Background Iloprost has been used to test acute pulmonary vasoreactivity in idiopathic pulmonary arterial hypertension （PAH）. We aimed to investigate the acute hemodynamic and oxygenation responses and tolerability ...Background Iloprost has been used to test acute pulmonary vasoreactivity in idiopathic pulmonary arterial hypertension （PAH）. We aimed to investigate the acute hemodynamic and oxygenation responses and tolerability to 20 pg aerosolized Iloprost in Chinese patients with pulmonary hypertension. Methods Between March 2005 and May 2010, 212 pulmonary hypertension patients inhaled a single dose of 20 pg Iloprost over 10-15 minutes for vasoreactivity testing. The acute hemodynamic and oxygenation responses and adverse events were recorded. Results Iloprost decreased total pulmonary resistance （（1747±918） dyn.s-cm-5 vs. （1581±937） dyn.s.cm-5, P 〈0.001）, increased stroke volume （（45.0±22.1） ml vs. （47.0±24.2） ml, P=0.002）, and cardiac output （（3.7±1.7） L/ml vs. （3.9±1.9） L/min, P=0.009）. Heart rate and systemic vascular resistance remained stable during inhalation. However, systemic arterial blood oxygen saturation fell slightly （（91.0±6.8）% vs. （90.3±6.7）%, P=0.002）. Pulmonary and systemic arterial blood pressures declined within 1-3 minutes after inhalation initiation and reached their lowest levels within 10-15 minutes. Idiopathic PAH responded more favorably than pulmonary hypertension due to other causes （P 〈0.001） and patients with less severe pulmonary hypertension have better responses to Iloprost. No adverse events requiring medical care or leading to termination of inhalation occurred. Conclusions Inhalation of 20 pg Iloprost showed potent and selective pulmonary hemodynamic effects and was well tolerated in the Chinese pulmonary hypertension patients. Patients with idiopathic PAH and less severe pulmonary hypertension responded more favorably to inhalation of Iloprost.展开更多
Pulmonary arterial hypertension （PAH） is a common and serious complication of congenital heart disease （CHD）.Many studies have confirmed that the prostacyclin analogues,5-phosphodiesterase （PDE-5） inhibitors,and...Pulmonary arterial hypertension （PAH） is a common and serious complication of congenital heart disease （CHD）.Many studies have confirmed that the prostacyclin analogues,5-phosphodiesterase （PDE-5） inhibitors,and endothelin receptor antagonists,were safe and effective in the treatment for PAH due to CHD.1,2 But whether the combination of targeted PAH therapy drugs provides similar synergistic effects is still controversial.1,2 Therefore,we investigated whether adult patients with severe PAH secondary to CHD would benefit from iloprost combined with low-dose tadalafil.展开更多
Background Previous studies have shown that prostaglandins （PGs） dramatically stimulate healing processes in bone.However,the effect of prostaglandin l2 （PGI2） on fracture healing remains unclear.To investigate th...Background Previous studies have shown that prostaglandins （PGs） dramatically stimulate healing processes in bone.However,the effect of prostaglandin l2 （PGI2） on fracture healing remains unclear.To investigate the effect of PGI2,a study on fracture healing process in closed tibia fractures was designed.Methods Thirty-six Sprague-Dawley male rats were randomized into two groups.On the first day,their right tibias were fractured by three-point bending technique.The study group （n=18） received a single injection of 10 μg/kg iloprost for 5 days,while the control group （n=18） received saline solution in the same way.On the 7th,14th and 28th days following the fracture,six rats were sacrificed and their right legs were harvested in each group.The progression of fracture healing was assessed for each specimen by the scores of radiography （by Lane-Sandhu） and histology （by Huo et al）.Results On the 7th day,the radiographic and histologic scores were equal.On the 14th day radiographic total score was 6 and histologic total score was 23 in the iloprost group,whereas radiographic total score was 11 and histologic total score was 33 in the control group.On the 14th day radiographic and histologic scores were significantly decreased in the iloprost group compared to the control group （P 〈0.05）.On the 28th day radiographic total score was 12 and histologic total score was 37 in the iloprost group,whereas radiographic total score was 15 and histologic total score was 40 in the control group.On the 28th day although there was a decrease in radiographic and histologic scores of the iloprost group acording to control group,it was not statistically significant （P 〉0.05）.Conclusion Iloprost delays fracture healing in early stage in rats.展开更多
文摘Background Iloprost has been used to test acute pulmonary vasoreactivity in idiopathic pulmonary arterial hypertension （PAH）. We aimed to investigate the acute hemodynamic and oxygenation responses and tolerability to 20 pg aerosolized Iloprost in Chinese patients with pulmonary hypertension. Methods Between March 2005 and May 2010, 212 pulmonary hypertension patients inhaled a single dose of 20 pg Iloprost over 10-15 minutes for vasoreactivity testing. The acute hemodynamic and oxygenation responses and adverse events were recorded. Results Iloprost decreased total pulmonary resistance （（1747±918） dyn.s-cm-5 vs. （1581±937） dyn.s.cm-5, P 〈0.001）, increased stroke volume （（45.0±22.1） ml vs. （47.0±24.2） ml, P=0.002）, and cardiac output （（3.7±1.7） L/ml vs. （3.9±1.9） L/min, P=0.009）. Heart rate and systemic vascular resistance remained stable during inhalation. However, systemic arterial blood oxygen saturation fell slightly （（91.0±6.8）% vs. （90.3±6.7）%, P=0.002）. Pulmonary and systemic arterial blood pressures declined within 1-3 minutes after inhalation initiation and reached their lowest levels within 10-15 minutes. Idiopathic PAH responded more favorably than pulmonary hypertension due to other causes （P 〈0.001） and patients with less severe pulmonary hypertension have better responses to Iloprost. No adverse events requiring medical care or leading to termination of inhalation occurred. Conclusions Inhalation of 20 pg Iloprost showed potent and selective pulmonary hemodynamic effects and was well tolerated in the Chinese pulmonary hypertension patients. Patients with idiopathic PAH and less severe pulmonary hypertension responded more favorably to inhalation of Iloprost.
文摘Pulmonary arterial hypertension （PAH） is a common and serious complication of congenital heart disease （CHD）.Many studies have confirmed that the prostacyclin analogues,5-phosphodiesterase （PDE-5） inhibitors,and endothelin receptor antagonists,were safe and effective in the treatment for PAH due to CHD.1,2 But whether the combination of targeted PAH therapy drugs provides similar synergistic effects is still controversial.1,2 Therefore,we investigated whether adult patients with severe PAH secondary to CHD would benefit from iloprost combined with low-dose tadalafil.
文摘Background Previous studies have shown that prostaglandins （PGs） dramatically stimulate healing processes in bone.However,the effect of prostaglandin l2 （PGI2） on fracture healing remains unclear.To investigate the effect of PGI2,a study on fracture healing process in closed tibia fractures was designed.Methods Thirty-six Sprague-Dawley male rats were randomized into two groups.On the first day,their right tibias were fractured by three-point bending technique.The study group （n=18） received a single injection of 10 μg/kg iloprost for 5 days,while the control group （n=18） received saline solution in the same way.On the 7th,14th and 28th days following the fracture,six rats were sacrificed and their right legs were harvested in each group.The progression of fracture healing was assessed for each specimen by the scores of radiography （by Lane-Sandhu） and histology （by Huo et al）.Results On the 7th day,the radiographic and histologic scores were equal.On the 14th day radiographic total score was 6 and histologic total score was 23 in the iloprost group,whereas radiographic total score was 11 and histologic total score was 33 in the control group.On the 14th day radiographic and histologic scores were significantly decreased in the iloprost group compared to the control group （P 〈0.05）.On the 28th day radiographic total score was 12 and histologic total score was 37 in the iloprost group,whereas radiographic total score was 15 and histologic total score was 40 in the control group.On the 28th day although there was a decrease in radiographic and histologic scores of the iloprost group acording to control group,it was not statistically significant （P 〉0.05）.Conclusion Iloprost delays fracture healing in early stage in rats.
