Laser-accelerated high-flux-intensity heavy-ion beams are important for new types of accelerators.A particle-in-cell program(Smilei) is employed to simulate the entire process of Station of Extreme Light(SEL) 100 PW l...Laser-accelerated high-flux-intensity heavy-ion beams are important for new types of accelerators.A particle-in-cell program(Smilei) is employed to simulate the entire process of Station of Extreme Light(SEL) 100 PW laser-accelerated heavy particles using different nanoscale short targets with a thickness of 100 nm Cr, Fe, Ag, Ta, Au, Pb, Th and U, as well as 200 nm thick Al and Ca. An obvious stratification is observed in the simulation. The layering phenomenon is a hybrid acceleration mechanism reflecting target normal sheath acceleration and radiation pressure acceleration, and this phenomenon is understood from the simulated energy spectrum,ionization and spatial electric field distribution. According to the stratification, it is suggested that high-quality heavy-ion beams could be expected for fusion reactions to synthesize superheavy nuclei. Two plasma clusters in the stratification are observed simultaneously, which suggest new techniques for plasma experiments as well as thinner metal targets in the precision machining process.展开更多
For the discovery and analysis of Jebel Waqf as Suwwan (JWS) Impact Crater, Jordan pushed the authors to consequently focusing on other unusual geologic phenomena such as circular/oval structures (some of “crypto-vol...For the discovery and analysis of Jebel Waqf as Suwwan (JWS) Impact Crater, Jordan pushed the authors to consequently focusing on other unusual geologic phenomena such as circular/oval structures (some of “crypto-volcanic” origin), disharmonic folding, horizontal stylolites, and a broad stripe of?Sanidine-Hornfels-Facies, all of them hosted in Upper Cretaceous/Paleogene carbonate rocks exposed across Jordan and adjacent areas. Shatter cones are the most useful tools during field work in the realm of circular structures. In addition to the impact-geologic data of JWS Impact Structure hitherto available, the cooling process of melted Lower Cretaceous Kurnub-Sandstone could be verified by microscopically identified SiO2-modifications between the melting point (1714°C) and low temperatures. In comparison with the Suffield 500 tons explosion tests [20] and with the Ries Impact Crater, Germany, excavation and vaporization processes of target rocks demand drilling between Central Uplift and Inner Ring of the JWS Impact Structure (“Chert-Carbonate-Impact-Chess Game”). In a scenario: “Impacting meets Plate Tectonics”, phenomena like disharmonic folding, horizontal stylolites, and an abundance of circular/oval structures of high diameter variation through northwest Jordan are discussed under aspects of gravitational gliding, effects of seismic surface waves (Love-), transpressional structures related to Jordan Rift-Tectonics, and possible impact processes of unknown number occurred on the Arabian Plate in southeastern direction with northwest-directed impulse. The so-called “Mottled Zone” of Jordan and Palestine owning a high number (~100) of mineral neoformations with formation temperatures up to ~1120°C(pseudo-wollastonite = β-CaSiO3), is to be interpreted as of “Sanidine-Hornfels-Impact Facies” under ricochet conditions along an “Avenue of Ricochet-Impact-Thermo-Cataclysm”. Marble-related travertines represent a low temperature facies of the impact event. The temporal projection of patterns like Rapid Climate Change (RCC), astrophysical data [Hoyle’s Comet: 47], acid events in ice-cores, tektite fall, Rise and Fall of Neolithic/Bronze Age Cultures, reveals an amazing “Ensemble” of coincidences among all of these parameters since the Middle/Upper Pleistocene boundary throughout Holocene. Ten short Interval Cases are discussed as being “Rare Event”- suspicious. Myths like the “Gilgamesch Epos” and “John’s Apocalypse” surprisingly provide realistic hints on impact events comparable with modern observations and experiments, which are: approach of extraterrestrial bodies, impact cratering, earthquakes and faulting, supercyclonic whirl-storms (wildfires), effects of hot ejecta, destruction of fauna, flora, and cities, long-lasting flooding, darkness caused by ashes and dust circulating in atmosphere and stratosphere (sintwinter), and environmental pollution. Such hints were handed down in myths of ~180 ethnic peoples around the globe. “High probability Cases” focus on impact events on ~9600 yr B.P and on ~6000 yr B.P. Other “Rare Events” may have possibly occurred about ~8000 yr B.P. and on ~3200 yr. B.P. (all radiocarbon yr.cal.). Core-drilling in the pull-apart basins of the Jordan Rift System (Dead Sea, Lake Tiberias) as traps having possibly preserved volcanic and impact ejecta would be a challenging international and interdisciplinary project.展开更多
Despite the enormous interest in inorganic/polymer composite solid-state electrolytes(CSEs)for solid-state batteries(SSBs),the underlying ion transport phenomena in CSEs have not yet been elucidated.Here,we address th...Despite the enormous interest in inorganic/polymer composite solid-state electrolytes(CSEs)for solid-state batteries(SSBs),the underlying ion transport phenomena in CSEs have not yet been elucidated.Here,we address this issue by formulating a mechanistic understanding of bi-percolating ion channels formation and ion conduction across inorganic-polymer electrolyte interfaces in CSEs.A model CSE is composed of argyrodite-type Li_6PS_5Cl(LPSCl)and gel polymer electrolyte(GPE,including Li~+-glyme complex as an ion-conducting medium).The percolation threshold of the LPSCl phase in the CSE strongly depends on the elasticity of the GPE phase.Additionally,manipulating the solvation/desolvation behavior of the Li~+-glyme complex in the GPE facilitates ion conduction across the LPSCl-GPE interface.The resulting scalable CSE(area=8×6(cm×cm),thickness~40μm)can be assembled with a high-mass-loading LiNi_(0.7)Co_(0.15)Mn_(0.15)O_(2)cathode(areal-mass-loading=39 mg cm~(-2))and a graphite anode(negative(N)/positive(P)capacity ratio=1.1)in order to fabricate an SSB full cell with bi-cell configuration.Under this constrained cell condition,the SSB full cell exhibits high volumetric energy density(480 Wh L_(cell)~(-1))and stable cyclability at 25℃,far exceeding the values reported by previous CSE-based SSBs.展开更多
Lymph node targeting is a commonly used strategy for particulate vaccines,particularly for Pickering emulsions.However,extensive research on the internal delivery mechanisms of these emulsions,especially the complex i...Lymph node targeting is a commonly used strategy for particulate vaccines,particularly for Pickering emulsions.However,extensive research on the internal delivery mechanisms of these emulsions,especially the complex intercellular interactions of deformable Pickering emulsions,has been surprisingly sparse.This gap in knowledge holds significant potential for enhancing vaccine efficacy.This study aims to address this by summarizing the process of lymph-node-targeting transport and introducing a dissipative particle dynamics simulation method to evaluate the dynamic processes within cell tissue.The transport of Pickering emulsions in skeletal muscle tissue is specifically investigated as a case study.Various factors impacting the transport process are explored,including local cellular tissue environmental factors and the properties of the Pickering emulsion itself.The simulation results primarily demonstrate that an increase in radial repulsive interaction between emulsion particles can decrease the transport efficiency.Additionally,larger intercellular gaps also diminish the transport efficiency of emulsion droplet particles due to the increased motion complexity within the intricate transport space compared to a single channel.This study sheds light on the nuanced interplay between engineered and biological systems influencing the transport dynamics of Pickering emulsions.Such insights hold valuable potential for optimizing transport processes in practical biomedical applications such as drug delivery.Importantly,the desired transport efficiency varies depending on the specific application.For instance,while a more rapid transport might be crucial for lymph-node-targeted drug delivery,certain applications requiring a slower release of active components could benefit from the reduced transport efficiency observed with increased particle repulsion or larger intercellular gaps.展开更多
基金support from the Strategic Priority Research Program of the Chinese Academy of Sciences (No.XDB34030000)the National Key R & D Program of China (No.2022YFA1602404)+2 种基金National Natural Science Foundation of China (No. U1832129)the Youth Innovation Promotion Association of the Chinese Academy of Sciences (No.2017309)the Program for Innovative Research Team (in Science and Technology) in University of Henan Province of China (No.21IRTSTHN011)。
文摘Laser-accelerated high-flux-intensity heavy-ion beams are important for new types of accelerators.A particle-in-cell program(Smilei) is employed to simulate the entire process of Station of Extreme Light(SEL) 100 PW laser-accelerated heavy particles using different nanoscale short targets with a thickness of 100 nm Cr, Fe, Ag, Ta, Au, Pb, Th and U, as well as 200 nm thick Al and Ca. An obvious stratification is observed in the simulation. The layering phenomenon is a hybrid acceleration mechanism reflecting target normal sheath acceleration and radiation pressure acceleration, and this phenomenon is understood from the simulated energy spectrum,ionization and spatial electric field distribution. According to the stratification, it is suggested that high-quality heavy-ion beams could be expected for fusion reactions to synthesize superheavy nuclei. Two plasma clusters in the stratification are observed simultaneously, which suggest new techniques for plasma experiments as well as thinner metal targets in the precision machining process.
文摘For the discovery and analysis of Jebel Waqf as Suwwan (JWS) Impact Crater, Jordan pushed the authors to consequently focusing on other unusual geologic phenomena such as circular/oval structures (some of “crypto-volcanic” origin), disharmonic folding, horizontal stylolites, and a broad stripe of?Sanidine-Hornfels-Facies, all of them hosted in Upper Cretaceous/Paleogene carbonate rocks exposed across Jordan and adjacent areas. Shatter cones are the most useful tools during field work in the realm of circular structures. In addition to the impact-geologic data of JWS Impact Structure hitherto available, the cooling process of melted Lower Cretaceous Kurnub-Sandstone could be verified by microscopically identified SiO2-modifications between the melting point (1714°C) and low temperatures. In comparison with the Suffield 500 tons explosion tests [20] and with the Ries Impact Crater, Germany, excavation and vaporization processes of target rocks demand drilling between Central Uplift and Inner Ring of the JWS Impact Structure (“Chert-Carbonate-Impact-Chess Game”). In a scenario: “Impacting meets Plate Tectonics”, phenomena like disharmonic folding, horizontal stylolites, and an abundance of circular/oval structures of high diameter variation through northwest Jordan are discussed under aspects of gravitational gliding, effects of seismic surface waves (Love-), transpressional structures related to Jordan Rift-Tectonics, and possible impact processes of unknown number occurred on the Arabian Plate in southeastern direction with northwest-directed impulse. The so-called “Mottled Zone” of Jordan and Palestine owning a high number (~100) of mineral neoformations with formation temperatures up to ~1120°C(pseudo-wollastonite = β-CaSiO3), is to be interpreted as of “Sanidine-Hornfels-Impact Facies” under ricochet conditions along an “Avenue of Ricochet-Impact-Thermo-Cataclysm”. Marble-related travertines represent a low temperature facies of the impact event. The temporal projection of patterns like Rapid Climate Change (RCC), astrophysical data [Hoyle’s Comet: 47], acid events in ice-cores, tektite fall, Rise and Fall of Neolithic/Bronze Age Cultures, reveals an amazing “Ensemble” of coincidences among all of these parameters since the Middle/Upper Pleistocene boundary throughout Holocene. Ten short Interval Cases are discussed as being “Rare Event”- suspicious. Myths like the “Gilgamesch Epos” and “John’s Apocalypse” surprisingly provide realistic hints on impact events comparable with modern observations and experiments, which are: approach of extraterrestrial bodies, impact cratering, earthquakes and faulting, supercyclonic whirl-storms (wildfires), effects of hot ejecta, destruction of fauna, flora, and cities, long-lasting flooding, darkness caused by ashes and dust circulating in atmosphere and stratosphere (sintwinter), and environmental pollution. Such hints were handed down in myths of ~180 ethnic peoples around the globe. “High probability Cases” focus on impact events on ~9600 yr B.P and on ~6000 yr B.P. Other “Rare Events” may have possibly occurred about ~8000 yr B.P. and on ~3200 yr. B.P. (all radiocarbon yr.cal.). Core-drilling in the pull-apart basins of the Jordan Rift System (Dead Sea, Lake Tiberias) as traps having possibly preserved volcanic and impact ejecta would be a challenging international and interdisciplinary project.
基金the Basic Science Research Program(2018M3D1A1058744,2021R1A5A6002853,2021R1A2B5B03001615,and 2022M3J1A1085397)through the National Research Foundation of Korea(NRF)grant by the Korean Government(MSIT)provided by KISTI(KSC-2020-CRE-0301)supported by the Hyundai NGV program。
文摘Despite the enormous interest in inorganic/polymer composite solid-state electrolytes(CSEs)for solid-state batteries(SSBs),the underlying ion transport phenomena in CSEs have not yet been elucidated.Here,we address this issue by formulating a mechanistic understanding of bi-percolating ion channels formation and ion conduction across inorganic-polymer electrolyte interfaces in CSEs.A model CSE is composed of argyrodite-type Li_6PS_5Cl(LPSCl)and gel polymer electrolyte(GPE,including Li~+-glyme complex as an ion-conducting medium).The percolation threshold of the LPSCl phase in the CSE strongly depends on the elasticity of the GPE phase.Additionally,manipulating the solvation/desolvation behavior of the Li~+-glyme complex in the GPE facilitates ion conduction across the LPSCl-GPE interface.The resulting scalable CSE(area=8×6(cm×cm),thickness~40μm)can be assembled with a high-mass-loading LiNi_(0.7)Co_(0.15)Mn_(0.15)O_(2)cathode(areal-mass-loading=39 mg cm~(-2))and a graphite anode(negative(N)/positive(P)capacity ratio=1.1)in order to fabricate an SSB full cell with bi-cell configuration.Under this constrained cell condition,the SSB full cell exhibits high volumetric energy density(480 Wh L_(cell)~(-1))and stable cyclability at 25℃,far exceeding the values reported by previous CSE-based SSBs.
基金supported by the National Natural Science Foundation of China(22373104 and 22293024)the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(21821005)+1 种基金supported by the National Key Research and Development Program of China(2021YFE020527)support by the Distinguished Young Scholars of the National Natural Science Foundation of China(T2222022).
文摘Lymph node targeting is a commonly used strategy for particulate vaccines,particularly for Pickering emulsions.However,extensive research on the internal delivery mechanisms of these emulsions,especially the complex intercellular interactions of deformable Pickering emulsions,has been surprisingly sparse.This gap in knowledge holds significant potential for enhancing vaccine efficacy.This study aims to address this by summarizing the process of lymph-node-targeting transport and introducing a dissipative particle dynamics simulation method to evaluate the dynamic processes within cell tissue.The transport of Pickering emulsions in skeletal muscle tissue is specifically investigated as a case study.Various factors impacting the transport process are explored,including local cellular tissue environmental factors and the properties of the Pickering emulsion itself.The simulation results primarily demonstrate that an increase in radial repulsive interaction between emulsion particles can decrease the transport efficiency.Additionally,larger intercellular gaps also diminish the transport efficiency of emulsion droplet particles due to the increased motion complexity within the intricate transport space compared to a single channel.This study sheds light on the nuanced interplay between engineered and biological systems influencing the transport dynamics of Pickering emulsions.Such insights hold valuable potential for optimizing transport processes in practical biomedical applications such as drug delivery.Importantly,the desired transport efficiency varies depending on the specific application.For instance,while a more rapid transport might be crucial for lymph-node-targeted drug delivery,certain applications requiring a slower release of active components could benefit from the reduced transport efficiency observed with increased particle repulsion or larger intercellular gaps.