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Evidence-Based Nursing Practice of Reducing Immune-Related Skin Toxicity of Tumor Patients Guided by Sensitive Indicators
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作者 Lingling Tang Qiong Wen 《Journal of Biosciences and Medicines》 2024年第4期210-215,共6页
Purpose research on nursing sensitive indicators in tumor Patients application effect in immune-related skin toxicity management. Method select our hospital April to June, 202360 cases patients with immune therapy set... Purpose research on nursing sensitive indicators in tumor Patients application effect in immune-related skin toxicity management. Method select our hospital April to June, 202360 cases patients with immune therapy settings as the control group. August-October, 2023 60 cases the patients treated with immune therapy were the experimental group. The control group adopted regular nursing methods, while the experimental group sensitive Indicators, evidence-based give preventive care. The social situation, psychological state, physical function, quality of life score, incidence of skin toxicity caused by immune checkpoint inhibitors, moderate and above of the two groups of patients were compared. Incidence of skin toxicity. Result: experience group SAS score, SDS score higher than the control group, the difference was statistically significant (P < 0.05);The incidence of skin toxic reactions caused by immune checkpoint inhibitors and the incidence of moderate and above skin toxic reactions in the experimental group are lower than those in the control group, and the difference is statistically significant (P < 0.05). Conclusion: sensitive indicator guidance evidence-based preventive care can reduce the degree of immune-related skin toxicity, improve the psychological state and quality of life of tumor patients treated with immune therapy and reduce the incidence of adverse reactions, improve nursing quality and patient satisfaction. 展开更多
关键词 Sensitive Indicators immune-related skin toxicity Evidence-Based Practice TUMOR
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Development and Application of Procedures for the Management of Skin Toxicity Related to Immune Checkpoint Inhibitors in Patients with Lung Cancer
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作者 Qianru Xu Qiong Wen 《Journal of Biosciences and Medicines》 2024年第7期289-300,共12页
Objective: To establish the procedures for the management of skin toxicity related to immune checkpoint inhibitors in patients with lung cancer and explore the effect of application. Methods: A total of 24 evidence-ba... Objective: To establish the procedures for the management of skin toxicity related to immune checkpoint inhibitors in patients with lung cancer and explore the effect of application. Methods: A total of 24 evidence-based evidences were collected from 7 aspects, including risk factors, baseline screening, ICIs monitoring, daily skin care, multidisciplinary management, symptom management and health education. A total of 157 lung cancer patients and 94 nurses from 8 wards of the Oncology department of our hospital from November 2022 to May 2023 were selected by convenience sampling. A total of 77 patients and 46 nurses from ward 1 - 4 were divided into the baseline group. There were 80 patients and 48 nurses in Ward 5 - 8 as the evidence-based practice group. In the baseline group, patients were treated with routine methods such as assessing skin symptoms, taking medication according to symptoms, guiding to keep skin clean and moist, eating a light diet, and avoiding scratching. The evidence-based practice group adopts an evidence-based continuous improvement model for nursing. The differences in the severity of symptoms of skin toxicity in the second cycle of medication and the knowledge and practice of self-care of skin toxicity were compared between the two groups before and after the use of the syndrome, as well as the differences in the implementation rate of review indicators, evidence-based ability and knowledge and practice of skin toxicity care before and after the use of the syndrome. Results: The incidence and severity of cutaneous toxicity were significantly lower after treatment than before treatment (P P < 0.05). Conclusion: The implementation of immune checkpoint inhibitor-related skin toxicity management procedures can effectively reduce the incidence and severity of skin toxicity symptoms, optimize the clinical pathway, and improve the quality of care. 展开更多
关键词 Lung Cancer Immune Checkpoint Inhibitors skin toxicity Process Management NURSE
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Skin Toxicity of Wufang Babu Ointment to Zebrafish
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作者 Xiaoxia LI Jiabao MA +2 位作者 Jing FU Jinhua LIU Xiongbin GUI 《Medicinal Plant》 2024年第2期40-42,47,共4页
[Objectives]Using wild-type AB strain of zebrafish as experimental animal,this study investigated the damaging effect of Wufang Babu Ointment on skin cells,in order to evaluate the skin toxicity of Wufang Babu Ointmen... [Objectives]Using wild-type AB strain of zebrafish as experimental animal,this study investigated the damaging effect of Wufang Babu Ointment on skin cells,in order to evaluate the skin toxicity of Wufang Babu Ointment.[Methods]Wild-type AB strain of zebrafish with an age of 2 d were taken and fed in different concentrations of Wufang Babu Ointment solution for 24 h.The number of deaths in each group of zebrafish was recorded,and the mortality rate was calculated.Using Origin 8.0 software,the maximum non lethal concentration(MNLC)was simulated.Zebrafish raised in different concentrations of Wufang Babu Ointment solution for 24 h were placed under an anatomical microscope for taking photos,to analyze and calculate the incidence of skin damage in zebrafish.Based on the statistical analysis results of this indicator,the skin toxicity of Wufang Babu Ointment was evaluated.[Results]The MNLC of Wufang Babu Ointment on zebrafish was 671μg/mL;Wufang Babu Ointment can induce skin damage at the concentrations of 224μg/mL(1/3 MNLC)and 671μg/mL(MNLC).[Conclusions]Wufang Babu Ointment had certain skin toxicity to zebrafish. 展开更多
关键词 Wufang Babu Ointment ZEBRAFISH skin toxicity
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Biomarkers of skin toxicity induced by anti-epidermal growthfactor receptor antibody treatment in colorectal cancer 被引量:1
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作者 Akiko Kubo Hironobu Hashimoto +1 位作者 Naoki Takahashi Yasuhide Yamada 《World Journal of Gastroenterology》 SCIE CAS 2016年第2期887-894,共8页
Skin toxicity is a common symptom of anti-epidermal rowth factor receptor(EGFR) antibody treatment and is also a predictive marker of its efficacy in colorectal cancer patients. However, severe skin disorders induced ... Skin toxicity is a common symptom of anti-epidermal rowth factor receptor(EGFR) antibody treatment and is also a predictive marker of its efficacy in colorectal cancer patients. However, severe skin disorders induced by such antibodies negatively impact on the quality of life of patients and decreases drug compliance during treatment. If we can predict the high-risk group susceptible to severe skin toxicity before treatment, we can undertake the early management of any arising skin disorders and formulate a more accurate prognosis for anti-EGFR antibody treatment. Previous studies have identified molecular markers of skin toxicity induced by anti-EGFR antibody, such as EGFR polymorphisms, the expression of inflammatory chemokines and serum levels of EGFR ligands. A clinical trial was undertaken involving the escalation of cetuximab doses, guided by the grade of skin toxicity observed, such as no or low-grade, in metastatic colorectal cancer(the EVEREST study). The dose escalation of cetuximab was confirmed by a safety profile and had the tendency to achieve a higher response rate in KRAS wild-type patients. A large, prospective randomized trial is now ongoing(EVEREST 2) and the results of this trial may contribute to personalized medicine in KRAS wild-type colorectal cancer patients. 展开更多
关键词 COLORECTAL cancer skin toxicity Epidermalgrowth factor RECEPTOR EPIDERMAL growth factorreceptor POLYMORPHISM LIGAND
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Cytotoxicity,in Vivo Skin Irritation and Acute Systemic Toxicity of the Mesoporous Magnesium Carbonate Upsalite^(█) 被引量:1
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作者 Sara Frykstrand Johan Forsgren +2 位作者 Peng Zhang Maria Stromme Natalia Ferraz 《Journal of Biomaterials and Nanobiotechnology》 2015年第4期257-266,共10页
Upsalite&reg;is a mesoporous magnesium carbonate synthesized without using surfactants and therefore highly attractive from environmental and production economy points of view. The material has recently been sugge... Upsalite&reg;is a mesoporous magnesium carbonate synthesized without using surfactants and therefore highly attractive from environmental and production economy points of view. The material has recently been suggested as drug delivery vehicle and as topical bacteriostatic agent. In order to continue exploring these and other bio-related applications of the material, primary biocompatibility studies are needed. Herein we present the first in vivo acute systemic toxicity and skin irritation analyses as well as in vitro cytotoxicity evaluations of Upsalite&reg;. The material was found to be non-toxic for human dermal fibroblasts cells up to a concentration of 1000 μg/ml and 48 h exposure in contrast to the mesoporous silica material SBA-15, used as reference, which significantly affected cell viability at particle concentration of 500 and 1000 μg/ml after the same exposure time. Topical application of Upsalite&reg;resulted in negligible cutaneous reactions in a rabbit skin irritation model and no evidence of significant systemic toxicity was found when saline extracts of Upsalite&reg;were injected in mice. Injection of sesame oil extract, however, resulted in transient weight loss, most likely due to injection of particles, and not toxic leachables. The presented results form the basis for future development of Upsalite&reg;and similar mesoporous materials in biomedical applications and further toxicity as well as biocompatibility studies should be directed towards specific areas of use. 展开更多
关键词 MESOPOROUS Magnesium Carbonate CYTOtoxicity skin Irritation Acute Systemic toxicity
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Association between Subjective Evaluation of Skin Toxicities and Quality of Life in Patients with Lung Cancer Undergoing Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Treatment: A Pilot Study for Developing Skin Toxicity Assessment
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作者 Kengo Hirayama Ya Su +3 位作者 Yasuyuki Ikezawa Megumi Chiba Kenichiro Ito Michiko Yuki 《Open Journal of Nursing》 2019年第12期1226-1239,共14页
Purposes: Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) exert satisfactory therapeutic effects in lung cancer patients. However, the resultant skin toxicity can deteriorate patients’ quali... Purposes: Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) exert satisfactory therapeutic effects in lung cancer patients. However, the resultant skin toxicity can deteriorate patients’ quality of life (QoL). Differences exist in skin toxicity evaluation between patients and clinicians. We aimed to clarify the association between the subjective evaluation of skin toxicities and QoL in lung cancer patients and to establish a document of scale development in the subjective evaluation of skin toxicity. Methods: We used self-administered questionnaires to evaluate 12 lung cancer patients receiving EGFR-TKI treatment. Indices of QoL were generated using the Functional Assessment of Cancer Therapy-Lung and Hospital Anxiety and Depression Scale, and a subjective evaluation questionnaire concerning skin toxicity was completed. The data were collected immediately before treatment initiation and at 4 weeks post treatment. Results: In the subjective evaluation of skin toxicity, four patients (33.3%) were classified as ≥Grade 2 (painful group), experiencing painful pruritus at the emergence site of the skin rash or xerosis. In this group, the QoL scores of physical and emotional aspects declined after treatment. Conversely, patients in the painless group (Grade 0 - 1) demonstrated an improved emotional QoL following treatment (p = 0.028). Conclusions: Lung cancer patients suffering from painful skin toxicity tended to show a decline in the physical and emotional aspects of QoL following EGFR-TKI treatment. The skin toxicity questionnaire was useful from the point of view of a subjective evaluation and could be a powerful assessment tool in future clinical settings with further modification. 展开更多
关键词 Lung Cancer EGFR-Tyrosine KINASE Inhibitors skin toxicity Quality of Life
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Reactive capillary hemangiomas: a novel dermatologic toxicity following anti-PD-1 treatment with SHR-1210 被引量:61
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作者 Xuelian Chen Lanying Ma +7 位作者 Xi Wang Hongnan Mo Dawei Wu Bo Lan Dong Qu Hongtu Zhang Jing Huang Binghe Xu 《Cancer Biology & Medicine》 SCIE CAS CSCD 2019年第1期173-180,共8页
Objective: SHR-1210 is a new and promising anti-PD-1 agent for solid tumors. During the phase I study of SHR-1210, we encountered a novel but prevalent immune-related dermatologic toxicity: reactive capillary hemangio... Objective: SHR-1210 is a new and promising anti-PD-1 agent for solid tumors. During the phase I study of SHR-1210, we encountered a novel but prevalent immune-related dermatologic toxicity: reactive capillary hemangiomas(RCHs). Thus we tried to summarize the features of RCHs and estimate their relationship with tumor response.Methods: This prospective observational study systematically enrolled 98 patients with advanced solid tumors from April 27th,2016 to June 8th, 2017 in the context of the phase I clinical study of SHR-1210. This report focused on the skin toxicities. Patients underwent entire skin inspection every two weeks while taking medication. The clinical course of RCHs was recorded and their association with tumor response was estimated. The data cut-off date was November 15th, 2017.Results: After a median follow-up of 242(range, 29–567) days, RCHs were observed in 85.7%(84/98) of patients on cutaneous/mucosal surfaces; 84.5%(71/84) of the RCHs were evaluated as grade 1 adverse events. No grade 3 or 4 RCHs were observed. The time of onset of RCHs was dose dependent and shortest in the 400 mg-dose cohort(P < 0.001). Spontaneous and complete regression of RCHs was observed both during and after treatment. The objective response rate of tumors for patients with RCHs was 28.9%(24/83). However, no responders were observed among the patients without RCHs.Conclusions: RCHs were prevalent but manageable during treatment with SHR-1210. It might add to the expanding literature regarding immune-related dermatologic adverse events. 展开更多
关键词 REACTIVE capillary HEMANGIOMAS SHR-1210 skin toxicity ANTI-TUMOR efficacy
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Experimental Studies of Toxicity on HNIW and Its Intermediates 被引量:3
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作者 张颖 陈树森 +1 位作者 金韶华 崔照宽 《Defence Technology(防务技术)》 SCIE EI CAS 2006年第3期202-205,共4页
关键词 毒性 HNIW 中间物 火药
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Endoscopic evaluation of immunotherapy-induced gastrointestinal toxicity
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作者 Isabel Iranzo Jose María Huguet +3 位作者 Patricia Suárez Luis Ferrer-Barceló Vega Iranzo Javier Sempere 《World Journal of Gastrointestinal Endoscopy》 CAS 2018年第12期392-399,共8页
Immunotherapy is any treatment aimed at boosting or enhancing the immune system. It includes a wide range of options, from vaccines to treatment for conditions such as allergy and cancer. In the case of cancer, unlike... Immunotherapy is any treatment aimed at boosting or enhancing the immune system. It includes a wide range of options, from vaccines to treatment for conditions such as allergy and cancer. In the case of cancer, unlike other available treatments, immunotherapy is not aimed at destroying the tumor cells but at stimulating the patient's immune system so that it attacks the tumor. In cancer,immunotherapy provides a series of advantages. Nevertheless, immunotherapy administered for treatment of cancer is associated with immune-mediated enterocolitis. Colitis mediated by monoclonal anti-cytotoxic T lymphocyte–associated antigen 4 and to programmed cell death protein 1 and its ligand PDL1 shares characteristics with chronic inflammatory bowel disease(IBD), and similar findings have been reported for both the endoscopy images and the segment involved. The most frequent lesions on endoscopy are ulcer and erythema, and the most frequently affected site is the sigmoid colon. A segmental pattern has been reported to be slightly more frequent than a continuous pattern.In addition, upper gastrointestinal lesions have been reported in up to half of patients, with the most frequent findings being gastritis and erosive duodenitis.As is the case in IBD, systemic corticosteroids and immunosuppressive treatment(anti-TNF agents) are the approaches used in patients with a more unfavorable progression. Immunotherapy must be suspended completely in some cases. 展开更多
关键词 ENTEROCOLITIS IPILIMUMAB IMMUNOTHERAPY immune-related ADVERSE event Nivolumab toxicity ENDOSCOPY
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Autologous scalp skin grafting to treat toxic epidermal necrolysis in a patient with a large skin injury:A case report
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作者 Dong-Dong Xue Ling Zhou +1 位作者 Yong Yang Si-Yuan Ma 《World Journal of Clinical Cases》 SCIE 2021年第7期1646-1653,共8页
BACKGROUND Toxic epidermal necrolysis(TEN)is often associated with skin wounds affecting large areas.Healing of this type of wound is difficult because of pressure,infection and other factors.It can increase the lengt... BACKGROUND Toxic epidermal necrolysis(TEN)is often associated with skin wounds affecting large areas.Healing of this type of wound is difficult because of pressure,infection and other factors.It can increase the length of hospital stay and result in wound sepsis and even death.CASE SUMMARY A 49-year-old woman developed a skin lesion covering 80%of the total body surface area after using a kind of Chinese medicinal ointment on a burn wound on her back;she developed life-threatening wound sepsis and septic shock.Methicillin-resistant Staphylococcus aureus,carbapenem-resistant Acinetobacter baumannii,carbapenem-resistant Pseudomonas aeruginosa and other bacteria were cultured from wound tissue,deep venous catheter and blood samples.Imipenem cilastatin sodium,tigecycline and teicoplanin were used for anti-infection therapy.Finally,the patient was transferred to the burn department because of severe wound sepsis.In the burn intensive care unit,pain-free dressing changes and autologous scalp skin grafting were performed to heal the wound in addition to reasonable and effective antibacterial treatment according to microbial susceptibility test results.After three operations within 2 wk,the wound healed and sepsis resolved.CONCLUSION TEN patients with large areas of skin injury may develop wound infection and life-threatening wound sepsis.Autologous scalp skin grafting may be beneficial for rapid wound healing and reducing the risk of sepsis in TEN patients,and it leaves no scar at the donor site. 展开更多
关键词 toxic epidermal necrolysis Wound sepsis Autologous skin grafting SCALP BURN Case report
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Management of skin toxicities during panitumumab treatment in metastatic colorectal cancer
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作者 Olivier Bouche Meher Ben Abdelghani +4 位作者 Jean-Luc Labourey Simon Triby René-Jean Bensadoun Thomas Jouary Gaétan Des Guetz 《World Journal of Gastroenterology》 SCIE CAS 2019年第29期4007-4018,共12页
BACKGROUND Anti-epidermal growth factor receptor therapy is associated with skin adverse events not previously reported with conventional chemotherapy. Prophylactic actions are recommended, but routine clinical manage... BACKGROUND Anti-epidermal growth factor receptor therapy is associated with skin adverse events not previously reported with conventional chemotherapy. Prophylactic actions are recommended, but routine clinical management of these toxicities and their impact on quality of life remain unknown. AIM To assess the dermatological toxicities reported after panitumumab initiation, their impact on the quality of life and the clinical practices for their management. METHODS Patients included in this prospective multicenter observational study were over 18 years of age and began treatment with panitumumab for wild-type KRAS metastatic colorectal cancer. The incidence of dermatological toxicities, clinical practices for their management and impact on quality of life were recorded during a 6-mo follow-up. RESULTS Overall, 229 patients (males, 57.6%;mean age, 66.2 years) were included. At day 15, 59.3% of patients had dermatological toxicity;the rate peaked at month 2 (74.7%) and decreased at month 6 (46.5%). The most frequent dermatological toxicities were rash/acneiform rash, xerosis and skin cracks. At least one preventive treatment was administered to 65.9% of patients (oral antibiotics, 84.1%;emollients, 75.5%;both, 62.9%). The rates of patients who received at least one curative treatment peaked at month 2 (63.4%) and decreased at month 6 (44.8%). The impact of the dermatological toxicities on quality of life was limited as assessed with Dermatology Life Quality Index scores and inconvenience visual analogic scale score. The rates of topical corticosteroids administration and visits to specialists were low. CONCLUSION The rates of the different skin toxicities peaked at various times and were improved at the end of follow-up. Nevertheless, their clinical management could be optimized with a better adherence to current recommendations. The impact of skin toxicities on patient’s quality of life appeared to be limited. 展开更多
关键词 Metastatic colorectal cancer Epidermal growth factor receptor inhibitors PANITUMUMAB skin toxicity Quality of life
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Acute Toxic Effects of Mercuric Chloride on the Mucocytes of the Epithelial Lining of the Accessory Respiratory Organ and Skin of the Air Breathing Catfish Heteropneustes fossilis(Bloch)^1
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作者 M.T.RAJAN T.K.BANERJEE 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1992年第4期325-335,共11页
Acute toxicity of 0.3 ppm mercuric chloride on the mucocytes of the branchial diverticulum and skin of Heteropneustes fossilis results in cyclic increases followed by decreases in the density, area occupancy and volum... Acute toxicity of 0.3 ppm mercuric chloride on the mucocytes of the branchial diverticulum and skin of Heteropneustes fossilis results in cyclic increases followed by decreases in the density, area occupancy and volume at different intervals of exposure. The alterations in the two tissues do not follow the same path perhaps due to different modes of action of the mercury salt: The skin comes under direct contact effects, while the branchial diverticulum may be affected by hormonal imbalance caused by a stress effect. 展开更多
关键词 Acute toxic Effects of Mercuric Chloride on the Mucocytes of the Epithelial Lining of the Accessory Respiratory Organ and skin of the Air Breathing Catfish Heteropneustes fossilis BLOCH
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中药跌打膏质量标准提升与安全性研究
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作者 韩杰 金万清 +2 位作者 任国武 谢小中 徐志为 《辽宁中医药大学学报》 CAS 2024年第2期12-18,共7页
目的 建立中药跌打膏质量控制方法,验证中药跌打膏安全性,为临床提供参考。方法 根据配方组成,采用薄层色谱法(TLC)对方中川乌、草乌、大黄、续断、泽兰进行定性鉴别,采用高效液相色谱法(HPLC)定量测定中药跌打膏中大黄素,以用于对中药... 目的 建立中药跌打膏质量控制方法,验证中药跌打膏安全性,为临床提供参考。方法 根据配方组成,采用薄层色谱法(TLC)对方中川乌、草乌、大黄、续断、泽兰进行定性鉴别,采用高效液相色谱法(HPLC)定量测定中药跌打膏中大黄素,以用于对中药跌打膏的质量控制;此外,通过皮肤急性毒性实验、皮肤刺激性实验、皮肤过敏性实验以及豚鼠皮肤组织病理学检查对中药跌打膏的安全性进行评价。结果 该实验中川乌、草乌、大黄、续断、泽兰定性鉴别方法操作简便,分离度好,专属性强。大黄素平均加样回收率为84.917 3%,RSD为1.466 1%。大黄素含量范围为1.099 9%~1.123 8%;精密度、稳定性、重复性试验的RSD分别为0.229 4%、1.835 9%、1.025 0%,均小于3.00%(n=6);安全性实验中,中药跌打膏对小鼠皮肤无刺激性,对小鼠体质量、肝肾功能无影响。一次给药后,14 d观察期间各组小鼠行为活动、精神状态、饮食情况及排便均未出现异常;给药14 d后,取小鼠血液进行血常规检查,后对小鼠进行解剖取血,血常规各项指标及肝肾功能无异常,各脏器未出现肉眼可见病理变化;中药跌打膏干预后的豚鼠皮肤病理检查均未见组织病理学改变。中药跌打膏对豚鼠皮肤无刺激性,中药跌打膏对豚鼠皮肤无明显致敏。结论该实验建立的中药跌打膏中川乌、草乌、大黄、续断、泽兰的TLC鉴别方法和大黄素含量测定方法有良好的精密度、稳定性和重复性,可用于中药跌打膏的质量控制。中药跌打膏对小鼠局部皮肤无毒性,对豚鼠皮肤无刺激性,对豚鼠皮肤无致敏性,说明中药跌打膏外用治疗疾病安全可靠。 展开更多
关键词 中药跌打膏 质量标准 大黄素 皮肤急性毒性 皮肤刺激性 皮肤过敏性
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肿瘤免疫检查点抑制剂相关皮肤毒性管理的证据总结
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作者 杨智慧 罗园园 +5 位作者 卢睿琦 刘欣琪 柳涵钰 张丰翼 黄琛 张立力 《护理学杂志》 CSCD 北大核心 2024年第20期46-50,共5页
目的评价并总结免疫检查点抑制剂相关皮肤毒性管理的相关证据,为医护人员对肿瘤免疫检查点抑制剂相关皮肤毒性患者进行管理提供依据。方法系统检索国内外相关网站和数据库,查询关于肿瘤免疫检查点抑制剂相关皮肤毒性管理方面的指南、专... 目的评价并总结免疫检查点抑制剂相关皮肤毒性管理的相关证据,为医护人员对肿瘤免疫检查点抑制剂相关皮肤毒性患者进行管理提供依据。方法系统检索国内外相关网站和数据库,查询关于肿瘤免疫检查点抑制剂相关皮肤毒性管理方面的指南、专家共识、证据总结、系统评价等证据。检索时间为建库至2024年4月30日,由2名具有循证护理知识的研究人员独立对文献进行质量评价和证据级别评定。结果共纳入19篇文献,包括指南7篇、专家共识10篇、系统评价1篇、临床决策1篇,从预防、评估、检查、治疗与护理、监测5个方面形成19条最佳证据。结论有效管理免疫检查点抑制剂相关皮肤毒性可改善皮肤症状,提高患者的生活质量。医护人员需考虑患者的意见,结合临床情境,为肿瘤免疫检查点抑制剂相关皮肤毒性患者提供个性化的指导。 展开更多
关键词 肿瘤 免疫治疗 免疫检查点抑制剂 皮肤毒性 药物不良反应 循证护理 皮肤护理
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黑老虎叶提取物纯化及其在化妆品原料中的应用研究
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作者 陆英 罗静玲 +1 位作者 王欣 祝加玉 《中国野生植物资源》 CSCD 2024年第10期42-48,85,共8页
目的:探讨黑老虎叶提取物在化妆品原料开发中的潜在应用。方法:以黄酮含量为评价标准,构建了大孔吸附树脂对黑老虎叶提取物的纯化流程,并结合动物实验、细胞实验及化学实验,开展提取物的急性毒性及其功能特性研究。结果:AB-8大孔吸附树... 目的:探讨黑老虎叶提取物在化妆品原料开发中的潜在应用。方法:以黄酮含量为评价标准,构建了大孔吸附树脂对黑老虎叶提取物的纯化流程,并结合动物实验、细胞实验及化学实验,开展提取物的急性毒性及其功能特性研究。结果:AB-8大孔吸附树脂对黑老虎叶黄酮具有良好的吸附和解吸性能;上样条件为:总黄酮浓度1.0 mg/mL的料液调节pH 3,以3 BV/h流速上样5 BV;洗脱条件为:用80%乙醇以3 BV/h流速洗脱5 BV;动物实验表明,提取物无急性毒性;细胞实验显示,在2.5~50.0μg/mL浓度范围内,提取物能显著减少H_(2)O_(2)引起的人皮肤成纤维细胞死亡,有效降低细胞中ROS、MDA水平,增强SOD、CAT活性;在0.1~2.0 mg/mL浓度范围内,提取物能显著降低小鼠B16F10细胞中TYR活性;提取物抑制HAase的IC_(50)为4.748μg/mL。结论:利用AB-8大孔吸附树脂纯化的黑老虎叶提取物没有表现出急性毒性,同时展现了抗衰老、美白、抗过敏等功效,在作为化妆品原料应用上具有一定开发潜力。 展开更多
关键词 黑老虎叶提取物 化妆品原料 急性毒性 美白 抗衰老 抗过敏
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从“浊毒泛肤”角度探讨慢性肾脏病相关瘙痒症
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作者 王婧 张勉之 《实用中医内科杂志》 2024年第9期57-60,共4页
尿毒症性瘙痒或慢性肾脏病相关瘙痒症(chronic kidney disease-associated pruritus,CKD-aP)是晚期或终末期肾病患者的最易被忽视和低估的症状,会大大降低患者的生活质量。CKD-aP的发病机制仍不明确。激素、组胺、阿片受体紊乱和微炎症... 尿毒症性瘙痒或慢性肾脏病相关瘙痒症(chronic kidney disease-associated pruritus,CKD-aP)是晚期或终末期肾病患者的最易被忽视和低估的症状,会大大降低患者的生活质量。CKD-aP的发病机制仍不明确。激素、组胺、阿片受体紊乱和微炎症是发病的可能原因。CKD-aP核心病机为脏腑虚损,浊毒内生,泛肤发痒,其中脏腑虚损内生浊毒为致病之本,湿瘀阻络浊毒泛肤为致病之标,病理性质当属本虚标实之证。治疗时当扶正补虚,排浊解毒,使气血盈而脏气充,浊毒去而肤润泽。 展开更多
关键词 慢性肾脏病 皮肤瘙痒 浊毒泛肤 病因病机
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Comparative Study of the Biological Activities of the Skin Secretions from Six Common Chinese Amphibians 被引量:28
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作者 赖仞 赵宇 +3 位作者 杨东明 查宏光 李文辉 张云 《Zoological Research》 CAS CSCD 北大核心 2002年第2期113-119,共7页
Water soluble skin secretions of six common Chinese amphibians were studied for their biological and enzymatic activities.The skin secretions of Tylototriton verrucosus,Bombina maxima ,and Bufo andrewsi were f... Water soluble skin secretions of six common Chinese amphibians were studied for their biological and enzymatic activities.The skin secretions of Tylototriton verrucosus,Bombina maxima ,and Bufo andrewsi were found toxic to mice with the intraperitoneal LD 50 of 11 5?mg/kg,18 8?mg/kg,and 264?mg/kg,respectively.No acute lethal toxicities were observed for the skin secretions of Rana nigromaculata,Rana guentheri and Rana limnocharis in a dose up to 500?mg/kg.The lethal toxicities of the skin secretions of T verrucosus and B maxima to mice are in the same grade as those of Viperidae snake venoms.The toxic components in T verrucosus and B maxima skin secretions are the proteins with molecular weights ranging from 3 to 60?kDa.All the skin secretions had both proteolytic activity and trypsin inhibitory activity.The skin secretions from T verrucosus , B maxima and B andrewsi also displayed wide spectrum antimicrobial activity.On the other hand,the skin secretions from B andrewsi and B maxima showed cytotoxicity on human cancer cells.All the six samples had not significant effects on mammalian blood coagulation system.Phospholipase A 2 activity was only found in the skin secretions of T verrucosus .None of these skin secretions showed acetylcholine esterase activity. 展开更多
关键词 AMPHIBIAN toxicity ANTIMICROBIAL skin secretions Biological activity
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一例老年中毒性表皮坏死松解症合并消化道穿孔患者的护理
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作者 石琳 李兵发 +3 位作者 黄思婷 李君 韩辉武 孙絮财 《护士进修杂志》 2024年第5期548-551,共4页
总结2022年9月我院收治的1例老年中毒性表皮坏死松解症(TEN)合并消化道穿孔患者的护理经验。护理要点:早期识别消化道穿孔,及早进行急诊手术;在全面皮损评估的基础上,分别从预防表皮分离、创面处理及黏膜护理3个方面制定有效的创面护理... 总结2022年9月我院收治的1例老年中毒性表皮坏死松解症(TEN)合并消化道穿孔患者的护理经验。护理要点:早期识别消化道穿孔,及早进行急诊手术;在全面皮损评估的基础上,分别从预防表皮分离、创面处理及黏膜护理3个方面制定有效的创面护理方案;适时采取多种疼痛干预措施;多学科协作为患者制定个性化的营养支持方案;做好体液管理和用药护理。经过12d的精心治疗和护理,患者病情好转出院。出院1周后随访,患者皮损完全愈合,术后恢复良好。 展开更多
关键词 中毒性表皮坏死松解症 消化道穿孔 皮损护理 营养支持 老年人
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葡萄果皮提取物对砷致小鼠小肠毒性的缓解作用
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作者 赵丹瑜 仪慧兰 《食品工业科技》 CAS 北大核心 2024年第4期305-312,共8页
目的:探究砷摄入对小肠的毒性及葡萄果皮提取物(grape skin extract,GSE)的干预效应。方法:模拟人类饮水砷暴露,小鼠饮用浓度10 mg/L的砷溶液56 d,建立小鼠砷中毒模型,并用不同浓度GSE隔天灌胃干预(150 mg/kg bw和300 mg/kg bw);取小鼠... 目的:探究砷摄入对小肠的毒性及葡萄果皮提取物(grape skin extract,GSE)的干预效应。方法:模拟人类饮水砷暴露,小鼠饮用浓度10 mg/L的砷溶液56 d,建立小鼠砷中毒模型,并用不同浓度GSE隔天灌胃干预(150 mg/kg bw和300 mg/kg bw);取小鼠小肠组织,显微镜观察组织形态结构;试剂盒法检测还原型谷胱甘肽(glutathione,GSH)、丙二醛(malondialdehyde,MDA)和H_(2)O_(2)含量,及总超氧化物歧化酶(total superoxide dismutase,T-SOD)活性;qRT-PCR检测紧密连接基因和炎症通路IL-6/JAK2/STAT-3基因表达水平。结果:砷染毒后,小鼠小肠绒毛变短、排列紊乱,黏膜固有层及黏膜下层大量炎细胞浸润;小肠组织的GSH含量和TSOD活性分别降低17.1%和25.2%,MDA和H_(2)O_(2)含量分别增加68.8%和54.3%(P<0.05);细胞紧密连接基因ZO-1、ZO-2、occludin、claudin-1和claudin-7显著下调表达(P<0.05);炎症通路IL-6/JAK2/STAT-3基因转录水平显著增高(P<0.05)。GSE高浓度干预组(300 mg/kg bw),小肠黏膜损伤减轻,肠绒毛趋于正常,炎症浸润减轻;与砷染毒组比较,GSH含量增加17.9%、T-SOD活性升高14.3%、MDA和H_(2)O_(2)含量分别减少33.8%和25.4%(P<0.05);紧密连接基因显著上调表达(P<0.05);炎症通路IL-6/JAK2/STAT-3基因转录显著降低(P<0.05)。GSE低浓度干预(150 mg/kg bw)对砷毒性有一定的缓解作用,但差异不显著,无统计学意义(P>0.05)。结论:GSE通过抑制砷暴露诱导的小肠组织氧化应激、炎症反应及功能基因转录下调,缓解砷的小肠毒性,对机体具有保护作用。 展开更多
关键词 砷摄入 小肠毒性 葡萄果皮提取物 氧化应激 炎症反应
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养肤润肠汤治疗EGFRI相关皮肤毒性反应的疗效及对美观性的影响
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作者 孟雅楠 蒋玥 +2 位作者 李金红 胡志伟 段腾 《中国美容医学》 CAS 2024年第1期78-81,共4页
目的:探讨养肤润肠汤治疗表皮生长因子受体酪氨酸激酶抑制剂(Epidermal growth factor receptor tyrosine kinase inhibitor,EGFRI)相关皮肤毒性反应的疗效及对美观性的影响。方法:纳入2016年11月-2019年11月笔者医院收治的EGFRI相关皮... 目的:探讨养肤润肠汤治疗表皮生长因子受体酪氨酸激酶抑制剂(Epidermal growth factor receptor tyrosine kinase inhibitor,EGFRI)相关皮肤毒性反应的疗效及对美观性的影响。方法:纳入2016年11月-2019年11月笔者医院收治的EGFRI相关皮肤毒性反应患者90例,以随机数字法分为对照组与观察组各45例,对照组使用莫匹罗星软膏涂抹患处(每日3次),观察组在对照组基础上加用养肤润肠汤(每日1付,分早晚2次服用),均连续治疗14 d。比较两组的临床疗效、中医证候评分、皮肤生理指标(油脂含量、皮肤含水量)、安全性及皮肤美观性评分。结果:治疗后,观察组总有效率(93.33%vs 77.78%)明显高于对照组(P<0.05);观察组皮疹、瘙痒、痤疮、干燥中医证候积分均明显低于对照组(P<0.05);治疗后两组的皮肤含水量均较治疗前较升高,且观察组明显高于对照组(P<0.05),两组油脂含量比较差异无统计学意义(P>0.05);观察组皮肤美观性评分明显高于对照组(P<0.05)。两组均无明显肝肾功能异常及不良反应发生。结论:养肤润肠汤能明显提高EGFRI相关皮肤毒性反应的临床治疗效果,改善皮肤生理功能及皮肤美观性,安全性好。 展开更多
关键词 表皮生长因子受体酪氨酸激酶抑制剂 皮肤毒性反应 养肤润肠汤 临床疗效 美观性
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