Objective The scientific community knows little about the long-term influence of coronavirus disease2019(COVID-19) on olfactory dysfunction(OD). With the COVID-19 pandemic ongoing worldwide, the risk of imported cases...Objective The scientific community knows little about the long-term influence of coronavirus disease2019(COVID-19) on olfactory dysfunction(OD). With the COVID-19 pandemic ongoing worldwide, the risk of imported cases remains high. In China, it is necessary to understand OD in imported cases.Methods A prospective follow-up design was adopted. A total of 11 self-reported patients with COVID-19 and OD from Xi’an No. 8 Hospital were followed between August 19, 2021, and December 12, 2021.Demographics, clinical characteristics, laboratory and radiological findings, and treatment outcomes were analyzed at admission. We surveyed the patients via telephone for recurrence and sequelae at the1-, 6-, and 12-month follow-up.Results Eleven patients with OD were enrolled;of these, 54.5%(6/11) had hyposmia and 45.5%(5/11)had anosmia. 63.6%(7/11) reported OD before or on the day of admission as their initial symptom;of these, 42.9%(3/7) described OD as the only symptom. All patients in the study received combined treatment with traditional Chinese medicine and Western medicine, and 72.7%(8/11) had partially or fully recovered at discharge. In terms of OD recovery at the 12-month follow-up, 45.5%(5/11) reported at least one sequela, 81.8%(9/11) had recovered completely, 18.2%(2/11) had recovered partially, and there were no recurrent cases.Conclusions Our data revealed that OD frequently presented as the initial or even the only symptom among imported cases. Most OD improvements occurred in the first 2 weeks after onset, and patients with COVID-19 and OD had favorable treatment outcomes during long-term follow-up. A better understanding of the pathogenesis and appropriate treatment of OD is needed to guide clinicians in the care of these patients.展开更多
The first imported Middle East respiratory syndrome （MERS） case in China was identified in May 2015. We determined the kinetics of antibody （IgG and IgM） and neutralizing antibodies against MERS-coronavirus （MERS...The first imported Middle East respiratory syndrome （MERS） case in China was identified in May 2015. We determined the kinetics of antibody （IgG and IgM） and neutralizing antibodies against MERS-coronavirus （MERS-CoV） in this case before discharge. Moreover, no seroconversion was found among 53 close contacts by anti-MERS IgG antibody enzyme-linked immunosorbent assay （ELISA） of paired serum samples. These findings suggest that neither community nor nosocomial transmission of MERS-CoV occurred in China.展开更多
In the era of coronavirus disease 2019(COVID-19)pandemic,imported COVID-19 cases pose great challenges to many countries.Chest CT examination is considered to be complementary to nucleic acid test for COVID-19 detecti...In the era of coronavirus disease 2019(COVID-19)pandemic,imported COVID-19 cases pose great challenges to many countries.Chest CT examination is considered to be complementary to nucleic acid test for COVID-19 detection and diagnosis.Wie report the first community infected COVID-19 patient by an imported case in Beijing,which manifested as nodular lesions on chest CT imaging at the early stage.Deep Learning(DL)-based diagnostic systems quantitatively monitored the progress of pulmonary lesions in 6 days and timely made alert for suspected pneumonia,so that prompt medical isolation was taken.The patient was confirmed as COVID-19 case after nucleic acid test,for which the community transmission was prevented timely.The roles of DL-assisted diagnosis in helping radiologists screening suspected COVID cases were discussed.展开更多
While the spread of COVID-19 in China is under control,the pandemic is developing rapidly around the world.Due to the normal migration of population,China is facing the high risk from imported cases.The potential spec...While the spread of COVID-19 in China is under control,the pandemic is developing rapidly around the world.Due to the normal migration of population,China is facing the high risk from imported cases.The potential specific medicine and vaccine are still in the process of clinical trials.Currently,controlling the impact of imported cases is the key to prevent new outbreak of COVID-19 in China.In this paper,we propose two impulsive systems to describe the impact of multilateral imported cases of COVID-19.Based on the published data,we simulate and analyze the epidemic trends under different control strategies.In particular,we compare four different scenarios and show the corresponding medical burden.The results can be useful in designing appropriate control strategy for imported cases in practice.展开更多
Objective: To ascertain the role of imported cases and serotypes on dengue outbreaks in Taiwan which have been sporadic yet highly volatile during the past two decades, exhibiting record-breaking magnitude in recent y...Objective: To ascertain the role of imported cases and serotypes on dengue outbreaks in Taiwan which have been sporadic yet highly volatile during the past two decades, exhibiting record-breaking magnitude in recent years. Methods: Confirmed case and serotype data from Taiwan Centers for Disease Control during 1998-2017 were fully examined, with fitting of weekly and daily case data of each city/county to a mathematical model to pinpoint the waves of cases and their locations. Moreover, we quantify the timing of turning point and transmission potential of each wave and determine its circulating serotype, to ascertain any pattern or connection between the variations in circulating serotypes and the magnitude/transmissibility of outbreak. Results: While the number of imported case increased steadily during past two decades, the yearly number of indigenous cases fluctuated wildly. Moreover, while yearly percentages of serotypes for imported cases remains steady, that of indigenous cases does not exhibit any clear pattern. There was at least one wave of reported cases somewhere in Taiwan every year from 1998 to 2015, except in 2016-2017. The effective reproduction number R for all waves in all locations ranged from 1.14 to 2.87, with the exception of two Tainan waves, in 2010(3.95) and 2015(6.84). Four major outbreaks of over 2000 cases reveal circulation of one dominant serotype. Conclusions: Correlation between imported cases and indigenous outbreak prove to be difficult to ascertain, even with the availability of serotype data. However, although there had been occasional co-circulation of serotypes in one location, and for some years with different serotypes circulating in different locations, all major outbreaks of over 2 000 cases during the past two decades are due to circulation of mainly a single serotype, perhaps indicating greater transmission potential with one dominating serotype.展开更多
基金funded by the COVID-19 Project of Shaanxi Administration of Traditional Chinese Medicine[SZY-KJCYC-2020-YJ002]the COVID-19 Project of National Administration of Traditional Chinese Medicine[2020ZYLCYJ06-4]and the CACMS Innovation Fund[CI2021A00704].
文摘Objective The scientific community knows little about the long-term influence of coronavirus disease2019(COVID-19) on olfactory dysfunction(OD). With the COVID-19 pandemic ongoing worldwide, the risk of imported cases remains high. In China, it is necessary to understand OD in imported cases.Methods A prospective follow-up design was adopted. A total of 11 self-reported patients with COVID-19 and OD from Xi’an No. 8 Hospital were followed between August 19, 2021, and December 12, 2021.Demographics, clinical characteristics, laboratory and radiological findings, and treatment outcomes were analyzed at admission. We surveyed the patients via telephone for recurrence and sequelae at the1-, 6-, and 12-month follow-up.Results Eleven patients with OD were enrolled;of these, 54.5%(6/11) had hyposmia and 45.5%(5/11)had anosmia. 63.6%(7/11) reported OD before or on the day of admission as their initial symptom;of these, 42.9%(3/7) described OD as the only symptom. All patients in the study received combined treatment with traditional Chinese medicine and Western medicine, and 72.7%(8/11) had partially or fully recovered at discharge. In terms of OD recovery at the 12-month follow-up, 45.5%(5/11) reported at least one sequela, 81.8%(9/11) had recovered completely, 18.2%(2/11) had recovered partially, and there were no recurrent cases.Conclusions Our data revealed that OD frequently presented as the initial or even the only symptom among imported cases. Most OD improvements occurred in the first 2 weeks after onset, and patients with COVID-19 and OD had favorable treatment outcomes during long-term follow-up. A better understanding of the pathogenesis and appropriate treatment of OD is needed to guide clinicians in the care of these patients.
基金Funds from the Nationl Health and Family Planning Commission of China:grants 2014ZX10004-001 and 2013ZX10004601
文摘The first imported Middle East respiratory syndrome （MERS） case in China was identified in May 2015. We determined the kinetics of antibody （IgG and IgM） and neutralizing antibodies against MERS-coronavirus （MERS-CoV） in this case before discharge. Moreover, no seroconversion was found among 53 close contacts by anti-MERS IgG antibody enzyme-linked immunosorbent assay （ELISA） of paired serum samples. These findings suggest that neither community nor nosocomial transmission of MERS-CoV occurred in China.
文摘In the era of coronavirus disease 2019(COVID-19)pandemic,imported COVID-19 cases pose great challenges to many countries.Chest CT examination is considered to be complementary to nucleic acid test for COVID-19 detection and diagnosis.Wie report the first community infected COVID-19 patient by an imported case in Beijing,which manifested as nodular lesions on chest CT imaging at the early stage.Deep Learning(DL)-based diagnostic systems quantitatively monitored the progress of pulmonary lesions in 6 days and timely made alert for suspected pneumonia,so that prompt medical isolation was taken.The patient was confirmed as COVID-19 case after nucleic acid test,for which the community transmission was prevented timely.The roles of DL-assisted diagnosis in helping radiologists screening suspected COVID cases were discussed.
基金National Natural Science Foundation of China(Grant Nos.41704116,11901234,11926104)Jilin Provincial Excellent Youth Talents Foundation(Grant No.20180520093JH)+1 种基金Scientific Research Project of Education Department of Jilin Province(Grant No.JJKH20200933KJ)Scientific Research Project of Shanghai Science and Technology Commission(Grant No.19511132000)。
文摘While the spread of COVID-19 in China is under control,the pandemic is developing rapidly around the world.Due to the normal migration of population,China is facing the high risk from imported cases.The potential specific medicine and vaccine are still in the process of clinical trials.Currently,controlling the impact of imported cases is the key to prevent new outbreak of COVID-19 in China.In this paper,we propose two impulsive systems to describe the impact of multilateral imported cases of COVID-19.Based on the published data,we simulate and analyze the epidemic trends under different control strategies.In particular,we compare four different scenarios and show the corresponding medical burden.The results can be useful in designing appropriate control strategy for imported cases in practice.
基金supported by funding from grants from Taiwan Ministry of Science and Technology(MOST 103-2314-B-039-010-MY3)China Medical UniversityTaiwan(CMU106-S-02)
文摘Objective: To ascertain the role of imported cases and serotypes on dengue outbreaks in Taiwan which have been sporadic yet highly volatile during the past two decades, exhibiting record-breaking magnitude in recent years. Methods: Confirmed case and serotype data from Taiwan Centers for Disease Control during 1998-2017 were fully examined, with fitting of weekly and daily case data of each city/county to a mathematical model to pinpoint the waves of cases and their locations. Moreover, we quantify the timing of turning point and transmission potential of each wave and determine its circulating serotype, to ascertain any pattern or connection between the variations in circulating serotypes and the magnitude/transmissibility of outbreak. Results: While the number of imported case increased steadily during past two decades, the yearly number of indigenous cases fluctuated wildly. Moreover, while yearly percentages of serotypes for imported cases remains steady, that of indigenous cases does not exhibit any clear pattern. There was at least one wave of reported cases somewhere in Taiwan every year from 1998 to 2015, except in 2016-2017. The effective reproduction number R for all waves in all locations ranged from 1.14 to 2.87, with the exception of two Tainan waves, in 2010(3.95) and 2015(6.84). Four major outbreaks of over 2000 cases reveal circulation of one dominant serotype. Conclusions: Correlation between imported cases and indigenous outbreak prove to be difficult to ascertain, even with the availability of serotype data. However, although there had been occasional co-circulation of serotypes in one location, and for some years with different serotypes circulating in different locations, all major outbreaks of over 2 000 cases during the past two decades are due to circulation of mainly a single serotype, perhaps indicating greater transmission potential with one dominating serotype.
