LEAFM ANIA的第二家店铺位于东京台东区(Taito Ward)CABO综合大楼的一层和二层。CABO综合大楼位于Yoyogi-Uehara车站旁,2023年刚建成,是一个集合了办公、住宅和娱乐设施于一体的多功能综合性大楼。LEAFM AN IA兼具零售、画廊和茶室双重...LEAFM ANIA的第二家店铺位于东京台东区(Taito Ward)CABO综合大楼的一层和二层。CABO综合大楼位于Yoyogi-Uehara车站旁,2023年刚建成,是一个集合了办公、住宅和娱乐设施于一体的多功能综合性大楼。LEAFM AN IA兼具零售、画廊和茶室双重功能,2层的结构为其分区提供了有利的条件,将动与静、冷清与热闹、分散与聚集自然地区分开来。展开更多
Ilexonin A is a compound isolated from the root of Ilex pubescens,a traditional Chinese medicine.Ilexonin A has been shown to play a neuroprotective role by regulating the activation of astrocytes and microglia in the...Ilexonin A is a compound isolated from the root of Ilex pubescens,a traditional Chinese medicine.Ilexonin A has been shown to play a neuroprotective role by regulating the activation of astrocytes and microglia in the peri-infarct area after ischemia.However,the effects of ilexonin A on astrocytes and microglia in the infarct-free region of the hippocampal CA1 region remain unclear.Focal cerebral ischemia models were established by 2-hour occlusion of the middle cerebral artery in rats.Ilexonin A(20,40 or 80 mg/kg)was administered immediately after ischemia/reperfusion.The astrocyte marker glial fibrillary acidic protein,microglia marker Iba-1,neural stem cell marker nestin and inflammation markers were detected by immunohistochemistry and western blot assay.Expression levels of tumor necrosis factor-αand interleukin 1βwere determined by enzyme linked immunosorbent assay in the hippocampal CA1 tissue.Astrocytes were activated immediately in progressively increasing numbers from 1,3,to 7 days post-ischemia/reperfusion.The number of activated astrocytes further increased in the hippocampal CA1 region after treatment with ilexonin A.Microglial cells remained quiescent after ischemia/reperfusion,but became activated after treatment with ilexonin A.Ilexonin A enhanced nestin expression and reduced the expression of tumor necrosis factor-αand interleukin 1βin the hippocampus post-ischemia/reperfusion.The results of the present study suggest that ilexonin A has a neuroprotective effect in the hippocampus after ischemia/reperfusion,probably through regulating astrocytes and microglia activation,promoting neuronal stem cell proliferation and reducing the levels of pro-inflammatory factors.This study was approved by the Animal Ethics Committee of the Fujian Medical University Union Hospital,China.展开更多
机场场面情景意识显示和告警(Enhanced Traffic Situational Awareness on the Airport Surface with Indications and Alerts, SURF IA)作为广播式自动相关监视(Automatic Dependent Surveillance-Broadcast IN, ADS-B IN)下的一种监...机场场面情景意识显示和告警(Enhanced Traffic Situational Awareness on the Airport Surface with Indications and Alerts, SURF IA)作为广播式自动相关监视(Automatic Dependent Surveillance-Broadcast IN, ADS-B IN)下的一种监视应用,可以使航空器在机场运行时的安全和效率大大提高。以北斗卫星导航系统(BDS)/GPS双系统作为ADS-B IN的数据源,在利用所有可见卫星达到SURF IA运行的性能要求的基础上,为了减少可见卫星的使用数量,降低工作负荷,采用了粒子群算法(Particle Swarm Optimization, PSO)对导航卫星进行筛选,使得采用更少的卫星运行满足SURF IA的要求。仿真结果表明,经过PSO筛选后,可以以更少的卫星满足SURF IA运行最低监视性能要求,提高了机场场面运行监视性能。展开更多
Based on the idea of hypothetical 4-dimensial substance with an inverse population of energy levels, a model of accelerated expansion of the Universe has been developed, which describes Hubble diagrams with great accu...Based on the idea of hypothetical 4-dimensial substance with an inverse population of energy levels, a model of accelerated expansion of the Universe has been developed, which describes Hubble diagrams with great accuracy for type Ia supernovae, quasars and gamma-ray burst sources at the Hubble parameter value of 67.7 km/s/Mpc, coinciding with the value obtained from analysis of inhomogeneities of relic radiation. Calculations at the Hubble parameter value of 73.5 km/s/Mpc, obtained using the ΛCDM model based on the analysis of data on type Ia supernovae and cepheids, differ markedly from the observed data. An explanation of the two values of the Hubble constant is proposed. It is shown that in this model, the magnitude of 13.8 billion years characterizes not the age of the Universe, but the time of propagation of light from those galaxes whose acceleration of removal has a minimal value. Based on the recently discovered curvature of the Universe, estimates are given of the lower limits of its size and lifetime, which turned out to be at least 270 billon years. The probability of transition from the excited state to the underlying energy levels of a hypothetical 4-dimensial substance, as well as the low of increasing energy density as a result of transitions to the underlying levels of this substance, is determined.展开更多
To reduce additional mass, this work proposes a nonlinear energy sink(NES)with an inertial amplifier(NES-IA) to control the vertical vibration of the objects under harmonic and shock excitations. Moreover, this paper ...To reduce additional mass, this work proposes a nonlinear energy sink(NES)with an inertial amplifier(NES-IA) to control the vertical vibration of the objects under harmonic and shock excitations. Moreover, this paper constructs pure nonlinear stiffness without neglecting the gravity effect of the oscillator. Both analytical and numerical methods are used to evaluate the performance of the NES-IA. The research findings indicate that even if the actual mass is 1% of the main oscillator, the NES-IA with proper inertia angles and mass distribution ratios can still effectively attenuate the steady-state and transient responses of the main oscillator. Nonlinear stiffness and damping also have important effects. Due to strongly nonlinear factors, the coupled system may exhibit higher branch responses under harmonic excitation. In shock excitation environment, the NES-IA with a large dynamic mass can trigger energy capture of both main resonance and high-frequency resonance. Furthermore, the comparison with the traditional NES also confirms the advantages of the NES-IA in overcoming mass dependence.展开更多
文摘LEAFM ANIA的第二家店铺位于东京台东区(Taito Ward)CABO综合大楼的一层和二层。CABO综合大楼位于Yoyogi-Uehara车站旁,2023年刚建成,是一个集合了办公、住宅和娱乐设施于一体的多功能综合性大楼。LEAFM AN IA兼具零售、画廊和茶室双重功能,2层的结构为其分区提供了有利的条件,将动与静、冷清与热闹、分散与聚集自然地区分开来。
基金supported by the Natural Science Foundation of Fujian Province of China,No.2014J01327the Program for New Century Excellent Talents in Colleges and Universities of Fujian Province of China,No.NCETFJ-0704the Professorial Academic Development Foundation of Fujian Medical University of China,No.JS09014(all to GYZ)
文摘Ilexonin A is a compound isolated from the root of Ilex pubescens,a traditional Chinese medicine.Ilexonin A has been shown to play a neuroprotective role by regulating the activation of astrocytes and microglia in the peri-infarct area after ischemia.However,the effects of ilexonin A on astrocytes and microglia in the infarct-free region of the hippocampal CA1 region remain unclear.Focal cerebral ischemia models were established by 2-hour occlusion of the middle cerebral artery in rats.Ilexonin A(20,40 or 80 mg/kg)was administered immediately after ischemia/reperfusion.The astrocyte marker glial fibrillary acidic protein,microglia marker Iba-1,neural stem cell marker nestin and inflammation markers were detected by immunohistochemistry and western blot assay.Expression levels of tumor necrosis factor-αand interleukin 1βwere determined by enzyme linked immunosorbent assay in the hippocampal CA1 tissue.Astrocytes were activated immediately in progressively increasing numbers from 1,3,to 7 days post-ischemia/reperfusion.The number of activated astrocytes further increased in the hippocampal CA1 region after treatment with ilexonin A.Microglial cells remained quiescent after ischemia/reperfusion,but became activated after treatment with ilexonin A.Ilexonin A enhanced nestin expression and reduced the expression of tumor necrosis factor-αand interleukin 1βin the hippocampus post-ischemia/reperfusion.The results of the present study suggest that ilexonin A has a neuroprotective effect in the hippocampus after ischemia/reperfusion,probably through regulating astrocytes and microglia activation,promoting neuronal stem cell proliferation and reducing the levels of pro-inflammatory factors.This study was approved by the Animal Ethics Committee of the Fujian Medical University Union Hospital,China.
文摘Based on the idea of hypothetical 4-dimensial substance with an inverse population of energy levels, a model of accelerated expansion of the Universe has been developed, which describes Hubble diagrams with great accuracy for type Ia supernovae, quasars and gamma-ray burst sources at the Hubble parameter value of 67.7 km/s/Mpc, coinciding with the value obtained from analysis of inhomogeneities of relic radiation. Calculations at the Hubble parameter value of 73.5 km/s/Mpc, obtained using the ΛCDM model based on the analysis of data on type Ia supernovae and cepheids, differ markedly from the observed data. An explanation of the two values of the Hubble constant is proposed. It is shown that in this model, the magnitude of 13.8 billion years characterizes not the age of the Universe, but the time of propagation of light from those galaxes whose acceleration of removal has a minimal value. Based on the recently discovered curvature of the Universe, estimates are given of the lower limits of its size and lifetime, which turned out to be at least 270 billon years. The probability of transition from the excited state to the underlying energy levels of a hypothetical 4-dimensial substance, as well as the low of increasing energy density as a result of transitions to the underlying levels of this substance, is determined.
基金Project supported by the National Natural Science Foundation of China (Nos. 12172014 and11972050)the Key Laboratory of Vibration and Control of Aero-Propulsion System (Northeastern University),Ministry of Education of China (No. VCAME 202004)。
文摘To reduce additional mass, this work proposes a nonlinear energy sink(NES)with an inertial amplifier(NES-IA) to control the vertical vibration of the objects under harmonic and shock excitations. Moreover, this paper constructs pure nonlinear stiffness without neglecting the gravity effect of the oscillator. Both analytical and numerical methods are used to evaluate the performance of the NES-IA. The research findings indicate that even if the actual mass is 1% of the main oscillator, the NES-IA with proper inertia angles and mass distribution ratios can still effectively attenuate the steady-state and transient responses of the main oscillator. Nonlinear stiffness and damping also have important effects. Due to strongly nonlinear factors, the coupled system may exhibit higher branch responses under harmonic excitation. In shock excitation environment, the NES-IA with a large dynamic mass can trigger energy capture of both main resonance and high-frequency resonance. Furthermore, the comparison with the traditional NES also confirms the advantages of the NES-IA in overcoming mass dependence.
