Micro fabricated and multilayered perforated cantilever beam immunosensor was modeled using CoventorWare for the estimation of bacterial antigens of Bacillus Anthrax, Pseudomonas aeruginosa, Coryne Bacterium Diptheria...Micro fabricated and multilayered perforated cantilever beam immunosensor was modeled using CoventorWare for the estimation of bacterial antigens of Bacillus Anthrax, Pseudomonas aeruginosa, Coryne Bacterium Diptheria and Treponema pallidum. A rectangular cantilever beam with perforations was simulated with dimensions as length-200 μm, width-10 μm and thickness-0.5 μm. Each perforation is rectangular with length-10 μm, width-5 μm and thickness-0.5 μm. The theoretical and FEM simulations were carried out with five immunoglobulin antibodies, IgA, IgD, IgE, IgG and IgM for the estimation of bacterial antigens. The effect of perforation in cantilever beam and molecular size of antibody and antigen on the performance of the sensor has been studied. The cantilever beam without perforation showed a deflection of 1.8 e + 02 μm whereas the cantilever beam with perforation showed an increase deflection of 1.9 e + 02 μm. With IgG, the difference between analytical and simulation values is positive and low especially with low molecular weight antigens Pseudomonas aeruginosa and Treponema pallidum. The low molecular weight IgG influences the antigen-antibody interaction more fvourably. The simulated perforated rectangular cantilever beam with IgG antibody is a more promising model for the fabrication of a sensor for the estimation of highly motile Pseudomonas aeruginosa and Treponema pallidum.展开更多
INTRODUCTIONHepatitis B virus (HBV) is the most commonetiologic agent for infectious liver diseases. It isestimated that there are more than 250 millionchronic HBV carriersin the world today and thereis a significant ...INTRODUCTIONHepatitis B virus (HBV) is the most commonetiologic agent for infectious liver diseases. It isestimated that there are more than 250 millionchronic HBV carriersin the world today and thereis a significant association among persistentinfection, liver cirrhosis and hepatocellularcarcinoma[1-3].展开更多
A contrast study on the effects of manual acupuncture and electroacupuncture wasconducted in 60 cases of chronic hepatitis B carriers.The results demonstrated that theimmunological functions,both cellular and humoral,...A contrast study on the effects of manual acupuncture and electroacupuncture wasconducted in 60 cases of chronic hepatitis B carriers.The results demonstrated that theimmunological functions,both cellular and humoral,were markedly regulated asevidenced by the negative turnover rates of HBsAg,HBeAg,anti-HBc and HBcAg,as wellas the positive turnover rate of anti-HBe.展开更多
文摘Micro fabricated and multilayered perforated cantilever beam immunosensor was modeled using CoventorWare for the estimation of bacterial antigens of Bacillus Anthrax, Pseudomonas aeruginosa, Coryne Bacterium Diptheria and Treponema pallidum. A rectangular cantilever beam with perforations was simulated with dimensions as length-200 μm, width-10 μm and thickness-0.5 μm. Each perforation is rectangular with length-10 μm, width-5 μm and thickness-0.5 μm. The theoretical and FEM simulations were carried out with five immunoglobulin antibodies, IgA, IgD, IgE, IgG and IgM for the estimation of bacterial antigens. The effect of perforation in cantilever beam and molecular size of antibody and antigen on the performance of the sensor has been studied. The cantilever beam without perforation showed a deflection of 1.8 e + 02 μm whereas the cantilever beam with perforation showed an increase deflection of 1.9 e + 02 μm. With IgG, the difference between analytical and simulation values is positive and low especially with low molecular weight antigens Pseudomonas aeruginosa and Treponema pallidum. The low molecular weight IgG influences the antigen-antibody interaction more fvourably. The simulated perforated rectangular cantilever beam with IgG antibody is a more promising model for the fabrication of a sensor for the estimation of highly motile Pseudomonas aeruginosa and Treponema pallidum.
基金Project supported by the grant from Science Foundation of Ministry of Health of China, No. 96-1-347.
文摘INTRODUCTIONHepatitis B virus (HBV) is the most commonetiologic agent for infectious liver diseases. It isestimated that there are more than 250 millionchronic HBV carriersin the world today and thereis a significant association among persistentinfection, liver cirrhosis and hepatocellularcarcinoma[1-3].
文摘A contrast study on the effects of manual acupuncture and electroacupuncture wasconducted in 60 cases of chronic hepatitis B carriers.The results demonstrated that theimmunological functions,both cellular and humoral,were markedly regulated asevidenced by the negative turnover rates of HBsAg,HBeAg,anti-HBc and HBcAg,as wellas the positive turnover rate of anti-HBe.
