We aimed to investigate the differences in renal histopathological changes and laboratory parameters between adult and pediatric patients with Henoch-Sch？nlein purpura nephritis（HSPN）, and to analyze the correlatio...We aimed to investigate the differences in renal histopathological changes and laboratory parameters between adult and pediatric patients with Henoch-Sch？nlein purpura nephritis（HSPN）, and to analyze the correlation between laboratory parameters and renal histopathological grading. A total of 139 patients diagnosed with HSPN between September 2010 and December 2014 at the First Hospital of Jilin University, China, were retrospectively reviewed. The clinical and pathological characteristics were examined and compared between the adult and the pediatric patients. A majority of adult（75.0%） and pediatric（66.2%） patients were categorized as pathological grade Ⅲ HSPN. Adults having crescent lesions, interstitial fibrosis and renal artery involvement significantly outnumbered child counterparts（all P〈0.05）. Pathological grading showed a positive correlation with 24-h urine protein（r=0.307, P=0.009）, microalbuminuria（r=0.266, P=0.000） and serum globulin（r=0.307, P=0.014）, and a negative correlation with serum albumin（r=0.249, P=0.037） in pediatric patients with HSPN. Among adult patients with HSPN, histopathological grading showed a positive correlation with 24-h urine protein（r=0.294, P=0.015）, microalbuminuria（r=0.352, P=0.006）, α1-microglobulin（r=0.311, P=0.019） and immunoglobulin G（r=0.301, P=0.023） in urine, and serum creatinine（r=0.292, P=0.018）. Further, a negative correlation between serum albumin and pathological grading was also observed（r=0.291, P=0.018）. In conclusion, the severity of renal pathological lesions in HSPN patients is well reflected by the levels of proteinuria. Adult patients have more severe renal histopathological changes than pediatric patients.展开更多
AIM: To compare the prevalence of Helicobacter pylori(Hpylori) infection in autoimmune thrombocytopenic purpura (AITP) patients with that of nonthrombocytopenic controls,and to evaluate the efficacy of the treatment i...AIM: To compare the prevalence of Helicobacter pylori(Hpylori) infection in autoimmune thrombocytopenic purpura (AITP) patients with that of nonthrombocytopenic controls,and to evaluate the efficacy of the treatment in Hpylori(+)and Hpylori(-) AITP patients.METHODS: The prevalence of gastric Hpyloriinfection in 38 adult AITP patients (29 female and 9 male; median age 27 years; range 18-39 years) who consecutively admitted to our clinic was investagated.RESULTS: Hpyloriinfection was found in 26 of 38 AITP patients (68.5%). Hpyloriinfection was found in 15 of 23 control subjects (65.2%). The difference in Hpyloriinfection between the 2 groups was not significant. Thrombocyte count of Hpylori-positive AITP patients was significantly lower than that of Hpylori-negative AITP patients (P＜0.05).Thrombocyte recovery of Hpylori-positive group was less than that of Hpylori-negative group (P＜0.05).CONCLUSION: Hpyloriinfection should be considerecd in the treatment of AITP patients with Hpyloriinfection.展开更多
免疫球蛋白A血管炎(immunoglobulin A vasculitis,IgAV),也称过敏性紫癜,病因及发病机制较为复杂,目前尚未完全阐明。最新研究表明,新型冠状病毒及相关疫苗、人乳头瘤疫苗及其他生物制剂等也可以诱发IgAV。大多研究认为,半乳糖缺陷型IgA...免疫球蛋白A血管炎(immunoglobulin A vasculitis,IgAV),也称过敏性紫癜,病因及发病机制较为复杂,目前尚未完全阐明。最新研究表明,新型冠状病毒及相关疫苗、人乳头瘤疫苗及其他生物制剂等也可以诱发IgAV。大多研究认为,半乳糖缺陷型IgA1(galactose-deficient IgA1,Gd-IgA1)及含Gd-IgA1的免疫复合物形成在IgAV发病机制中起至关重要的作用。也有假设提出IgAV的发生与IgA1和抗内皮细胞抗体的结合有关。此外,遗传学也是IgAV研究的重点。该文综述IgAV病因的新进展,并总结Gd-IgA1、含Gd-IgA1的免疫复合物、抗内皮细胞抗体和IgA1的结合物、T细胞免疫及遗传因素在IgAV发病机制中的作用。展开更多
文摘We aimed to investigate the differences in renal histopathological changes and laboratory parameters between adult and pediatric patients with Henoch-Sch？nlein purpura nephritis（HSPN）, and to analyze the correlation between laboratory parameters and renal histopathological grading. A total of 139 patients diagnosed with HSPN between September 2010 and December 2014 at the First Hospital of Jilin University, China, were retrospectively reviewed. The clinical and pathological characteristics were examined and compared between the adult and the pediatric patients. A majority of adult（75.0%） and pediatric（66.2%） patients were categorized as pathological grade Ⅲ HSPN. Adults having crescent lesions, interstitial fibrosis and renal artery involvement significantly outnumbered child counterparts（all P〈0.05）. Pathological grading showed a positive correlation with 24-h urine protein（r=0.307, P=0.009）, microalbuminuria（r=0.266, P=0.000） and serum globulin（r=0.307, P=0.014）, and a negative correlation with serum albumin（r=0.249, P=0.037） in pediatric patients with HSPN. Among adult patients with HSPN, histopathological grading showed a positive correlation with 24-h urine protein（r=0.294, P=0.015）, microalbuminuria（r=0.352, P=0.006）, α1-microglobulin（r=0.311, P=0.019） and immunoglobulin G（r=0.301, P=0.023） in urine, and serum creatinine（r=0.292, P=0.018）. Further, a negative correlation between serum albumin and pathological grading was also observed（r=0.291, P=0.018）. In conclusion, the severity of renal pathological lesions in HSPN patients is well reflected by the levels of proteinuria. Adult patients have more severe renal histopathological changes than pediatric patients.
文摘AIM: To compare the prevalence of Helicobacter pylori(Hpylori) infection in autoimmune thrombocytopenic purpura (AITP) patients with that of nonthrombocytopenic controls,and to evaluate the efficacy of the treatment in Hpylori(+)and Hpylori(-) AITP patients.METHODS: The prevalence of gastric Hpyloriinfection in 38 adult AITP patients (29 female and 9 male; median age 27 years; range 18-39 years) who consecutively admitted to our clinic was investagated.RESULTS: Hpyloriinfection was found in 26 of 38 AITP patients (68.5%). Hpyloriinfection was found in 15 of 23 control subjects (65.2%). The difference in Hpyloriinfection between the 2 groups was not significant. Thrombocyte count of Hpylori-positive AITP patients was significantly lower than that of Hpylori-negative AITP patients (P＜0.05).Thrombocyte recovery of Hpylori-positive group was less than that of Hpylori-negative group (P＜0.05).CONCLUSION: Hpyloriinfection should be considerecd in the treatment of AITP patients with Hpyloriinfection.
文摘免疫球蛋白A血管炎(immunoglobulin A vasculitis,IgAV),也称过敏性紫癜,病因及发病机制较为复杂,目前尚未完全阐明。最新研究表明,新型冠状病毒及相关疫苗、人乳头瘤疫苗及其他生物制剂等也可以诱发IgAV。大多研究认为,半乳糖缺陷型IgA1(galactose-deficient IgA1,Gd-IgA1)及含Gd-IgA1的免疫复合物形成在IgAV发病机制中起至关重要的作用。也有假设提出IgAV的发生与IgA1和抗内皮细胞抗体的结合有关。此外,遗传学也是IgAV研究的重点。该文综述IgAV病因的新进展,并总结Gd-IgA1、含Gd-IgA1的免疫复合物、抗内皮细胞抗体和IgA1的结合物、T细胞免疫及遗传因素在IgAV发病机制中的作用。
