目的:研究肿瘤患者血清IAP和T淋巴细胞等免疫指标与抑郁之间的关系.方法:对65例晚期肿瘤患者采用ZUNG量表进行抑郁调查,同时检测血清IAP、T淋巴细胞亚群和NK细胞数量,分析肿瘤患者抑郁与免疫功能之间的关系.结果:免疫功能与肿瘤部位、...目的:研究肿瘤患者血清IAP和T淋巴细胞等免疫指标与抑郁之间的关系.方法:对65例晚期肿瘤患者采用ZUNG量表进行抑郁调查,同时检测血清IAP、T淋巴细胞亚群和NK细胞数量,分析肿瘤患者抑郁与免疫功能之间的关系.结果:免疫功能与肿瘤部位、病情进展情况、性别之间无显著相关性,而抑郁与免疫功能检测指标之间呈显著相关:抑郁组肿瘤患者血清IAP和CD8高于非抑郁组(IAP:696.76±331.78 vs 499.03±233.74.P<0.01;CD8:36.65±14.20 vs 30.02±9.78,P<0.05),而NK和CD4低于非抑郁组(NK:17.03±11.36 vs 23.63±13.24.P<0.05;CD4:35.59±13.10 vs 41.41±8.14),CD3、CD4/CD8两组间比较无统计学差异:IAP与CD4和CD4/CD8呈负相关,与CD8呈正相关,与NK和CD3间无显著相关性.展开更多
AIM:To investigate the serovirological prevalence and clinical features of hepatitis E virus(HEV) infection in end-stage renal failure patients and in the healthy population.METHODS:HEV infection is a viral disease th...AIM:To investigate the serovirological prevalence and clinical features of hepatitis E virus(HEV) infection in end-stage renal failure patients and in the healthy population.METHODS:HEV infection is a viral disease that can cause sporadic and epidemic hepatitis.Previous studies unexpectedly showed a high prevalence of HEV antibodies in immunosuppressed subjects,including hemodialysis(HD)patients and patients who had undergone kidney transplant.A cohort/case-control study was carried out from January 2012 to August 2013 in two hospitals in southern Italy(Foggia and S.Giovanni Rotondo,Apulia).The seroprevalence of HEV was determined in 801 subjects;231 HD patients,120 renal transplant recipients,and450 health individuals.All HD patients and the recipients of renal transplants were attending the Departments of Nephrology and Dialysis at two hospitals located in Southern Italy,and were included progressively in this study.Serum samples were tested for HEV antibodies(Ig G/Ig M);in the case of positivity they were confirmed by a Western blot assay and were also tested for HEV-RNA,and the HEV genotypes were determined.RESULTS:A total of 30/801(3.7%)patients were positive for anti-HEV Ig(Ig G and/or Ig M)and by Western blot.The healthy population presented with a prevalence of 2.7%,HD patients had a prevalence of 6.0%,and transplant recipients had a prevalence of 3.3%.The overall combined HEV-positive prevalence in the two groups with chronic renal failure was 5.1%.The rates of exposure to HEV(positivity of HEV-Ig G/M in the early samples)were lower in the healthy controls,but the difference among the three groups was not statistically significant(P>0.05).Positivity for anti-HEV/Ig M was detected in 4/30(13.33%)anti-HEV Ig positive individuals,in 2/14 HD patients,in1/4 transplant individuals,and in 1/12 of the healthy population.The relative risk of being HEV-Ig M-positive was significantly higher among transplant recipients compared to the other two groups(OR=65.4,95%CI:7.2-592.7,P<0.001),but the subjects with HEV-Ig M positivity were numerically too few to calculate a significant difference.No patient presented with chronic hepatitis from HEV infection alone.CONCLUSION:This study indicated a higher,but not significant,circulation of HEV in hemodialysis patients vs the healthy population.Chronic hepatitis due to the HEV virus was not observed.展开更多
文摘目的:研究肿瘤患者血清IAP和T淋巴细胞等免疫指标与抑郁之间的关系.方法:对65例晚期肿瘤患者采用ZUNG量表进行抑郁调查,同时检测血清IAP、T淋巴细胞亚群和NK细胞数量,分析肿瘤患者抑郁与免疫功能之间的关系.结果:免疫功能与肿瘤部位、病情进展情况、性别之间无显著相关性,而抑郁与免疫功能检测指标之间呈显著相关:抑郁组肿瘤患者血清IAP和CD8高于非抑郁组(IAP:696.76±331.78 vs 499.03±233.74.P<0.01;CD8:36.65±14.20 vs 30.02±9.78,P<0.05),而NK和CD4低于非抑郁组(NK:17.03±11.36 vs 23.63±13.24.P<0.05;CD4:35.59±13.10 vs 41.41±8.14),CD3、CD4/CD8两组间比较无统计学差异:IAP与CD4和CD4/CD8呈负相关,与CD8呈正相关,与NK和CD3间无显著相关性.
文摘AIM:To investigate the serovirological prevalence and clinical features of hepatitis E virus(HEV) infection in end-stage renal failure patients and in the healthy population.METHODS:HEV infection is a viral disease that can cause sporadic and epidemic hepatitis.Previous studies unexpectedly showed a high prevalence of HEV antibodies in immunosuppressed subjects,including hemodialysis(HD)patients and patients who had undergone kidney transplant.A cohort/case-control study was carried out from January 2012 to August 2013 in two hospitals in southern Italy(Foggia and S.Giovanni Rotondo,Apulia).The seroprevalence of HEV was determined in 801 subjects;231 HD patients,120 renal transplant recipients,and450 health individuals.All HD patients and the recipients of renal transplants were attending the Departments of Nephrology and Dialysis at two hospitals located in Southern Italy,and were included progressively in this study.Serum samples were tested for HEV antibodies(Ig G/Ig M);in the case of positivity they were confirmed by a Western blot assay and were also tested for HEV-RNA,and the HEV genotypes were determined.RESULTS:A total of 30/801(3.7%)patients were positive for anti-HEV Ig(Ig G and/or Ig M)and by Western blot.The healthy population presented with a prevalence of 2.7%,HD patients had a prevalence of 6.0%,and transplant recipients had a prevalence of 3.3%.The overall combined HEV-positive prevalence in the two groups with chronic renal failure was 5.1%.The rates of exposure to HEV(positivity of HEV-Ig G/M in the early samples)were lower in the healthy controls,but the difference among the three groups was not statistically significant(P>0.05).Positivity for anti-HEV/Ig M was detected in 4/30(13.33%)anti-HEV Ig positive individuals,in 2/14 HD patients,in1/4 transplant individuals,and in 1/12 of the healthy population.The relative risk of being HEV-Ig M-positive was significantly higher among transplant recipients compared to the other two groups(OR=65.4,95%CI:7.2-592.7,P<0.001),but the subjects with HEV-Ig M positivity were numerically too few to calculate a significant difference.No patient presented with chronic hepatitis from HEV infection alone.CONCLUSION:This study indicated a higher,but not significant,circulation of HEV in hemodialysis patients vs the healthy population.Chronic hepatitis due to the HEV virus was not observed.
