On the molecular level, it is believed that polymers containing zwitterionic structures should be compatible withblood. In this work polyurethane films were grafted with sulfobetaine by a three-step procedure. In the ...On the molecular level, it is believed that polymers containing zwitterionic structures should be compatible withblood. In this work polyurethane films were grafted with sulfobetaine by a three-step procedure. In the first step, the films'surfaces were treated with hexamethylene diisocyanate (HDI) in toluene at 50℃ in the presence of di-n-butyl tin dilaurate(DBTDL) as a catalyst. The extent of the reaction was monitored by ATR-IR spectra; a maximum number of free NCOgroups was obtained after a reaction time of 90 min. In the second step, the hydroxyl groups of N,N-dimethylethylethanolamine (DMEA) were allowed to react in toluene with NCO groups bound on the surface. In the thirdstep, sulfobetaines were formed on the surface through the ring-opening reaction between tertiary amine of DMEA and 1,3-propanesultone (PS). The surfaces of the films were characterized by ATR-IR and XPS showing that the grafted surfaceswere composed of sulfobetaine. The results of the contact angle measurement show that the surface was strongly hydrophilic.The platelet adhesion test demonstrated that the films grafted with sulfobetaine have excellent blood compatibility.展开更多
背景:作为骨科内植物的主要材料,钛及其合金在包括骨科在内的多个医学领域得到广泛的应用,内植物相关性感染也随之增多,采取不同的制备方法将优异且机制清楚的抗菌金属铜加入其中,在不影响生物力学性能的同时可使其具备一定的抗菌能力...背景:作为骨科内植物的主要材料,钛及其合金在包括骨科在内的多个医学领域得到广泛的应用,内植物相关性感染也随之增多,采取不同的制备方法将优异且机制清楚的抗菌金属铜加入其中,在不影响生物力学性能的同时可使其具备一定的抗菌能力。目的:综述医用含铜钛合金的抗菌性能研究进展及发展趋势。方法:应用计算机检索PubMed、Web of Science数据库中2003年1月至2022年3月的相关文献,检索词为“Titanium alloy,Copper,Antibacterial,Surface modification,Coating”,根据纳入排除标准对选定的76篇文献进行分析讨论。结果与结论:①加入铜的钛合金在体内外抗菌实验中均显示出良好的抗菌性能,并随着铜含量的提升其抗菌性能更加明显。②但目前仍存在较多问题有待解决:探索、优化加入铜的含量、方式及采取合适的制备工艺使合金的抗菌性能、生物相容性、机械性能达到平衡需要进一步的实验;表面改性对合金表面的微损伤是否会对合金造成不利影响;铜离子释放速率的控制以及如何避免早期突然大量释放铜离子的“突释现象”。展开更多
Initial bacterial adhesion on dental implant abutment is related to its surface chemical composition and physical characteristics.Selection of appropriate abutment materials resistant to bacterial adhesion is importan...Initial bacterial adhesion on dental implant abutment is related to its surface chemical composition and physical characteristics.Selection of appropriate abutment materials resistant to bacterial adhesion is important for dental implant maintenance.The aim of present study was to evaluate the effect of different properties of abutment materials on initial bacterial adhesion in vitro.Polished zirconia(PZ group), polished titanium(PT group) and ground titanium(GT group) samples were prepared to simulate clinical dental implant abutments.Chemical compositions, morphology, roughness, hydrophilicity and surface free energy of materials were analyzed.Oral commensal bacterium Streptococcus mitis was used to evaluate initial bacterial adhesion via turbidity test and colony-forming unit counting.The results showed that GT group presented the highest roughness, hydrophilicity and surface free energy.After 6-h incubation, GT group showed the significantly highest adhered bacteria counts;while non-significant difference existed between PT and PZ groups.Within the clinically applicable range used in present study, the surface physical characteristics, instead of surface chemical composition, of dental abutment material have the pronounced influence on initial 6-h bacterial adhesion.展开更多
基金Project of 973 State key Foundation Research and Development (No. 1999064705) sponsored and supported by Ministry of Science and Technology of China.
文摘On the molecular level, it is believed that polymers containing zwitterionic structures should be compatible withblood. In this work polyurethane films were grafted with sulfobetaine by a three-step procedure. In the first step, the films'surfaces were treated with hexamethylene diisocyanate (HDI) in toluene at 50℃ in the presence of di-n-butyl tin dilaurate(DBTDL) as a catalyst. The extent of the reaction was monitored by ATR-IR spectra; a maximum number of free NCOgroups was obtained after a reaction time of 90 min. In the second step, the hydroxyl groups of N,N-dimethylethylethanolamine (DMEA) were allowed to react in toluene with NCO groups bound on the surface. In the thirdstep, sulfobetaines were formed on the surface through the ring-opening reaction between tertiary amine of DMEA and 1,3-propanesultone (PS). The surfaces of the films were characterized by ATR-IR and XPS showing that the grafted surfaceswere composed of sulfobetaine. The results of the contact angle measurement show that the surface was strongly hydrophilic.The platelet adhesion test demonstrated that the films grafted with sulfobetaine have excellent blood compatibility.
文摘背景:作为骨科内植物的主要材料,钛及其合金在包括骨科在内的多个医学领域得到广泛的应用,内植物相关性感染也随之增多,采取不同的制备方法将优异且机制清楚的抗菌金属铜加入其中,在不影响生物力学性能的同时可使其具备一定的抗菌能力。目的:综述医用含铜钛合金的抗菌性能研究进展及发展趋势。方法:应用计算机检索PubMed、Web of Science数据库中2003年1月至2022年3月的相关文献,检索词为“Titanium alloy,Copper,Antibacterial,Surface modification,Coating”,根据纳入排除标准对选定的76篇文献进行分析讨论。结果与结论:①加入铜的钛合金在体内外抗菌实验中均显示出良好的抗菌性能,并随着铜含量的提升其抗菌性能更加明显。②但目前仍存在较多问题有待解决:探索、优化加入铜的含量、方式及采取合适的制备工艺使合金的抗菌性能、生物相容性、机械性能达到平衡需要进一步的实验;表面改性对合金表面的微损伤是否会对合金造成不利影响;铜离子释放速率的控制以及如何避免早期突然大量释放铜离子的“突释现象”。
基金financially supported by the National Yang-Ming University Hospital (Nos.RD 2011-009, RD 2012-021 and RD 2013-013), Taiwan
文摘Initial bacterial adhesion on dental implant abutment is related to its surface chemical composition and physical characteristics.Selection of appropriate abutment materials resistant to bacterial adhesion is important for dental implant maintenance.The aim of present study was to evaluate the effect of different properties of abutment materials on initial bacterial adhesion in vitro.Polished zirconia(PZ group), polished titanium(PT group) and ground titanium(GT group) samples were prepared to simulate clinical dental implant abutments.Chemical compositions, morphology, roughness, hydrophilicity and surface free energy of materials were analyzed.Oral commensal bacterium Streptococcus mitis was used to evaluate initial bacterial adhesion via turbidity test and colony-forming unit counting.The results showed that GT group presented the highest roughness, hydrophilicity and surface free energy.After 6-h incubation, GT group showed the significantly highest adhered bacteria counts;while non-significant difference existed between PT and PZ groups.Within the clinically applicable range used in present study, the surface physical characteristics, instead of surface chemical composition, of dental abutment material have the pronounced influence on initial 6-h bacterial adhesion.
