Cells in the body are exposed to physiological and pathophysiological stimuli that encompass both chemical and mechanical factors,which coordinately modulate cellular functions. Compared to the large amount of informa...Cells in the body are exposed to physiological and pathophysiological stimuli that encompass both chemical and mechanical factors,which coordinately modulate cellular functions. Compared to the large amount of information on cellular re-展开更多
A principal direction Gaussian image （PDGI）-based algorithm is proposed to extract the regular swept surface from point cloud. Firstly, the PDGI of the regular swept surface is constructed from point cloud, then the...A principal direction Gaussian image （PDGI）-based algorithm is proposed to extract the regular swept surface from point cloud. Firstly, the PDGI of the regular swept surface is constructed from point cloud, then the bounding box of the Gaussian sphere is uniformly partitioned into a number of small cubes （3D grids） and the PDGI points on the Gaussian sphere are associated with the corresponding 3D grids. Secondly, cluster analysis technique is used to sort out a group of 3D grids containing more PDGI points among the 3D grids. By the connected-region growing algorithm, the congregation point or the great circle is detected from the 3D grids. Thus the translational direction is determined by the congregation point and the direction of the rotational axis is determined by the great circle. In addition, the positional point of the rotational axis is obtained by the intersection of all the projected normal lines of the rotational surface on the plane being perpendicular to the estimated direction of the rotational axis. Finally, a pattem search method is applied to optimize the translational direction and the rotational axis. Some experiments are used to illustrate the feasibility of the above algorithm.展开更多
Theranostics is an appealing approach in precision medicine and it is still a critical challenge to design smart strategies which can precisely accumulate the functional probes/drugs into targeted disease areas.Cell-s...Theranostics is an appealing approach in precision medicine and it is still a critical challenge to design smart strategies which can precisely accumulate the functional probes/drugs into targeted disease areas.Cell-surface cascaded landing location is an effective strategy to develop functional drug-loading platforms to explore basic physiological processes at the cellular level and to facilitate the development of nanotheranostics for disease treatment.展开更多
基金supported in part by grants from NIH HL098472, CA139272, NS063405NSF CBET0846429,CMMI0800870the Wallace H Coulter Foundation,and the Beckman Laser Institute Inc
文摘Cells in the body are exposed to physiological and pathophysiological stimuli that encompass both chemical and mechanical factors,which coordinately modulate cellular functions. Compared to the large amount of information on cellular re-
基金This project is supported by Key Program of National Natural Science Foundation of China(No.50435020).
文摘A principal direction Gaussian image （PDGI）-based algorithm is proposed to extract the regular swept surface from point cloud. Firstly, the PDGI of the regular swept surface is constructed from point cloud, then the bounding box of the Gaussian sphere is uniformly partitioned into a number of small cubes （3D grids） and the PDGI points on the Gaussian sphere are associated with the corresponding 3D grids. Secondly, cluster analysis technique is used to sort out a group of 3D grids containing more PDGI points among the 3D grids. By the connected-region growing algorithm, the congregation point or the great circle is detected from the 3D grids. Thus the translational direction is determined by the congregation point and the direction of the rotational axis is determined by the great circle. In addition, the positional point of the rotational axis is obtained by the intersection of all the projected normal lines of the rotational surface on the plane being perpendicular to the estimated direction of the rotational axis. Finally, a pattem search method is applied to optimize the translational direction and the rotational axis. Some experiments are used to illustrate the feasibility of the above algorithm.
基金supported by the Major State Basic Research Development Program of China(Nos.2017YFA0205201,2014CB744503,and 2013CB733802)the National Natural Science Foundation of China(NSFC)(Nos.81422023,81371596,51273165,and U1505221)
文摘Theranostics is an appealing approach in precision medicine and it is still a critical challenge to design smart strategies which can precisely accumulate the functional probes/drugs into targeted disease areas.Cell-surface cascaded landing location is an effective strategy to develop functional drug-loading platforms to explore basic physiological processes at the cellular level and to facilitate the development of nanotheranostics for disease treatment.
