Divergent synthesis of useful skeletons has been realized via rhodium(Ⅲ)-catalyzed C-H activation of iminopyridinium ylides and coupling with various unsaturated coupling reagents.Isocoumarins and isoquinolones were ...Divergent synthesis of useful skeletons has been realized via rhodium(Ⅲ)-catalyzed C-H activation of iminopyridinium ylides and coupling with various unsaturated coupling reagents.Isocoumarins and isoquinolones were obtained via cleavage of the C-N or N-N bond in the ylidic di recti ng group,while fluorinated alkenes were delivered with the di recti ng group in tact.The reactions occurred with wide substrate scopes and good efficiency under redox-neutral and air-tolerant conditions.Representative products exhibit solid-state fluoresce nt property and bioactivity of in hibiti on toward huma n cancer cells.展开更多
基金The NSFC(Nos.21801066,2152520&U1804283 and 21801067)the Central Plains Scholars and Scientists Studio Fund(2018002)China Postdoctoral Science Foundation(2020M682307)are acknowledged.We also thank the financial support from Henan Key Laboratory of Organic Functional Molecules and Drug Innovation.
文摘Divergent synthesis of useful skeletons has been realized via rhodium(Ⅲ)-catalyzed C-H activation of iminopyridinium ylides and coupling with various unsaturated coupling reagents.Isocoumarins and isoquinolones were obtained via cleavage of the C-N or N-N bond in the ylidic di recti ng group,while fluorinated alkenes were delivered with the di recti ng group in tact.The reactions occurred with wide substrate scopes and good efficiency under redox-neutral and air-tolerant conditions.Representative products exhibit solid-state fluoresce nt property and bioactivity of in hibiti on toward huma n cancer cells.
