038（4）, c = 28.413（6） A, V = 7798.28（3） A3, Z = 8, Dc= 1.109 g/cm3, Mr = 650.82, F（000） = 2832, andμ = 0.080 mm-1. The final R = 0.0765 and wR = 0.1736 for 15117 observed reflections （I 〉 2σ（I））. The molecular crystal structure of pedunculoside shows relative stereochemistry of 3β, 19α,23-trihydroxy-urs- 12-en-28-oic acid-28-O-β-D-glucopy- rainosyl ester. The molecule is composed of one glucopyranosyl ring and five six-membered rings with ring junctures of A/B trans, B/C trans, and D/E cis. There are two C36H50O10 molecules in an asymmetric unit, and the title compound is stacked into a 2D layer structure through hydrogen bonds.展开更多
基金CAMS Innovation Fund for Medicial Sciences(CIFMS-2019-I2M-1-005)。
文摘Seven new triterpenoid saponins,including five ursane-type saponins,ilexchinenosides R–V(1–5),and two oleananetype saponins,ilexchinenosides W–X(6–7),with four known triterpenoid saponins(8–11)were isolated from the leaves of Ilex chinensis.Their structures were elucidated by comprehensive spectroscopic 1 D and 2 D NMR and HR-ESI-MS data.Their sugar moieties were determined by HPLC analysis compared with standards after hydrolysis and derivatization.Compounds 1,2,4,9 and 10 exhibited potential hepatoprotective activity against N-acetyl-p-aminophenol(APAP)-induced Hep G2 cell injury in vitro.
基金financially supported by the Postgraduate Innovation Project of Jiangsu Province,China(No. CX09B_284Z)
文摘A new triterpene saponin with 28-nor-urs-12（13）,18（17）-dien-3β-ol as aglycone,named ilexsaponin C（1） was isolated from the roots of Ilex pubescens,together with three known saponins 2,3 and 4.The structure of 1 was elucidated on the basis of spectral analysis including 1D and 2D NMR and HR-ESI-MS.Saponins 1 and 4 exhibited significant XOD inhibitory activity in the test.
基金National Key Technology R&D Program "New Drug Innovation" of China (Grant No.2012ZX09201-201-001,2012ZX09301002-002-002 and 2012ZX09304-005)Doctoral Fund of Ministry of Education (Grant No.20110001130003)
文摘Phytochemical investigation of the leaves of Ilex aspralla （Hook. et Am.） Champ. ex Benth. led to the isolation of eleven compounds （1-11）. By comparison with those reported data in the literatures their structures were identified as kaempferol-3-O-β-D- 6＂-acetylglucopyranoside （1）, kaempferol-4＇-methylether （2）, quercetin （3）, quercetin-3-O-glucopyranoside （4）, tormentoside （5）, suavissimoside R1 （6）, 3β,19α-dihydroxyolean-12-ene-24,28-dioicacid-28-O-β-D-glucopyranoside （7）, 3-O-β-sulfooxy-19-hydroxy- urs-12-ene-28-oic acid （8）, coniferin （9）, adenoside （10）, 1＇-O-benzyl-ct-L-rhamnopyranosyl-（l＂→6＇）-β-D-glucopyranoside （11）. Among these, six compounds （1, 2, 5, 9-11） were firstly reported from the genus Ilex, and five compounds （3, 4, 6-8） were isolated for the first time from llex aspralla.
文摘从枸骨(IlexcornutaLindl.exPaxt.)中分离得到20个化合物,鉴定了16个,分别为:枸骨甙1(Gouguside1,Ⅴ)即坡摸酸3 β O α L 吡喃阿拉伯糖甙;枸骨甙2(Gouguside2,Ⅵ)即3 β O D 吡喃葡萄糖基坡摸酸 β 28 O D 吡喃葡萄糖酯;枸骨甙3(Gouguside3,Ⅶ)即3 β O (β D 吡喃葡萄糖基) α L 吡喃葡萄糖基坡摸酸 β 28 O D 吡喃葡萄糖酯的类似物;枸骨甙4(Gouguside4,ⅩⅦ)即3 β O (β D 吡喃葡萄糖基) α L 吡喃葡萄糖基坡摸酸 β 28 O D 吡喃葡萄糖酯;枸骨甙5(Gouguside5,ⅩⅧ)即坡摸酸3 β O α L 2′ 乙酰氧基吡喃阿拉伯糖基 28 O β D 吡喃葡萄糖酯,枸骨甙6(Gouguside6,ⅩⅨ)即3 β O (β D 吡喃葡萄糖基) α L 4 乙酰氧基吡喃阿拉伯糖基坡摸酸 β 28 O D 吡喃葡萄糖酯;枸骨甙7(Gouguside7,ⅩⅩ)即3 β O α L 吡喃阿拉伯糖基 28 O β D 吡喃葡萄糖酯;胡萝卜甙(daucostorolⅧ);2,4 二羟基苯甲酸(2,4 dihydroxybenzoicacidⅠ);3,4 二羟基桂皮酸(3,4 dihyroxycinnamunicacidⅡ、Ⅳ);长链脂肪酸或醇5个(Longchainfattyacid,Ⅲ、Ⅵ、Ⅶ、Ⅷ、ⅩⅣ)。在鉴定的16个化合物中,枸骨甙1、枸骨甙2、枸骨甙6和枸骨甙7为首次从枸骨中分离得到,枸骨甙3和枸骨甙4为新化合物。
基金Supported by the public welfare research special project in State Administration for Quality Supervision and Inspection and Quarantine (No. 201210209)
文摘The title compound of pedunculoside （C36H58O10）, a main active triterpenoid saponin of Ilicis Rotundae Cortex, was isolated from the dried bark of Ilex rotunda Thunb., and characterized by X-ray diffraction analysis. It crystallizes in the orthorhombic system, space group P212121 with C36H58O10, a = 13.046（3）, b = 21.038（4）, c = 28.413（6） A, V = 7798.28（3） A3, Z = 8, Dc= 1.109 g/cm3, Mr = 650.82, F（000） = 2832, andμ = 0.080 mm-1. The final R = 0.0765 and wR = 0.1736 for 15117 observed reflections （I 〉 2σ（I））. The molecular crystal structure of pedunculoside shows relative stereochemistry of 3β, 19α,23-trihydroxy-urs- 12-en-28-oic acid-28-O-β-D-glucopy- rainosyl ester. The molecule is composed of one glucopyranosyl ring and five six-membered rings with ring junctures of A/B trans, B/C trans, and D/E cis. There are two C36H50O10 molecules in an asymmetric unit, and the title compound is stacked into a 2D layer structure through hydrogen bonds.
