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Novel metabolic and physiological functions of branched chain amino acids: a review 被引量:39
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作者 Shihai Zhang Xiangfang Zeng +2 位作者 Man Ren Xiangbing Mao Shiyan Qiao 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2017年第3期501-512,共12页
It is widely known that branched chain amino acids(BCAA) are not only elementary components for building muscle tissue but also participate in increasing protein synthesis in animals and humans. BCAA(isoleucine, le... It is widely known that branched chain amino acids(BCAA) are not only elementary components for building muscle tissue but also participate in increasing protein synthesis in animals and humans. BCAA(isoleucine, leucine and valine) regulate many key signaling pathways, the most classic of which is the activation of the m TOR signaling pathway. This signaling pathway connects many diverse physiological and metabolic roles. Recent years have witnessed many striking developments in determining the novel functions of BCAA including:(1) Insufficient or excessive levels of BCAA in the diet enhances lipolysis.(2) BCAA, especially isoleucine, play a major role in enhancing glucose consumption and utilization by up-regulating intestinal and muscular glucose transporters.(3)Supplementation of leucine in the diet enhances meat quality in finishing pigs.(4) BCAA are beneficial for mammary health, milk quality and embryo growth.(5) BCAA enhance intestinal development, intestinal amino acid transportation and mucin production.(6) BCAA participate in up-regulating innate and adaptive immune responses.In addition, abnormally elevated BCAA levels in the blood(decreased BCAA catabolism) are a good biomarker for the early detection of obesity, diabetes and other metabolic diseases. This review will provide some insights into these novel metabolic and physiological functions of BCAA. 展开更多
关键词 Amino acid transporters Glucose transporters Gut health Immunity Lipolysis Mammary health Meat quality milk production
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